C. Thomsen

发表

The role of the innate immune system in psychiatric disorders

K. Jones, C. Thomsen, 2013, Molecular and Cellular Neuroscience.

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

Terri L. Gilbert, E. Mulvihill, P. O'Hara, 1993, Neuron.

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB‐1893 and MPEP

J. M. Mathiesen, H. Bräuner‐Osborne, C. Thomsen, 2003, British journal of pharmacology.

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.

F. Gasparini, L. Prézeau, I. Vranesic, 1999, Molecular pharmacology.

Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.

A. Ritzén, J. M. Mathiesen, C. Thomsen, 2005, Basic & clinical pharmacology & toxicology.

Novel heterocyclic compounds as mGlu5 antagonists: WO2009015897

D. Doller, C. Thomsen, R. Brodbeck, 2010, Expert opinion on therapeutic patents.

Phenylglycines can Evoke Quisqualate‐primed Depolarizations in Rat Cingulate Cortex: An Effect Associated with [3H]DL‐AP4 Uptake

C. Thomsen, M. Sheardown, 1996, The European journal of neuroscience.

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Caleb Webber, Guy B. Williams, Mara Cercignani, 2019, Brain : a journal of neurology.

Lu 28-179 labels a σ2-site in rat and human brain

J. Mikkelsen, C. Thomsen, K. K. Søby, 2002, Neuropharmacology.

Rescue of hippocampal LTP and learning deficits in a rat model of psychosis by inhibition of glycine transporter‐1 (GlyT1)

D. Manahan‐Vaughan, C. Thomsen, Verena Wildförster, 2008, The European journal of neuroscience.

Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands.

G. Costantino, R. Pellicciari, C. Thomsen, 2006, Bioorganic & medicinal chemistry.

Asc‐1 Transporter Regulation of Synaptic Activity via the Tonic Release of d‐Serine in the Forebrain

J. Billard, C. Bundgaard, C. Christoffersen, 2016, Cerebral cortex.

The synthesis and biochemical evaluation of new A1 selective adenosine receptor agonists containing 6-hydrazinopurine moieties

C. Thomsen, M. Sheardown, J. Lau, 1993 .

Contrasting effects of adenosine A1 and A2 receptor ligands in different chemoconvulsive rodent models.

C. Thomsen, H. Klitgaard, L. Knutsen, 1993, European journal of pharmacology.

Adenosine A1 and A3 selective N‐alkoxypurines as novel cytokine modulators and neuroprotectants

C. Thomsen, M. Sheardown, S. Roberts, 1998 .

Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.

C. Christoffersen, R. Pellicciari, A. Macchiarulo, 2009, Bioorganic & medicinal chemistry.

Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist.

G. Costantino, F. Moroni, B. Natalini, 1996, Journal of medicinal chemistry.

Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells.

F. Bymaster, A. Fink-Jensen, C. Mitch, 1998, Biochemical and biophysical research communications.

Increased insulin secretion and normalization of glucose tolerance by cholinergic agonism in high fat-fed mice.

B. Ahrén, C. Thomsen, P. Sauerberg, 1999, The American journal of physiology.

Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.

F. Gasparini, P. Flor, G. Costantino, 2007, Bioorganic & medicinal chemistry.

(S)‐Carboxy‐3‐Hydroxyphenylglycine, an Antagonist of Metabotropic Glutamate Receptor (mGluR)1a and an Agonist of mGluR2, Protects Against Audiogenic Seizures in DBA/2 Mice

P. Suzdak, H. Jackson, C. Thomsen, 1994, Journal of neurochemistry.

4-Carboxy-3-hydroxyphenylglycine, an antagonist at type I metabotropic glutamate receptors.

P. Suzdak, C. Thomsen, 1993, European journal of pharmacology.

L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type iv metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

P. Suzdak, E. Mulvihill, P. Kristensen, 1992 .

Development of 123I-labelled NNC 13-8241 as a radioligand for SPECT visualization of benzodiazepine receptor binding.

C. Halldin, T. Suhara, L. Farde, 1996, Nuclear medicine and biology.

Cloning and Characterization of a Metabotropic Glutamate Receptor, mGluR4b

P. O'Hara, D. Hampson, C. Thomsen, 1997, Neuropharmacology.

A highly selective agonist for the metabotropic glutamate receptor mGluR2

J. Greenwood, P. Norrby, R. Clausen, 2011 .

(8‐Naphthalen‐1‐ylmethyl‐4‐oxo‐1‐phenyl‐1,3,8‐triaza‐spiro[4.5]dec‐3‐yl)‐acetic acid methyl ester (NNC 63‐0532) is a novel potent nociceptin receptor agonist

C. Thomsen, R. Hohlweg, 2000, British journal of pharmacology.

Synthesis of 3‐Hydroxy‐ and 3‐Carboxy‐Δ2‐isoxazoline Amino Acids and Evaluation of Their Interaction with GABA Receptors and Transporters

A. Pinto, L. Tamborini, P. Conti, 2006 .

ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation.

A. Hansen, J. Lundbaek, C. Thomsen, 2002, European journal of pharmacology.

Pentylenetetrazol-induced seizures increase [3H]L-2-amino-4-phosphonobutyrate binding in discrete regions of the rat brain

C. Thomsen, 1999, Neuroscience Letters.

Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor.

P. Suzdak, C. Thomsen, 1993, Neuroreport.

New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.

J. Pin, T. Gefflaut, L. Bunch, 2016, Journal of medicinal chemistry.

Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family.

P. Suzdak, E. Boel, C. Thomsen, 1994, European journal of pharmacology.

The effect of lorazepam tolerance and withdrawal on metabotropic glutamate receptor function.

P. Suzdak, M. Mortensen, C. Thomsen, 1995, The Journal of pharmacology and experimental therapeutics.

1‐(3‐(9H‐Carbazol‐9‐yl)‐1‐propyl)‐4‐(2‐methoxyphenyl)‐4‐piperidinol, a novel subtype selective inhibitor of the mouse type II GABA‐transporter

C. Thomsen, J. Egebjerg, P. O. Sørensen, 1997, British journal of pharmacology.

Preparative resolution of 1-aminoindan-1,5-dicarboxylic acid (AIDA) by chiral ligand-exchange chromatography.

B. Natalini, R. Pellicciari, C. Thomsen, 2004, Chirality.

Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.

G. Costantino, R. Pellicciari, C. Thomsen, 2006, Bioorganic & medicinal chemistry letters.

Metabotropic glutamate receptor subtype 1a activates adenylate cyclase when expressed in baby hamster kidney cells

C. Thomsen, 1996, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Enhanced type 1alpha metabotropic glutamate receptor-stimulated phosphoinositide signaling after pertussis toxin treatment.

R. Challiss, R. Mistry, C. Thomsen, 1997, Molecular pharmacology.

Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist.

G. Lombardi, F. Moroni, R. Pellicciari, 1997, The Journal of pharmacology and experimental therapeutics.

Molecular Cloning, Expression, and Characterization of Metabotropic Glutamate Receptor Subtypes

P. Suzdak, E. Mulvihill, P. Kristensen, 1994 .

The L-AP4 receptor.

C. Thomsen, Christian Thomsen, 1997, General pharmacology.

Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA)

J. Wroblewski, Shaomeng Wang, A. Kozikowski, 1996 .

Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress.

Thomas Farkas, M. Jäättelä, M. Høyer-Hansen, 2005, Cancer research.

The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles.

C. Thomsen, S. Roberts, L. Knutsen, 1998, Bioorganic & medicinal chemistry letters.

Characterization of [3H]‐N‐[R‐(2‐ Benzothiazolyl)thio‐2‐propyl]‐2‐chloroadenosine ([3H]‐NNC 21‐0136) binding to rat brain: Profile of a novel selective agonist for adenosine A1 receptors

C. Foged, C. Thomsen, L. Knutsen, 1997 .

Anticonvulsant Actions of Novel and Reference Adenosine Agonists

M. Judge, J. Weis, C. Thomsen, 1995 .

(S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist.

M. Raimondo, G. Costantino, B. Natalini, 1996, Journal of medicinal chemistry.

1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors.

G. Lombardi, G. Costantino, F. Moroni, 1995, Journal of medicinal chemistry.

A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line

P. Suzdak, E. Mulvihill, D. Hampson, 1993, Brain Research.

A Comparison of Two Alternatively Spliced Forms of a Metabotropic Glutamate Receptor Coupled to Phosphoinositide Turnover

E. J. Fletcher, P. Suzdak, J. Macdonald, 1993, Journal of neurochemistry.

Selegiline induces a wake promoting effect in rats which is related to formation of its active metabolites

C. Bundgaard, A. Mørk, C. Thomsen, 2016, Pharmacology Biochemistry and Behavior.

Effects of chronic tiagabine treatment on [3H]GABAA, [3H]GABAB and [3H]tiagabine binding to sections from mice brain

P. Suzdak, C. Thomsen, 1995, Epilepsy Research.

[3H]‐L‐2‐amino‐4‐phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a

C. Thomsen, Lisbeth Eriksen, 1995, British journal of pharmacology.

Synthesis and biological evaluation of novel carbon-11-labelled analogues of citalopram as potential radioligands for the serotonin transporter.

M. Bergström, B. Långström, G. Knudsen, 2003, Bioorganic & medicinal chemistry.

Distribution and pharmacology of alanine–serine–cysteine transporter 1 (asc‐1) in rodent brain

L. Helboe, C. Thomsen, J. Egebjerg, 2003, The European journal of neuroscience.

Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation.

F. Bymaster, A. Fink-Jensen, J. Ward, 1998, Bioorganic & Medicinal Chemistry Letters.

Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.

P. Suzdak, Michael D B Swedberg, R. Henry, 1999, Journal of medicinal chemistry.

Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.

R. Pellicciari, A. Macchiarulo, C. Thomsen, 2007, Journal of medicinal chemistry.

Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor

P. Suzdak, P. Kristensen, C. Thomsen, 1993, Neuroscience Letters.

Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist.

C. Foged, P. Wahl, C. Thomsen, 2001, Molecular pharmacology.

Lu 28-179 labels a sigma(2)-site in rat and human brain.

J. Mikkelsen, C. Thomsen, K. K. Søby, 2002, Neuropharmacology.

Regional pattern of binding and c-Fos induction by (R)- and (S)-citalopram in rat brain

L. Helboe, C. Thomsen, 2003, Neuroreport.

Persistent astrocyte activation in the fragile X mouse cerebellum

Sihui Guan, D. Hampson, C. Thomsen, 2015, Brain and behavior.

Delayed myelination in a mouse model of fragile X syndrome.

R. Henkelman, Sihui Guan, D. Hampson, 2013, Human molecular genetics.

Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.

J. Hornberg, J. Kilburn, T. Möller, 2021, Journal of medicinal chemistry.

N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.

M. Judge, A. Hansen, J. Weis, 1999, Journal of medicinal chemistry.

(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors.

R. Pellicciari, C. Thomsen, F. Nicoletti, 1996, Molecular pharmacology.

Synthesis and Preliminary Biological Evaluation of 2′‐Substituted 2‐(3′‐Carboxybicyclo[1.1.1]pentyl)glycine Derivatives as Group I Selective Metabotropic Glutamate Receptor Ligands

B. Natalini, R. Pellicciari, A. Macchiarulo, 2006, ChemMedChem.

Probing the Ligand-binding Domain of the mGluR4 Subtype of Metabotropic Glutamate Receptor*

Xi-Ping Huang, D. Hampson, H. Thøgersen, 1999, The Journal of Biological Chemistry.

Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice

N. O. Dalby, C. Thomsen, 1998, Neuropharmacology.

Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice.

F. Bymaster, A. Fink-Jensen, Michael D B Swedberg, 2000, European journal of pharmacology.

l‐Glutamate Uptake Inhibitors May Stimulate Phosphoinositide Hydrolysis in Baby Hamster Kidney Cells Expressing mGluR1a via Heteroexchange with l‐Glutamate Without Direct Activation of mGluR1a

P. Suzdak, C. Thomsen, L. Hansen, 1994, Journal of neurochemistry.

Modulators of the GABAA receptor: Novel therapeutic prospects

C. Thomsen, B. Ebert, 2001 .

Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1

A. Fink-Jensen, N. O. Dalby, B. Meldrum, 1997, Epilepsy Research.

Effects of t-ACPD on neural survival and second messengers in cultured cerebral cortical neurones.

A. Schousboe, P. Suzdak, A. Frandsen, 1993, Neuroreport.

Increased insulin secretion and normalization of glucose tolerance by cholinergic agonism in high fat-fed mice.

B. Ahrén, C. Thomsen, P. Sauerberg, 1999, American journal of physiology. Endocrinology and metabolism.

Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats.

F. Bymaster, A. Fink-Jensen, P. Kristensen, 1998, Neuroreport.

Astroglia Contain a Specific Transport Mechanism for N‐Acetyl‐l‐Aspartate

A. Hansen, C. Thomsen, H. Laursen, 1999, Journal of neurochemistry.

[3H]ac-RYYRWK-NH2, a novel specific radioligand for the nociceptin/orphanin FQ receptor

C. Foged, K. Madsen, N. L. Johansen, 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

Modulation of seizure activity in mice by metabotropic glutamate receptor ligands.

N. O. Dalby, C. Thomsen, 1996, The Journal of pharmacology and experimental therapeutics.

Contribution of Metabotropic Glutamate Receptor mGluR4 to L‐2‐[3H]Amino‐4‐Phosphonobutyrate Binding in Mouse Brain

D. Hampson, C. Thomsen, 1999, Journal of neurochemistry.

Autoradiographic visualization of group III metabotropic glutamate receptors using [3H]‐L‐2‐amino‐4‐phosphonobutyrate

C. Thomsen, Camilla Hudtloff, 1998, British journal of pharmacology.

The role of the innate immune system in psychiatric disorders

K. Jones, C. Thomsen, 2013, Molecular and Cellular Neuroscience.

tolerance by cholinergic agonism in high fat-fed mice Increased insulin secretion and normalization of glucose

B. Ahrén, C. Thomsen, P. Sauerberg, 2016 .

Nociceptin receptor agonists

C. Thomsen, 2001 .

Metabotropic glutamate receptor subtype 1a activates adenylate cyclase when expressed in baby hamster kidney cells

C. Thomsen, 1996, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase.

P. Suzdak, E. Mulvihill, P. Kristensen, 1993, European journal of pharmacology.

Glycine transporter inhibitors as novel antipsychotics

C. Thomsen, 2006 .