B. W. Penman

发表

Gene-Locus Mutation Assays in Diploid Human Lymphoblast Lines

E. Furth, T. Skopek, H. Liber, 1980 .

Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450.

B. W. Penman, C L Crespi, B W Penman, 1997, Analytical biochemistry.

A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing.

F. Gonzalez, R. Langenbach, B. W. Penman, 1991, Chemical research in toxicology.

Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6.

F. Gonzalez, C. S. Yang, B. W. Penman, 1993, Pharmacogenetics.

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

S. Tannenbaum, J. S. Wishnok, B. W. Penman, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3.

F. Gonzalez, B. W. Penman, H. Gelboin, 1991, Carcinogenesis.

Seasonal and Spatial Variations in Human Cell Mutagenicity of Respirable Airborne Particles in the Northeastern United States

G. Cass, H. Hemond, J. Durant, 1999 .

Human cell mutagens in Los Angeles air

W. Thilly, M. Hannigan, G. Cass, 1997 .

Human cell mutagenicity of mono- and dinitropyrenes in metabolically competent MCL-5 cells.

W. Busby, B. W. Penman, C. Crespi, 1994, Mutation research.

Human Cells as an Expression System for Cytochromes P450

F. Gonzalez, R. Langenbach, B. W. Penman, 1994 .

Mutagenicity of 1,2-dichloroethane and 1,2-dibromoethane in two human lymphoblastoid cell lines.

B. W. Penman, C. Crespi, T. Turner, 1985, Mutation research.

Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay.

T. Skopek, H. Liber, W. Thilly, 1978, Biochemical and biophysical research communications.

Mutation of human lymphoblasts exposed to low concentrations of chemical mutagens for long periods of time.

H. Liber, W. Thilly, E. Komives, 1983, Mutation research.

Genetic toxicology using human cell lines expressing human P-450.

F. Gonzalez, R. Langenbach, B. W. Penman, 1993, Biochemical Society transactions.

Mutagenicity of benzo[a]pyrene and dibenzopyrenes in the Salmonella typhimurium TM677 and the MCL-5 human cell forward mutation assays.

W. Busby, B. W. Penman, C. Crespi, 1995, Mutation research.

Human-cell mutagens in respirable airborne particles in the northeastern United States. 1. Mutagenicity of fractionated samples.

G. Cass, H. Hemond, J. Durant, 2004, Environmental science & technology.

Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols.

J. Durant, W. Busby, A. Lafleur, 1996, Mutation research.

Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: substrate specificity with model substrates and promutagens.

F. Gonzalez, B. W. Penman, H. Gelboin, 1994, Carcinogenesis.

Phenotypic lag and mutation to 6-thioguanine resistance in diploid human lymphoblasts.

W. Thilly, J. Deluca, H. Hoppe, 1978, Mutation research.

Comparison of substrate metabolism by wild type CYP2D6 protein and a variant containing methionine, not valine, at position 374.

K. Korzekwa, J. Idle, F. Gonzalez, 1995, Pharmacogenetics.

Mutation of human lymphoblasts by methylnitrosourea.

W. Thilly, J. Deluca, H. Hoppe, 1976, Chemico-biological interactions.

Coexpression of cytochrome P4502A6 and human NADPH-P450 oxidoreductase in the baculovirus system.

F. Gonzalez, J. Buters, J. Hardwick, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Concentration-dependent mutation of diploid human lymphoblasts by methylnitronitrosoguanidine: The importance of phenotypic lag

W. Thilly, B. W. Penman, 1976, Somatic cell genetics.

Analysis of human lymphoblast mutation assays by using historical negative control data bases

B. W. Penman, C. Crespi, 1987, Environmental and molecular mutagenesis.

Mutagenicity of 5-halodeoxyuridines to diploid human lymphoblasts.

W. Thilly, B. W. Penman, M. Wong, 1976, Life sciences.

Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates.

E. Furth, H. Liber, W. Thilly, 1981, Analytical biochemistry.

A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6.

F. Gonzalez, B. W. Penman, H. Gelboin, 1991, Carcinogenesis.

Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions.

B. W. Penman, C. Crespi, 1997, Advances in pharmacology.

Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation.

D. Waxman, F. Gonzalez, T. Chang, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Perylene is a more potent mutagen than benzo[a]pyrene for S. typhimurium.

T. Skopek, H. Liber, D. Kaden, 1980, Mutation research.

Human cell mutagenicity of chlorinated and unchlorinated water and the disinfection byproduct 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX).

J. Durant, B. W. Penman, C. Crespi, 2001, Mutation research.

The mutagenic activity of selected compounds at the TK locus: rodent vs. human cells.

R. Langenbach, B. W. Penman, W. Caspary, 1988, Mutation research.

Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450.

R. Langenbach, B. W. Penman, C. Crespi, 1993, Toxicology.

Transport and Metabolic Characterization of Caco-2 Cells Expressing CYP3A4 and CYP3A4 Plus Oxidoreductase

Shiew-Mei Huang, K. Thummel, B. W. Penman, 1999, Pharmaceutical Research.

Mutagenicity of C24H14 PAH in human cells expressing CYP1A1.

J. Durant, W. Busby, A. Lafleur, 1999, Mutation research.

Development of a human lymphoblastoid cell line constitutively expressing human CYP1B1 cDNA: substrate specificity with model substrates and promutagens.

T. Sutter, C. S. Yang, B. W. Penman, 1997, Mutagenesis.

Human cytochrome P450IIA3: cDNA sequence role of the enzyme in the metabolic of promutagens comparison to nitrosamine activation by human cytochrome P450IIE1

M. P. Arlotto, R. Langenbach, J. Leakey, 1990 .

Human cytochrome P450IIA3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1.

M. P. Arlotto, J. Leakey, B. W. Penman, 1990, Carcinogenesis.

Bioassay-directed chemical analysis of Los Angeles airborne particulate matter using a human cell mutagenicity assay

W. Thilly, M. Hannigan, G. Cass, 1998 .

Mutagenicity of the atmospheric transformation products 2-nitrofluoranthene and 2-nitrodibenzopyranone in Salmonella and human cell forward mutation assays.

W. Busby, A. Lafleur, B. W. Penman, 1997, Mutation research.

Development of Caco-2 Cells Expressing High Levels of cDNA-Derived Cytochrome P4503A4

B. W. Penman, C. Crespi, Ming Hu, 1996, Pharmaceutical Research.

The development of a panel of human cell lines expressing specific human cytochrome P450 cDNAs.

R. Langenbach, B. W. Penman, C L Crespi, 1990, Progress in clinical and biological research.

Concentration-dependent mutation by alkylating agents in human lymphoblasts and Salmonella typhimurium: N-methyl-N-nitrosourethane and beta-propiolactone.

W. Thilly, H. Hoppe, B. W. Penman, 1979, Journal of the National Cancer Institute.

Sodium fluoride is a less efficient human cell mutagen at low concentrations

B. W. Penman, C. Crespi, T. Turner, 1990, Environmental and molecular mutagenesis.

The induction of aneuploidy by nitrogen mustard in a human lymphoblastoid cell line.

B. W. Penman, C. Crespi, G. M. Seixas, 1987, Mutation research.