N. Trevaskis

发表

Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

C. Porter, W. Charman, N. Trevaskis, 2007, Nature Reviews Drug Discovery.

Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation.

P. Tso, C. Porter, W. Charman, 2013, Molecular pharmaceutics.

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

Christopher J. H. Porter, L. Kaminskas, C. Porter, 2015, Nature Reviews Drug Discovery.

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.

Christine M. Madla, L. Marciani, D. V. van Riet-Nales, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

years of oral lipid-based formulations : Provenance , progress and future perspectives ☆

Christopher J. H. Porter, Colin W. Pouton, Christel A. S. Bergström, 2016 .

Constitutive Triglyceride Turnover into the Mesenteric Lymph Is Unable to Support Efficient Lymphatic Transport of a Biomimetic Triglyceride Prodrug.

C. Porter, N. Trevaskis, T. Quach, 2016, Journal of pharmaceutical sciences.

The impact of lymphatic transport on the systemic disposition of lipophilic drugs.

C. Porter, N. Trevaskis, J. Bulitta, 2013, Journal of pharmaceutical sciences.

A Mouse Model to Evaluate the Impact of Species, Sex, and Lipid Load on Lymphatic Drug Transport

P. Tso, C. Porter, W. Charman, 2013, Pharmaceutical Research.

Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update☆

Christopher J H Porter, Natalie L Trevaskis, C. Porter, 2007, Advanced Drug Delivery Reviews.

Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice.

U. V. von Andrian, J. Mintern, C. Nowell, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Lymphatic Transport and Lymphocyte Targeting of a Triglyceride Mimetic Prodrug Is Enhanced in a Large Animal Model: Studies in Greyhound Dogs.

G. Edwards, C. Porter, N. Trevaskis, 2016, Molecular pharmaceutics.

Targeted delivery of a model immunomodulator to the lymphatic system: comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies.

V. Stella, C. Porter, W. Charman, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Profiling the Role of Deacylation-Reacylation in the Lymphatic Transport of a Triglyceride-Mimetic Prodrug

C. Porter, N. Trevaskis, T. Quach, 2014, Pharmaceutical Research.

Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption.

C. Porter, W. Charman, N. Trevaskis, 2011, Molecular pharmaceutics.

Bile Increases Intestinal Lymphatic Drug Transport in the Fasted Rat

C. Porter, W. Charman, N. Trevaskis, 2005, Pharmaceutical Research.

The Lymph Lipid Precursor Pool Is a Key Determinant of Intestinal Lymphatic Drug Transport

C. Porter, W. Charman, N. Trevaskis, 2006, Journal of Pharmacology and Experimental Therapeutics.

An Acute and Coincident Increase in FABP Expression and Lymphatic Lipid and Drug Transport Occurs During Intestinal Infusion of Lipid-Based Drug Formulations to Rats

P. Tso, C. Porter, W. Charman, 2006, Pharmaceutical Research.

Promoting intestinal lymphatic transport targets a liver‐X receptor (LXR) agonist (WAY‐252,623) to lymphocytes and enhances immunomodulation

S. Martinsson, E. Michaëlsson, C. Porter, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Therapeutic delivery to the peritoneal lymphatics: current understanding, potential treatment benefits and future prospects.

J. Windsor, A. Phillips, N. Trevaskis, 2019, International journal of pharmaceutics.

In vitro-in vivo evaluation of lipid based formulations of the CETP inhibitors CP-529,414 (torcetrapib) and CP-532,623.

G. Edwards, C. Porter, N. Trevaskis, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

High density lipoprotein composition influences lymphatic transport after subcutaneous administration.

A. Johnston, C. Porter, N. Trevaskis, 2020, Molecular pharmaceutics.

Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability.

C. Porter, N. Trevaskis, T. Quach, 2016, Angewandte Chemie.

Lymphatic targeting by albumin-hitchhiking: Applications and optimisation.

J. Quinn, N. Trevaskis, M. Whittaker, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Lymphatic uptake of liposomes after intraperitoneal administration primarily occurs via the diaphragmatic lymphatics and is dependent on liposome surface properties.

J. Windsor, C. Porter, A. Phillips, 2019, Molecular pharmaceutics.

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.

D. Owen, D. Ascher, T. Velkov, 2015, Molecular pharmaceutics.

Association of a vaccine adjuvant with endogenous HDL increases lymph uptake and dendritic cell activation.

N. Trevaskis, E. Cao, Ruby Kochappan, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte?

C. Porter, M. Scanlon, N. Trevaskis, 2011, Pharmaceutical Research.

Systematic Down-Selection of Repurposed Drug Candidates for COVID-19

S. Murugesan, M. Cooper, S. Vasan, 2022, Data.

Intra-articular injection of biologic anti-rheumatic drugs enhances local exposure to the joint-draining lymphatics.

N. Trevaskis, O. Feeney, E. Cao, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size‐dependent and primarily occurs within the liver and mesentery

A. Johnston, Laura I. Selby, C. Nowell, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Organ-specific lymphatics play distinct roles in regulating HDL trafficking and composition.

A. Johnston, C. Porter, N. Trevaskis, 2020, American journal of physiology. Gastrointestinal and liver physiology.

Methods for studying pulmonary lymphatics

J. Windsor, Jiwon Hong, N. Trevaskis, 2021, European Respiratory Journal.

Correction to "targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?".

C. Porter, W. Charman, N. Trevaskis, 2011, Molecular pharmaceutics.

Targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?

C. Porter, W. Charman, N. Trevaskis, 2010, Molecular pharmaceutics.

The potential for drug supersaturation during intestinal processing of lipid-based formulations may be enhanced for basic drugs.

C. Porter, N. Trevaskis, Yan Yan Yeap, 2013, Molecular pharmaceutics.

TPGS Decorated Liposomes as Multifunctional Nano-Delivery Systems

N. Trevaskis, M. Farooq, 2022, Pharmaceutical Research.

Obesity-associated mesenteric lymph leakage impairs the trafficking of lipids, lipophilic drugs and antigens from the intestine to mesenteric lymph nodes.

N. Trevaskis, Reyaj Mikrani, D. Senyschyn, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection

S. Murugesan, N. Singanallur, S. Vasan, 2022, Viruses.

The Gut-Lymph Model Gives New Treatment Strategies for Organ Failure.

J. Windsor, N. Trevaskis, A. Phillips, 2022, JAMA surgery.

Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH

M. Febbraio, A. Murphy, N. Trevaskis, 2022, iScience.

Strategies to Address Low Drug Solubility in Discovery and Development

Hywel D Williams, Christopher J H Porter, Colin W Pouton, 2013, Pharmacological Reviews.

Single Intravenous Dose of Novel Flurbiprofen-Loaded Proniosome Formulations Provides Prolonged Systemic Exposure and Anti-inflammatory Effect.

P. Verma, N. Trevaskis, Rajbharan Yadav, 2016, Molecular pharmaceutics.

From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases

S. Kent, A. Wheatley, C. Pouton, 2021, Acta Biomaterialia.

Lymph-directed immunotherapy - Harnessing endogenous lymphatic distribution pathways for enhanced therapeutic outcomes in cancer.

C. Porter, N. Trevaskis, O. Feeney, 2020, Advanced drug delivery reviews.

Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles

C. Porter, N. Trevaskis, T. Quach, 2021, Pharmaceutical Research.

A new in vitro lipid digestion – in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations

Christopher J. H. Porter, Colin W. Pouton, C. Pouton, 2015, Pharmaceutical Research.

Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: an UNGAP review.

Clive G. Wilson, Christine M. Madla, B. Griffin, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans

J. Windsor, C. Porter, A. Phillips, 2020, Frontiers in Physiology.

Development and application of a novel cervical lymph collection method to assess lymphatic transport in rats

J. Nicolazzo, N. Trevaskis, E. Cao, 2023, Frontiers in Pharmacology.

Smart design approaches for orally administered lipophilic prodrugs to promote lymphatic transport.

C. Prestidge, C. Porter, N. Trevaskis, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity

J. Windsor, C. Nowell, C. Porter, 2021, Nature Metabolism.

Intestinal delivery in a long-chain fatty acid formulation enables lymphatic transport and systemic exposure of orlistat.

J. Windsor, C. Porter, A. Phillips, 2021, International journal of pharmaceutics.

The Mechanism of Lymphatic Access of Two Cholesteryl Ester Transfer Protein Inhibitors (CP524,515 and CP532,623) and Evaluation of Their Impact on Lymph Lipoprotein Profiles

Christopher J. H. Porter, R. Shanker, C. Porter, 2010, Pharmaceutical Research.

Lipid-Based Formulations and Drug Supersaturation: Harnessing the Unique Benefits of the Lipid Digestion/Absorption Pathway

C. Pouton, C. Porter, H. Williams, 2013, Pharmaceutical Research.

Tissue uptake of DDT is independent of chylomicron metabolism

P. Tso, R. Jandacek, C. Porter, 2006, Archives of Toxicology.

Triglyceride-Mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport

C. Porter, N. Trevaskis, T. Quach, 2022, Frontiers in Pharmacology.

50years of oral lipid-based formulations: Provenance, progress and future perspectives.

Christel A. S. Bergström, Hywel D Williams, Christopher J H Porter, 2016, Advanced drug delivery reviews.

Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies.

Christopher J H Porter, Natalie L Trevaskis, C. Porter, 2012, Journal of pharmaceutical sciences.

The mesenteric lymph duct cannulated rat model: application to the assessment of intestinal lymphatic drug transport.

C. Porter, N. Trevaskis, Luojuan Hu, 2015, Journal of visualized experiments : JoVE.

Sex-specific adipose tissue imprinting of regulatory T cells

David Chisanga, W. Shi, Yang Liao, 2020, Nature.

Editorial: Modulating Vascular Lymphatic Growth in Disease: Current and Potential Pharmacological Approaches for Prevention and Treatment

M. García-Caballero, N. Trevaskis, I. Martinez-Corral, 2022, Frontiers in Pharmacology.

Lymphatic Contractile Function: A Comprehensive Review of Drug Effects and Potential Clinical Application.

J. Windsor, N. Martin, Jiwon Hong, 2021, Cardiovascular research.

Vmeasur: A software package for experimental and clinical measurement of mesenteric lymphatic contractile function over an extended vessel length

J. Windsor, N. Trevaskis, C. E. Angel, 2022, Microcirculation.

A new in vitro lipid digestion – in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations

C. Pouton, C. Porter, H. Williams, 2016, Pharmaceutical Research.

Lipid-Based Formulations and Drug Supersaturation: Harnessing the Unique Benefits of the Lipid Digestion/Absorption Pathway

Christopher J. H. Porter, Colin W. Pouton, C. Pouton, 2013, Pharmaceutical Research.

The Role of the Intestinal Lymphatics in the Absorption of Two Highly Lipophilic Cholesterol Ester Transfer Protein Inhibitors (CP524,515 and CP532,623)

G. Edwards, C. Porter, W. Charman, 2010, Pharmaceutical Research.

Lipid Absorption Triggers Drug Supersaturation at the Intestinal Unstirred Water Layer and Promotes Drug Absorption from Mixed Micelles

Christopher J. H. Porter, C. Porter, N. Trevaskis, 2013, Pharmaceutical Research.

The impact of conjugation position and linker chemistry on the lymphatic transport of a series of glyceride and phospholipid mimetic prodrugs.

C. Porter, N. Trevaskis, T. Quach, 2020, Journal of pharmaceutical sciences.

Increasing Linker Chain Length and Intestinal Stability Enhances Lymphatic Transport and Lymph Node Exposure of Triglyceride Mimetic Prodrugs of a Model Immunomodulator Mycophenolic Acid.

Garima Sharma, C. Porter, N. Trevaskis, 2023, Molecular pharmaceutics.

Profiling the Role of Deacylation-Reacylation in the Lymphatic Transport of a Triglyceride-Mimetic Prodrug

C. Porter, N. Trevaskis, T. Quach, 2015, Pharmaceutical Research.

Sex-specific adipose tissue imprinting of regulatory T cells

David Chisanga, W. Shi, Yang Liao, 2020, Nature.

Transient Supersaturation Supports Drug Absorption from Lipid-Based Formulations for Short Periods of Time, but Ongoing Solubilization Is Required for Longer Absorption Periods.

C. Pouton, C. Porter, N. Trevaskis, 2017, Molecular pharmaceutics.

Carbon-based nanostructures for cancer therapy and drug delivery applications.

B. Bagheri, Yeu‐Chun Kim, N. Trevaskis, 2022, Journal of materials chemistry. B.

Lipid Absorption Triggers Drug Supersaturation at the Intestinal Unstirred Water Layer and Promotes Drug Absorption from Mixed Micelles

C. Porter, N. Trevaskis, Yan Yan Yeap, 2013, Pharmaceutical Research.

Effect of 6-week treatment with topical betamethasone dipropionate in patients with symptomatic hand osteoarthritis: A randomized double-blind, placebo-controlled trial

F. Cicuttini, A. Wluka, S. Hussain, 2023, Osteoarthritis and cartilage open.

AN EXAMINATION OF THE INTERPLAY BETWEEN ENTEROCYTE-BASED METABOLISM AND LYMPHATIC DRUG TRANSPORT IN THE RAT

Christopher J H Porter, Natalie L Trevaskis, C. Porter, 2006, Drug Metabolism and Disposition.

Correlating in Vitro Solubilization and Supersaturation Profiles with in Vivo Exposure for Lipid Based Formulations of the CETP Inhibitor CP-532,623.

Christopher J H Porter, Natalie L Trevaskis, G. Edwards, 2017, Molecular pharmaceutics.

Intra-articular Injection of a B Cell Depletion Antibody Enhances Local Exposure to the Joint-Draining Lymph Node in Mice with Collagen-Induced Arthritis.

C. Nowell, C. Porter, N. Trevaskis, 2023, Molecular pharmaceutics.

A Mouse Model to Evaluate the Impact of Species, Sex, and Lipid Load on Lymphatic Drug Transport

P. Tso, C. Porter, W. Charman, 2013, Pharmaceutical Research.

Intestinal Lymphatic Transport Enhances the Post-Prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-Pass Metabolism

Christopher J. H. Porter, David M. Shackleford, G. Edwards, 2009, Pharmaceutical Research.