A. Heckel

发表

BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.

W. Sommergruber, F. Hilberg, Ulrike Tontsch-Grunt, 2008, Cancer research.

Phenocopy – A Strategy to Qualify Chemical Compounds during Hit-to-Lead and/or Lead Optimization

Roland Eils, Florian Gantner, Werner Rust, 2010, PloS one.

Crystal structure of glucokinase regulatory protein.

A. Pautsch, H. Nar, S. Kauschke, 2013, Biochemistry.

Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120).

F. Hilberg, Ulrike Tontsch-Grunt, F. Colbatzky, 2009, Journal of medicinal chemistry.

6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors.

T. Müller, A. Heckel, H. Weisenberger, 1994, Journal of medicinal chemistry.

Modulation of multidrug resistance by BIBW22BS in blasts of de novo or relapsed or persistent acute myeloid leukemia ex vivo

S. Seeber, M. Scheulen, A. Heckel, 2005, Journal of Cancer Research and Clinical Oncology.

In Vitro Modulation of Multidrug Resistance by BIBW22BS in Blasts of De Novo or Relapsed or Persistent AML

S. Seeber, M. Scheulen, A. Heckel, 1996 .

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

J. Peters, C. Rieder, R. Cole, 2003, The Journal of cell biology.

Lumazinesulfenates - a new class of stable sulfenic acids

A. Heckel, W. Pfleiderer, 1984 .

BIBW 22, a dipyridamole analogue, acts as a bifunctional modulator on tumor cells by influencing both P-glycoprotein and nucleoside transport.

Y. Cheng, A. Heckel, H. X. Chen, 1993, Cancer research.

Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction

Jochen H Weishaupt, F. Gillardon, A. Heckel, 2003, Molecular and Cellular Neuroscience.

BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells.

E. Georges, A. Heckel, J. Pouliot, 1996, Molecular Pharmacology.

Energetics of the structure and chain tilting of antiparallel β‐barrels in proteins

H. Scheraga, G. Némethy, K. Chou, 1990, Proteins.

Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist.

H. Nar, A. Heckel, Stefan Hoerer, 2004, Journal of molecular biology.

Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI).

D. Mennerich, A. Schnapp, G. Roth, 2010, Journal of medicinal chemistry.

Prediction of the three-dimensional structure of the enzymatic domain of t-PA

A. Heckel, K. M. Hasselbach, A. Heckel, 1988, J. Comput. Aided Mol. Des..

Biochemical modulation of 'classical' multidrug resistance by BIBW22BS, a potent derivative of dipyridamole.

H. Pinedo, A. Heckel, W. Jansen, 1994, Annals of oncology : official journal of the European Society for Medical Oncology.