J. Jacobsen

发表

Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies

A. Müllertz, Karen Kleberg, J. Jacobsen, 2010, The Journal of pharmacy and pharmacology.

Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

P. Hatton, Katharina H. Clitherow, C. Murdoch, 2019, Molecular pharmaceutics.

Fabrication of mucoadhesive buccal films for local administration of ketoprofen and lidocaine hydrochloride by combining fused deposition modeling and inkjet printing.

J. Rantanen, J. Boetker, D. Fatouros, 2020, Journal of pharmaceutical sciences.

Effect of food intake and co-administration of placebo self-nanoemulsifying drug delivery systems on the absorption of cinnarizine in healthy human volunteers.

B. Abrahamsson, A. Müllertz, J. R. Andersen, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Buccal iontophoretic delivery of atenolol.HCl employing a new in vitro three-chamber permeation cell.

J. Jacobsen, Jette Jacobsen, 2001, Journal of controlled release : official journal of the Controlled Release Society.

A mechanistic based approach for enhancing buccal mucoadhesion of chitosan.

J. Jacobsen, E. Meng-Lund, Christian Muff-Westergaard, 2014, International journal of pharmaceutics.

Ex vivo correlation of the permeability of metoprolol across human and porcine buccal mucosa.

A. Pedersen, A. Müllertz, R. Holm, 2014, Journal of pharmaceutical sciences.

Mucin dispersions as a model for the oromucosal mucus layer in in vitro and ex vivo buccal permeability studies of small molecules

J. Jacobsen, Eva Marxen, M. D. Mosgaard, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

TR146 cells grown on filters as a model for human buccal epithelium: I. Morphology, growth, barrier properties, and permeability

B. Deurs, J. Jacobsen, M. Pedersen, 1995 .

Investigating the effect of graphene oxide in chitosan/alginate-based foams on the release and antifungal activity of clotrimazole in vitro.

H. M. Nielsen, A. Müllertz, S. Larsen, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films.

C. Nielsen, J. Østergaard, H. Mu, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

B. Abrahamsson, A. Müllertz, R. Holm, 2015, Molecular pharmaceutics.

Generic benzalkonium chloride‐preserved travoprost eye drops are not identical to the branded polyquarternium‐1‐preserved travoprost eye drop

G. Petrovski, S. Heegaard, S. Larsen, 2022, Acta ophthalmologica.

An Evaluation of the Physicochemical Properties of Preservative-Free 0.005% (w/v) Latanoprost Ophthalmic Solutions, and the Impact on In Vitro Human Conjunctival Goblet Cell Survival

G. Petrovski, S. Heegaard, J. Jacobsen, 2022, Journal of clinical medicine.

Characterization of burning mouth syndrome profiles based on response to a local anaesthetic lozenge.

J. Jacobsen, O. Andersen, S. Mogensen, 2019, Oral diseases.

Cinnarizine food-effects in beagle dogs can be avoided by administration in a Self Nano Emulsifying Drug Delivery System (SNEDDS).

B. Abrahamsson, A. Müllertz, R. Holm, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The role of citric acid in oral peptide and protein formulations: relationship between calcium chelation and proteolysis inhibition.

David J Brayden, U. Rahbek, D. Brayden, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Medicated chewing gum

Niels H. Jensen, L. Christrup, J. Jacobsen, 2004 .

Acids 'generally recognized as safe' affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers.

H. M. Nielsen, H. Sørensen, I. Chronakis, 2019, Carbohydrate polymers.

Development of an ex vivo retention model simulating bioadhesion in the oral cavity using human saliva and physiologically relevant irrigation media.

A. Pedersen, S. Baldursdóttir, J. Jacobsen, 2013, International journal of pharmaceutics.

TR146 cells as a model for human buccal epithelium : II. Optimisation and use of a cellular sensitivity MTS/PMS assay

J. Jacobsen, M. Pedersen, M. Rassing, 1996 .

Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa.

H. M. Nielsen, I. Chronakis, Feng Wan, 2020, Carbohydrate Polymers.

Absorption of Bupivacaine after Administration of a Lozenge as Topical Treatment for Pain from Oral Mucositis

K. Jensen, A. Jensen, C. Kristensen, 2017, Basic & clinical pharmacology & toxicology.

Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum.

J. Rantanen, Mingshi Yang, J. Jacobsen, 2013, International journal of pharmaceutics.

Cyclodextrin inclusion complexes of miconazole and econazole--isolation, toxicity on human cells, and confirmation of a new interpretation of the drug supersaturation phenomenon.

J. Jacobsen, M. Pedersen, A. M. Sørensen, 1999, Drug development and industrial pharmacy.

A genuine clotrimazole γ-cyclodextrin inclusion complex-isolation, antimycotic activity, toxicity and an unusual dissolution rate

S. Bjerregaard, J. Jacobsen, M. Pedersen, 1998 .

An econazole β-cyclodextrin inclusion complex: an unusual dissolution rate, supersaturation, and biological efficacy example

A. Larsen, S. Bjerregaard, J. Jacobsen, 1998 .

Development and in vitro/in vivo testing of mucoadhesive buccal patches releasing benzydamine and lidocaine

J. Jacobsen, S. Burgalassi, M. Saettone, 1996 .

Polymer coated liposomes for use in the oral cavity – a study of the in vitro toxicity, effect on cell permeability and interaction with mucin

A. Kjøniksen, G. Smistad, J. Jacobsen, 2018, Journal of liposome research.

Analytical aspects of printed oral dosage forms

Jukka Rantanen, Natalja Genina, Magnus Edinger, 2018, International journal of pharmaceutics.

Cyclodextrin inclusion complexes of antimycotics intended to act in the oral cavity--drug supersaturation, toxicity on TR146 cells and release from a delivery system.

S. Bjerregaard, J. Jacobsen, M. Pedersen, 1999, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Filter-grown TR146 cells as an in vitro model of human buccal epithelial permeability.

N. Tommerup, K. Brøndum‐Nielsen, J. Jacobsen, 1999, European journal of oral sciences.

Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging

C. Janfelt, J. Nicolazzo, J. Jacobsen, 2018, Pharmaceutical Research.

Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.

A. Müllertz, R. Holm, M. Lind, 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Multivariate toxicity screening of liposomal formulations on a human buccal cell line.

S. A. Sande, G. Smistad, J. Jacobsen, 2007, International journal of pharmaceutics.

Effect of cryoprotectants for maintaining drug permeability barriers in porcine buccal mucosa.

J. Jacobsen, Eva Marxen, A. Pedersen, 2016, International journal of pharmaceutics.

Graphene oxide as a functional excipient in buccal films for delivery of clotrimazole: effect of molecular interactions on drug release and antifungal activity in vitro.

H. M. Nielsen, A. Müllertz, M. van de Weert, 2020, International journal of pharmaceutics.

Buccal delivery of small molecules – Impact of levulinic acid, oleic acid, sodium dodecyl sulfate and hypotonicity on ex vivo permeability and spatial distribution in mucosa

C. Janfelt, J. Jacobsen, Eva Marxen, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Dissolution Model Development: Formulation Effects and Filter Complications

B. Abrahamsson, A. Müllertz, R. Holm, 2016 .

Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example.

B. Abrahamsson, A. Müllertz, R. Holm, 2014, International journal of pharmaceutics.

Polymeric microcontainers improve oral bioavailability of furosemide.

A. Boisen, S. Keller, T. Rades, 2016, International journal of pharmaceutics.

Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration.

H. M. Nielsen, J. Rantanen, J. Jacobsen, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Title Safety and efficacy of sodium caprate in promoting oral drugabsorption : from in vitro to the clinic

David J Brayden, J. Jacobsen, S. Maher, 2017 .

Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic.

David J Brayden, J. Jacobsen, S. Maher, 2009, Advanced drug delivery reviews.

Evaluation of the use of Göttingen minipigs to predict food effects on the oral absorption of drugs in humans.

B. Abrahamsson, A. Müllertz, R. Holm, 2015, Journal of pharmaceutical sciences.

In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and Göttingen minipigs.

R. Holm, J. Jacobsen, E. Jørgensen, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Buccal delivery of metformin: TR146 cell culture model evaluating the use of bioadhesive chitosan discs for drug permeability enhancement.

H. M. Nielsen, J. Jacobsen, Camilla Sander, 2013, International journal of pharmaceutics.

Microenvironmental pH modifying films for buccal delivery of saquinavir: effects of organic acids on pH and drug release in vitro.

C. Nielsen, J. Østergaard, H. Mu, 2020, International journal of pharmaceutics.

A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs.

P. Holm, A. Müllertz, R. Holm, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Bupivacaine Lozenge Compared with Lidocaine Spray as Topical Pharyngeal Anesthetic before Unsedated Upper Gastrointestinal Endoscopy: A Randomized, Controlled Trial

J. Jacobsen, O. Andersen, S. Mogensen, 2014, Clinical medicine insights. Gastroenterology.

New lidocaine lozenge as topical anesthesia compared to lidocaine viscous oral solution before upper gastrointestinal endoscopy

J. Jacobsen, O. Andersen, S. Mogensen, 2012, Local and regional anesthesia.

Colon targeting of fluticasone propionate inclusion complex: a novel approach in inflammatory bowel disease

D. K. Majumdar, A. Ray, J. Jacobsen, 2013, Journal of Inclusion Phenomena and Macrocyclic Chemistry.

Polymeric Lids for Microcontainers for Oral Protein Delivery.

A. Boisen, C. Gundlach, A. Müllertz, 2019, Macromolecular bioscience.

Assessing acute colitis induced by dextran sulfate sodium in rats and its impact on gastrointestinal fluids

T. Rades, A. Müllertz, R. Berthelsen, 2023, Drug Delivery and Translational Research.

Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS.

Anette Müllertz, Bertil Abrahamsson, Jakob Kristensen, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Impact of benzalkonium chloride-preserved and preservative-free latanoprost eye drops on cultured human conjunctival goblet cells upon acute exposure and differences in physicochemical properties of the eye drops

Jeffrey A. Bair, G. Petrovski, S. Heegaard, 2021, BMJ Open Ophthalmology.

Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery

C. Janfelt, J. Jacobsen, Anne Mette Handler, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Conscious and anaesthetised Göttingen mini-pigs as an in-vivo model for buccal absorption – pH-dependent absorption of metoprolol from bioadhesive tablets

R. Holm, J. Jacobsen, E. Jørgensen, 2014, Drug development and industrial pharmacy.

Effect of different surfactants in biorelevant medium on the secretion of a lipophilic compound in lipoproteins using Caco-2 cell culture.

Anette Müllertz, René Holm, Jette Jacobsen, 2006, Journal of pharmaceutical sciences.

Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin

H. M. Nielsen, I. Chronakis, J. Jacobsen, 2022, International journal of molecular sciences.

Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery.

H. M. Nielsen, J. Rantanen, I. Chronakis, 2022, Carbohydrate polymers.

Electrospun α-lactalbumin nanofibers for site-specific and fast-onset delivery of nicotine in the oral cavity: an in vitro, ex vivo and tissue spatial distribution study.

I. Chronakis, V. Foderà, C. Janfelt, 2020, Molecular pharmaceutics.

In Vitro and Ex Vivo Evaluation of Bi-Layered Effervescent Microenvironmental PH Modifying Buccal Films with Saquinavir

C. Nielsen, H. Mu, J. Jacobsen, 2022, SSRN Electronic Journal.

Multi-material 3D printing of programmable and stretchable oromucosal patches for delivery of saquinavir.

H. Mu, J. Jacobsen, Shaolong He, 2021, International journal of pharmaceutics.

Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms.

A. Müllertz, R. Holm, M. Lind, 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Development of a μDissolution-Permeation model with in situ drug concentration monitoring

B. Abrahamsson, A. Müllertz, R. Holm, 2016 .

Azone® decreases the buccal mucosal permeation of diazepam in a concentration-dependent manner via a reservoir effect.

A. Müllertz, C. Janfelt, R. Holm, 2014, Journal of pharmaceutical sciences.

Impact of sodium dodecyl sulphate on the dissolution of poorly soluble drug into biorelevant medium from drug-surfactant discs.

P. Bertelsen, A. Müllertz, J. Ostergaard, 2014, International journal of pharmaceutics.

Waterborne Electrospinning of α-Lactalbumin Generates Tunable and Biocompatible Nanofibers for Drug Delivery

H. M. Nielsen, I. Chronakis, Fatemeh Ajalloueian, 2020 .

Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats

Anette Müllertz, Huiling Mu, René Holm, 2011, The Journal of pharmacy and pharmacology.

Effect of a local anesthetic lozenge in relief of symptoms in burning mouth syndrome.

J. Jacobsen, O. Andersen, S. Mogensen, 2016, Oral Diseases.

In vivo human buccal permeability of nicotine.

K. Dalhoff, J. Jacobsen, H. B. Olin, 2006, International journal of pharmaceutics.

Generic benzalkonium chloridepreserved travoprost eye drops are not identical to the branded polyquarternium1preserved travoprost eye drop Effect on cultured human conjunctival goblet cells and their physicochemical properties

G. Petrovski, S. Heegaard, S. Larsen, 2022 .

Buccal absorption of diazepam is improved when administered in bioadhesive tablets-An in vivo study in conscious Göttingen mini-pigs.

A. Müllertz, R. Holm, J. Jacobsen, 2016, International journal of pharmaceutics.

Mucin dispersions as a model for the oromucosal mucus layer in in vitro and ex vivo buccal permeability studies of small molecules

J. Jacobsen, Eva Marxen, M. D. Mosgaard, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and Göttingen minipigs.

R. Holm, J. Jacobsen, E. Jørgensen, 2013, European Journal of Pharmaceutical Sciences.

The role of citric acid in oral peptide and protein formulations: relationship between calcium chelation and proteolysis inhibition.

David J Brayden, U. Rahbek, S. Buckley, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Waterborne Electrospinning of -Lactalbumin Generates Tunable and Biocompatible Nanofibers for Drug Delivery

I. Chronakis, Fatemeh Ajalloueian, J. Jacobsen, 2022 .

Characterizing interregional differences in the rheological properties and composition of rat small intestinal mucus.

R. Berthelsen, M. Klitgaard, J. Jacobsen, 2024, Drug delivery and translational research.