V. Gokhale

发表

The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4.

L. Hurley, Adam Siddiqui-Jain, Jeyaprakashnarayanan Seenisamy, 2004, Journal of the American Chemical Society.

Psorospermin structural requirements for P-glycoprotein resistance reversal

L. Hurley, V. Gokhale, S. Carey, 2008, Molecular Cancer Therapeutics.

Identification of a novel inhibitor of urokinase-type plasminogen activator

D. V. Von Hoff, L. Hurley, Hyounggee Baek, 2007, Molecular Cancer Therapeutics.

A simple mathematical approach to the analysis of polypharmacology and polyspecificity data

G. Maggiora, V. Gokhale, 2017, F1000Research.

Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid derivatives.

N. Raghunand, Dezheng Zhao, V. Gokhale, 2012, Journal of medicinal chemistry.

Understanding the antifungal activity of terbinafine analogues using quantitative structure-activity relationship (QSAR) models.

V. Kulkarni, V. Gokhale, 2000, Bioorganic & medicinal chemistry.

Non-specificity of drug-Target interactions - Consequences for drug discovery

G. Maggiora, V. Gokhale, 2016 .

Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4

L. Hurley, E. M. Rezler, V. Gokhale, 2007, Nucleic acids research.

Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents

A. Hohmann, M. Patek, M. Khanna, 2021, Science Translational Medicine.

In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells

David W. Lee, R. Arceci, C. Wetmore, 2019, BMC Cancer.

An N-ethyl-N-nitrosourea-induced mutation in N-acetyltransferase 1 in mice.

Y. Sakaki, A. Toyoda, Y. Gondo, 2008, Biochemical and biophysical research communications.

Discovery of a novel class of AKT pleckstrin homology domain inhibitors

Lei Du-Cuny, Benjamin George, Nikhil Shirahatti, 2008, Molecular Cancer Therapeutics.

Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers

E. Meuillet, V. Gokhale, Hui-Hua Chang, 2012, Investigational New Drugs.

Design, synthesis, and evaluation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid derived, redox-sensitive contrast agents for magnetic resonance imaging.

N. Raghunand, V. Gokhale, G. Nichol, 2010, Journal of medicinal chemistry.

Homology‐guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2‐derived peptides

Yue Wang, M. Khanna, R. Khanna, 2018, British journal of pharmacology.

Remodeling the interactions between TDP43 and RNA for development of therapeutics for ALS

D. Zarnescu, M. Khanna, V. Gokhale, 2019, The FASEB Journal.

Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth.

L. Rimsza, L. Hurley, V. Gokhale, 2017, Journal of medicinal chemistry.

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

C. Dominguez, I. Eperon, L. Hurley, 2017, Nucleic acids research.

G-Quadruplex-Mediated Transcriptional Regulation of PDGFR-β

V. Gokhale, Christine E. Kaiser, 2014 .

Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death.

Hyun-Jin Kang, A. Kraft, Jin H. Song, 2019, Cell chemical biology.

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex–interactive agents

L. Hurley, S. Ebbinghaus, V. Gokhale, 2008, Molecular Cancer Therapeutics.

Small Molecule Targeting TDP-43’s RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)

M. Khanna, R. Khanna, V. Gokhale, 2019 .

Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.

Vijay Gokhale, Kazuo Shin-Ya, Daekyu Sun, 2005, Journal of the American Chemical Society.

Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors.

Justin D Dietrich, L. Hurley, Xiadong Wang, 2010, Bioorganic & medicinal chemistry.

Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.

Justin D Dietrich, C. Hulme, E. Meuillet, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.

Justin D Dietrich, C. Hulme, E. Meuillet, 2013, Bioorganic & medicinal chemistry letters.

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme–CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain

Yue Wang, M. Khanna, R. Khanna, 2018, Pain.

Comparative molecular field analysis of fungal squalene epoxidase inhibitors.

V. Kulkarni, V. Gokhale, 1999, Journal of medicinal chemistry.

Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus 1

L. Hurley, M. Scalabrin, V. Gokhale, 2022, Antiviral research.

Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene

L. Hurley, V. Gokhale, K. Guo, 2008, Nucleic acids research.

Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene.

L. Hurley, V. Gokhale, K. Guo, 2007, Journal of the American Chemical Society.

Selectivity analysis of 5-(arylthio)-2,4-diaminoquinazolines as inhibitors of Candida albicans dihydrofolate reductase by molecular dynamics simulations

Vithal M. Kulkarni, Vijay M. Gokhale, V. Kulkarni, 2000, J. Comput. Aided Mol. Des..

A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters.

J. Trent, Hyun-Jin Kang, H. Mao, 2016, Journal of the American Chemical Society.

TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors

J. Schatz, V. Gokhale, Mengdie Wang, 2016, Oncotarget.

The Quinone Methide Aurin Is a Heat Shock Response Inducer That Causes Proteotoxic Stress and Noxa-dependent Apoptosis in Malignant Melanoma Cells*

G. Wondrak, Montserrat Rojo de la Vega, V. Gokhale, 2014, The Journal of Biological Chemistry.

Tertiary DNA structure in the single-stranded hTERT promoter fragment unfolds and refolds by parallel pathways via cooperative or sequential events.

Zhongbo Yu, Vijay Gokhale, Hyun-Jin Kang, 2012, Journal of the American Chemical Society.

Demonstration that Drug-targeted Down-regulation of MYC in Non-Hodgkins Lymphoma Is Directly Mediated through the Promoter G-quadruplex*

L. Hurley, V. Gokhale, T. Brooks, 2011, The Journal of Biological Chemistry.

Correction to “The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure”

Hyun-Jin Kang, Danzhou Yang, S. Hecht, 2016, Journal of the American Chemical Society.

The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure

Hyun-Jin Kang, Danzhou Yang, S. Hecht, 2014, Journal of the American Chemical Society.

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1

Lauren B. Murata, L. Hurley, E. Meuillet, 2009, Molecular Cancer Therapeutics.

PRL phosphatases as potential molecular targets in cancer

D. V. Von Hoff, Haiyong Han, B. Stephens, 2005, Molecular Cancer Therapeutics.

The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downre

Danzhou Yang, L. Hurley, S. Camp, 2017, Journal of the American Chemical Society.

Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter.

L. Hurley, V. Gokhale, S. Hahn, 2012, Journal of medicinal chemistry.

Structure–Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants

Y. Ishii, S. Dudek, B. Santarsiero, 2015, PloS one.

Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?

T. Dunckley, C. Hulme, V. Gokhale, 2012, ACS chemical neuroscience.

Beyond secretases: Kinase inhibitors for the treatment of Alzheimer's disease

T. Dunckley, C. Hulme, A. Shaw, 2013 .

A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

T. Hughes, Q. Morris, D. Ray, 2018, ACS chemical biology.

A small molecule targeting TDP-43's RNA recognition motifs reduces locomotor defects in a Drosophila model of ALS.

Daniela C. Zarnescu, D. Zarnescu, M. Khanna, 2019, ACS chemical biology.

Regulation of the activity of the tumor suppressor PTEN by thioredoxin in Drosophila melanogaster.

E. Meuillet, V. Gokhale, M. Brabant, 2007, Experimental cell research.

Dyrk1 inhibition improves Alzheimer's disease‐like pathology

T. Dunckley, C. Hulme, A. Shaw, 2017, Aging cell.

Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay.

Danzhou Yang, L. Hurley, V. Gokhale, 2013, Topics in current chemistry.

Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.

Ki Duk Park, M. Khanna, R. Khanna, 2019, Pain.

Targeting the CaVα-β interaction yields a selective antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy

Ki Duk Park, M. Khanna, R. Khanna, 2018, bioRxiv.

mPGES-1 as a target for cancer suppression: A comprehensive invited review "Phospholipase A2 and lipid mediators".

D. Rosenberg, E. Meuillet, M. Nakanishi, 2010, Biochimie.

Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex

E. M. Reyes-Reyes, L. Hurley, C. Miranti, 2020, Oncotarget.

Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c.

Srinivas Malladi, T. Monks, S. Lau, 2007, Biochemistry.

Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels

M. Khanna, R. Khanna, V. Gokhale, 2018, Channels.

In Silico Targeting of the Long Noncoding RNA MALAT1.

M. Khanna, V. Gokhale, L. François-Moutal, 2021, ACS medicinal chemistry letters.

An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties.

M. Khanna, V. Gokhale, S. Barmada, 2020, ACS chemical biology.

Tertiary DNA structure in the single-stranded hTERT promoter fragment unfolds and refolds by parallel pathways via cooperative or sequential events.

Hyun-Jin Kang, H. Mao, L. Hurley, 2012, Journal of the American Chemical Society.

The Quinone Methide Aurin Is a Heat Shock Response Inducer That Causes Proteotoxic Stress and Noxa-dependent Apoptosis in Malignant Melanoma Cells*

G. Wondrak, Montserrat Rojo de la Vega, V. Gokhale, 2014, The Journal of Biological Chemistry.

Small Molecule Targeting TDP-43’s RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)

M. Khanna, R. Khanna, V. Gokhale, 2019 .