E. Gullen

发表

The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity

Yung-chi Cheng, W. Lam, S. Bussom, 2010, Science Translational Medicine.

Analysis of deoxyribonucleotide pools in human cancer cell lines using a liquid chromatography coupled with tandem mass spectrometry technique.

Yung-chi Cheng, E. Chu, Wei Zhang, 2011, Biochemical pharmacology.

Synthesis and biological evaluation of a series of 2'-fluorinated-2',3'-dideoxy-2',3'-didehydro-(L)-nucleosides.

Y. Cheng, T. Doyle, E. Gullen, 1998, Bioorganic & medicinal chemistry letters.

Methylenecyclopropane analogues of nucleosides: synthesis, absolute configuration, and enantioselectivity of antiviral effect of (R)-(-)- and (S)-(+)-synadenol.

R. Ptak, A. Camerman, N. Camerman, 1999, Nucleosides & nucleotides.

New and bioactive natural products from an endophyte of Panax notoginseng

Yung-chi Cheng, Yi-Xuan Zhang, E. Gullen, 2017 .

Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors.

H. Hsieh, Jen‐Shin Song, Yu-Wei Liu, 2015, Journal of medicinal chemistry.

Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents.

S. Bussom, E. Gullen, Samson Francis, 2007, Bioorganic & medicinal chemistry letters.

Impacts of baicalein analogs with modification of the 6th position of A ring on the activity toward NF-kappaB-, AP-1-, or CREB-mediated transcription.

Yashang Lee, E. Gullen, Yung‐chi Cheng, 2008, Bioorganic & medicinal chemistry letters.

Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication

Sangwon Lee, Y. Ha, A. Fürstner, 2017, Scientific Reports.

Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold.

A. Hamilton, E. Gullen, M. Telpoukhovskaia, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of 2′,3′-Didehydro-2′,3′-Dideoxy-9-Deazaguanosine, a Monophosphate Prodrug and Two Analogues, 2′,3′-Dideoxy-9-Deazaguanosine and 2′,3′-Didehydro-2′,3′-Dideoxy-9-Deazainosine

A. Sartorelli, E. Gullen, G. Dutschman, 2005, Nucleosides, nucleotides & nucleic acids.

Mechanism of Anti-Human Immunodeﬁciency Virus Activity of (cid:2) - D -6-Cyclopropylamino-2 (cid:3) ,3 (cid:3) -Didehydro-2 (cid:3) ,3 (cid:3) -Dideoxyguanosine

K. Anderson, R. Schinazi, C. K. Chu, 2005 .

Favorable interaction of beta-L(-) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus.

Y. Cheng, E. Gullen, E. Bridges, 1996, Biochemical pharmacology.

Synthesis and anti-HIV activity of 4'-substituted 4'-thiothymidines: a new entry based on nucleophilic substitution of the 4'-acetoxy group.

M. Baba, E. Gullen, K. Haraguchi, 2008, Journal of medicinal chemistry.

Design and Synthesis of 2‘,3‘-Dideoxy- 2‘,3‘-didehydro-β-l-cytidine (β-l-d4C) and 2‘,3‘-Dideoxy-2‘,3‘-didehydro-β-l-5- fluorocytidine (β-l-Fd4C), Two Exceptionally Potent Inhibitors of Human Hepatitis B Virus (HBV) and Potent Inhibitors of Human Immunodeficiency Virus (HIV) in Vitro

E. Gullen, G. Dutschman, Tai-shun Lin, 1996 .

Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2', 3'-unsaturated L-nucleosides.

R. Schinazi, Y. Cheng, C. K. Chu, 1999, Journal of medicinal chemistry.

Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.

E. Gullen, E. Kern, Zhaohua Yan, 2005, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of 1,3-Oxathiolane 5-Azapyrimidine, 6-Azapyrimidine, and Fluorosubstituted 3-Deazapyrimidine Nucleosides

Maohui Luo, A. Sartorelli, E. Gullen, 2000, Nucleosides, Nucleotides & Nucleic Acids.

(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.

H. Mitsuya, E. Gullen, E. Kern, 2004, Journal of medicinal chemistry.

Inhibition of Hepatitis B Virus Gene Expression and Replication by Helioxanthin and its Derivative

Y. Li, D. Austin, C. Chou, 2005, Antiviral chemistry & chemotherapy.

Synthesis and antiviral activity of helioxanthin analogues.

E. Huang, D. Austin, Yashang Lee, 2005, Journal of medicinal chemistry.

Novel Role of 3-Phosphoglycerate Kinase, a Glycolytic Enzyme, in the Activation of L-Nucleoside Analogs, a New Class of Anticancer and Antiviral Agents*

Elizabeth A. Gullen, Wing Lam, W. Lam, 2003, Journal of Biological Chemistry.

Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.

Y. Cheng, C. K. Chu, E. Gullen, 2000, Journal of medicinal chemistry.

Structural analogs of tylophora alkaloids may not be functional analogs.

C. Leung, A. Fürstner, K. Lee, 2008, Bioorganic & medicinal chemistry letters.

9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.

H. Mitsuya, E. Gullen, E. Kern, 2006, Journal of medicinal chemistry.

Synthesis and antiviral activity of oxaselenolane nucleosides.

S. Olgen, R. Schinazi, Y. Cheng, 2000, Journal of medicinal chemistry.

Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.

E. Gullen, E. Kern, J. Breitenbach, 2004, Journal of medicinal chemistry.

Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino-4'-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents.

C. Leung, Shin-Young Park, Hao Zhu, 2012, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of L- and D-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides.

A. Sartorelli, Y. Cheng, T. Lin, 2000, Bioorganic & medicinal chemistry letters.

Novel 4′-Substituted Stavudine Analog with Improved Anti-Human Immunodeficiency Virus Activity and Decreased Cytotoxicity

M. Baba, E. Gullen, S. Grill, 2004, Antimicrobial Agents and Chemotherapy.

Synthesis and comparative evaluation of two antiviral agents: β-l-Fd4C and β-d-Fd4C

T. Doyle, E. Gullen, Stanley L. Lin, 1998 .

Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library.

Hui Yang, Dik-Lung Ma, Daniel Shiu-Hin Chan, 2014, Chemical communications.

Design and Synthesis of 2′,3′‐Dideoxy‐2′,3′‐didehydro‐β‐L‐ cytidine (β‐L‐d4C) and 2′,3′‐Dideoxy‐2′,3′‐didehydro‐β‐L‐5‐ fluorocytidine (β‐L‐Fd4C), Two Exceptionally Potent Inhibitors of Human Hepatitis B Virus (HBV) and Potent Inhibitors of Human Immunodeficiency Virus (HIV) in vitro.

E. Gullen, G. Dutschman, M. Luo, 1996 .

Metabolism of 2′,3′-Dideoxy-2′,3′-Didehydro-β-l(−)-5-Fluorocytidine and Its Activity in Combination with Clinically Approved Anti-Human Immunodeficiency Virus β-d(+) Nucleoside Analogs In Vitro

M. Kukhanova, E. Gullen, Shwu-Huey Liu, 1998, Antimicrobial Agents and Chemotherapy.

Structure-activity relationships of L-dioxolane uracil nucleosides as anti-Epstein Barr virus agents.

Y. Cheng, C. K. Chu, E. Gullen, 1999, Journal of medicinal chemistry.

Structure-activity relationships of (S,Z)-2-aminopurine methylenecyclopropane analogues of nucleosides. Variation of purine-6 substituents and activity against herpesviruses and hepatitis B virus.

E. Gullen, E. Kern, J. Drach, 2003, Journal of medicinal chemistry.

Synthesis of 4'-Ethynyl-2'-deoxy-4'-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI.

M. Baba, J. Balzarini, H. Abe, 2011, ACS medicinal chemistry letters.

Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine

K. Anderson, H. McClure, R. Schinazi, 2005, Antimicrobial Agents and Chemotherapy.

Favorable interaction of β-l(−) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus

E. Gullen, E. Bridges, G. Dutschman, 1996 .

Synthesis and Enantioselectivity of the Antiviral Effects of (R,Z)-,(S,Z)-methylenecyclopropane Analogues of Purine Nucleosides and Phosphoralaninate Prodrugs: Influence of Heterocyclic Base, Type of Virus and Host Cells

E. Gullen, Y. Qiu, J. Žemlička, 2000, Antiviral chemistry & chemotherapy.

A Novel Class of meso-Tetrakis-Porphyrin Derivatives Exhibits Potent Activities against Hepatitis C Virus Genotype 1b Replicons In Vitro

B. Lindenbach, A. Hamilton, E. Gullen, 2009, Antimicrobial Agents and Chemotherapy.

Synthesis and Biological Evaluation of L‐ and D‐Configurations of 2′,3′‐Dideoxy‐4′‐C‐methyl‐3′‐oxacytidine Analogues.

Maohui Luo, A. Sartorelli, Y. Cheng, 2001 .

Metabolism and mode of inhibition of varicella-zoster virus by L-beta-5-bromovinyl-(2-hydroxymethyl)-(1,3-dioxolanyl)uracil is dependent on viral thymidine kinase.

Y. Cheng, C. K. Chu, E. Gullen, 2000, Molecular pharmacology.

Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides.

E. Gullen, E. Kern, L. Polin, 2006, Bioorganic & medicinal chemistry.

(R)-(-)- and (S)-(+)-Synadenol: synthesis, absolute configuration, and enantioselectivity of antiviral effect.

R. Ptak, A. Camerman, N. Camerman, 1998, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of L‐ and D‐Configurations of 2′,3′‐Dideoxy‐4′‐C‐methyl‐3′‐oxacytidine Analogues.

A. Sartorelli, E. Gullen, G. Dutschman, 2001 .

SYNTHESIS OF HALOGEN-SUBSTITUTED 3-DEAZAADENOSINE AND 3-DEAZAGUANOSINE ANALOGUES AS POTENTIAL ANTITUMOR/ANTIVIRAL AGENTS

A. Sartorelli, E. Gullen, G. Dutschman, 2001, Nucleosides, nucleotides & nucleic acids.

Phosphoralaninate Pronucleotides of Pyrimidine Methylenecyclopropane Analogues of Nucleosides: Synthesis and Antiviral Activity

E. Gullen, E. Kern, J. Drach, 2005, Nucleosides, nucleotides & nucleic acids.

Synthesis and Biological Evaluation of 1,3-Oxathiolane 5-Azapyrimidine, 6-Azapyrimidine, and Fluorosubstituted 3-Deazapyrimidine Nucleosides.

A. Sartorelli, E. Gullen, G. Dutschman, 2000 .

Butyrate mediates nucleotide‐binding and oligomerisation domain (NOD) 2‐dependent mucosal immune responses against peptidoglycan

C. Leung, Dik‐Lung Ma, W. Lam, 2009, European journal of immunology.

Cryptopleurine Analogs with Modification of E Ring Exhibit Different Mechanism to Rac-Cryptopleurine and Tylophorine

K. Lee, W. Lam, E. Gullen, 2012, PloS one.

Study of Malformin C, a Fungal Source Cyclic Pentapeptide, as an Anti-Cancer Drug

C. Zeiss, Chunfu Wu, Ee-chun Cheng, 2015, PloS one.

Promotion of quality standard of Chinese herbal medicine by the integrated and efficacy-oriented quality marker of Effect-constituent Index.

Yin Xiong, Qin Dong, Jiabo Wang, 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.