T. Lynagh

发表

Unique Contributions of an Arginine Side Chain to Ligand Recognition in a Glutamate-gated Chloride Channel*

T. Lynagh, Vitaly V. Komnatnyy, S. Pless, 2017, The Journal of Biological Chemistry.

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels

A. Wolstenholme, R. Beech, B. Cromer, 2015, Scientific Reports.

Peptide Inhibitors of the α-Cobratoxin–Nicotinic Acetylcholine Receptor Interaction

A. H. Laustsen, C. Olsen, M. Dufva, 2020, Journal of medicinal chemistry.

A glycine residue essential for high ivermectin sensitivity in Cys-loop ion channel receptors.

J. Lynch, T. Lynagh, 2010, International journal for parasitology.

Structure‐activity analysis of ginkgolide binding in the glycine receptor pore

J. Lynch, T. Lynagh, Judith A. Heads, 2008, Journal of neurochemistry.

Ivermectin binding sites in human and invertebrate Cys-loop receptors.

J. Lynch, T. Lynagh, 2012, Trends in pharmacological sciences.

Peptide Inhibitors of the α-Cobratoxin–Nicotinic Acetylcholine Receptor Interaction

A. H. Laustsen, C. Olsen, M. Dufva, 2020, Journal of medicinal chemistry.

Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels.

V. Carnevale, M. Kasimova, D. Granata, 2020, Biophysical journal.

Mechanism and site of action of big dynorphin on ASIC1a

E. Bennett, S. Heusser, Jacob Andersen, 2019, Proceedings of the National Academy of Sciences.

Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen.

T. Lynagh, S. Pless, Camilla Lund, 2017, Journal of medicinal chemistry.

An Improved Ivermectin-activated Chloride Channel Receptor for Inhibiting Electrical Activity in Defined Neuronal Populations*

J. Lynch, T. Lynagh, 2010, The Journal of Biological Chemistry.

Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics

B. Cromer, T. Lynagh, B. Laube, 2014, International journal for parasitology. Drugs and drug resistance.

Molecular Determinants of Ivermectin Sensitivity at the Glycine Receptor Chloride Channel*

J. Lynch, B. Cromer, T. Lynagh, 2011, The Journal of Biological Chemistry.

Principles of agonist recognition in Cys-loop receptors

T. Lynagh, S. Pless, 2014, Front. Physiol..

A selectivity filter at the intracellular end of the acid-sensing ion channel pore

T. Allen, T. Lynagh, Vitaly V. Komnatnyy, 2017, eLife.

Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution

A. Hejnol, T. Lynagh, Paul Bump, 2022, bioRxiv.

Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin

J. Lynch, T. Lynagh, Joseph W. Lynch, 2012, Front. Mol. Neurosci..

Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes

T. Lynagh, S. Pless, J. Glover, 2018, Proceedings of the National Academy of Sciences.

High Throughput Techniques for Discovering New Glycine Receptor Modulators and their Binding Sites

Robiul Islam, Timothy Lynagh, J. Lynch, 2009, Front. Mol. Neurosci..

Opposing Effects of the Anesthetic Propofol at Pentameric Ligand-Gated Ion Channels Mediated by a Common Site

T. Lynagh, B. Laube, 2014, The Journal of Neuroscience.

Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activation.

T. Lynagh, B. Laube, A. Kunz, 2013, ACS chemical neuroscience.

A hypothalamic circuit for the circadian control of aggression

C. Saper, P. Fuller, B. Lowell, 2018, Nature Neuroscience.

Author Correction: Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

R. Marek, P. Sah, Jingji Jin, 2018, Nature Neuroscience.

Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

P. Fitzgerald, R. Marek, P. Sah, 2018, Nature Neuroscience.

Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels

T. Allen, T. Lynagh, S. Pless, 2020, The Journal of general physiology.

Structural basis for excitatory neuropeptide signaling

C. Paulino, T. Lynagh, V. Kalienkova, 2023, bioRxiv.

Comparative analysis defines a broader FMRFamide-gated sodium channel family and determinants of neuropeptide sensitivity

H. Hausen, T. Lynagh, Mowgli Dandamudi, 2022, bioRxiv.

Role of an Absolutely Conserved Tryptophan Pair in the Extracellular Domain of Cys-Loop Receptors.

P. Biggin, T. Lynagh, S. Pless, 2016, ACS chemical neuroscience.

Extracellular loop 3 of the noradrenaline transporter contributes to substrate and inhibitor selectivity

L. Bryan-Lluka, T. Lynagh, T. Khamu, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs

S. Friis, T. Lynagh, S. Pless, 2021, bioRxiv.

Constitutive activity of ionotropic glutamate receptors via a hydrophobic plug in the ligand-binding domain

T. Lynagh, O. Sintsova, S. Seljeset, 2023, bioRxiv.

Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

P. Fitzgerald, R. Marek, P. Sah, 2018, Nature Neuroscience.

Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen.

T. Lynagh, S. Pless, Camilla Lund, 2017, Journal of medicinal chemistry.

Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activation.

T. Lynagh, B. Laube, A. Kunz, 2013, ACS chemical neuroscience.

Avidity within the N-terminal anchor drives -synuclein membrane interaction and insertion

T. Allen, T. Lynagh, S. Pless, 2020 .

Receptors | Glycine Receptors

T. Lynagh, B. Laube, J. Schaffer, 2021, Encyclopedia of Biological Chemistry III.