R. I. Storer

发表

Ion channels as therapeutic targets: a drug discovery perspective.

R. M. Owen, A. Brown, E. Stevens, 2013, Journal of medicinal chemistry.

Enantioselective Brønsted acid-catalyzed N-acyliminium cyclization cascades.

D. Dixon, R. I. Storer, Michael E Muratore, 2009, Journal of the American Chemical Society.

Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter

C. C. Jorgensen, Rubben Torella, C. Benn, 2017, Front. Mol. Neurosci..

Structural Basis for Targeting the Folded P-Loop Conformation of c-MET

C. Stubbs, I. Dale, U. Börjesson, 2020, ACS medicinal chemistry letters.

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling.

R. Grimley, J. Warmus, E. Tate, 2016, Molecular bioSystems.

Fragment-Based Discovery of Novel Allosteric MEK1 Binders.

R. Lewis, U. Börjesson, Magnus Nilsson, 2021, ACS medicinal chemistry letters.

Targeting the cAMP and Transforming Growth Factor‐β Pathway Increases Proliferation to Promote Re‐Epithelialization of Human Stem Cell‐Derived Retinal Pigment Epithelium

R. M. Owen, Alex Gutteridge, P. Whiting, 2016, Stem cells translational medicine.

Application of an Integrated GPCR SAR-Modeling Platform To Explain the Activation Selectivity of Human 5-HT2C over 5-HT2B.

P. Biggin, M. Bodkin, Iñaki Morao, 2016, ACS chemical biology.

Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains

S. Knapp, G. Morris, P. Biggin, 2022, ACS chemical biology.

Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of furanyl (γ)- and pyranyl (δ)-lactols

S. Ley, D. Dixon, R. I. Storer, 2004 .

Enantioselective Broensted Acid Catalyzed N-Acyliminium Cyclization Cascades.

D. Dixon, R. I. Storer, Michael E Muratore, 2010 .

Design, synthesis, and evaluation of tetrasubstituted pyridines as potent 5-HT2CReceptor agonists

P. Fish, S. Ley, G. McMurray, 2020 .

Selective 5-HT2C receptor agonists: Design and synthesis of pyridazine-fused azepines.

G. McMurray, R. I. Storer, M. P. Green, 2016, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists.

P. Fish, S. Ley, G. McMurray, 2015, ACS medicinal chemistry letters.

The design , synthesis and evaluation of tetra-substituted pyridines as potent 5-HT 2 C receptor agonists

P. Fish, S. Ley, G. McMurray, 2015 .

Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.

M. Andrews, A. Brown, P. Fish, 2011, Bioorganic & medicinal chemistry letters.

Squaramides: physical properties, synthesis and applications.

R. I. Storer, L. Jones, Caroline Aciro, 2011, Chemical Society reviews.

A concise synthesis of chiral indanes as α1A adrenoceptor partial agonists

Steven J. Fussell, R. I. Storer, Alan S. Jessiman, 2015 .

Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation

Steven V. Ley, R. Ian Storer, Andrew G. Leach, 2000 .

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.

P. A. Bradley, Brian E Marron, Ian K Gurrell, 2017, Journal of medicinal chemistry.

Borohydride Exchange Resin

S. Ley, R. I. Storer, 2002 .

A total synthesis of epothilones using solid-supported reagents and scavengers.

Steven V Ley, S. Ley, P. Jackson, 2003, Angewandte Chemie.

Enantioselective organocatalytic aldehyde-aldehyde cross-aldol couplings. The broad utility of α-thioacetal aldehydes

R. I. Storer, D. MacMillan, 2004 .

Enantioselective organocatalytic reductive amination.

Y. Ni, R. I. Storer, D. MacMillan, 2006, Journal of the American Chemical Society.

Recent progress in sodium channel modulators for pain.

Sharan K Bagal, Brian E Marron, S. Bagal, 2014, Bioorganic & medicinal chemistry letters.

Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.

Steven V Ley, Ian R Baxendale, S. Ley, 2004, Chemistry.

A polymer-supported thionating reagent

Steven V. Ley, R. Ian Storer, Andrew G. Leach, 2001 .

Put a ring on it: application of small aliphatic rings in medicinal chemistry.

M. Bauer, S. Lucas, R. I. Storer, 2021, RSC medicinal chemistry.

Enantioselective Organocatalytic Aldehyde—Aldehyde Cross‐Aldol Couplings. The Broad Utility of α‐Thioacetal Aldehydes.

R. I. Storer, D. MacMillan, 2004 .

Exploiting a novel size exclusion phenomenon for enantioselective acid/base cascade catalysis.

D. Dixon, R. I. Storer, Michael E Muratore, 2012, Chemical communications.

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.

Yogesh Sabnis, J. Chrencik, G. Whitlock, 2017, Journal of medicinal chemistry.

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

Sulayman D. Dib-Hajj, Stephen G. Waxman, R. Ian Storer, 2016, PloS one.

Physiology of Hyperuricemia and Urate-Lowering Treatments

R. Gurrell, C. Vangjeli, C. Benn, 2018, Front. Med..

The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout

R. M. Owen, A. Pike, M. Bictash, 2016 .

Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.

Robert P. DePianta, V. Shanmugasundaram, A. Brown, 2014, Journal of medicinal chemistry.

Voltage gated sodium channels as drug discovery targets

Sharan K Bagal, Brian E Marron, R. M. Owen, 2015, Channels.

Structural Basis for Targeting the Folded P-Loop Conformation of c-MET

C. Stubbs, I. Dale, U. Börjesson, 2020, ACS medicinal chemistry letters.

Design and Evaluation of a Low Hydrogen Bond Donor Count Fragment Screening Set to Aid Hit Generation of PROTACs Intended for Oral Delivery.

M. Bauer, A. Gunnarsson, C. Margreitter, 2023, Journal of medicinal chemistry.

Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor

E. Hennessy, T. Moss, C. Stubbs, 2023, Journal of medicinal chemistry.

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.

Brian E Marron, Neil A Castle, Rubben Torella, 2017, Bioorganic & medicinal chemistry letters.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

Gebhard F. X. Schertler, Christofer S. Tautermann, Philip C. Biggin, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Supported Reagents and Scavengers in Multi‐step Organic Synthesis

S. Ley, I. Baxendale, R. I. Storer, 2005 .

Direct Enantioselective Broensted Acid Catalyzed N‐Acyliminium Cyclization Cascades of Tryptamines and Ketoacids.

D. Dixon, R. I. Storer, Michael E Muratore, 2011 .

Enantioselective Brønsted acid-catalyzed N-acyliminium cyclization cascades.

D. Dixon, R. I. Storer, Michael E Muratore, 2009, Journal of the American Chemical Society.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

T. Ceska, P. Biggin, M. Bodkin, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.