S. Skerratt

发表

Ion channels as therapeutic targets: a drug discovery perspective.

R. M. Owen, A. Brown, E. Stevens, 2013, Journal of medicinal chemistry.

Synthesis of α,α-disubstituted unnatural amino acid derivatives using the aza-[2,3]-Wittig sigmatropic rearrangement

S. Skerratt, James C. Anderson, 2002 .

Discovery of a novel binding pocket for CYP 2C9 inhibitors: crystallography, pharmacophore modelling and inhibitor SAR

S. Skerratt, C. Phillips, M. Groot, 2016 .

Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter

C. C. Jorgensen, Rubben Torella, C. Benn, 2017, Front. Mol. Neurosci..

The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain.

A. Brown, E. Stevens, J. Warmus, 2019, Bioorganic & medicinal chemistry.

Evaluation and Characterization of Trk Kinase Inhibitors for the Treatment of Pain: Reliable Binding A ﬃ nity Predictions from Theory and Computation

Agastya P. Bhati, P. Coveney, V. Shanmugasundaram, 2017 .

Identification of a novel BODIPY minihepcidin tool for the high content analysis of ferroportin (SLC40A1) pharmacology

C. C. Jorgensen, Rita R. Ferreira, J. Warmus, 2016 .

Ion channel therapeutics for pain

S. Skerratt, C. W. West, 2015, Channels.

Characterization of the EP receptor subtype that mediates the inhibitory effects of prostaglandin E2 on IgE‐dependent secretion from human lung mast cells

N. Pullen, S. Skerratt, L. Kay, 2013, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Synthesis of NP25302.

J. Robertson, S. Skerratt, A. Tyrrell, 2011, Organic letters.

Synthesis of pyrrolidin-3-ones from dihydropyran precursors via spiro-N,O-acetals

J. Robertson, S. Skerratt, A. Tyrrell, 2009 .

Oxidation products of 2-acyl-4,5-dihydrofurans

J. Robertson, S. Skerratt, A. J. Tyrrell, 2006 .

The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.

Kiyoyuki Omoto, Angus Nedderman, Sharan K Bagal, 2016, Journal of medicinal chemistry.

Recent Progress in the Discovery and Development of TRPA1 Modulators.

S. Skerratt, 2017, Progress in medicinal chemistry.

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.

Gareth J Waldron, R. Grimley, M. Andrews, 2018, Journal of medicinal chemistry.

Identification of false positives in “HTS hits to lead”: The application of Bayesian models in HTS triage to rapidly deliver a series of selective TRPV4 antagonists

Sarah Elizabeth Skerratt, James Edward John Mills, Jayesh Mistry, 2013 .

The discovery of a potent series of carboxamide TRPA1 antagonists

J. Warmus, T. Ryckmans, P. Cox, 2016 .

SAR mining and its application to the design of TRPA1 antagonists

Sarah Elizabeth Skerratt, James Edward John Mills, Alan Daniel Brown, 2012 .

The Discovery and Chemical Development of PF-06273340: A Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor for Pain

S. Skerratt, D. Blakemore, T. Brandt, 2019, ACS Symposium Series.

Recent trends in medicinal chemistry and enabling technologies. Highlights from the Society for Medicines Research Conference. London - December 8, 2022

S. Skerratt, M. Swarbrick, A. Merritt, 2023, Drugs of the future.

Evaluation and Characterization of Trk Kinase Inhibitors for the Treatment of Pain: Reliable Binding Affinity Predictions from Theory and Computation

Peter V. Coveney, Agastya Bhati, Kiyoyuki Omoto, 2017, J. Chem. Inf. Model..

Advancing structural biology through breakthroughs in AI.

Sergey Bartunov, T. J. Lane, C. Cooper, 2023, Current opinion in structural biology.