I. Moskowitz

发表

A common genetic variant within SCN10A modulates cardiac SCN5A expression.

J. Seidman, M. Nóbrega, C. Seidman, 2014, The Journal of clinical investigation.

Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development

Dana E. Cullen, Lizhi Liu, Chelsea Ray, 2015, Proceedings of the National Academy of Sciences.

A Molecular Pathway Including Id2, Tbx5, and Nkx2-5 Required for Cardiac Conduction System Development

J. Shendure, J. Seidman, M. Nóbrega, 2007, Cell.

Many ways to break a heart

I. Moskowitz, Megan Rowton, 2015, eLife.

disease has wider effects than previously thought.

Ashley J. Waardenberg, S. Bhattacharya, R. Harvey, 2015 .

Genome-wide identification of mouse congenital heart disease loci.

Karen L Svenson, Monica J Justice, Kathryn E. Hentges, 2010, Human molecular genetics.

The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model

S. Camper, R. Reeves, Huiqing Li, 2015, BMC Developmental Biology.

A promoter interaction map for cardiovascular disease genetics

M. Nóbrega, I. Aneas, N. Sakabe, 2018, bioRxiv.

Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription

Adrian T. Grzybowski, Rohan N. Shah, A. Ruthenburg, 2017, Nature Structural &Molecular Biology.

Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria.

J. Lieb, Kohta Ikegami, I. Moskowitz, 2020, Developmental cell.

Phosphorylated Lamin A targets active enhancers and is associated with abnormal transcriptional activation in progeria

J. Lieb, Kohta Ikegami, I. Moskowitz, 2019, bioRxiv.

Phosphorylated Lamin A/C in the nuclear interior binds active enhancers associated with abnormal transcription in progeria

J. Lieb, Kohta Ikegami, I. Moskowitz, 2019 .

Chamber-specific transcriptional responses in atrial fibrillation

I. Moskowitz, S. Rentschler, Q. Guo, 2020, JCI insight.

A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

Francisco J. Alvarado, C. Weber, M. Broman, 2019, eLife.

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm

Christopher R. Weber, M. Zhang, J. Seidman, 2016, Science Translational Medicine.

Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation

P. Kirchhof, P. Ellinor, W. de Laat, 2020, Circulation research.

Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis.

Christopher R. Weber, M. Broman, Brigitte Laforest, 2019, The Journal of clinical investigation.

Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development

Gerald C. Chu, J. Seidman, W. Pu, 2011, Proceedings of the National Academy of Sciences.

Sarcomere Mutations in Cardiomyopathy With Left Ventricular Hypertrabeculation

D. Waggoner, B. Mora, E. McNally, 2009, Circulation. Cardiovascular genetics.

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system

J. Seidman, B. Bruneau, D. Roden, 2004, Development.

Summary The T-Box transcription factor Tbx 5 is required for the patterning and maturation of the murine cardiac conduction system

J. Seidman, B. Bruneau, D. Roden, 2004 .

A Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation

A. Basu, A. Moon, Junghun Kweon, 2019, bioRxiv.

De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects

M. Hurles, E. Eichler, V. Sheffield, 2016, PLoS genetics.

Detecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors

J. Cunningham, X. Yang, I. Moskowitz, 2022, Nucleic acids research.

Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy.

A. Husain, E. McNally, M. Burke, 2010, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

sonic hedgehog is required in pulmonary endoderm for atrial septation

J. Friedland-Little, I. Moskowitz, Michael A. Peterson, 2009, Development.

DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.

M. L. Le Beau, A. Melnick, M. Figueroa, 2010, Cancer research.

A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.

K. Anderson, J. Bosman, Steven Y. Cheng, 2011, Human molecular genetics.

Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation

Menglan Xiang, I. Moskowitz, Linglin Xie, 2017, Proceedings of the National Academy of Sciences.

ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction

N. Kasthuri, I. Efimov, Mingyi Wang, 2020, Circulation research.

Expression of Sumoylation Deficient Nkx2.5 Mutant in Nkx2.5 Haploinsufficient Mice Leads to Congenital Heart Defects

E. Y. Kim, Jiang Chang, Yanlin Ma, 2011, PloS one.

The Role of Cardiac Troponin T Quantity and Function in Cardiac Development and Dilated Cardiomyopathy

Stephen H. Smith, Ferhaan Ahmad, J. Seidman, 2008, PloS one.

A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human

J. V. van Berlo, W. Gong, Bhairab N. Singh, 2018, Nature Communications.

Identification of direct transcriptional targets of NFATC2 that promote β-cell proliferation.

S. Keleş, Rhonda Bacher, C. Kendziorski, 2021, The Journal of clinical investigation.

Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation

S. Vokes, A. McMahon, X. Yang, 2014, PLoS genetics.

Frem1 activity regulated by Sonic Hedgehog signaling in the cranial neural crest mesenchyme guides midfacial morphogenesis

M. Sheets, Joshua W. M. Theisen, R. Lipinski, 2022, bioRxiv.

Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.

M. Kyba, Kohta Ikegami, X. Yang, 2022, Developmental cell.

Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency.

H. Laufs, H. Oettgen, A. Perez-Atayde, 2002, Mayo Clinic proceedings.

Transcriptional Patterning of the Ventricular Cardiac Conduction System

M. Nóbrega, I. Efimov, Kohta Ikegami, 2020, Circulation research.

Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice

C. Berul, H. Wakimoto, S. Izumo, 2003, Genesis.

Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types

J. Corbo, C. Cepko, Carlos Perez-Cervantes, 2020, Development.

Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types

J. Corbo, C. Cepko, Carlos Perez-Cervantes, 2019, bioRxiv.

Control of cardiomyocyte differentiation timing by intercellular signaling pathways.

I. Moskowitz, Ariel B. Rydeen, Megan Rowton, 2021, Seminars in cell & developmental biology.

Defective sumoylation pathway directs congenital heart disease.

Jun Wang, Huiping Zhu, Wei Yu, 2011, Birth defects research. Part A, Clinical and molecular teratology.

A promoter interaction map for cardiovascular disease genetics

Ivy Aneas, M. Nóbrega, I. Aneas, 2018, bioRxiv.

WITHDRAWN: The cardiac lncRNA Chantico directly regulates Cxcl1 chemokine transcription

J. Piccirilli, Carlos Perez-Cervantes, A. Ruthenburg, 2021, bioRxiv.

Filamin A (FLNA) is required for cell–cell contact in vascular development and cardiac morphogenesis

Luis Vidali, Christopher A Walsh, Fumihiko Nakamura, 2006, Proceedings of the National Academy of Sciences.

ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment

Kohta Ikegami, B. Black, J. Cunningham, 2021, bioRxiv.

Hedgehog–FGF signaling axis patterns anterior mesoderm during gastrulation

A. Moon, H. Eckart, Junghun Kweon, 2020, Proceedings of the National Academy of Sciences.

Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

Christopher R. Weber, W. de Laat, X. Yang, 2017, eLife.

TBX5: A Key Regulator of Heart Development.

I. Moskowitz, J. Steimle, Jeffrey D. Steimle, 2017, Current topics in developmental biology.

Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease.

M. Nóbrega, J. Krieger, A. Pereira, 2012, Human molecular genetics.

Hedgehog signaling activates a heterochronic gene regulatory network to control differentiation timing across lineages

M. Kyba, Kohta Ikegami, X. Yang, 2020, bioRxiv.

Low-dose cyclosporin A therapy in children with refractory immune thrombocytopenic purpura.

P. Gaynon, T. Cripe, I. Moskowitz, 1999, Journal of pediatric hematology/oncology.

Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation

S. Vokes, A. McMahon, X. Yang, 2016, PLoS genetics.

Single-cell genomics improves the discovery of risk variants and genes of cardiac traits

L. Smith, H. Eckart, I. Moskowitz, 2022, medRxiv.

Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.

J. Shendure, C. Maslen, X. Yang, 2016, Human molecular genetics.

Regional and TBX5-Dependent Gene Expression in the Atria: Implications for Pulmonary Vein Development and Atrial Fibrillation

M. Broman, Brigitte Laforest, I. Moskowitz, 2020, Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension.

Depolymerized lamins link nuclear envelope breakdown to mitotic transcriptional quiescence

J. Lieb, Kohta Ikegami, I. Moskowitz, 2018, bioRxiv.

MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus

Ronald Berezney, Kasper Lage, Raymond M. Anchan, 2015, Human molecular genetics.

MATR 3 disruption in human and mouse associated with bicuspid aortic valve , aortic coarctation and patent ductus arteriosus

K. Lage, J. Gusella, C. Morton, 2015 .

TBX5 drives Scn5a expression to regulate cardiac conduction system function.

M. Nóbrega, Gene Kim, S. Smemo, 2012, The Journal of clinical investigation.

Differential Etv2 threshold requirement for endothelial and erythropoietic development

D. Dickel, K. Pollard, L. Pennacchio, 2022, Cell reports.

Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.

J. Friedland-Little, Ozanna Burnicka-Turek, I. Moskowitz, 2012, Developmental cell.

Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development

Menglan Xiang, Bingruo Wu, I. Moskowitz, 2019, PLoS genetics.

Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics

A. Di Rienzo, M. Civelek, M. Whalen, 2018, Proceedings of the National Academy of Sciences.

The emerging genetic landscape underlying cardiac conduction system function.

Marcelo A Nobrega, M. Nóbrega, D. Arnolds, 2011, Birth defects research. Part A, Clinical and molecular teratology.

A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines

M. Justice, A. Bradley, B. Liu, 2009, BMC Genetics.

Complex Interactions Between Genes Controlling Trafficking in Primary Cilia

K. Anderson, I. Moskowitz, J. Eggenschwiler, 2011, Nature Genetics.

Evolutionarily conserved Tbx5–Wnt2/2b pathway orchestrates cardiopulmonary development

R. Ho, M. Kyba, F. Conlon, 2018, Proceedings of the National Academy of Sciences.

Transgenic Mice Overexpressing Mutant PRKAG2 Define the Cause of Wolff-Parkinson-White Syndrome in Glycogen Storage Cardiomyopathy

Ferhaan Ahmad, J. Schmitt, J. Seidman, 2003, Circulation.

Molecular Basis of Cardiac Development

I. Moskowitz, Laura A Dyer, W. C. Patterson, 2014 .

lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans.

J. Rothman, I. Moskowitz, 1996, Development.

Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.

Jun Wang, Jiang Chang, Yanlin Ma, 2012, Journal of molecular and cellular cardiology.

The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.

F. Conlon, I. Cristea, X. Yang, 2016, Developmental cell.

Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

Kohta Ikegami, X. Yang, P. Chaturvedi, 2021, bioRxiv.

Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq

Xiangying Sun, Zhezhen Wang, Carlos Perez-Cervantes, 2019, bioRxiv.

Gata4 drives Hh-signaling for second heart field migration and outflow tract development

Menglan Xiang, I. Moskowitz, Linglin Xie, 2018, bioRxiv.

Alignment of recombination sites in Hin-mediated site-specific DNA recombination.

R. C. Johnson, K. Heichman, I. Moskowitz, 1991, Genes & development.

Configuration of DNA strands and mechanism of strand exchange in the Hin invertasome as revealed by analysis of recombinant knots.

R. C. Johnson, K. Heichman, I. Moskowitz, 1991, Genes & development.

Inducible recombination in the cardiac conduction system of minK: CreERT2 BAC transgenic mice

D. Arnolds, I. Moskowitz, 2011, Genesis.

Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.

Edwin K Silverman, Daniel Bernstein, Kiran Musunuru, 2018, Circulation. Genomic and precision medicine.

Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome.

J. Seidman, C. Seidman, C. Berul, 2003, Journal of the American College of Cardiology.

Characterization of sinoatrial node in four conduction system marker mice.

G. Fishman, J. Burch, I. Moskowitz, 2007, Journal of molecular and cellular cardiology.

Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex.

J. Rothman, I. Moskowitz, K. Kontani, 2005, Developmental cell.

Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.

Christopher Semsarian, Christine E Seidman, J. Seidman, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Hedgehog signaling controls progenitor differentiation timing during heart development

M. Kyba, Kohta Ikegami, X. Yang, 2018 .

Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization

R. Vasan, E. Behr, Qiong Yang, 2022, Circulation.

Tbx5 maintains atrial identity by regulating an atrial enhancer network

J. Seidman, W. Pu, C. Seidman, 2023, bioRxiv.

E2F3 plays an essential role in cardiac development and function

Ferhaan Ahmad, J. Seidman, J. Lees, 2008, Cell cycle.

A genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics

A. Rienzo, M. Civelek, M. Whalen, 2018, bioRxiv.

Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis

M. Sheets, Joshua W. M. Theisen, R. Lipinski, 2022, Developmental dynamics : an official publication of the American Association of Anatomists.

Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans.

J. Rothman, I. Moskowitz, S. Gendreau, 1994, Development.

Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation

Kaixuan Luo, Xin He, H. Eckart, 2023, Nature communications.

A promoter interaction map for cardiovascular disease genetics

I. Aneas, N. Sakabe, Débora R. Sobreira, 2018, bioRxiv.

The cGAS-STING pathway is dispensable in a mouse model of LMNA -cardiomyopathy despite nuclear envelope rupture

Kohta Ikegami, Atsuki En, Alexis V. Stutzman, 2023 .

Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.

Ozanna Burnicka-Turek, I. Moskowitz, Linglin Xie, 2012, Developmental cell.

TBX5: A Key Regulator of Heart Development.

I. Moskowitz, Jeffrey D. Steimle, 2017, Current topics in developmental biology.

A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines

M. Justice, A. Bradley, B. Liu, 2009, BMC Genetics.

The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model

S. Camper, R. Reeves, Huiqing Li, 2015, BMC Developmental Biology.

The potential to differentiate epidermis is unequally distributed in the AB lineage during early embryonic development in C. elegans.

J. Rothman, I. Moskowitz, S. Gendreau, 1994, Developmental biology.

An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract

A. Tsirigos, Colin K. L. Phoon, I. Moskowitz, 2023, Circulation.