M. Vertzoni

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Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds.

J. Dressman, C. Reppas, M. Vertzoni, 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Luminal lipid phases after administration of a triglyceride solution of danazol in the fed state and their contribution to the flux of danazol across Caco-2 cell monolayers.

C. Reppas, M. Vertzoni, C. Markopoulos, 2012, Molecular pharmaceutics.

An In Vitro Methodology for Forecasting Luminal Concentrations and Precipitation of Highly Permeable Lipophilic Weak Bases in the Fasted Upper Small Intestine

J. Dressman, C. Reppas, D. Busby, 2012, Pharmaceutical Research.

Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: case studies with fenofibrate.

B. Griffin, J. Dressman, M. Kuentz, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state

C. Reppas, P. O’Dwyer, M. Vertzoni, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Factors Affecting Successful Extrapolation of Ibuprofen Exposure from Adults to Pediatric Populations After Oral Administration of a Pediatric Aqueous Suspension

R. Holm, N. Fotaki, C. Reppas, 2020, The AAPS Journal.

Successful Extrapolation of Paracetamol Exposure from Adults to Infants After Oral Administration of a Pediatric Aqueous Suspension Is Highly Dependent on the Study Dosing Conditions

R. Holm, N. Fotaki, C. Reppas, 2020, The AAPS Journal.

Estimating drug solubility in the gastrointestinal tract.

J. Dressman, K. Goumas, C. Reppas, 2007, Advanced drug delivery reviews.

In vivo performance of innovative polyelectrolyte matrices for hot melt extrusion of amorphous drug systems.

M. Kuentz, R. Holm, M. Vertzoni, 2020, Molecular pharmaceutics.

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.

Christine M. Madla, L. Marciani, D. V. van Riet-Nales, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Mechanistic investigation of the negative food effect of modified release zolpidem

Xavier Pepin, Christos Reppas, Jennifer B Dressman, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In vitro simulation of the environment in the upper gastrointestinal lumen after drug administration in the fed state using the TIM-1 system and comparison with luminal data in adults.

M. Minekus, S. Bellmann, C. Reppas, 2021, Journal of pharmaceutical sciences.

On the usefulness of compendial setups and tiny-TIM system in evaluating the in vivo performance of oral drug products with various release profiles in the fasted state: Case example sodium salt of A6197.

R. Havenaar, C. Reppas, M. Vertzoni, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

In‐vitro evaluation of performance of solid immediate release dosage forms of weak bases in upper gastrointestinal lumen: experience with miconazole and clopidogrel salts

C. Reppas, M. Vertzoni, M. Dimopoulou, 2016, The Journal of pharmacy and pharmacology.

In vitro models for the prediction of in vivo performance of oral dosage forms.

Anette Müllertz, Patrick Augustijns, Bertil Abrahamsson, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Biorelevant in vitro dissolution testing of products containing micronized or nanosized fenofibrate with a view to predicting plasma profiles.

Christos Reppas, Christian Wagner, Jennifer B Dressman, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Toward simplified oral lipid-based drug delivery using mono-/di-glycerides as single component excipients

B. Griffin, M. Kuentz, R. Holm, 2020, Drug development and industrial pharmacy.

Measuring pH and Buffer Capacity in Fluids Aspirated from the Fasted Upper Gastrointestinal Tract of Healthy Adults

J. Dressman, C. Reppas, M. Vertzoni, 2020, Pharmaceutical Research.

Structural features of colloidal species in the human fasted upper small intestine

A. Müllertz, D. Fatouros, C. Reppas, 2015, The Journal of pharmacy and pharmacology.

Biorelevant In Vitro Performance Testing of Orally Administered Dosage Forms—Workshop Report

Cynthia K. Brown, John C. Kraemer, V. Shah, 2012, Pharmaceutical Research.

Biorelevant Media to Simulate Fluids in the Ascending Colon of Humans and Their Usefulness in Predicting Intracolonic Drug Solubility

J. Dressman, B. Abrahamsson, C. Reppas, 2010, Pharmaceutical Research.

Simulation of gastric lipolysis and prediction of felodipine release from a matrix tablet in the fed stomach.

B. Abrahamsson, M. Vertzoni, J. Dressman, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Estimation of Intragastric Solubility of Drugs: In What Medium?

L. Kalantzi, C. Reppas, M. Vertzoni, 2007, Pharmaceutical Research.

Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review

R. Holm, N. Fotaki, C. Reppas, 2018, The Journal of pharmacy and pharmacology.

Characterization of the Ascending Colon Fluids in Ulcerative Colitis

J. Dressman, B. Abrahamsson, K. Goumas, 2010, Pharmaceutical Research.

Estimation of intragastric drug solubility in the fed state: comparison of various media with data in aspirates

M. Vertzoni, J. Dressman, C. Reppas, 2009, Biopharmaceutics & drug disposition.

Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications.

Jason R. Baker, G. Amidon, M. Bermejo, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance

G. Amidon, J. Brasseur, M. Bermejo, 2018, The AAPS Journal.

In Vitro and Ex Vivo Investigation of the Impact of Luminal Lipid Phases on Passive Permeability of Lipophilic Small Molecules Using PAMPA

C. Reppas, N. Parrott, M. Vertzoni, 2013, Pharmaceutical Research.

Development and validation of a simple reversed-phase high-performance liquid chromatography method for the determination of testosterone in serum of males.

M. Vertzoni, A. Vryonidou, C. Phenekos, 2006, Journal of pharmaceutical and biomedical analysis.

Optimization and validation of a high-performance liquid chromatographic method with UV detection for the determination of ketoconazole in canine plasma.

M. Vertzoni, C. Reppas, H. Archontaki, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Optimized determination of lycopene in canine plasma using reversed-phase high-performance liquid chromatography.

M. Vertzoni, C. Reppas, H. Archontaki, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Development and optimization of a reversed-phase high-performance liquid chromatographic method for the determination of acetaminophen and its major metabolites in rabbit plasma and urine after a toxic dose.

M. Vertzoni, H. Archontaki, P. Galanopoulou, 2003, Journal of pharmaceutical and biomedical analysis.

Stability of oleuropein in the human proximal gut

C. Reppas, P. Magiatis, M. Vertzoni, 2009 .

Biorelevant Dissolution Methods and Their Applications in In Vitro- In Vivo Correlations for Oral Formulations~!2009-09-14~!2009-11-02~!2010-04-29~!

N. Fotaki, M. Vertzoni, 2010 .

Solubilization and quantification of lycopene in aqueous media in the form of cyclodextrin binary systems.

C. Reppas, M. Vertzoni, G. Valsami, 2006, International journal of pharmaceutics.

Disposition of two highly permeable drugs in stomach and in upper small intestine of healthy adults after a standard high-calorie, high-fat meal.

K. Goumas, C. Reppas, M. Vertzoni, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

1 Disposition of two highly permeable drugs in the stomach and the upper small intestine of healthy adults after a standard high-calorie , high-fat meal

K. Goumas, C. Reppas, M. Vertzoni, 2020 .

An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation.

P. Augustijns, J. Brouwers, C. Reppas, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Gastrointestinal transfer: in vivo evaluation and implementation in in vitro and in silico predictive tools.

M. Corsetti, B. Hens, P. Augustijns, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Plasma profiles of lycopene after single oral and intravenous administrations in dogs

C. Reppas, M. Vertzoni, G. Valsami, 2006, The Journal of pharmacy and pharmacology.

On the usefulness of four in vitro 1 methods in assessing the intraluminal 2 performance of poorly soluble , ionisable 3 compounds in the fasted state 4 5

C. Reppas, M. Vertzoni, G. Imanidis, 2021 .

Identification of key factors affecting the oral absorption of salts of lipophilic weak acids: a case example

K. Goumas, C. Reppas, F. Kesisoglou, 2015, The Journal of pharmacy and pharmacology.

Characteristics of contents of lower intestine in the 65-74 years of age range could impact the performance of safe and efficacious modified release products.

K. Goumas, C. Reppas, M. Vertzoni, 2020, Journal of pharmaceutical sciences.

Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug – Drug Interaction Studies

Wei Xu, C. Reppas, F. Kesisoglou, 2016, Pharmaceutical Research.

On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants: an Exploratory Study Highlighting the Importance of Infant Food

R. Holm, N. Fotaki, K. Goumas, 2019, The AAPS Journal.

1H NMR monitoring of the canine metabolic profile after oral administration of xenobiotics using multivariate statistics.

A. Tsantili-Kakoulidou, E. Mikros, C. Reppas, 2007, Molecular pharmaceutics.

The BioGIT System: a Valuable In Vitro Tool to Assess the Impact of Dose and Formulation on Early Exposure to Low Solubility Drugs After Oral Administration

P. Augustijns, R. Holm, C. Reppas, 2018, The AAPS Journal.

In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT.

B. Hens, P. Augustijns, J. Brouwers, 2016, International journal of pharmaceutics.

Biorelevant media for transport experiments in the Caco-2 model to evaluate drug absorption in the fasted and the fed state and their usefulness.

C. Reppas, N. Parrott, M. Vertzoni, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Usefulness of Optimized Human Fecal Material in Simulating the Bacterial Degradation of Sulindac and Sulfinpyrazone in the Lower Intestine.

S. Arora, C. Reppas, M. Vertzoni, 2022, Molecular pharmaceutics.

Exploring the impact of Crohn’s disease on the intragastric environment of fasted adults

K. Goumas, C. Reppas, M. Vertzoni, 2020, ADMET & DMPK.

UNGAP best practice for improving solubility data quality of orally administered drugs.

A. Bauer-Brandl, J. Alsenz, P. Augustijns, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Study on the inclusion complexes of bromazepam with β- and β-hydroxypropyl-cyclodextrins☆

M. Vertzoni, H. Archontaki, M. H. Athanassiou-Malaki, 2002 .

In vitro vs. canine data for assessing early exposure of doxazosin base and its mesylate salt.

C. Reppas, M. Vertzoni, M. Dumić, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Effect of pH and water‐soluble polymers on the aqueous solubility of nimesulide in the absence and presence of β‐cyclodextrin derivatives

M. Vertzoni, G. Valsami, H. Archontaki, 2008 .

Supersaturated lipid-based drug delivery systems – exploring impact of lipid composition type and drug properties on supersaturability and physical stability

B. Griffin, M. Kuentz, R. Holm, 2020, Drug development and industrial pharmacy.

Degradation kinetics of metronidazole and olsalazine by bacteria in ascending colon and in feces of healthy adults.

Christos Reppas, Bertil Abrahamsson, B. Abrahamsson, 2011, International journal of pharmaceutics.

Biorelevant dissolution methods and their applications in in vitroin vivo correlations for oralformulations

N. Fotaki, M. Vertzoni, 2010 .

Dissolution media simulating the intralumenal composition of the small intestine: physiological issues and practical aspects

Christos Reppas, Erika S. Stippler, Christian Leuner, 2004, The Journal of pharmacy and pharmacology.

Study on the inclusion complexes of bromazepam with beta- and beta-hydroxypropyl-cyclodextrins.

M. Vertzoni, H. Archontaki, M. H. Athanassiou-Malaki, 2002, Journal of pharmaceutical and biomedical analysis.

Application of biorelevant dissolution tests to the prediction of in vivo performance of diclofenac sodium from an oral modified-release pellet dosage form.

Jennifer B Dressman, J. Dressman, M. Vertzoni, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Comparison of simulated cumulative drug versus time data sets with indices.

A. Iliadis, C. Reppas, M. Vertzoni, 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

A LC-MS-MS method for determination of low doxazosin concentrations in plasma after oral administration to dogs.

Mario Cindrić, C. Reppas, M. Vertzoni, 2010, Journal of chromatographic science.

The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations: a PEARRL review

J. Dressman, C. Reppas, M. Vertzoni, 2018, The Journal of pharmacy and pharmacology.

Performance Evaluation of Montelukast Pediatric Formulations: Part I—Age-Related In Vitro Conditions

P. Somville, N. Fotaki, M. Vertzoni, 2022, The AAPS journal.

Performance Evaluation of Montelukast Pediatric Formulations: Part I—Age-Related In Vitro Conditions

P. Somville, N. Fotaki, M. Vertzoni, 2022, The AAPS Journal.

Predicting the oral absorption of a poorly soluble, poorly permeable weak base using biorelevant dissolution and transfer model tests coupled with a physiologically based pharmacokinetic model.

Filippos Kesisoglou, Christos Reppas, Christian Wagner, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The effect of reduced gastric acid secretion on the gastrointestinal disposition of a ritonavir amorphous solid dispersion in fasted healthy volunteers: an in vivo - in vitro investigation.

J. Tack, P. Augustijns, C. Reppas, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

Anette Müllertz, Filippos Kesisoglou, Christos Reppas, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Understanding the impact of age-related changes in paediatric gastrointestinal solubility by multivariate data analysis

N. Fotaki, M. Vertzoni, A. Edginton, 2018 .

Performance Evaluation of Montelukast Pediatric Formulations: Part II — a PBPK Modelling Approach

N. Fotaki, M. Vertzoni, Mariana Guimarães, 2022, The AAPS journal.

Performance Evaluation of Montelukast Pediatric Formulations: Part II — a PBPK Modelling Approach

N. Fotaki, M. Vertzoni, Mariana Guimarães, 2022, The AAPS Journal.

Oral biopharmaceutics tools: recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration.

B. Griffin, J. Dressman, C. Reppas, 2021, The Journal of pharmacy and pharmacology.

Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: an UNGAP review.

Clive G. Wilson, Christine M. Madla, B. Griffin, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network.

Clive G. Wilson, B. Griffin, P. Artursson, 2021, Advanced drug delivery reviews.

Investigating the critical variables of azithromycin oral absorption using in vitro tests and PBPK Modeling.

P. Somville, N. Fotaki, M. Vertzoni, 2021, Journal of pharmaceutical sciences.

In-vitro simulation of luminal conditions for evaluation of performance of oral drug products: Choosing the appropriate test media.

Christos Reppas, Jennifer Dressman, J. Dressman, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review.

Clive G. Wilson, M. Grimm, W. Weitschies, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The Impact of Handling and Storage of Human Fecal Material on Bacterial Activity.

C. Reppas, M. Vertzoni, E. Karatza, 2016, Journal of pharmaceutical sciences.

Physiologically Based Absorption Modeling of Salts of Weak Bases Based on Data in Hypochlorhydric and Achlorhydric Biorelevant Media

C. Reppas, F. Kesisoglou, M. Vertzoni, 2018, AAPS PharmSciTech.

Precipitation in and Supersaturation of Contents of the Upper Small Intestine After Administration of Two Weak Bases to Fasted Adults

K. Goumas, V. Kalioras, C. Reppas, 2011, Pharmaceutical Research.

The mechanism of solifenacin release from a pH-responsive ion-complex oral suspension in the fasted upper gastrointestinal lumen.

N. Ouwerkerk, C. Reppas, M. Vertzoni, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Drug supersaturation in simulated and human intestinal fluids representing different nutritional states.

J. Tack, P. Annaert, P. Augustijns, 2010, Journal of pharmaceutical sciences.

Prediction of food effects on the absorption of celecoxib based on biorelevant dissolution testing coupled with physiologically based pharmacokinetic modeling.

Filippos Kesisoglou, Christos Reppas, Jennifer B Dressman, 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective.

Clive G. Wilson, L. Aarons, P. Augustijns, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

On the usefulness of four in vitro methodologies in screening for product related differences in tacrolimus exposure after oral administration of amorphous solid dispersions with modified release characteristics in the fasted state

L. Kalantzi, C. Reppas, P. O’Dwyer, 2021, Journal of Drug Delivery Science and Technology.

In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance

G. Amidon, J. Brasseur, M. Bermejo, 2018, The AAPS Journal.

Evaluation of Dissolution in the Lower Intestine and Its Impact on the Absorption Process of High Dose Low Solubility Drugs.

C. Reppas, F. Kesisoglou, M. Vertzoni, 2017, Molecular pharmaceutics.

Two-Stage Single-Compartment Models to Evaluate Dissolution in the Lower Intestine.

C. Reppas, F. Kesisoglou, M. Vertzoni, 2015, Journal of pharmaceutical sciences.

Characterization of Contents of Distal Ileum and Cecum to Which Drugs/Drug Products are Exposed During Bioavailability/Bioequivalence Studies in Healthy Adults

Eleni Karatza, Christos Reppas, C. Reppas, 2015, Pharmaceutical Research.

The impact of reduced gastric acid secretion on dissolution of salts of weak bases in the fasted upper gastrointestinal lumen: Data in biorelevant media and in human aspirates

W. Xu, C. Reppas, F. Kesisoglou, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Characterization of Contents of Distal Ileum and Cecum to Which Drugs/Drug Products are Exposed During Bioavailability/Bioequivalence Studies in Healthy Adults

C. Reppas, M. Vertzoni, C. Markopoulos, 2015, Pharmaceutical Research.

Characterization of the Contents of Ascending Colon to Which Drugs are Exposed After Oral Administration to Healthy Adults

Christos Reppas, Bertil Abrahamsson, Jennifer Dressman, 2009, Pharmaceutical Research.

Evaluating the clinical importance of bacterial degradation of therapeutic agents in the lower intestine of adults using adult fecal material

C. Reppas, M. Vertzoni, U. Muenster, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Toward the establishment of a standardized pre-clinical porcine model to predict food effects – Case studies on fenofibrate and paracetamol

Niklas J. Koehl, B. Griffin, Joseph P O'Shea, 2019, International journal of pharmaceutics: X.

Intestinal permeability and excretion into bile control the arrival of amlodipine into the systemic circulation after oral administration

N. Fotaki, C. Reppas, M. Z. Khan, 2006, The Journal of pharmacy and pharmacology.

Development and evaluation of a biorelevant medium simulating porcine gastrointestinal fluids.

Niklas J. Koehl, B. Griffin, R. Holm, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Simulation of Intraluminal Performance of Lipophilic Weak Bases in Fasted Healthy Adults Using DDDPlusTM

M. Vertzoni, Marina Statelova, A. Kourentas, 2022, The AAPS Journal.

Sensitive and simple liquid chromatographic method with ultraviolet detection for the determination of nifedipine in canine plasma.

C. Reppas, M. Vertzoni, C. Reppas, 2006, Analytica chimica acta.

Nasal powders of quercetin-β-cyclodextrin derivatives complexes with mannitol/lecithin microparticles for Nose-to-Brain delivery: In vitro and ex vivo evaluation.

E. Ioannou, G. Colombo, P. Dallas, 2021, International journal of pharmaceutics.

Understanding the Impact of Age-Related Changes in Pediatric GI Solubility by Multivariate Data Analysis

N. Fotaki, M. Vertzoni, A. Edginton, 2022, Pharmaceutics.

Measuring pH and Buffer Capacity in Fluids Aspirated from the Fasted Upper Gastrointestinal Tract of Healthy Adults

J. Dressman, C. Reppas, M. Vertzoni, 2020, Pharmaceutical Research.

Usefulness of the Beagle Model in the Evaluation of Paracetamol and Ibuprofen Exposure after Oral Administration to Pediatric Populations: An Exploratory Study.

N. Fotaki, C. Reppas, M. Vertzoni, 2023, Molecular pharmaceutics.

Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo.

Anette Müllertz, Christos Reppas, Dimitrios G Fatouros, 2012, Molecular pharmaceutics.

Usefulness of the BioGIT system in screening for differences in early exposure in the fasted state on an a priori basis.

C. Reppas, M. Vertzoni, Jan Bevernage, 2023, International journal of pharmaceutics.

The BioGIT System: a Valuable In Vitro Tool to Assess the Impact of Dose and Formulation on Early Exposure to Low Solubility Drugs After Oral Administration

P. Augustijns, R. Holm, C. Reppas, 2018, The AAPS Journal.

Screening for differences in early exposure in the fasted state with in vitro methodologies can be challenging: Experience with the BioGIT system.

C. Reppas, M. Vertzoni, Jan Bevernage, 2023, Journal of pharmaceutical sciences.

Evaluation of the Impact of Excipients and an Albendazole Salt on Albendazole Concentrations in Upper Small Intestine Using an In Vitro Biorelevant Gastrointestinal Transfer (BioGIT) System.

C. Reppas, M. Vertzoni, J. Butler, 2016, Journal of pharmaceutical sciences.

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review.

Cordula Stillhart, W. Weitschies, C. Matthys, 2023, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Characteristics of contents in the upper gastrointestinal lumen after a standard high-calorie high-fat meal and implications for the in vitro drug product performance testing conditions.

J. Dressman, K. Goumas, C. Reppas, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Physiological Considerations and In Vitro Strategies for Evaluating the Influence of Food on Drug Release from Extended-Release Formulations

M. Koziolek, E. Kostewicz, M. Vertzoni, 2018, AAPS PharmSciTech.

Determination of intralumenal individual bile acids by HPLC with charged aerosol detection Published, JLR Papers in Press, August 7, 2008.

C. Reppas, M. Vertzoni, H. Archontaki, 2008, Journal of Lipid Research.

Evaluating pediatric and adult simulated fluids solubility: Abraham solvation parameters and multivariate analysis

M. Kuentz, N. Fotaki, M. Vertzoni, 2021, Pharmaceutical Research.

Effectiveness of supersaturation promoting excipients on albendazole concentrations in upper gastrointestinal lumen of fasted healthy adults.

K. Goumas, C. Reppas, M. Vertzoni, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Physiologically Based Absorption Modeling of Salts of Weak Bases Based on Data in Hypochlorhydric and Achlorhydric Biorelevant Media

C. Reppas, F. Kesisoglou, M. Vertzoni, 2018, AAPS PharmSciTech.

Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug – Drug Interaction Studies

Wei Xu, C. Reppas, F. Kesisoglou, 2016, Pharmaceutical Research.

An In Vitro Methodology for Forecasting Luminal Concentrations and Precipitation of Highly Permeable Lipophilic Weak Bases in the Fasted Upper Small Intestine

J. Dressman, C. Reppas, D. Busby, 2012, Pharmaceutical Research.

Exploring precipitation inhibitors to improve in vivo absorption of cinnarizine from supersaturated lipid-based drug delivery systems.

B. Griffin, M. Kuentz, R. Holm, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across PermeapadⓇ membrane and in vivo absorption.

B. Griffin, M. Brandl, M. Kuentz, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Physiological Considerations and In Vitro Strategies for Evaluating the Influence of Food on Drug Release from Extended-Release Formulations

M. Koziolek, E. Kostewicz, M. Vertzoni, 2018, AAPS PharmSciTech.

Ex vivo evaluation of degradation rates of metronidazole and olsalazine in distal ileum and in cecum: The impact of prandial state.

C. Reppas, M. Vertzoni, C. Goumas, 2017, International journal of pharmaceutics.

Mapping the intermediate digestion phases of human healthy intestinal contents from distal ileum and caecum at fasted and fed state conditions

A. Müllertz, D. Fatouros, C. Reppas, 2017, The Journal of pharmacy and pharmacology.

Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy

A. Müllertz, D. Fatouros, C. Reppas, 2013, The Journal of pharmacy and pharmacology.

Orally Administered Drug Products: Dissolution Data Analysis with a View to In Vitro‚ÄìIn Vivo Correlation

A. Iliadis, C. Reppas, M. Vertzoni, 2005 .

Cogrinding enhances the oral bioavailability of EMD 57033, a poorly water soluble drug, in dogs.

J. Dressman, K. Kunath, C. Reppas, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Physiologically Based Pharmacokinetic (PBPK) Modelling of Oral Drug Absorption in Older Adults - an AGePOP review.

J. Tournoy, P. Augustijns, J. Schlender, 2023, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

LEVERAGING THE USE OF IN VITRO AND COMPUTATIONAL METHODS TO SUPPORT THE DEVELOPMENT OF ENABLING ORAL DRUG PRODUCTS: AN INPHARMA COMMENTARY.

B. Griffin, M. Kuentz, Cordula Stillhart, 2023, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Managing the clinical effects of drug-induced intestinal dysbiosis with a focus to antibiotics: challenges and opportunities.

C. Reppas, M. Vertzoni, G. Ismailos, 2023, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Controlled Release from Solid Pharmaceutical Formulations of two Nalkanoyl- 4-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-ethanamines with Melatoninergic Activity

A. Tsotinis, D. Sugden, M. Vlachou, 2015 .

Challenges in Permeability Assessment for Oral Drug Product Development

J. Polli, W. Weitschies, P. Augustijns, 2023, Pharmaceutics.

Combining species specific in vitro & in silico models to predict in vivo food effect in a preclinical stage - case study of Venetoclax.

Niklas J. Koehl, B. Griffin, Joseph P O'Shea, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Luminal lipid phases after administration of a triglyceride solution of danazol in the fed state and their contribution to the flux of danazol across Caco-2 cell monolayers.

C. Reppas, M. Vertzoni, Moira Symillides, 2012, Molecular pharmaceutics.

In Vitro and Ex Vivo Investigation of the Impact of Luminal Lipid Phases on Passive Permeability of Lipophilic Small Molecules Using PAMPA

C. Reppas, N. Parrott, M. Vertzoni, 2013, Pharmaceutical Research.

Application of biorelevant dissolution tests to the prediction of in vivo performance of diclofenac sodium from an oral modified-release pellet dosage form.

J. Dressman, M. Vertzoni, Vincenzo De Maio, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Estimation of intragastric drug solubility in the fed state: comparison of various media with data in aspirates

J. Dressman, C. Reppas, M. Vertzoni, 2009, Biopharmaceutics & drug disposition.

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.

Christine M. Madla, L. Marciani, D. V. van Riet-Nales, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In vivo predictive dissolution and simulation workshop report: Facilitating the 1 development of oral drug formulation and the prediction of oral bioperformance 2

R. Lionberger, G. Amidon, N. Fotaki, 2018 .

On the processes limiting oral drug absorption when amorphous solid dispersions are administered after a high-calorie, high-fat meal: Sporanox® pellets.

K. Goumas, C. Reppas, M. Vertzoni, 2024, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The Use of Population Pharmacokinetics to Extrapolate Food Effects from Human Adults and Beagle Dogs to the Pediatric Population Illustrated with Paracetamol as a Test Case

M. Vertzoni, Marina Statelova, Elke Gasthuys, 2023, Pharmaceuticals.

Stability of oleuropein in the human proximal gut

C. Reppas, P. Magiatis, M. Vertzoni, 2009, The Journal of pharmacy and pharmacology.