S. Melnyk

David W. Gaylor, Mario A. Cleves, Stepan Melnyk, 2010, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.

I. Rusyn, T. Bagnyukova, I. Pogribny, 2008, Mutation research.

Epigenetic reprogramming of liver cells in tamoxifen‐induced rat hepatocarcinogenesis

O. Kovalchuk, I. Pogribny, S. Ross, 2007, Molecular carcinogenesis.

Abnormal transsulfuration and glutathione metabolism in the micropig model of alcoholic liver disease.

S. J. James, S. Melnyk, C. Halsted, 2006, Alcoholism, clinical and experimental research.

Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies.

C. Kappen, B. Wlodarczyk, R. Finnell, 2005, Toxicology and applied pharmacology.

Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism.

M. Cleves, S. J. James, S. Melnyk, 2005, The American journal of clinical nutrition.

Increased plasma homocysteine and S-adenosylhomocysteine and decreased methionine is associated with altered phosphatidylcholine and phosphatidylethanolamine in cystic fibrosis.

S. J. James, R. Dyer, S. Innis, 2003, The Journal of pediatrics.

Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate

P. Casey, A. Winter-Vann, M. Bergo, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.

S. J. James, R. Carmel, S. Melnyk, 2003, Blood.

Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig

S. J. James, A. Devlin, M. Shigenaga, 2002, Proceedings of the National Academy of Sciences of the United States of America.

S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine beta-synthase.

S. J. James, W. Kruger, S. Melnyk, 2002, Molecular genetics and metabolism.

Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect.

I. Pogribny, M. Pogribna, S. J. James, 2001, American journal of medical genetics.

Homocysteine metabolism in children with Down syndrome: in vitro modulation.

I. Pogribny, M. Pogribna, S. J. James, 2001, American journal of human genetics.

Lack of embryotoxicity of homocysteine thiolactone in mouse embryos in vitro.

S. J. James, D. Hansen, S. Melnyk, 2001, Reproductive toxicology.

Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation*

I. Pogribny, M. Pogribna, S. J. James, 2000, The Journal of Biological Chemistry.

Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.

V. L. Wilson, D. Gaylor, I. Pogribny, 1999, The American journal of clinical nutrition.

A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection.

I. Pogribny, M. Pogribna, S. J. James, 1999, The Journal of nutritional biochemistry.

Trans-HHS Workshop : Diet , DNA Methylation Processes and Health Elevation in S-Adenosylhomocysteine and DNA Hypomethylation : Potential Epigenetic Mechanism for Homocysteine-Related Pathology 1

Stepan Melnyk, Igor P. Pogribny, I. Pogribny, 2002 .

Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism.

David W Gaylor, Stepan Melnyk, D. Gaylor, 2009, The American journal of clinical nutrition.

Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency

R. Rozen, S. J. James, S. Melnyk, 2008, Journal of Inherited Metabolic Disease.

Expression Changes in Epigenetic Gene Pathways Associated With One‐Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non‐Typical Neurodevelopment

I. Hertz-Picciotto, M. Fallin, S. J. James, 2020, Autism research : official journal of the International Society for Autism Research.

Expression changes in immune and epigenetic gene pathways associated with nutritional metabolites in maternal blood from pregnancies resulting in autism and atypical neurodevelopment

I. Hertz-Picciotto, M. Fallin, S. J. James, 2020, bioRxiv.

Dietary rice protein isolate attenuates atherosclerosis in apoE-deficient mice by upregulating antioxidant enzymes.

Xianli Wu, P. Thampi, S. Melnyk, 2010, Atherosclerosis.

Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis.

I. Pogribny, M. Pogribna, S. J. James, 2003, The Journal of nutrition.

Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice

S. Melnyk, R. Simmen, F. Simmen, 2021, Frontiers in Physiology.

Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation

Uwe Kruger, Daniel Howsmon, Juergen Hahn, 2017, PLoS Comput. Biol..

Differential Susceptibilities to Azithromycin Treatment of Chlamydial Infection in the Gastrointestinal Tract and Cervix

R. Rank, S. Melnyk, A. Bowlin, 2013, Antimicrobial Agents and Chemotherapy.

Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.

Zhoutao Chen, I. Pogribny, R. Rozen, 2004, The Biochemical journal.

Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells.

I. Pogribny, A. Basnakian, M. Pogribna, 1999, Cancer letters.

Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice.

Y. L. Liu, S. Melnyk, R. Simmen, 2016, Endocrine-related cancer.

Postnatal exposure to trichloroethylene alters glutathione redox homeostasis, methylation potential, and neurotrophin expression in the mouse hippocampus.

S. J. James, C. Cooney, S. Melnyk, 2012, Neurotoxicology.

One-carbon metabolism and ionizing radiation: a multifaceted interaction

I. Koturbash, M. Boerma, A. Cheema, 2017, Biomolecular concepts.

The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study

S. J. James, D. Rossignol, S. Melnyk, 2007, BMC pediatrics.

Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

Stepan Melnyk, Paul Cutler, D. Gaylor, 2006, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups

R. Frye, J. M. Sequeira, E. Quadros, 2016, Front. Neurosci..

Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder

R. Frye, D. Macfabe, S. Melnyk, 2013, Translational Psychiatry.

Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines

S. J. James, R. Frye, S. Rose, 2014, Translational Psychiatry.

Redox metabolism abnormalities in autistic children associated with mitochondrial disease

S. J. James, R. Frye, J. Slattery, 2013, Translational Psychiatry.

Intracellular and Extracellular Redox Status and Free Radical Generation in Primary Immune Cells from Children with Autism

S. J. James, S. Rose, S. Melnyk, 2011, Autism research and treatment.

Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism

Stepan Melnyk, S. J. James, S. Rose, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum

I. Pogribny, S. J. James, V. Tryndyak, 2014, PloS one.

Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum

I. Pogribny, S. J. James, S. Melnyk, 2014, Translational Psychiatry.

Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum

Stepan Melnyk, I. Pogribny, S. J. James, 2013, Translational Psychiatry.

Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice

R. Rozen, S. J. James, S. Krupenko, 2008, Pharmacogenetics and genomics.

Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines

S. J. James, R. Frye, S. Rose, 2015, Translational Psychiatry.

Chemo brain or tumor brain - that is the question: the presence of extracranial tumors profoundly affects molecular processes in the prefrontal cortex of TumorGraft mice

B. Kolb, O. Kovalchuk, Y. Ilnytskyy, 2017, Aging.

Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypes.

S. Melnyk, R. Simmen, F. Simmen, 2014, Carcinogenesis.

DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation.

I. Pogribny, B. Wlodarczyk, R. Finnell, 2002, The Journal of nutrition.

Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart.

E. Moros, M. Boerma, V. Sridharan, 2016, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

PubMed articles by these authors

I. Pogribny, M. Pogribna, S. J. James, 2001 .

Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction.

Sumit K. Shah, M. Hauer-Jensen, S. Melnyk, 2016, Free radical biology & medicine.

Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines

R. Frye, S. Rose, S. Bennuri, 2016, Translational Psychiatry.

Metabolic changes and DNA hypomethylation in cerebellum are associated with behavioral alterations in mice exposed to trichloroethylene postnatally.

C. Cooney, S. Melnyk, C. Swearingen, 2013, Toxicology and applied pharmacology.

Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart

I. Koturbash, M. Boerma, Preeti Singh, 2017, PloS one.

Effects of Obesity on Serum Concentration of Methylation and Oxidative/ Nitrosative Stress Metabolites Following DMBA Treatment of Female Zucker Rats

R. Hakkak, S. Melnyk, 2012 .

Editor’s Highlight: Organ-Specific Epigenetic Changes Induced by the Nongenotoxic Liver Carcinogen Methapyrilene in Fischer 344 Rats

Tao Chen, I. Pogribny, Jian Yan, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

I. Koturbash, N. Deutz, R. Landes, 2017, Genes & Nutrition.

Thyroid dysfunction in children with autism spectrum disorder is associated with folate receptor α autoimmune disorder

R. Frye, J. M. Sequeira, E. Quadros, 2017, Journal of neuroendocrinology.

The Frequency of Polymorphisms affecting Lead and Mercury Toxicity among Children with Autism

Mario A. Cleves, Stepan Melnyk, M. Cleves, 2008 .

Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism

I. Rusyn, J. Fuscoe, T. Han, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Effects of Obesity on Pro-Oxidative Conditions and DNA Damage in Liver of DMBA-Induced Mammary Carcinogenesis Models

R. Hakkak, S. Melnyk, O. Pavliv, 2017, Metabolites.

Increased Susceptibility to Ethylmercury-Induced Mitochondrial Dysfunction in a Subset of Autism Lymphoblastoid Cell Lines

Stepan Melnyk, S. J. James, R. Frye, 2015, Journal of toxicology.

Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders

S. J. James, S. Melnyk, O. Pavliv, 2013, Autism research and treatment.

Inflammatory and oxidative stress‐related effects associated with neurotoxicity are maintained after exclusively prenatal trichloroethylene exposure

C. Cooney, S. Melnyk, S. Blossom, 2017, Neurotoxicology.

Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology

R. Palmer, S. J. James, R. Frye, 2020, Molecular Psychiatry.

Obesity, Oxidative Stress and Breast Cancer Risk

R. Hakkak, S. Melnyk, S. Korourian, 2013 .

Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells

Mitchell R. McGill, I. Koturbash, I. Miousse, 2022, Journal of dietary supplements.

Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene: evaluating gene-environment interactions.

M. Cleves, S. J. James, S. Melnyk, 2006, American journal of obstetrics and gynecology.

Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism

David W Gaylor, Stepan Melnyk, D. Gaylor, 2008, Journal of autism and developmental disorders.

Redox Imbalance and Methylation Disturbances in Early Childhood Obesity

Gabriela R. Moura, E. Børsheim, E. Carvalho, 2021, Oxidative medicine and cellular longevity.

Elevation in S‐adenosylhomocysteine and DNA hypomethylation in parents and children with autism

S. Melnyk, S. Jernigan, A. Savenka, 2007 .

Effect of Metformin Treatment on Serum Metabolic Profile Changes in Lean and Obese Zucker Rat Model for Fatty Liver Disease

R. Hakkak, S. Melnyk, 2023, Biomolecules.

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.

I. Rusyn, T. Bagnyukova, I. Pogribny, 2009, Journal of hepatology.

Acetaminophen-induced acute liver injury in HCV transgenic mice.

I. Rusyn, I. Pogribny, O. Kosyk, 2013, Toxicology and applied pharmacology.

A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism

M. Cleves, S. Melnyk, O. Pavliv, 2010, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism

S. Rose, S. Melnyk, O. Pavliv, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.

I. Rusyn, A. Knap, H. Clewell, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles

I. Miousse, P. Demokritou, Jodene K Moore, 2016, Nanotoxicology.

Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet

T. Han, I. Pogribny, V. Tryndyak, 2008, Brain Research.

Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.

Zhoutao Chen, I. Pogribny, R. Rozen, 2004, Biochemical Journal.