I. Flamme

发表

Overexpression of vascular endothelial growth factor in the avian embryo induces hypervascularization and increased vascular permeability without alterations of embryonic pattern formation.

W. Risau, M. von Reutern, I. Flamme, 1995, Developmental biology.

Copper-dependent activation of hypoxia-inducible factor ( HIF ) – 1 : implications for ceruloplasmin regulation

G. Camenisch, R. Wenger, F. Martin, 2005 .

Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

Till Acker, Hiltrud Brauch, H. Brauch, 2000, Oncogene.

Nuclear Oxygen Sensing: Induction of Endogenous Prolyl-hydroxylase 2 Activity by Hypoxia and Nitric Oxide*

J. Fandrey, U. Berchner‐Pfannschmidt, C. Wotzlaw, 2008, Journal of Biological Chemistry.

Determination and modulation of prolyl-4-hydroxylase domain oxygen sensor activity.

G. Camenisch, R. Wenger, S. Barth, 2007, Methods in enzymology.

implications for ceruloplasmin regulation Copper-dependent activation of hypoxia-inducible factor ( HIF )-1 :

Mukhopadhyay, G. Camenisch, F. Martin, 2005 .

Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects

J. Keldenich, I. Flamme, F. Oehme, 2014, PloS one.

A nonradioactive 96-well plate assay for the detection of hypoxia-inducible factor prolyl hydroxylase activity.

I. Flamme, F. Oehme, Willi Jonghaus, 2004, Analytical biochemistry.

Molecular mechanisms of vasculogenesis and embryonic angiogenesis

W. Risau, Thomas Frölich, I. Flamme, 1997, Journal of cellular physiology.

Thrombomucin, a Novel Cell Surface Protein that Defines Thrombocytes and Multipotent Hematopoietic Progenitors

M. Mann, A. Shevchenko, T. Graf, 1997, The Journal of cell biology.

mRNA cloning and expression studies of the quail homologue of HIF-2α

A. Kappel, I. Flamme, S. Lanz, 1999, Mechanisms of Development.

Short Communication Up-Regulation of Vascular Endothelial Growth Factor in Stromal Cells of Hemangioblastomas Is Correlated with Up-Regulation of the Transcription Factor HRF/HIF-2a

K. Plate, I. Flamme, M. Krieg, 1998 .

The impact of N‐nitrosomelatonin as nitric oxide donor in cell culture experiments

J. Fandrey, U. Berchner‐Pfannschmidt, I. Flamme, 2008, Journal of pineal research.

A new model of vasculogenesis and angiogenesis in vitro as compared with vascular growth in the avian area vasculosa

W. Risau, I. Flamme, A. Baranowski, 1993, The Anatomical record.

Vascular Growth in the Extraembryonic Mesoderm of Avian Embryos

W. Risau, M. Messerli, I. Flamme, 1992 .

A comparative study on the effects of tumor necrosis factor‐α (TNF‐α), human angiogenic factor (h‐AF) and basic fibroblast growth factor (bFGF) on the chorioallantoic membrane of the chick embryo

K. Schulze-Osthoff, I. Flamme, H. J. Jacob, 1992, The Anatomical record.

Induction of vasculogenesis in quail blastodisc-derived embryoid bodies.

W. Risau, I. Flamme, V. Mironov, 1994, Developmental biology.

Induction of vasculogenesis and hematopoiesis in vitro.

W. Risau, I. Flamme, Ingo Flamme, 1992, Development.

Reexpression of alpha-smooth muscle actin isoform in cultured adult rat cardiomyocytes.

H. Eppenberger, I. Flamme, M. Eppenberger-Eberhardt, 1990, Developmental biology.

The in vivo activity of vascular endothelial growth factor isoforms in the avian embryo.

I. Flamme, M. Schmidt, 1998, Growth factors.

Edge cell migration in the extraembryonic mesoderm of the chick embryo

I. Flamme, 1987, Anatomy and Embryology.

FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase

Thilo Krüger, I. Flamme, P. Ellinghaus, 2017, PloS one.

Developing brain cells produce factors capable of inducing the HT7 antigen, a blood-brain barrier-specific molecule, in chick endothelial cells

W. Risau, I. Flamme, E. Ikeda, 1996, Neuroscience Letters.

Identification of vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice.

G. Breier, W. Risau, A. Kappel, 1999, Blood.

Reexpression of α-smooth muscle actin isoform in cultured adult rat cardiomyocytes

H. Eppenberger, I. Flamme, M. Eppenberger-Eberhardt, 1990 .

Is extraembryonic angiogenesis in the chick embryo controlled by the endoderm?

I. Flamme, 1989, Anatomy and Embryology.

The Role of Vascular Endothelial Growth Factors and Their Receptors During Embryonic Vascular Development

G. Breier, I. Flamme, 2002 .

Flk-1 as a target for tumor growth inhibition.

A. Ullrich, G. Kéri, G. Mcmahon, 1996, Cancer research.

Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development.

S. Orkin, T. Schlaeger, G. Breier, 2000, Blood.

Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (flk-1) are expressed during vasculogenesis and vascular differentiation in the quail embryo.

G. Breier, W. Risau, I. Flamme, 1995, Developmental biology.

BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I

A. Ehrmann, K. Thierauch, K. Ziegelbauer, 2013, Cancer medicine.

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels

W. Risau, T. Fröhlich, A. Kappel, 1997, Mechanisms of Development.

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

Makoto Hasegawa, Hiroki Tsumoto, Yukihiro Itoh, 2010, Journal of medicinal chemistry.

Up-Regulation of Vascular Endothelial Growth Factor in Stromal Cells of Hemangioblastomas Is Correlated with Up-Regulation of the Transcription Factor HRF/HIF-2α

K. Plate, I. Flamme, M. Krieg, 1998 .

Genetic evidence for a tumor suppressor role of HIF-2alpha.

P. Carmeliet, R. Jain, T. Acker, 2005, Cancer cell.

PHD4 Stimulates Tumor Angiogenesis in Osteosarcoma Cells via TGF-α

G. Breier, I. Prade, B. Wielockx, 2013, Molecular Cancer Research.

Graduate Program in Pharmacology and Experimental Therapeutics – A Joint Endeavor of the University of Cologne and Bayer Schering

I. Flamme, M. Rozowski, Stefan Herzig, 2011 .

Discovery of Molidustat (BAY 85‐3934): A Small‐Molecule Oral HIF‐Prolyl Hydroxylase (HIF‐PH) Inhibitor for the Treatment of Renal Anemia

J. Keldenich, Hans-Christian Militzer, I. Flamme, 2018, ChemMedChem.

Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.

T. Acker, K. Plate, I. Flamme, 2010, Cancer research.

Characterization of novel nuclear targeting and apoptosis-inducing domains in FAS associated factor 1.

W. Risau, T. Fröhlich, I. Flamme, 1998, Journal of cell science.

Expression and proteolysis of vascular endothelial growth factor is increased in chronic wounds.

T. Krieg, S. Eming, I. Flamme, 2000, The Journal of investigative dermatology.

Cooperative Interaction of Hypoxia-inducible Factor-2α (HIF-2α) and Ets-1 in the Transcriptional Activation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1)*

Till Acker, Georg Breier, Andreas Kappel, 2003, The Journal of Biological Chemistry.

disrupts embryonic cardiovascular development Inhibition of hypoxia-inducible factor activity in endothelial cells

G. Breier, I. Flamme, A. Licht, 2013 .

Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development.

G. Breier, I. Flamme, A. Licht, 2006, Blood.

Chimeric protein probes for C5a receptors through fusion of the anaphylatoxin C5a core region with a small-molecule antagonist

Lei Liu, D. Bierer, E. Pook, 2019, Science China Chemistry.

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors.

Matthias Schramm, P. Kolkhof, I. Flamme, 2002, Biochemical and biophysical research communications.

Mitogenic activity of chicken chorioallantoic fluid is temporally correlated to vascular growth in the chorioallantoic membrane and related to fibroblast growth factors.

H. Jacob, K. Schulze-Osthoff, I. Flamme, 1991, Development.

by Hypoxia and Nitric Oxide Endogenous Prolyl-hydroxylase 2 Activity Nuclear Oxygen Sensing: Induction of

J. Fandrey, U. Berchner‐Pfannschmidt, C. Wotzlaw, 2013 .

Rational design of highly stabilized and selective adrenomedullin analogs.

A. Beck‐Sickinger, B. Riedl, I. Flamme, 2023, Journal of peptide science : an official publication of the European Peptide Society.

Identification of vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice.

G. Breier, W. Risau, A. Kappel, 1999, Blood.

Prolonged and simplified in vitro culture of explanted chick embryos

I. Flamme, 2004, Anatomy and Embryology.

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.

H. Brauch, K. Plate, I. Flamme, 2000, Oncogene.

The role of fibronectin and laminin in the migration of the Wolffian duct of avian embryos

R. Poelmann, I. Flamme, B. Christ, 1989 .

Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha.

K. Plate, I. Flamme, M. Krieg, 1998, The American journal of pathology.