W. Stanley

发表

Mitochondrial dysfunction in heart failure: potential for therapeutic interventions?

C. Hoppel, W. Stanley, 2000, Cardiovascular research.

High-sugar intake does not exacerbate metabolic abnormalities or cardiac dysfunction in genetic cardiomyopathy.

S. Gupte, K. O’Shea, P. Hecker, 2012, Nutrition.

Role of diet and fuel overabundance in the development and progression of heart failure.

D. Chess, W. Stanley, 2008, Cardiovascular research.

Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy.

R. Testa, L. Menichetti, D. Neglia, 2007, American journal of physiology. Heart and circulatory physiology.

Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart.

D. Sosnowska, F. Recchia, Z. Ungvari, 2014, American journal of physiology. Heart and circulatory physiology.

Myocardial energy metabolism in

W. Stanley, 2011 .

Myocardial energy metabolism in dilated cardiomyopathy

W. Stanley, 2010 .

Reverse changes in cardiac substrate oxidation in dogs recovering from heart failure.

F. Recchia, S. Gupte, H. Sabbah, 2008, American journal of physiology. Heart and circulatory physiology.

Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments.

J. Wisneski, E. Gertz, R. Neese, 1988, The Journal of clinical investigation.

Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work.

J. Mccormack, J. Wisneski, G. Lopaschuk, 1996, The American journal of physiology.

Partial fatty acid oxidation inhibitors for stable angina

W. Stanley, 2002, Expert opinion on investigational drugs.

Impaired Myocardial Fatty Acid Oxidation and Reduced Protein Expression of Retinoid X Receptor-&agr; in Pacing-Induced Heart Failure

William C Stanley, Ashish R Panchal, Axel Linke, 2002, Circulation.

Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure.

M. Chandler, V. Lionetti, F. Recchia, 2004, Journal of molecular and cellular cardiology.

Myocardial substrate metabolism in the normal and failing heart.

William C Stanley, F. Recchia, G. Lopaschuk, 2005, Physiological reviews.

Update on innovative initiatives for the American Journal of Physiology-Heart and Circulatory Physiology.

William C Stanley, W. Stanley, Kara Hansell Keehan, 2013, American journal of physiology. Heart and circulatory physiology.

Potential Impact of Carbohydrate and Fat Intake on Pathological Left Ventricular Hypertrophy

K. O’Shea, D. Chess, W. Stanley, 2022 .

Low Carbohydrate/High-Fat Diet Attenuates Cardiac Hypertrophy, Remodeling, and Altered Gene Expression in Hypertension

P. Ernsberger, M. Chandler, B. Hoit, 2006, Hypertension.

Regulation of Malonyl-CoA Concentration and Turnover in the Normal Heart*

H. Brunengraber, C. Des Rosiers, F. David, 2004, Journal of Biological Chemistry.

Effects of Dopamine β-Hydroxylase Inhibition With Nepicastat on the Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Chronic Heart Failure

C. Benedict, S. Goldstein, H. Sabbah, 2000 .

Effects of Dopamineb-Hydroxylase Inhibition With Nepicastat on the Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Chronic Heart Failure

C. Benedict, S. Goldstein, H. Sabbah, 2000 .

Altered expression of the adenine nucleotide translocase isoforms and decreased ATP synthase activity in skeletal muscle mitochondria in heart failure.

F. Recchia, C. Hoppel, W. Stanley, 2009, Journal of molecular and cellular cardiology.

Extracellular matrix maturation in the left ventricle of normal and diabetic swine.

A. Vailas, W. Stanley, D. A. Martinez, 2003, Diabetes research and clinical practice.

The Role of Ca2+ in Coupling Cardiac Metabolism with Regulation of Contraction

G. Saidel, A. Landesberg, M. Cabrera, 2008, Annals of the New York Academy of Sciences.

Partitioning of pyruvate between oxidation and anaplerosis in swine hearts.

H. Brunengraber, C. Des Rosiers, C. Rosiers, 2000, American journal of physiology. Heart and circulatory physiology.

Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.

Hazel Huang, Wendy Keung, G. Lopaschuk, 2008, American journal of physiology. Heart and circulatory physiology.

Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia.

G. Saidel, M. Cabrera, W. Stanley, 2008, Journal of theoretical biology.

Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia.

Hazel Huang, W. Stanley, Lufang Zhou, 2008, American journal of physiology. Heart and circulatory physiology.

Differential effects of heptanoate and hexanoate on myocardial citric acid cycle intermediates following ischemia-reperfusion.

M. Chandler, Hazel Huang, H. Brunengraber, 2006, Journal of applied physiology.

reperfusion myocardial citric acid cycle intermediates following Differential effects of heptanoate and hexanoate

M. Chandler, Hazel Huang, H. Brunengraber, 2005 .

Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts to an adrenergic stress: benefits of a medium-chain fatty acid.

C. Des Rosiers, F. Labarthe, W. Stanley, 2005, American journal of physiology. Heart and circulatory physiology.

Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation

M. Chandler, Hazel Huang, W. Stanley, 2005, The Journal of physiology.

Post-Ischemic Treatment with Dipyruvyl-Acetyl-Glycerol Decreases Myocardial Infarct Size in the Pig

H. Brunengraber, A. Panchal, W. Stanley, 2003, Cardiovascular Drugs and Therapy.

Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation.

M. Chandler, C. Hoppel, Hazel Huang, 2004, American journal of physiology. Heart and circulatory physiology.

Effect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia.

M. Chandler, Hazel Huang, W. Stanley, 2003, American journal of physiology. Heart and circulatory physiology.

Partial inhibition of fatty acid oxidation increases regional contractile power and efficiency during demand-induced ischemia.

M. Chandler, Hazel Huang, W. Stanley, 2002, Cardiovascular research.

Increased nonoxidative glycolysis despite continued fatty acid uptake during demand-induced myocardial ischemia.

M. Chandler, Hazel Huang, W. Stanley, 2002, American journal of physiology. Heart and circulatory physiology.

Effects of acute hyperglycemia on myocardial glycolytic activity in humans.

J. Wisneski, E. Gertz, R. Neese, 1990, The Journal of clinical investigation.

Acute myocardial ischemia causes a transmural gradient in glucose extraction but not glucose uptake.

C. Stone, T. Hacker, W. Stanley, 1992, The American journal of physiology.

Pyruvate dehydrogenase activity and malonyl CoA levels in normal and ischemic swine myocardium: effects of dichloroacetate.

J. Mccormack, W. Stanley, J. Bringas, 1996, Journal of molecular and cellular cardiology.

Mitofusins 1 and 2 Are Essential for Postnatal Metabolic Remodeling in Heart

K. Walsh, I. Dominguez, W. Stanley, 2012, Circulation research.

Metabolomic analysis of two different models of delayed preconditioning.

S. Vatner, D. Vatner, Ji Yeon Park, 2013, Journal of molecular and cellular cardiology.

Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo.

M. Chandler, F. Recchia, T. Hintze, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Energy Metabolism in the Normal and Failing Heart: Potential for Therapeutic Interventions

M. Chandler, W. Stanley, 2002, Heart Failure Reviews.

Low-carbohydrate/high-fat diet attenuates pressure overload-induced ventricular remodeling and dysfunction.

W. Kop, B. Hoit, K. O’Shea, 2008, Journal of cardiac failure.

Decreased myocardial glucose uptake during ischemia in diabetic swine.

T. Hacker, W. Stanley, J. Hall, 1997, Metabolism: clinical and experimental.

Myocardial glucose transporters and glycolytic metabolism during ischemia in hyperglycemic diabetic swine.

G. Cartee, J. Wisneski, T. Hacker, 1994, Metabolism: clinical and experimental.

Does junk food lead to heart failure? Importance of dietary macronutrient composition in hypertension.

K. Shah, W. Stanley, M. Essop, 2009, Hypertension.

Composition in Hypertension Does Junk Food Lead to Heart Failure? Importance of Dietary Macronutrient

K. Shah, W. Stanley, M. Essop, 2009 .

High-sugar diets increase cardiac dysfunction and mortality in hypertension compared to low-carbohydrate or high-starch diets

P. Ernsberger, B. Hoit, H. Sabbah, 2008, Journal of hypertension.

Dopamine Beta-Hydroxylase Inhibition: A Potential Therapy for the Treatment of Congestive Heart Failure

W. Stanley, S. Hegde, 1998, Heart Failure Reviews.

Cardiovascular effects of nepicastat (RS-25560-197), a novel dopamine beta-hydroxylase inhibitor.

R. Eglen, W. Stanley, K. Lee, 1998, Journal of cardiovascular pharmacology.

Catecholamine modulatory effects of nepicastat (RS‐25560‐197), a novel, potent and selective inhibitor of dopamine‐β‐hydroxylase

R. Eglen, B. Li, D. Bonhaus, 1997, British journal of pharmacology.

MOUSE STRAIN‐SPECIFIC DIFFERENCES IN CARDIAC METABOLIC ENZYME ACTIVITIES OBSERVED IN A MODEL OF ISOPROTERENOL‐INDUCED CARDIAC HYPERTROPHY

M. Chandler, B. Hoit, W. Stanley, 2007, Clinical and experimental pharmacology & physiology.

Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction1[S]

Anup Mahurkar, Hong Wang, Yezhou Sun, 2013, Journal of Lipid Research.

CARNITINE PALMITOYL TRANSFERASE‐I INHIBITION IS NOT ASSOCIATED WITH CARDIAC HYPERTROPHY IN RATS FED A HIGH‐FAT DIET

P. Ernsberger, M. Chandler, B. Hoit, 2007, Clinical and experimental pharmacology & physiology.

Effects of chronic activation of peroxisome proliferator-activated receptor-alpha or high-fat feeding in a rat infarct model of heart failure.

M. Chandler, B. Hoit, M. Young, 2006, American journal of physiology. Heart and circulatory physiology.

Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin.

P. Ernsberger, M. Chandler, B. Hoit, 2006, American journal of physiology. Heart and circulatory physiology.

Regulation of muscle carbohydrate metabolism during exercise 1

W. Stanley, R. Connett, Richard J. Connett, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Glucose and lactate interrelations during moderate-intensity exercise in humans.

G. Brooks, J. Wisneski, E. Gertz, 1988, Metabolism: clinical and experimental.

Too much or not enough of a good thing? Cardiac glucolipotoxicity versus lipoprotection.

H. Taegtmeyer, W. Stanley, 2011, Journal of molecular and cellular cardiology.

Treatment with Docosahexaenoic Acid, but Not Eicosapentaenoic Acid, Delays Ca2+-Induced Mitochondria Permeability Transition in Normal and Hypertrophied Myocardium

K. O’Shea, C. Des Rosiers, W. Stanley, 2010, Journal of Pharmacology and Experimental Therapeutics.

omega-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential.

K. O’Shea, W. Stanley, M. Duda, 2009, Cardiovascular research.

Chronic Activation of PPAR α with Fenofibrate Prevents Alterations in Cardiac Metabolic Phenotype without Changing the Onset of Decompensation in Pacing-Induced Heart Failure

M. Chandler, V. Lionetti, F. Recchia, 2007 .

Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload.

K. Walsh, K. O’Shea, H. Sabbah, 2010, American journal of physiology. Heart and circulatory physiology.

v -3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential

K. O’Shea, W. Stanley, M. Duda, 2009 .

Short-Term Treatment With Ranolazine Improves Mechanical Efficiency in Dogs With Chronic Heart Failure

M. Chandler, H. Sabbah, G. Suzuki, 2002, Circulation research.

Altered cardiac metabolic phenotype after prolonged inhibition of NO synthesis in chronically instrumented dogs.

M. Chandler, V. Lionetti, F. Recchia, 2006, American journal of physiology. Heart and circulatory physiology.

Chronic Hypoxia Impairs Cytochrome Oxidase Activity Via Oxidative Stress in Selected Fetal Guinea Pig Organs

W. Stanley, L. Thompson, Yazan M. Al-Hasan, 2013, Reproductive Sciences.

Mechanical and metabolic functions in pig hearts after 4 days of chronic coronary stenosis.

A. Liedtke, W. Stanley, S. Nellis, 1995, Journal of the American College of Cardiology.

Preserved protein synthesis in the heart in response to acute fasting and chronic food restriction despite reductions in liver and skeletal muscle.

M. Hatzoglou, S. Previs, Celvie L. Yuan, 2008, American journal of physiology. Endocrinology and metabolism.

A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload.

K. O’Shea, D. Chess, W. Stanley, 2009, American journal of physiology. Heart and circulatory physiology.

Mitochondria in Cardiovascular Physiology and Disease Enhanced resistance to permeability transition in interfibrillar cardiac mitochondria in dogs : effects of aging and long-term aldosterone infusion

C. Hoppel, H. Sabbah, P. Hecker, 2013 .

Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction.

W. Harris, K. O’Shea, H. Sabbah, 2009, Cardiovascular research.

Effects of a high saturated fat diet on cardiac hypertrophy and dysfunction in response to pressure overload.

B. Hoit, D. Chess, B. Lei, 2008, Journal of cardiac failure.

Dietary supplementation with omega-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload.

W. Kop, B. Hoit, K. O’Shea, 2007, Cardiovascular research.

The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet.

W. Kop, K. O’Shea, D. Chess, 2008, American journal of physiology. Heart and circulatory physiology.

High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet.

P. Ernsberger, M. Chandler, B. Hoit, 2007, American journal of hypertension.

Heart High Fructose Diet Increases Mortality in Hypertensive Rats Compared to a Complex Carbohydrate or High Fat Diet

P. Ernsberger, M. Chandler, B. Hoit, 2007 .

diabetes mellitus contractile dysfunction in streptozotocin-induced High-dose benfotiamine rescues cardiomyocyte

H. Hammes, Paul J Thornalley, Shi-Yan Li, 2006 .

[Overview on omega-3 polyunsaturated fatty acids and heart failure].

K. O’Shea, W. Stanley, M. Duda, 2010, Kardiologia polska.

Cardiac mitochondrial proteome dynamics with heavy water reveals stable rate of mitochondrial protein synthesis in heart failure despite decline in mitochondrial oxidative capacity.

R. Sadygov, F. Recchia, P. Hecker, 2014, Journal of molecular and cellular cardiology.

Glucose 6-Phosphate Dehydrogenase Deficiency Increases Redox Stress and Moderately Accelerates the Development of Heart Failure

V. Lionetti, F. Recchia, S. Gupte, 2013, Circulation. Heart failure.

Acute vagal stimulation attenuates cardiac metabolic response to β‐adrenergic stress

F. Recchia, H. Sabbah, Roberto Sarnari, 2012, The Journal of physiology.

ω-3 Polyunsaturated fatty acids prevent pressure overload-induced ventricular dilation and decrease in mitochondrial enzymes despite no change in adiponectin

K. Walsh, K. O’Shea, C. Des Rosiers, 2010, Lipids in Health and Disease.

Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart.

C. Hoppel, K. O’Shea, Hazel Huang, 2007, Journal of lipid research.

Diabetes or peroxisome proliferator-activated receptor α agonist increases mitochondrial thioesterase I activity in heart Published, JLR Papers in Press, April 16, 2007.

C. Hoppel, K. O’Shea, Hazel Huang, 2007, Journal of Lipid Research.

CVT-4325 Inhibits Myocardial Fatty Acid Uptake and Improves Left Ventricular Systolic Function without Increasing Myocardial Oxygen Consumption in Dogs with Chronic Heart Failure

M. Chandler, H. Sabbah, L. Belardinelli, 2007, Cardiovascular Drugs and Therapy.

Malonyl-CoA Decarboxylase Inhibition as a Novel Approach to Treat Ischemic Heart Disease

G. Lopaschuk, W. Stanley, 2006, Cardiovascular Drugs and Therapy.

Dissociation between gene and protein expression of metabolic enzymes in a rodent model of heart failure

M. Chandler, B. Hoit, M. Young, 2006, European journal of heart failure.

Chronic treatment with trimetazidine reduces the upregulation of atrial natriuretic peptide in heart failure

M. Chandler, B. Hoit, M. Young, 2006, Fundamental & clinical pharmacology.

[Potential impact of carbohydrate and fat intake on cardiac hypertrophy].

D. Chess, W. Stanley, A. Berȩsewicz, 2006, Kardiologia polska.

Metabolic therapies for heart disease: fish for prevention and treatment of cardiac failure?

F. Recchia, W. Stanley, I. Okere, 2005, Cardiovascular research.

Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia.

M. Chandler, Hazel Huang, G. Lopaschuk, 2005, American journal of physiology. Heart and circulatory physiology.

Metabolic Therapy for Ischemic Heart Disease: The Rationale for Inhibition of Fatty Acid Oxidation

H. Sabbah, W. Stanley, 2005, Heart Failure Reviews.

Malonyl Coenzyme A Decarboxylase Inhibition Protects the Ischemic Heart by Inhibiting Fatty Acid Oxidation and Stimulating Glucose Oxidation

M. Chandler, J. Dyck, T. Arrhenius, 2004, Circulation research.

Effects of dopamine beta-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure.

C. Benedict, S. Goldstein, H. Sabbah, 2000, Circulation.

Myocardial lactate metabolism during exercise.

W. Stanley, 1991, Medicine and science in sports and exercise.

Increased cardiac fatty acid uptake with dobutamine infusion in swine is accompanied by a decrease in malonyl CoA levels.

G. Lopaschuk, W. Stanley, J. Bringas, 1996, Cardiovascular research.

Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine

M. Marzilli, W. Stanley, 2003, Fundamental & clinical pharmacology.

beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content.

G. Lopaschuk, W. Stanley, Krista M. Kivilo, 2003, American journal of physiology. Heart and circulatory physiology.

Myocardial metabolism during hypoxia: maintained lactate oxidation during increased glycolysis.

B. Cason, C. Mazer, J. Wisneski, 1990, Metabolism: clinical and experimental.

Ranolazine: a novel metabolic modulator for the treatment of angina.

J. Mccormack, W. Stanley, A. Wolff, 1998, General pharmacology.

Partial fatty acid oxidation inhibitors: a potentially new class of drugs for heart failure

W. Stanley, Hani N. Sabbaha, 2002, European journal of heart failure.

Nitric oxide synthase inhibition and elevated endothelin increase oxygen consumption but do not affect glucose and palmitate oxidation in the isolated rat heart.

W. Stanley, W. Boemke, A. Berȩsewicz, 2004, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Ischemia produces an increase in ammonia output in swine myocardium.

A. Liedtke, T. Hacker, W. Stanley, 1994, Cardioscience.

Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure.

M. Chandler, H. Sabbah, G. Suzuki, 2002, Journal of cardiac failure.

Beta-receptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure.

H. Sabbah, A. Panchal, W. Stanley, 1998, Journal of cardiac failure.

Exercise training does not compensate for age-related decrease in myocardial GLUT-4 content.

G. Cartee, W. Stanley, R. Mazzeo, 1994, Journal of applied physiology.

Assessing the Reversibility of the Anaplerotic Reactions of the Propionyl-CoA Pathway in Heart and Liver*

C. Hoppel, H. Brunengraber, C. Des Rosiers, 2003, Journal of Biological Chemistry.

Experimental Studies Beta-Receptor Blockade Decreases Carnitine Palmitoyl Transferase I Activity in Dogs With Heart Failure

H. Sabbah, A. Panchal, W. Stanley, 1998 .

Myocardial Energy Metabolism During Ischemia and the Mechanisms of Metabolic Therapies

W. Stanley, 2004, Journal of cardiovascular pharmacology and therapeutics.

HIGH‐FAT DIET PREVENTS CARDIAC HYPERTROPHY AND IMPROVES CONTRACTILE FUNCTION IN THE HYPERTENSIVE DAHL SALT‐SENSITIVE RAT

P. Ernsberger, M. Chandler, B. Hoit, 2005, Clinical and experimental pharmacology & physiology.

Chronic treatment with the peroxisome proliferator-activated receptor α agonist Wy-14,643 attenuates myocardial respiratory capacity and contractile function

M. Young, W. Stanley, M. Essop, 2009, Molecular and Cellular Biochemistry.

Metabolic Therapy for Heart Disease: Impact of Trimetazidine

H. Sabbah, W. Stanley, 2005, Heart Failure Reviews.

The Cardioprotective Effects of Fish Oil During Pressure Overload Are Blocked by High Fat Intake: Role Of Cardiac Phospholipid Remodeling

R. Murphy, K. O’Shea, K. Shah, 2009, Hypertension.

Pacing-Induced Heart Failure α Receptor-Impaired Myocardial Fatty Acid Oxidation and Reduced Protein Expression of Retinoid X

F. Recchia, Q. Diep, G. Lopaschuk, 2002 .

Effect of a high-protein diet on development of heart failure in response to pressure overload.

P. Hecker, W. Stanley, Tatiana F G Galvão, 2014, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival.

K. O’Shea, H. Sabbah, C. Des Rosiers, 2013, American journal of physiology. Heart and circulatory physiology.

Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death.

K. Walsh, W. Stanley, Kyriakos N. Papanicolaou, 2012, American journal of physiology. Heart and circulatory physiology.

Dietary omega-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca2+-induced permeability transition.

G. Fiskum, T. Kristian, R. Murphy, 2009, Journal of molecular and cellular cardiology.

Metabolic Approaches to the Treatment of Ischemic Heart Disease: The Clinicians' Perspective

R. Ferrari, W. Stanley, A. Wolff, 2002, Heart Failure Reviews.

Docosahexaenoic Acid Supplementation Alters Key Properties of Cardiac Mitochondria and Modestly Attenuates Development of Left Ventricular Dysfunction in Pressure Overload-Induced Heart Failure

C. Rosiers, C. Daneault, P. Hecker, 2013, Cardiovascular Drugs and Therapy.

Evaluation of Docosahexaenoic Acid in a Dog Model of Hypertension Induced Left Ventricular Hypertrophy

S. Hoag, H. Sabbah, C. Rosiers, 2013, Journal of Cardiovascular Translational Research.

A radiochemical pyruvate dehydrogenase assay: activity in heart.

C. Hoppel, W. Stanley, J. Kerner, 2003, Analytical biochemistry.

IN SEARCH OF CARDIOPROTECTION: A REVIEW OF POTENTIAL AGENTS

W. Stanley, 2004 .

Glucose metabolism in the ischemic heart.

G. Lopaschuk, W. Stanley, 1997, Circulation.

Blood glutathione oxidation during human exercise.

G. Brooks, L. Packer, K. Gohil, 1988, Journal of applied physiology.

Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power.

M. Chandler, J. Dyck, G. Lopaschuk, 2005, American journal of physiology. Heart and circulatory physiology.

contentin vivo independent of changes in malonyl-CoA -Hydroxybutyrate inhibits myocardial fatty acid β

W. Stanley, Krista M. Kivilo, J. Am, 2016 .

Ranolazine: new approach for the treatment of stable angina pectoris

W. Stanley, 2005, Expert review of cardiovascular therapy.

Changes in cardiac metabolism: a critical step from stable angina to ischaemic cardiomyopathy

W. Stanley, 2001 .

In vivo models of myocardial metabolism during ischemia: application to drug discovery and evaluation.

W. Stanley, 2000, Journal of pharmacological and toxicological methods.

Regulation of energy substrate metabolism in the diabetic heart.

J. Mccormack, G. Lopaschuk, W. Stanley, 1997, Cardiovascular research.

Diabetes reduces right atrial beta-adrenergic signaling but not agonist stimulation of heart rate in swine.

J. Doré, W. Stanley, J. Hall, 2001, Canadian journal of physiology and pharmacology.

Tracer mixing: sites of tracer infusion and sampling.

G. Brooks, D. Morris, J. Wisneski, 1990, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

A model for measurement of lactate disappearance with isotopic tracers in the steady state.

S. Lehman, W. Stanley, 1988, The Biochemical journal.

Lactate extraction during net lactate release in legs of humans during exercise.

G. Brooks, D. Morris, J. Wisneski, 1986, Journal of applied physiology.

Adrenergic desensitization in left ventricle from streptozotocin diabetic swine.

W. Stanley, J. Hall, C. Hamilton, 1995, Journal of molecular and cellular cardiology.

Lipotoxicity and the development of heart failure: moving from mouse to man.

F. Recchia, W. Stanley, 2010, Cell metabolism.

Decreased interstitial glucose and transmural gradient in lactate during ischemia

W. Stanley, J. Hall, L. Hernandez, 1994, Basic Research in Cardiology.

Glucose 6-Phosphate Dehydrogenase Deficiency Increases Redox Stress and Moderately Accelerates the Development of Heart Failure Hecker et al: Glucose 6-Phosphate Dehydrogenase Deficiency and Heart Failure

V. Lionetti, F. Recchia, S. Gupte, 2017 .

Transient activation of p38 MAP kinase and up-regulation of Pim-1 kinase in cardiac hypertrophy despite no activation of AMPK.

K. O’Shea, Wendy Keung, G. Lopaschuk, 2008, Journal of molecular and cellular cardiology.

Mitochondria in Cardiovascular Physiology and Disease Marine n 3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival

K. O’Shea, H. Sabbah, C. Rosiers, 2012 .

Effects of Dopamine b -Hydroxylase Inhibition With Nepicastat on the Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Chronic Heart Failure

C. Benedict, S. Goldstein, H. Sabbah, 2000 .

Systemic lactate kinetics during graded exercise in man.

G. Brooks, D. Morris, J. Wisneski, 1985, The American journal of physiology.

Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids

W. Stanley, R. Khairallah, E. Dabkowski, 2012, Current opinion in clinical nutrition and metabolic care.

Improved Mitochondrial Function with Diet-Induced Increase in Either Docosahexaenoic Acid or Arachidonic Acid in Membrane Phospholipids

C. Hoppel, K. O’Shea, C. Rosiers, 2012, PloS one.

Inhibition of endogenous lactate turnover with lactate infusion in humans.

K. Feingold, E. Gertz, W. Stanley, 1989, Metabolism: clinical and experimental.

Lactate Kinetics During Submaximal Exercise in Humans: Studies With Isotopic Tracers

J. Wisneski, E. Gertz, R. Neese, 1988 .

Dipropionylcysteine Ethyl Ester Compensates for Loss of Citric Acid Cycle Intermediates During Post Ischemia Reperfusion in the Pig Heart

Hazel Huang, R. Kombu, H. Brunengraber, 2009, Cardiovascular Drugs and Therapy.

Hyperglycemia results in an increase in myocardial interstitial glucose and glucose uptake during ischemia.

W. Stanley, J. Hall, L. Hernandez, 1996, Metabolism: clinical and experimental.

Exercise training attenuates the reduction in myocardial GLUT-4 in diabetic rats.

W. Stanley, J. Hall, W. L. Sexton, 1995, Journal of applied physiology.

Measuring tracee turnover from tracer specific activity in the steady state.

S. Lehman, W. Stanley, 1988, The American journal of physiology.

Expression of mitochondrial regulatory genes parallels respiratory capacity and contractile function in a rat model of hypoxia-induced right ventricular hypertrophy

M. Young, W. Stanley, M. Essop, 2008, Molecular and Cellular Biochemistry.

Myocardial interstitial purine metabolites and lactate with increased work in swine.

W. Stanley, J. Hall, R. Pizzurro, 1995, Cardiovascular research.

Alanine, glutamate, and ammonia exchanges in acutely ischemic swine myocardium

C. Stone, T. Hacker, W. Stanley, 1992, Basic Research in Cardiology.

Myocardial fatty acid metabolism in health and disease.

C. Folmes, G. Lopaschuk, W. Stanley, 2010, Physiological reviews.

Fatty acid oxidation in cardiac and skeletal muscle mitochondria is unaffected by deletion of CD36.

C. Hoppel, M. Febbraio, W. Stanley, 2007, Archives of biochemistry and biophysics.

Measuring lactate production.

G. Brooks, W. Stanley, 1987, The American journal of physiology.

Plasma Proteome Dynamics: Analysis of Lipoproteins and Acute Phase Response Proteins with 2H2O Metabolic Labeling*

R. Sadygov, J. Kirwan, S. Previs, 2012, Molecular & Cellular Proteomics.

Cardiac energetics during ischaemia and the rationale for metabolic interventions.

W. Stanley, 2001, Coronary artery disease.

Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance.

J. Kirwan, T. P. Solomon, W. Stanley, 2009, American journal of physiology. Endocrinology and metabolism.

Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation

William Stanley, Hani N. Sabbah, Charles L. Hoppel, 2008, Cardiovascular research.

Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.

R. Lum, J. Linden, L. Belardinelli, 1997, Journal of medicinal chemistry.

Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions Potential for pharmacological interventions

J. Mccormack, G. Lopaschuk, W. Stanley, 1997 .

Acute hibernation decreases myocardial pyruvate carboxylation and citrate release.

M. Chandler, H. Brunengraber, C. Des Rosiers, 2001, American journal of physiology. Heart and circulatory physiology.

Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes

Aristide C. Chikando, K. Walsh, K. O’Shea, 2011, Molecular and Cellular Biology.

Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease.

F. Recchia, S. Gupte, J. Leopold, 2013, American journal of physiology. Heart and circulatory physiology.

Pharmacological evaluation of 1229U91, a novel high-affinity and selective neuropeptide Y-Y1 receptor antagonist.

R. Eglen, D. Bonhaus, W. Stanley, 1995, The Journal of pharmacology and experimental therapeutics.

Dietary fat and heart failure: moving from lipotoxicity to lipoprotection.

W. Stanley, Kelly O'connell, E. Dabkowski, 2012, Circulation research.

High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects.

K. O’Shea, H. Sabbah, C. Des Rosiers, 2012, Cardiovascular research.

Validation of echocardiographic methods for assessing left ventricular dysfunction in rats with myocardial infarction.

William C Stanley, M. Chandler, B. Hoit, 2004, American journal of physiology. Heart and circulatory physiology.

MK2‐Deficient Mice Are Bradycardic and Display Delayed Hypertrophic Remodeling in Response to a Chronic Increase in Afterload

J. Tardif, M. Gaestel, C. Fiset, 2021, Journal of the American Heart Association.

MK2-deficient mice are bradycardic and display delayed hypertrophic remodelling in response to a chronic increase in afterload

J. Tardif, M. Gaestel, C. Fiset, 2020, bioRxiv.

Alterations in enzymes involved in fat metabolism after acute and chronic altitude exposure.

A. Panchal, W. Stanley, R. Mazzeo, 2001, Journal of applied physiology.

Modulating fatty acid oxidation in heart failure.

F. Recchia, W. Stanley, Vincenzo Lionetti, 2011, Cardiovascular research.

, Marco idiopathic dilated cardiomyopathy selection flexibility during stress in patients with Impaired myocardial metabolic reserve and substrate

R. Testa, L. Menichetti, D. Neglia, 2007 .

Mechanistic Model of Myocardial Energy Metabolism Under Normal and Ischemic Conditions

Gerald M. Saidel, Marco E. Cabrera, G. Saidel, 2002, Annals of Biomedical Engineering.

Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure.

Vincenzo Lionetti, William C Stanley, Axel Linke, 2005, Cardiovascular research.

Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs.

William C Stanley, Ashish R Panchal, M. Chandler, 2002, American journal of physiology. Endocrinology and metabolism.

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria[S]

Hong Wang, C. Sztalryd, D. Gong, 2011, Journal of Lipid Research.

Effects of glucose-6-phosphate dehydrogenase deficiency on the metabolic and cardiac responses to obesogenic or high-fructose diets.

P. Hecker, W. Stanley, R. Mapanga, 2012, American journal of physiology. Endocrinology and metabolism.

Failure Left Ventricular Function and Remodeling in Dogs With Chronic Heart Therapy With Cardiac Contractility Modulation Electrical Signals Improves

D. Burkhoff, Ramesh C. Gupta, W. Stanley, 2010 .

Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure.

D. Burkhoff, S. Ben‐Haim, H. Sabbah, 2007, Journal of the American College of Cardiology.

Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure.

H. Sabbah, Ramesh C. Gupta, L. Belardinelli, 2008, American journal of physiology. Heart and circulatory physiology.

Hypertrophied rat hearts are less responsive to the metabolic and functional effects of insulin.

B. Rodrigues, G. Bondy, C. Lydell, 2000, American journal of physiology. Endocrinology and metabolism.

Cardiac Energy Metabolism in Obesity

G. Lopaschuk, W. Stanley, Clifford D. L. Folmes, 2007, Circulation research.

Nutrition and cardiovascular disease: putting a pathogenic framework into focus.

C. Napoli, L. Ignarro, W. Stanley, 2007, Cardiovascular research.

Rationale for a metabolic approach in diabetic coronary patients

W. Stanley, 2005, Coronary artery disease.

Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular performance in dogs with chronic heart failure

H. Sabbah, G. Suzuki, W. Stanley, 2000 .

Role of Cellular Compartmentation in the Metabolic Response to Stress

Xin Yu, M. Cabrera, W. Stanley, 2006, Annals of the New York Academy of Sciences.

Computational studies of the effects of myocardial blood flow reductions on cardiac metabolism

M. Cabrera, W. Stanley, J. Salem, 2004, Biomedical engineering online.

Quantitative assessment of anaplerosis from propionate in pig heart in vivo.

Henri Brunengraber, William C Stanley, C. Hoppel, 2003, American journal of physiology. Endocrinology and metabolism.

Mitochondria in Cardiovascular Physiology and Disease Assessment of cardiac proteome dynamics with heavy water : slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria

R. Sadygov, K. Walsh, S. Previs, 2013 .

Ventilatory control studied with circulatory occlusion during exercise recovery

G. Brooks, W. Stanley, William R. Lee, 2004, European Journal of Applied Physiology and Occupational Physiology.

Ventilation studied with circulatory occlusion during two intensities of exercise

G. Brooks, W. Stanley, William R. Lee, 2004, European Journal of Applied Physiology and Occupational Physiology.

Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studies.

Lufang Zhou, William C Stanley, M. Cabrera, 2006, American journal of physiology. Heart and circulatory physiology.

Assay of the activity of malonyl-coenzyme A decarboxylase by gas chromatography-mass spectrometry.

H. Brunengraber, Cory J Darrow, W. Stanley, 2007, Analytical Biochemistry.

Dietary saturated fat and docosahexaenoic acid differentially effect cardiac mitochondrial phospholipid fatty acyl composition and Ca2+ uptake, without altering permeability transition or left ventricular function

C. Daneault, W. Stanley, Wenhong Xu, 2013, Physiological reports.

Deleterious effects of sugar and protective effects of starch on cardiac remodeling, contractile dysfunction, and mortality in response to pressure overload.

B. Hoit, D. Chess, B. Lei, 2007, American journal of physiology. Heart and circulatory physiology.

Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition.

Gary Fiskum, William C Stanley, Peter A Hecker, 2010, Biochimica et biophysica acta.

Effects of environmental stress following myocardial infarction on behavioral measures and heart failure progression: The influence of isolated and group housing conditions

W. Kop, T. Gould, K. O’Shea, 2015, Physiology & Behavior.

Effects of High Arterial Oxygen Tension on Function, Blood Flow Distribution, and Metabolism in Ischemic Myocardium

B. Cason, J. Wisneski, E. Gertz, 1992, Circulation.

A mathematical model of skeletal muscle metabolism. Simulations of exercise responses after space travel and endurance training

G. Saidel, K. Radhakrishnan, J. Dibella, 2004 .

Dichloroacetate stimulates carbohydrate metabolism but does not improve systolic function in ischemic pig heart.

B. Cason, C. Mazer, J. Wisneski, 1995, The American journal of physiology.

Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity

J. Auwerx, S. Vatner, D. Vatner, 2012, Aging cell.

Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs

Lufang Zhou, William C Stanley, Celvie L Yuan, 2007, The Journal of physiology.

Step and ramp induction of myocardial ischemia: comparison of in vivo and in silico results.

M. Chandler, M. Cabrera, W. Stanley, 2004, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Abstract 19323: Disruption of Adenylyl Cyclase Type 5, a Novel Target for Obesity, Diabetes and Diabetic Cardiomyopathy

S. Vatner, D. Vatner, J. Pessin, 2012 .

Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusion.

C. Shaw, P. Hardin, M. Bray, 2007, Journal of molecular and cellular cardiology.

Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies

Lufang Zhou, Xin Yu, William C Stanley, 2005, The Journal of physiology.

Regulation of Cardiac Energetics: Role of Redox State and Cellular Compartmentation during Ischemia

G. Saidel, M. Cabrera, W. Stanley, 2005, Annals of the New York Academy of Sciences.

Abstract 2371: Dietary Supplementation with Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) Prevents Activation of Inflammation and Development of Left Ventricular Dysfunction Induced by Chronic Pressure Overload

W. Harris, K. O’Shea, W. Stanley, 2008 .

Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia.

Lufang Zhou, William C Stanley, G. Saidel, 2005, American journal of physiology. Heart and circulatory physiology.

Endurance Exercise Training Causes Adrenal Medullary Hypertrophy in Young and Old Fischer 344 Rats

L. Gosselin, W. Stanley, K. Schmidt, 1992, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions.

G. Lopaschuk, W. Stanley, J. Hall, 1997, Cardiovascular research.

EXERCISE TRAINING ATTENUATES THE REDUCTION IN MYOCARDIAL GLUT 4 IN DIABETIC RATS.: 237

W. Stanley, J. Hall, W. L. Sexton, 1995 .

Diabetes and ischaemic heart disease: essential role for metabolic therapies.

W. Stanley, 2005, Coronary artery disease.

Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance.

J. Kirwan, T. P. Solomon, W. Stanley, 2009, American journal of physiology. Endocrinology and metabolism.

Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy.

D. Chess, W. Stanley, N. Sharma, 2007, Cardiovascular research.

Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids

W. Stanley, R. Khairallah, E. Dabkowski, 2012, Current opinion in clinical nutrition and metabolic care.

Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity

J. Auwerx, S. Vatner, D. Vatner, 2012, Aging cell.

Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs.

M. Chandler, F. Recchia, G. Lopaschuk, 2002, American journal of physiology. Endocrinology and metabolism.

Too much or not enough of a good thing? Cardiac glucolipotoxicity versus lipoprotection.

H. Taegtmeyer, W. Stanley, 2011, Journal of molecular and cellular cardiology.

A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload.

D. Chess, W. Stanley, Wenhong Xu, 2009, American journal of physiology. Heart and circulatory physiology.