T. Higuchi

发表

DISSOLUTION BEHAVIOR OF CRYSTALLINE SOLVATED AND NONSOLVATED FORMS OF SOME PHARMACEUTICALS.

E. Shefter, T. Higuchi, 1963, Journal of pharmaceutical sciences.

MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES.

T. Higuchi, 1963, Journal of pharmaceutical sciences.

Preparation of some steroids in microcrystalline form by rapid freeze-sublimation technique.

D. Wurster, T. Higuchi, A. P. Lemberger, 1954, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Investigation of drug release from solids. II. Theoretical and experimental study of influences of bases and buffers on rates of dissolution of acidic solids.

W. Higuchi, E. L. Parrott, D. Wurster, 1958, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Binding specificity between small organic solutes in aqueous solution: classification of some solutes into two groups according to binding tendencies.

T. Higuchi, H. Kristiansen, T. Higuchi, 1970, Journal of pharmaceutical sciences.

Effect of various compounds on the rate of thiamine hydrolysis.

T. Higuchi, J J WINDHEUSER, T HIGUCHI, 1963, Journal of pharmaceutical sciences.

COMPLEXATION OF ORGANIC SUBSTANCES IN AQUEOUS SOLUTION BY HYDROXYAROMATIC ACIDS AND THEIR SALTS. II. INFLUENCE OF HALOGEN, NITRO, AND OTHER SUBSTITUENTS AND CORRELATION OF BINDING TENDENCIES TOWARD PREDNISOLONE, THEOPHYLLINE, AND PHENACETIN.

T. Higuchi, F. Pisano, 1961, Journal of pharmaceutical sciences.

Plastic electrodes specific for organic ions

J. Tossounian, T. Higuchi, C. R. Illian, 1970 .

Multiple intermediates generate fluorophore-derived light in the oxalate/peroxide chemiluminescence system

R. Schowen, R. Givens, F. J. Alvarez, 1986 .

Rate Studies On the Anaerobic Degradation of Ascorbic Acid III

I. Alsos, T. Higuchi, P. Finholt, 1965 .

RATE STUDIES ON THE ANAEROBIC DEGRADATION OF ASCORBIC ACID. 3. RATE OF FORMATION OF FURFURAL.

I. Alsos, T. Higuchi, P. Finholt, 1965, Journal of pharmaceutical sciences.

Investigation of some complexes formed in solution by caffeine. IV. Interactions between caffeine and sulfathiazole, sulfadiazine, p-aminobenzoic acid, benzocaine, phenobarbital, and barbital.

T. Higuchi, J. Lach, 2006, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Chemical equilibria in solutions of bisulfite salts.

T. Higuchi, D. Bourne, I. H. Pitman, 1974, Journal of pharmaceutical sciences.

Enhancement of percutaneous absorption by the use of volatile: nonvolatile systems as vehicles.

T. Higuchi, B. Poulsen, M. Coldman, 1969, Journal of Pharmacy and Science.

Interaction studies of cationic drugs with anionic polyelectrolytes. I. Sodium carboxymethylcellulose.

T. Higuchi, L. Kennon, 1956, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Diffusion of phenol in the presence of a complexing agent, tetrahydrofuran.

J. Dressman, K. Himmelstein, T. Higuchi, 1983, Journal of pharmaceutical sciences.

Simultaneous self-association and diffusion of phenol in isooctane.

J. Dressman, K. Himmelstein, T. Higuchi, 1982, Journal of pharmaceutical sciences.

Thermodynamic group contributions for hydroxyl, amino, and methylene groups.

T. Higuchi, J. H. Rytting, L. P. Huston, 1978, Journal of pharmaceutical sciences.

Improved delivery through biological membranes. 4. Prodrugs of L-dopa.

N. Bodor, T. Higuchi, K. Sloan, 1977, Journal of medicinal chemistry.

Lymphatic uptake of water‐soluble drugs after rectal administration

T. Higuchi, J. H. Rytting, L. Caldwell, 1982, The Journal of pharmacy and pharmacology.

Determination of dopamine, norepinephrine, and related trace amines by prechromatographic derivatization with naphthalene-2,3-dicarboxaldehyde.

K. Imai, T. Higuchi, T. Kawasaki, 1989, Analytical biochemistry.

N-substituted 1-cyanobenz[f]isoindole: evaluation of fluorescence efficiencies of a new fluorogenic label for primary amines and amino acids.

R. Givens, B. Matuszewski, T. Higuchi, 1987, Analytical chemistry.

Kinetics and mechanism of hydrolysis of labile quaternary ammonium derivatives of tertiary amines.

T. Higuchi, J. B. Bogardus, 1982, Journal of pharmaceutical sciences.

A kinetic study of acid-catalyzed racemization of epinephrine.

L. C. Schroeter, T. Higuchi, 1958, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Determination of thermodynamics of the methylene group in solutions of drug molecules.

S. Davis, T. Higuchi, J. H. Rytting, 1972, The Journal of pharmacy and pharmacology.

S. Davis, T. Higuchi, J. H. Rytting, 1972, Journal of pharmaceutical sciences.

Study of possible complex formation between macromolecules and certain pharmaceuticals. II. Polyvinylpyrrolidone with p-aminobenzoic acid, aminopyrine, benzoic acid, salicylic acid, p-hydroxybenzoic acid, m-hydroxybenzoic acid, citric acid, and phenobarbital.

T. Higuchi, R. Kuramoto, 1954, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Enhanced rectal absorption of insulin and heparin in rats in the presence of non‐surfactant adjuvants

T. Higuchi, J. H. Rytting, L. Caldwell, 1981, The Journal of pharmacy and pharmacology.

Kinetics of thiamine hydrolysis.

T. Higuchi, J. Windheuser, 1962, Journal of pharmaceutical sciences.

Effect of aprotinin on the rectal delivery of insulin

G. Liversidge, T. Higuchi, T. Nishihata, 1983, The Journal of pharmacy and pharmacology.

Quantitative analytical method for determination of drugs dispersed in polymers using differential scanning calorimetry.

T. Higuchi, A. Hussain, F. Theeuwes, 1974, Journal of pharmaceutical sciences.

Study of possible complex formation between macromolecules and certain pharmaceuticals. I. Polyvinylpyrrolidone with sulfathiazole, procaine hydrochloride, sodium salicylate, benzyl penicillin, chloramphenicol, mandelic acid, caffeine, theophylline, and cortisone.

T. Higuchi, R. Kuramoto, 1954, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Erosion of poly(ortho ester) matrices in buffered aqueous solutions

K. Himmelstein, T. Higuchi, T. Nguyen, 1986 .

Effect of suppository shape on the systemic availability of rectally administered insulin and sodium salicylate

G. Liversidge, T. Higuchi, K. Engle, 1986 .

Enhanced bioavailability of insulin after rectal administration with enamine as adjuvant in depancreatized dogs

R. Kawamori, M. Shichiri, T. Higuchi, 1985, The Journal of pharmacy and pharmacology.

Effect of rectal suppository formulation on the release of insulin and on the glucose plasma levels in dogs

G. Liversidge, T. Higuchi, K. Engle, 1985 .

Adjuvant effects of glyceryl esters of acetoacetic acid on rectal absorption of insulin and inulin in rabbits.

N. Yata, S. Morishita, T. Higuchi, 1983, Journal of pharmaceutical sciences.

Enhancement of rectal absorption of insulin using salicylates in dogs

T. Higuchi, J. H. Rytting, L. Caldwell, 1983, The Journal of pharmacy and pharmacology.

Effect of enamine derivatives on the rectal absorption of insulin in dogs and rabbits

T. Higuchi, A. Kamada, T. Nishihata, 1983, The Journal of pharmacy and pharmacology.

Enhanced rectal bioavailability of polypeptides using sodium 5-methoxysalicylate as an absorption promoter.

T. Higuchi, L. Caldwell, S. Yoshioka, 1982, Journal of pharmaceutical sciences.

Theoretical analysis of diffusional movement through heterogeneous barriers

W. Higuchi, T. Higuchi, 1960 .

The physics of tablet compression. V. Studies on aspirin, lactose, lactose-aspirin, and sulfadiazine tablets.

T. Higuchi, L. W. Busse, L. N. Elowe, 1954, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Possible complex formation between macromolecules and certain pharmaceuticals. X. The interaction of some phenolic compounds with polyethylene glycols, polypropylene glycols, and polyvinylpyrrolidone.

T. Higuchi, D. Guttman, 1956, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Study of Possible Complex Formation BetweenMacromolecules and Certain Pharmaceuticals IX: Formation of Iodine-Iodide Complexes with Polyethylene Glycol: Formation of Iodine-Iodi de Complexes with Polyethylene Glycol

T. Higuchi, D. Guttman, 1955 .

Phase solubility techniques

T. Higuchi, A. Connors, 1965 .

Collisionally induced dissociation in the study of A-ring hydroxylated vitamin D type compounds.

P. Vouros, M. Holick, T. Higuchi, 1992, Analytical chemistry.

Formation of complexes by N,N'-dimethyl-diketobenzodiazines in nonaqueous solutions.

T. Higuchi, A. Haddad, B. J. Sciarrone, 1959, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Molecular interactions and solubility of polar nonelectrolytes in nonpolar solvents.

T. Higuchi, H. Fung, 1971, Journal of pharmaceutical sciences.

Solvency and hydrogen bonding interactions in nonaqueous systems.

I H Pitman, T Higuchi, S. Davis, 1969, Journal of pharmaceutical sciences.

Oxidation of Thioethers by Iodine to Sulfoxides. Catalytic Role of Certain Inorganic Nucleophiles1

T. Higuchi, K. Gensch, 1966 .

An Improved Synthesis of 1-Alkyl-4-imidazolin-2-ones

T. Higuchi, Mark B Richardson, R. Konishi, 1987 .

Formation of molecular complexes by diketobenzodiazines and their methylated derivatives with phenol and dihydroxybenzenes in aqueous solutions.

T. Higuchi, A. Haddad, B. J. Sciarrone, 1961, Journal of medicinal and pharmaceutical chemistry.

Calculation of stability constants of hydrogen-bonded complexes from proton magnetic resonance data. Interactions of phenol with dimethylacetamide and various ketones. Solvent effect

T. Higuchi, M. Nakano, N. Nakano, 1967 .

RATES OF HYDROLYSIS OF CARBAMATE AND CARBONATE ESTERS IN ALKALINE SOLUTION.

T. Higuchi, L. Dittert, 1963, Journal of pharmaceutical sciences.

Improved delivery through biological membranes. 1. Synthesis and properties of 1-methyl-1,6-dihydropyridine-2-carbaldoxime, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride.

N. Bodor, E. Shek, T. Higuchi, 1976, Journal of medicinal chemistry.

Mechanism of chlorination of cresol by chloramine-T. Mediation by dichloramine-T

T. Higuchi, A. Hussain, 1967 .

Hydrolytic behavior of N-acyl phthalimides.

V. Stella, T. Higuchi, 1973, Journal of pharmaceutical sciences.

Naphthalene-2,3-dicarboxyaldehyde/cyanide ion: a rationally designed fluorogenic reagent for primary amines

R. Givens, T. Higuchi, L. Sternson, 1987 .

Complexation of organic substances in aqueous solution by hydroxyaromatic acids and their salts. Relative contributions of several factors to the overall effect.

T. Higuchi, A. Drubulis, 1961, Journal of Pharmacy and Science.

Investigation of complexes formed in solution by caffeine. VI. Comparison of complexing behaviors of methylated xanthines with p-aminobenzoic acid, salicylic acid, acetylsalicylic acid, and p-hydroxybenzoic acid.

T. Higuchi, J. Lach, 1954, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Acylation of phenol by cyclic and acyclic anhydrides in anhydrous acetic acid.

M. Haddadin, V. Stella, T. Higuchi, 1975, Journal of pharmaceutical sciences.

Solubility behavior of organic compounds

David J.W. Grant, D. Grant, T. Higuchi, 1990 .

Solubilizing action of caffeine on benzoic acid.

T. Higuchi, D. Zuck, 1952, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Investigation of some complexes formed in solution by caffeine. II. Benzoic acid and benzoate ion.

T. Higuchi, D. Zuck, 1953, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Phase Solubility Analysis

T. Higuchi, W. Mader, 1970 .

Electrometric Titration of Alcohols Using Lithium Aluminum Hydride

T. Higuchi, C. J. Lintner, R. H. Schleif, 1950 .

Inhibition of hydrolysis of esters in solution by formation of complexes. I. Stabilization of benzocaine with caffeine.

L. Lachman, T. Higuchi, 1955, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Complexation in formulation of parenteral solutions: solubilization of the cytotoxic agent hexamethylmelamine by complexation with gentisic acid species.

T Higuchi, T. Higuchi, B Kreilgård, 1975, Journal of pharmaceutical sciences.

Determination of stability constants from optical rotatory dispersion measurements. Camphor-phenol system in carbon tetrachloride.

T. Higuchi, J. Meier, 1965, Journal of pharmaceutical sciences.

Chromatographic Separation and Determination of Dicarboxylic Acids C4 to C10

T. Higuchi, N. Hill, G. B. Corcoran, 1952 .

Effect of solvent composition on association between small organic species.

T. Higuchi, M. Nakano, N. Nakano, 1970, Journal of pharmaceutical sciences.

Study of possible complex formation between macromolecules and certain pharmaceuticals. III. Interaction of polyethylene glycols with several organic acids.

T. Higuchi, J. Lach, 1954, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Improved delivery of methoxsalen.

J. Kreuter, T. Higuchi, 1979, Journal of pharmaceutical sciences.

Solubilization and stabilization of the cytotoxic agent coralyne.

T. Higuchi, M. Cho, A. Repta, 1975, Journal of pharmaceutical sciences.

Enhanced small intestinal absorption of cefmetazole and cefoxitin in rats in the presence of non‐surfactant adjuvants

T. Higuchi, T. Nishihata, H. Takahagi, 1983, The Journal of pharmacy and pharmacology.

Deuterium isotope effects on degradation of hydrocortisone in aqueous solution.

T. Higuchi, R. Wiley, I. H. Pitman, 1972, Journal of pharmaceutical sciences.

RATE OF ANHYDRIDE FORMATION IN TARTRATE BUFFER SYSTEM. NATURE OF REACTION PRODUCT WITH ANILINE.

T. Higuchi, H. Uno, I. Shimada, 1965, Journal of pharmaceutical sciences.

Micellar acceleration of organophosphate hydrolysis by hydroximinomethylpyridinium type surfactants

N. Bodor, T. Higuchi, R. Enever, 1978 .

Partial vapor pressures and solubilities of cyclic polar compounds iniso-octane solutions

D. Grant, T. Higuchi, J. H. Rytting, 1984 .

Evaluation of Amides and Other Very Weak Bases in Acetic Acid.

H. Ghassemi, T. Higuchi, C. Barnstein, 1962 .

Role of solvating agents in promoting ion pair extraction

T. Higuchi, J. H. Rytting, A. Michaelis, 1971 .

Ion pair extraction of pharmaceutical amines. Role of dipolar solvating agents in extraction of dextromethorphan.

T. Higuchi, A. Michaelis, A. Hurwitz, 1967, Analytical chemistry.

Solubility of polar organic solutes in nonaqueous systems: role of specific interactions.

T Higuchi, B. D. Anderson, T. Higuchi, 1980, Journal of pharmaceutical sciences.

Degradation of epinephrine induced by bisulfite.

L. C. Schroeter, T. Higuchi, E. Schuler, 1958, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

NMR evidence for self-association of teophylline in aqueous solution: a response.

T. Higuchi, D. Guttman, 1971, Journal of pharmaceutical sciences.

Phase solubility of solid species formed by magnesium aluminate from aqueous solutions containing sulfate ions.

F. S. Hom, T. Higuchi, 1963, Journal of pharmaceutical sciences.

The liquid-liquid counter current separation of a menthol-menthyl acetate mixture.

T. Higuchi, J. V. Swintosky, R. Kuramoto, 1953, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

The physics of tablet compression. IV. Relationship of ejection, and upper and lower punch forces during compressional process: application of measurements to comparison of tablet lubricants.

T. Higuchi, L. W. Busse, E. Nelson, 1954, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Photometric Determination of Indicator End Points

T. Higuchi, C. Barnstein, C. Rehm, 1956 .

A Thermometric Method for Thermodynamics Studies and Molecular Weight Determinations in Solutions

W. Higuchi, T. Higuchi, E. Rippie, 1959 .

Electrical charge conduction mechanism of a polymer membrane electrode selective for hydrophobic cations

T. Higuchi, L. Sternson, J. R. Luch, 1982 .

Analysis of hydrophobic amine antimalarials in biological fluids with the plastic ion-selective electrode.

T. Higuchi, L. Sternson, D. W. Mendenhall, 1979, Journal of pharmaceutical sciences.

Ion-pair extraction of pharmaceutical amines. IV. Influence of anion on enthalpic, entropic, and free energy changes resulting from phase transfer.

T. Higuchi, A. Michaelis, 1969, Journal of pharmaceutical sciences.

Mechanism and kinetics of ion pair extraction. Rate of extraction of dextromethorphanium ion

T. Higuchi, A. Michaelis, 1968 .

Interaction of di- and tricarboxylic acids with glutaric anhydride in aqueous solution.

J. Robinson, T. Higuchi, A. Repta, 1966, Journal of pharmaceutical sciences.

Solid state stability of some crystalline vitamin A compounds.

T. Higuchi, K. Guillory, 1962, Journal of pharmaceutical sciences.

Rate of release of medicaments from ointment bases containing drugs in suspension.

T. Higuchi, T HIGUCHI, Takeru Higuchi, 1961, Journal of pharmaceutical sciences.

Effect of particle size and food on gastric residence time of non‐disintegrating solids in beagle dogs

C. Gardner, T. Higuchi, T. Itoh, 1986, The Journal of pharmacy and pharmacology.

Unsaturated cyclic ureas as new non-toxic biodegradable transdermal penetration enhancers. II. Evaluation study

T. Higuchi, J. H. Rytting, T. Itoh, 1989 .

Esterase activity in snake skin

T. Higuchi, B. Nghiem, 1988 .

Solubility determination of barely aqueous-soluble organic solids.

T. Higuchi, J. H. Rytting, T. Kimura, 1979, Journal of pharmaceutical sciences.

Extrapolation Plot for Photometric Titration of Weak Bases in Aqueous and Nonaqueous Systems

T. Higuchi, C. Rehm, 1957 .

Kinetics of degradation in solution of epinephrine by molecular oxygen.

T. Higuchi, T. Sokoloski, 1962, Journal of pharmaceutical sciences.

Intramolecular bifunctional facilitation in complex molecules. Combined nucleophilic and general acid participation in hydrolysis of hexchlorophene monosuccinate

T. Higuchi, H. Fung, H. Takechi, 1971 .

The physics of tablet compression. II. The influence of degree of compression on properties of tablets.

T. Higuchi, L. W. Busse, J. V. Swintosky, 1953, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Enhancement of solubility of drug salts by hydrophilic counterions: properties of organic salts of an antimalarial drug.

T Higuchi, T. Higuchi, S. Lindenbaum, 1976, Journal of pharmaceutical sciences.

Clinical analysis of tamoxifen, an anti-neoplastic agent, in plasma.

T. Higuchi, L. Sternson, H. Kobayashi, 1978, Clinical chemistry.

Kinetics of degradation of amyl nitrite ampuls. II. Stabilization.

T. Higuchi, M. Yunker, 1958, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Effects of salicylate on rectal absorption of theophylline.

T. Higuchi, J. H. Rytting, T. Nishihata, 1981, Journal of pharmaceutical sciences.

RATE OF ANAEROBIC DEGRADATION OF ASCORBIC ACID IN AQUEOUS SOLUTION.

T. Higuchi, P. Finholt, R. B. Paulssen, 1963, Journal of pharmaceutical sciences.

Unsaturated cyclic ureas as new nontoxic biodegradable transdermal penetration enhancers I: Synthesis.

T. Higuchi, J. H. Rytting, R. Konishi, 1988, Journal of Pharmacy and Science.

Prodrugs of 6-thiopurines: enhanced delivery through the skin.

N. Bodor, M. Hashida, T. Higuchi, 1983, Journal of pharmaceutical sciences.

Enhanced rectal absorption of theophylline, lidocaine, cefmetazole, and levodopa by several adjuvants.

T. Higuchi, J. H. Rytting, T. Nishihata, 1982, Journal of pharmaceutical sciences.

Hydrolysis and dissolution behavior of a prolonged-release prodrug of theophylline: 7,7'-succinylditheophylline.

V. Stella, T. Higuchi, H. K. Lee, 1979, Journal of pharmaceutical sciences.

Improved delivery through biological membranes. 3. Delivery of N-methylpyridinium-2-carbaldoxime chloride through the blood-brain barrier in its dihydropyridine pro-drug form.

N. Bodor, E. Shek, T. Higuchi, 1976, Journal of medicinal chemistry.

Improved delivery through biological membranes. 2. Distribution, excretion, and metabolism of N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride.

N. Bodor, E. Shek, T. Higuchi, 1976, Journal of medicinal chemistry.

Delivery of a quaternary pyridinium salt across the blood-brain barrier by its dihydropyridine derivative

N. Bodor, E. Shek, T. Higuchi, 1975, Science.

The Chemistry of a Novel 5,5-Diphenylhydantoin Pro-drug

V. Stella, T. Higuchi, A. Hussain, 1975 .

The Metabolic Disposition of a Novel 5,5-Diphenylhydantoin Pro-drug

A. Glazko, W. Dill, V. Stella, 1975 .

Esters of hydantoic acids as prodrugs of hydantoins.

V. Stella, T. Higuchi, 1973, Journal of pharmaceutical sciences.

Conductometric Titration of Sulfuric and Hydrochloric Acids and Their Mixtures in Anhydrous Acetic Acid

T. Higuchi, C. Rehm, 1955 .

Determination of fluorescent cyanobenz[f]isoindole derivatives of dopamine and norepinephrine using high performance liquid chromatography with chemiluminescence detection.

K. Imai, T. Higuchi, T. Kawasaki, 1990, Biomedical chromatography : BMC.

N-hydroxymethyl derivatives of nitrogen heterocycles as possible prodrugs II: possible prodrugs of allopurinol, glutethimide, and phenobarbital.

T. Higuchi, P. Bansal, I. H. Pitman, 1981, Journal of pharmaceutical sciences.

N-halo derivatives III: stabilization of nitrogen-chlorine bond in N-chloroamino acid derivatives.

N. Bodor, T. Higuchi, J. Kaminski, 1976, Journal of pharmaceutical sciences.

N-Halo derivatives V: Comparative antimicrobial activity of soft N-chloramine systems.

N. Bodor, T. Higuchi, M. Huycke, 1976, Journal of pharmaceutical sciences.

IMPROVED DELIVERY THROUGH BIOLOGICAL MEMBRANES. 4. PRODRUGS OF L-DOPA

N. Bodor, T. Higuchi, K. Sloan, 1978 .

Unsaturated Cyclic Ureas as New Nontoxic Biodegradable Transdermal Penetration Enhancers. Part 1. Synthesis.

T. Higuchi, J. H. Rytting, R. Konishi, 1989 .

PRODRUGS OF 6-THIOPURINES: ENHANCED DELIVERY THROUGH THE SKIN

N. Bodor, M. Hashida, T. Higuchi, 1983 .

Reversible association of caffeine and of some caffeine homologs in aqueous solution.

T. Higuchi, D. Guttman, 1957, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Rational development of a soluble prodrug of a cytotoxic nucleoside: preparation and properties of arabinosyladenine 5'-formate.

N. Bodor, T. Higuchi, K. Sloan, 1975, Journal of pharmaceutical sciences.

Arabic acid and its salts. I. The preparation of arabic acid and sodium arabate powder.

T. Higuchi, L. W. Busse, R. H. Schleif, 1951, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Rectal absorption and lymphatic uptake of Ara-C in rats

G. Liversidge, T. Higuchi, T. Nishihata, 1986 .

Lymphatic transport of sodium cefoxitin in the presence of sodium 5‐methoxysalicylate after injection into rat rectal connective tissue, femoral muscle and femoral vein

T. Higuchi, A. Kamada, T. Nishihata, 1985, The Journal of pharmacy and pharmacology.

Effect of salicylate on the rectal absorption of lidocaine, levodopa, and cefmetazole in rats.

T. Higuchi, J. H. Rytting, T. Nishihata, 1982, Journal of pharmaceutical sciences.

Investigation of drug release from solids. I. Some factors influencing the dissolution rate.

E. L. Parrott, D. Wurster, T. Higuchi, 1955, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Potentiometric determination of oxygen using the dropping mercury electrode.

T. Higuchi, H. Laitinen, M. Czuha, 1948, Journal of the American Chemical Society.

Determination of molecular binding in aqueous solution from optical activity measurements. Interaction of tryptophan with alkylxanthines.

T. Higuchi, M. Nakano, 1968, Journal of pharmaceutical sciences.

Kinetics and Mechanism of Formation of Sulfonate from Epinephrine and Bisulfite

L. C. Schroeter, T. Higuchi, 1960 .

Reactivity of bisulfite with a number of pharmaceuticals.

L. C. Schroeter, T. Higuchi, 1959, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Caffeine complexes with low water solubility: synthesis and dissolution rates of 1:1 and 1:2 caffeine-gentisic acid complexes.

T. Higuchi, I. H. Pitman, 1973, Journal of pharmaceutical sciences.

Kinetic investigation of reversible reaction between methionine and iodine. Improved iodometric determination of methionine.

T. Higuchi, K. Gensch, 1967, Journal of pharmaceutical sciences.

Amino Acid Esters of Phenols as Prodrugs: Synthesis and Stability of Glycine, β-Aspartic acid, and α-Aspartic Acid Esters of p-Acetamidophenol

T. Higuchi, I. Kovach, I. H. Pitman, 1981 .

Specificity of esterases and structure of prodrug esters: reactivity of various acylated acetaminophen compounds and acetylaminobenzoated compounds.

T. Higuchi, H. Seki, T. Kawaguchi, 1988, Journal of pharmaceutical sciences.

Enhanced rectal absorption of sodium ampicillin by N-acyl derivatives of collagen peptide in rabbits and rats.

T. Murakami, T. Higuchi, Y. Higashi, 1985, Journal of pharmaceutical sciences.

Enhanced rectal absorption of cefmetazole and cefoxitin in the presence of epinephrine metabolites in rats and a high-performance liquid chromatographic assay for cephamycin antibiotics.

T. Higuchi, J. H. Rytting, M. Yamamoto, 1984, Journal of pharmaceutical sciences.

Quantitative analysis of microgram quantities of pilocarpine in aqueous solution.

T. Higuchi, A. Repta, 1971, Journal of pharmaceutical sciences.

Arabic acid and its salts. II. The effect of cations on the viscosity of arabic acid solutions.

T. Higuchi, L. W. Busse, R. H. Schleif, 1951, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Gas-chromatographic analysis for 1,2:5,6-dianhydrogalactitol, an anti-neoplastic agent, in plasma.

T. Higuchi, L. Sternson, T. Kimura, 1976, Clinical chemistry.

Acetylacroninium salts as soluble prodrugs of the antineoplastic agent acronine.

T. Higuchi, D. Bourne, A. Repta, 1977, Journal of pharmaceutical sciences.

Vapor pressure studies of self-association of alcohols in isooctane. I. the effect of chain length

B. D. Anderson, T. Higuchi, J. H. Rytting, 1978 .

Calorimetric study of the self-association of primary alcohols in isooctane

B. D. Anderson, T. Higuchi, J. H. Rytting, 1975 .

Gas Chromatographic Separation of Some Permanent Gases on Silica Gel at Reduced Temperatures

T. Higuchi, D. Szulczewski, 1957 .

Scientific EditionInhibition of Hydrolysis of Esters in Solution Formation of Complexes III.*: Stabilization of Tetracaine with Caffeine

L. Lachman, T. Higuchi, 1957 .

Inhibition of hydrolysis of esters in solution by formation of complexes. II. Stabilization of procaine with caffeine.

L. Lachman, T. Higuchi, L. J. Ravin, 1956, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Vapor pressure studies of the self-association of alcohols in isooctane. 2. The effect of chain branching

B. D. Anderson, T. Higuchi, J. H. Rytting, 1978 .

A dilatometric study of melting behaviors of some fats, waxes, and related substances of pharmaceutical importance. I. Polyethylene glycols, spermaceti, cetyl alcohol, petrolatum, white wax, and theobroma oil.

T. Higuchi, L. J. Ravin, 1957, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Dilatometric determination of relatively pure systems.

T. Higuchi, A. Simonelli, 1961, Journal of pharmaceutical sciences.

Enhancement of rectal absorption of drugs by adjuvants.

T. Higuchi, J. H. Rytting, T. Nishihata, 1980, Journal of pharmaceutical sciences.

Changes in Intestinal Mucosal Permeability Caused by Nonprotein Thiol Loss in Rats

T. Higuchi, A. Furuya, A. Kamada, 1986, Pharmaceutical Research.

Possible mechanism behind the adjuvant action of phosphate derivatives on rectal absorption of cefoxitin in rats and dogs.

T. Higuchi, T. Nishihata, C. Lee, 1984, Journal of pharmaceutical sciences.

Enhancement of rectal absorption of water-soluble antibiotics in dogs

T. Higuchi, J. H. Rytting, L. Caldwell, 1984 .

PHASE SOLUBILITY TECHNIQUE IN STUDYING THE FORMATION OF COMPLEX SALTS OF TRIAMTERENE.

D. R. Reese, T. Higuchi, L. Dittert, 1964, Journal of pharmaceutical sciences.

Ion-Pair Extraction of Pharmaceutical Amines II: Extraction Profile of Chlorpheniramine

T. Higuchi, K. Kato, 1966 .

High-performance liquid chromatographic analysis of dianhydrogalactitol in plasma by derivatization with sodium diethyldithiocarbamate.

T. Higuchi, L. Sternson, A. Repta, 1977, Journal of chromatography.

The physics of tablet compression. III. Design and construction of an instrumented tableting machine.

T. Higuchi, L. W. Busse, E. Nelson, 2006, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

The physics of tablet compression. IX. Fundamental aspects of tablet lubrication.

T. Higuchi, L. W. Busse, E. Nelson, 1956, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

ClinicalAnalysisof Tamoxifen, an Anti-NeoplasticAgent, in Plasma

C. Fabian, A. Kobayashi, T. Higuchi, 2004 .

Binding of bile acids to cholestyramine at gastric pH conditions.

T. Higuchi, S. Lindenbaum, 1975, Journal of pharmaceutical sciences.

Titration of Very Weak Acids with Lithium Aluminum Amides

T. Higuchi, R. Kuramoto, J. Concha, 1952 .

Letter: Amino acid esters of phenolic drugs as potentially useful prodrugs.

T. Higuchi, I. H. Pitman, I. M. Kovach, 1975, Journal of pharmaceutical sciences.

Effect of self-association of phenol on its transport across polyethylene film.

T. Higuchi, J. H. Rytting, S. Watanabe, 1980, Journal of pharmaceutical sciences.

Drug delivery from catalysed erodible polymeric matrices of poly(ortho ester)s.

K. Himmelstein, T. Higuchi, C. Shih, 1984, Biomaterials.

Pro-drugs as Novel Drug Delivery Systems

V. Stella, T. Higuchi, T. Higuchi, 1975 .

Effect of molecular conformation on interaction of organic species in water. Benzamides and anisamides with theophylline and riboflavin.

T. Higuchi, M. Nakano, 1968, Journal of pharmaceutical sciences.

N-Halo derivatives VI: Microbiological and chemical evaluations of 3-chloro-2-oxazolidinones.

N. Bodor, T. Higuchi, M. Kosugi,, 1976, Journal of pharmaceutical sciences.

Solvolytic reactions of cyclic anhydrides in anhydrous acetic acid.

M. Haddadin, V. Stella, T. Higuchi, 1975, Journal of pharmaceutical sciences.

Controlled delivery of theophylline: chemistry of 7-acyl- and 7,7'-acylditheophylline derivates.

N. Bodor, T. Higuchi, K. Sloan, 1978, Journal of pharmaceutical sciences.

Prodrug Approach in Current Drug Discovery

T. Higuchi, 2011 .

A note on the preparation of 1-(3,4-dihydroxyphenyl)-2-methylamino-ethane sulfonic acid from epinephrine.

L. C. Schroeter, T. Higuchi, 1960, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Bisulfite reduction of p-nitrobenzyl alcohol.

L. C. Schroeter, T. Higuchi, 1962, Journal of pharmaceutical sciences.

A pharmaceutical study of Jelene ointment base.

D. Wurster, T. Higuchi, L. W. Busse, 1951, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Kinetics of reaction between molecular oxygen and 2, 3-dimercapto-1-propanol in aqueous solution.

T. Higuchi, E. Rippie, 1962, Journal of pharmaceutical sciences.

The solubility and complexing properties of oxytetracycline and tetracycline. III. Interactions in aqueous solution with model compounds, biochemicals, metals, chelates, and hexametaphosphate.

S. Bolton, T. Higuchi, 1959, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Direct potentiometric and titrimetric determination of methadone in urine with plastic electrodes selectiive for hydrophobic cations.

S. Srianujata, T. Higuchi, L. Sternson, 1978, Analytical chemistry.

Titration of Functional Groups with Lithium Aluminum Hydride

T. Higuchi, 1950 .

Behavior of Acid-Base Indicators in Acetic Acid System

J. Feldman, T. Higuchi, C. Rehm, 1956 .

Hydroxylammonium Acetate as Carbonyl Reagent

T. Higuchi, C. Barnstein, 1956 .

A study of permeability to water vapor of fats, waxes, and other enteric coating materials.

T. Higuchi, A. Aguiar, 1959, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

The physics of tablet compression. XI. Determination of porosity of tablet granulations.

T. Higuchi, L. W. Busse, W. Strickland, 1956, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Possible utilization of polyelectrolytes in enhancing drug absorption.

T. Higuchi, T. Flanagan, L. Kennon, 1954, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Sabadilla alkaloids. III. Chromatographic separation of the water-soluble fraction; isolation of a new crystalline alkaloid, sabatine.

T. Higuchi, L. Parks, A. J. Hennig, 1951, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Sabadilla alkaloids; alkaloidal components of the petroleum ether extract.

T. Higuchi, L. Parks, C. E. Poetsch, 1949, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

ArticlesInvestigation of Human Skin Lipids I

D. Wurster, T. Higuchi, J. Tingstad, 1958 .

Investigation of human skin lipids. II.

D. Wurster, T. Higuchi, J. Tingstad, 1958, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Scientific EditionThe solubility and complexing properties of oxytetracycline and tetracycline II*: Interactions in nonaqueous solution

T. Higuchi, E. Gans, 1957 .

Synthesis, isolation, and some chemistry of citric acid anhydride.

T. Higuchi, A. Repta, 1969, Journal of pharmaceutical sciences.

Rate Studies on the Anaerobic Degradation of Ascorbic Acid IV: Catalytic Effect of Metal Ions

T. Higuchi, H. Kristiansen, L. Krówczyński, 1966 .

Behavior of some inorganic anions as bases in glacial acetic acid.

T. Higuchi, J. Concha, 1951, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

A general method for the chromatographic analysis of mono-, di-, and triglycerides and the mono- and diesters of ethylene glycol and polyethylene glycol

T. Higuchi, G. Papariello, S. Chulkaratana, 1960 .

Chromatographic analysis of mixtures of mono-, di-, and tristearin containing mineral oil

R. J. Meyer, T. Higuchi, L. J. Ravin, 1957 .

Thermodynamic analysis of structure-activity relationships of drugs. Prediction of optimal structure.

S. Davis, T. Higuchi, 1970, Journal of pharmaceutical sciences.

Potentiometric Studies on Sodium Acetate–Sodium Perchlorate Systems in Acetic Acid

T. Higuchi, A. D. Cooper, Maria L. Danguilan, 1954 .

Circulation Apparatus for Photometric Titrations

K. A. Connors, T. Higuchi, J. I. Bodin, 1959 .

Enhancement of bioavailability of a hydrophobic amine antimalarial by formulation with oleic acid in a soft gelatin capsule.

N. Yata, V. Stella, J. Haslam, 1978, Journal of pharmaceutical sciences.

The physics of tablet compression. VI. Compressional behavior of phenacetin and methacetin granulations.

T. Higuchi, L. W. Busse, L. N. Elowe, 1954, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Pro-drugs as novel drug delivery systems : a symposium

V. Stella, T. Higuchi, 1975 .

Mechanism and thermodynamics of chlorine transfer among organohalogenating agents. Part IV. Chlorine potentials and rates of exchange

T. Higuchi, A. Hussain, I. H. Pitman, 1969 .

Polymorphism and drug availability. Solubility relationships in the methylprednisolone system.

W. Higuchi, T. Higuchi, J. W. Shell, 1963, Journal of pharmaceutical sciences.

The solubility and complexing properties of oxytetracycline and tetracycline. II. Interactions in Nonaqueous solution.

T. Higuchi, E. Gans, 2006, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

The intramolecular facilitated hydrolytic rates of methyl-substituted succinanilic acids.

T. Higuchi, L. Eberson, A. K. Herd, 1966, Journal of the American Chemical Society.

Hydrolytic behavior of some alkyl-substituted succinanils.

T. Higuchi, L. Eberson, A. K. Herd, 1966, Journal of Pharmacy and Science.

N-chlorosaccharin as a possible chlorinating reagent: structure, chlorine potential, and stability in water and organic solvents.

T. Higuchi, I. H. Pitman, H. Dawn, 1970, Journal of pharmaceutical sciences.

GLC determination of whole blood antimalarial concentrations.

J. Haslam, T. Higuchi, R. Shaffer, 1979, Journal of pharmaceutical sciences.

The kinetics of degradation of chloramphenicol in solution. I. A study of the rate of formation of chloride ion in aqueous media.

C. Bias, T. Higuchi, 1953, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

The effects of salicylate on the rectal absorption of phenylalanine and some peptides, and the effects of these peptides on the rectal absorption of cefoxitin and cefmetazole.

T. Higuchi, J. H. Rytting, M. Yamamoto, 1984, Journal of Pharmacy and Science.

The kinetics of the hydrolysis of procaine.

T. Higuchi, L. W. Busse, A. Havinga, 1950, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Some equilibrium and kinetic aspects of water sorption in poly(ortho ester) s

K. Himmelstein, T. Higuchi, T. Nguyen, 1985 .

Importance of the Debye interaction in organic solutions: Henry's law constants for polar liquids in nonpolar solvents and vice versa

D. Grant, T. Higuchi, J. H. Rytting, 1986 .

Inhibition of hydrolysis of esters in solution by formation of complexes. IV. Stabilization of benzocaine with 1-ethyltheobromine.

L. Lachman, T. Higuchi, D. Guttman, 1957, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Oxidation of thioethers to sulfoxides by iodine. II. Catalytic role of some carboxylic acid anions

T. Higuchi, K. Gensch, I. H. Pitman, 1968 .

Rearrangement of chloramphenicol-3-monosuccinate.

T. Higuchi, J. Windheuser, D. Szulczewski, 1970, Journal of pharmaceutical sciences.

Complexes formed in aqueous solutions by sarcosine anhydride; interactions with organic acids, phenols, and aromatic alcohols.

T. Higuchi, J. W. Poole, 1959, American journal of pharmacy and the sciences supporting public health.

Acid anhydride-free acid equilibria in water in some substituted succinic acid systems and their interaction with aniline

T. Higuchi, L. Eberson, J. D. McRae, 1967 .

Acylation of ascorbic acid in water.

D. Chatterji, T. Higuchi, I. H. Pitman, 1975, Journal of pharmaceutical sciences.

Thermodynamic group contributions from ion pair extraction equilibriums for use in the prediction of partition coefficients. Correlation of surface area with group contributions

T. Higuchi, J. H. Rytting, S. Harris, 1973 .

Hydrolysis of some poly(ortho-ester)s in homogeneous solutions.

K. Himmelstein, T. Higuchi, C. Shih, 1984, Journal of pharmaceutical sciences.

Spectropolarimetric and circular dichroism methods for determining the activity of penicillin.

C. E. Rasmussen, T. Higuchi, 1971, Journal of pharmaceutical sciences.

Mechanism and thermodynamics of chlorine transfer among organochlorinating agents. Part II. Reversible disproportionation of chloramine-T

T. Higuchi, K. Ikeda, A. Hussain, 1967 .

An automated method for continuously monitoring diffusion cells in skin penetration studies

T. Higuchi, T. Itoh, R. Konishi, 1989 .

Pharmacy, pharmaceutics and modern drug delivery.

T. Higuchi, 1976, American journal of hospital pharmacy.

Kinetics of the acid-catalyzed closure of hydantoic acids. Effect of 2-aryl and 2-alkyl substituents

V. Stella, T. Higuchi, 1973 .

Photometric Indicator Titration of Weak Bases in Acetic Acid. Modified Type II Plot

K. A. Connors, T. Higuchi, 1960 .

Determination of epinephrine in the presence of degradation products.

L. C. Schroeter, T. Higuchi, T. Sokoloski, 1959, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

REVERSIBLE FORMATION OF AMIDES FROM FREE CARBOXYLIC ACID AND AMINE IN AQUEOUS SOLUTION. A CASE OF NEIGHBORING GROUP FACILITATION1

T. Higuchi, Tomonori. Miki, 1961 .

The physics of tablet compression. X. Mechanism of action and evaluation of tablet lubricants.

T. Higuchi, T HIGUCHI, W A STRICKLAND, 1960, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

A preliminary Pharmacokinetic study of dianhydrogalactitol (NSC-132313) disposition in the dog.

V. Stella, T. Higuchi, L. Sternson, 1977, Journal of the National Cancer Institute.

an Anti-NeoplasticAgent,in Plasma

T. Higuchi, Toshikiro Kimura, L. Sternson, 1976 .

ESTERS OF HYDANTOIC ACIDS AS PRODRUGS OF HYDANTOINS

V. Stella, T. Higuchi, 1973 .

Design of chemical structure for optimal dermal delivery.

T. Higuchi, 1978, Current problems in dermatology.

Melting and freezing behavior of methyl stearate.

T. Higuchi, A. Simonelli, 1962, Journal of Pharmacy and Science.

Prediction of chlorine potentials of N-chlorinated organic molecules

T. Higuchi, A. Hussain, I. H. Pitman, 1969 .

Effects of solute-solvent complexation reactions on dissolution kinetics: testing of a model by using a concentration jump technique.

T. Higuchi, I. H. Pitman, S. Dayal, 1972, Journal of pharmaceutical sciences.

Rates of hydrolysis of N-chlorinated molecules.

T. Higuchi, A. Hussain, I. H. Pitman, 1972, Journal of pharmaceutical sciences.

Unexpectedly rapid esterification of nitrite applied to the determination of nitrite in water.

T. Higuchi, L. Sternson, M. Chao, 1978, Analytical chemistry.

Rapidly Dissolving Forms of Digoxin: Hydroquinone Complex

T. Higuchi, M. Ikeda, 1974 .

Investigation and development of protective ointments. I. Development of a method for measuring permeation of mechanical barriers.

D. Wurster, T. Higuchi, A. P. Lemberger, 1957, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

The physics of tablet compression. I. A preliminary report.

T. Higuchi, L. W. Busse, R. D. Arnold, 1952, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

The physics of tablet compression. VII. Determination of energy expenditure in the tablet compression process.

T. Higuchi, L. W. Busse, E. Nelson, 1955, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.