D. Pryde

发表

Ion channels as therapeutic targets: a drug discovery perspective.

R. M. Owen, A. Brown, E. Stevens, 2013, Journal of medicinal chemistry.

Alkali-metal mediated zincation of N-heterocyclic substrates using the lithium zincate complex, (THF)Li(TMP)Zn(tBu)(2) and applications in in situ cross coupling reactions

V. Blair, D. Pryde, D. Blakemore, 2011 .

Trypanosoma brucei Glycogen Synthase Kinase-3, A Target for Anti-Trypanosomal Drug Development: A Public-Private Partnership to Identify Novel Leads

Tod P. Holler, L. Maes, Richard O. Oduor, 2011, PLoS neglected tropical diseases.

Analysis of Differential Efficacy and Affinity of GABAA (α1/α2) Selective Modulators.

Julian E. Fuchs, R. M. Owen, R. Glen, 2016, Molecular pharmaceutics.

An in situ oxidation strategy towards overcoming hERG affinity.

D. Pryde, Rhys M. Jones, D. Middleton, 2010, Bioorganic & medicinal chemistry letters.

The design and discovery of novel amide CCR5 antagonists.

David W. Gordon, D. Gordon, A. Wood, 2009, Bioorganic & medicinal chemistry letters.

Identification of HCV Inhibitors from a Cell-Based Sub-Genomic Replicon Screen

Stephen M. Shaw, D. Pryde, C. Pickford, 2013 .

Enhancing immunogenicity of a 3'aminomethylnicotine-DT-conjugate anti-nicotine vaccine with CpG adjuvant in mice and non-human primates.

In-Jeong Kim, H. Davis, M. McCluskie, 2013, International immunopharmacology.

Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.

P. H. van der Graaf, K. Beaumont, A. Stobie, 2007, Bioorganic & medicinal chemistry.

Antifungal activity of selective serotonin reuptake inhibitors attributed to non-specific cytotoxicity.

D. Pryde, M. Perros, T. Parkinson, 2003, The Journal of antimicrobial chemotherapy.

Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice

A. Brown, H. Davis, M. McCluskie, 2013, PloS one.

Therapeutic Opportunities in Infectious Diseases: Highlights from the Society of Medicines Research Symposium, held on March 14th 2013 at the National Heart & Lung Institute, London, UK

Rosaleen J. Anderson, W. Alderton, D. Pryde, 2013 .

Identification of Positive Allosteric Modulators of Glycine Receptors from a High-Throughput Screen Using a Fluorescent Membrane Potential Assay

Adam R. Brown, D. Pryde, Juhana I. Kammonen, 2016, Journal of biomolecular screening.

Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain.

R. M. Owen, M. Andrews, K. Beaumont, 2015, ACS medicinal chemistry letters.

Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K2P18.1.

Lishuang Cao, P. Saintot, A. Loucif, 2016, Bioorganic & medicinal chemistry letters.

The discovery of a potent Nav1.3 inhibitor with good oral pharmacokinetics.

J. Warmus, P. Cox, C. Markworth, 2017, MedChemComm.

Valproic acid interactions with the NavMs voltage-gated sodium channel

B. Wallace, Leo C. T. Ng, Rubben Torella, 2019, Proceedings of the National Academy of Sciences.

Lateral fenestrations in K + -channels explored using MD simulations

Rubben Torella, C. Domene, V. Oakes, 2016 .

G10 is a direct activator of human STING

D. Pryde, Rajib Ghosh, A. Surya, 2020, PloS one.

The discovery of potent small molecule activators of human STING.

D. Pryde, Rajib Ghosh, A. Surya, 2020, European journal of medicinal chemistry.

The discovery of potent small molecule cyclic urea activators of STING.

D. Pryde, Rajib Ghosh, A. Surya, 2021, European journal of medicinal chemistry.

A tandem radical macrocyclisation-transannular cyclisation approach towards the taxanes

A. J. Blake, S. Hitchcock, A. Blake, 1998 .

Studies towards the taxane ring system via a cascade macrocyclisation-transannulation strategy

D. Pryde, G. Pattenden, N. Thomson, 1997 .

Small, non-peptide C5a receptor antagonists: part 2.

K. Beaumont, J. Blagg, Esther F. Schmid, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of 2-tetralones via a novel 1,2-carbonyl transposition of 1-tetralones

D. Pryde, A. Meyers, S. Henry, 1996 .

α-Ketophosphonates as ester surrogates: isothiourea-catalyzed asymmetric diester and lactone synthesis.

A. Slawin, D. Pryde, Andrew D. Smith, 2014, Organic letters.

A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation–π Interaction**

Stefan Knapp, Robert S Paton, Susanne Müller, 2014, Angewandte Chemie.

Small, non-peptide C5a receptor antagonists: part 1.

K. Beaumont, J. Blagg, Esther F. Schmid, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of 2-Tetralones via a Novel 1,2-Carbonyl Transposition of 1- Tetralones.

D. Pryde, A. Meyers, S. Henry, 1996 .

α‐Ketophosphonates as Ester Surrogates: Isothiourea‐Catalyzed Asymmetric Diester and Lactone Synthesis.

A. Slawin, D. Pryde, Andrew D. Smith, 2014 .

Enantioselective NHC-Catalysed Formal [4+2] Cycloaddition of Alkylarylketenes with β,γ-Unsaturated α-Ketophosphonates

A. Slawin, D. Pryde, Andrew D. Smith, 2013 .

NHC-mediated enantioselective formal [4 + 2] cycloadditions of alkylarylketenes and β,γ-unsaturated α-ketocarboxylic esters and amides.

A. Slawin, D. Pryde, Andrew D. Smith, 2013, Organic & biomolecular chemistry.

Practical synthetic routes to carbon-substituted nucleosides

D. Pryde, D. Middleton, P. T. Stephenson, 2011 .

Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.

K. Beaumont, B. K. Park, R. Jenkins, 2007, Journal of medicinal chemistry.

Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.

P. H. van der Graaf, M. Tute, K. Beaumont, 2006, Journal of medicinal chemistry.

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile—Part 1

Stephen M. Shaw, J. Chiva, Florian Wakenhut, 2014, ChemMedChem.

New lithium-zincate approaches for the selective functionalisation of pyrazine: direct dideprotozincation vs. nucleophilic alkylation.

V. Blair, D. Pryde, D. Blakemore, 2012, Chemical communications.

Aldehyde oxidase: an enzyme of emerging importance in drug discovery.

Deepak Dalvie, R Scott Obach, R. Obach, 2010, Journal of medicinal chemistry.

CCR5 Antagonists in HIV

D. Pryde, Barber Christopher Gordon, 2011 .

Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus.

D. Pryde, T. Parkinson, 2010, Future medicinal chemistry.

Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase

D. Pryde, T. Parkinson, T. Holler, 2009, Expert opinion on drug discovery.

Selection, Optimization, and Pharmacokinetic Properties of a Novel, Potent Antiviral Locked Nucleic Acid-Based Antisense Oligomer Targeting Hepatitis C Virus Internal Ribosome Entry Site

R. Corbau, C. Laxton, D. Pryde, 2011, Antimicrobial Agents and Chemotherapy.

The Synthesis of Streptogramin Antibiotics: (−)‐Griseoviridin and Its C‐8 Epimer

C. Dvorak, Daniel J. Poon, D. Pryde, 2000 .

Synthesis and Biological Evaluation of Acyclic Phosphonic Acid Nucleoside Derivatives

D. Pryde, S. Sutton, D. Middleton, 2013, Nucleosides, nucleotides & nucleic acids.

Vaccin peptidique ige ch3

D. Gervais, A. Brown, B. Champion, 2009 .

Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs

W. Catterall, T. Scheuer, D. Pryde, 2016, Nature.

Discovery of an HIV integrase inhibitor with an excellent resistance profile

D. J. Bull, R. A. Bissell, S. Butler, 2013 .

Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action

David Pryde, Lyn H. Jones, Chris Pickford, 2011, Journal of Virology.

Antiviral applications of Toll-like receptor agonists.

D. Pryde, N. Horscroft, H. Bright, 2012, The Journal of antimicrobial chemotherapy.

TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype

V. Shanmugasundaram, Seungil Han, D. Pryde, 2018, Proceedings of the National Academy of Sciences.

Recent disclosures of clinical candidates. Highlights from the Society of Medicines Research Symposium, held December 4, 2014 - National Heart & Lung Institute, London, UK

D. Pryde, A. Ratcliffe, S. Collingwood, 2015, Drugs of the Future.

REDUCING ATTRITION THROUGH EARLY ASSESSMENT OF DRUG SAFETY

J. Holder, W. Alderton, D. Pryde, 2014 .

Development of a Practical Synthesis of Toll-like Receptor Agonist PF-4171455: 4-Amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo [4,5-c] pyridin-2-one

G. Bish, D. Hay, James R. Hitchin, 2011 .

Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865).

R. M. Owen, Chan Woo Huh, Lishuang Cao, 2019, Journal of medicinal chemistry.

Medicinal chemistry approaches to avoid aldehyde oxidase metabolism.

I. Gardner, S. Bagal, K. Omoto, 2012, Bioorganic & medicinal chemistry letters.

A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core

G. Bish, M. Fray, D. Hay, 2011 .

Discovery of a highly potent series of TLR7 agonists.

G. Bish, D. Hay, James R. Hitchin, 2011, Bioorganic & medicinal chemistry letters.

The Synthesis of Streptogramin Antibiotics: (‐)‐Griseoviridin and Its C‐8 Epimer.

C. Dvorak, Daniel J. Poon, D. Pryde, 2000 .

An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.

Jerry R. Hobbs, J. Pandit, R. Horst, 2018, Structure.

In silico identification of PAP-1 binding sites in the Kv1.2 potassium channel.

C. Domene, K. Vanommeslaeghe, K. Omoto, 2015, Molecular pharmaceutics.

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

B. L. de Groot, B. Fakler, E. Carpenter, 2019, Science.

The Discovery of Small Molecule Inhibitors of Neutral Endopeptidase. Structure–Activity Studies on Functionalized Glutaramides

K. Beaumont, A. Stobie, D. Pryde, 2006, Chemical biology & drug design.

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism

D. Clapham, B. Wallace, I. Nobeli, 2014, Proceedings of the National Academy of Sciences.

Exploring the Dynamics of the TWIK-1 Channel

S. Furini, C. Domene, V. Oakes, 2016, Biophysical journal.

Recent trends and technologies towards medicines of the future. A joint meeting of the SMR and the RSC BMCS. London, UK - December 8, 2017

D. Pryde, M. Swarbrick, N. Ahmad, 2018 .

Lateral Fenestrations in K(+)-Channels Explored Using Molecular Dynamics Simulations.

Rubben Torella, C. Domene, V. Oakes, 2016, Molecular pharmaceutics.

An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).

A. Wood, P. Dorr, D. Pryde, 2011, Journal of medicinal chemistry.

11th German Conference on Chemoinformatics (GCC 2015)

Timothy Clark, Jonathan W. Essex, Peter Kolb, 2016, J. Cheminformatics.

Discovery of a Series of Indazole TRPA1 Antagonists.

J. Warmus, P. Cox, K. Omoto, 2017, ACS medicinal chemistry letters.

The discovery of a potent series of carboxamide TRPA1 antagonists

J. Warmus, T. Ryckmans, P. Cox, 2016 .

Azogabazine; a photochromic antagonist of the GABAA receptor.

T. Smart, M. Mortensen, D. Pryde, 2016, Organic & biomolecular chemistry.