Toshikiro Kimura

发表

Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs.

M. Odomi, G. Liversidge, J. Jinno, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor.

Mitsuru Hashida, Susumu Nagayama, Ken-ichi Ogawara, 2007, International journal of pharmaceutics.

Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics.

K. Higaki, Toshikiro Kimura, Susumu Nagayama, 2007, International journal of pharmaceutics.

In vitro-in vivo correlation for wet-milled tablet of poorly water-soluble cilostazol.

Kazutaka Higaki, Naoki Kamada, M. Odomi, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Amino acids suppress apoptosis induced by sodium laurate, an absorption enhancer.

T. Fujita, K. Higaki, Toshikiro Kimura, 2009, Journal of pharmaceutical sciences.

Novel oral absorption system containing polyamines and bile salts enhances drug transport via both transcellular and paracellular pathways across Caco-2 cell monolayers.

K. Taniguchi, M. Odomi, M. Miyake, 2009, International journal of pharmaceutics.

Optimization of suppository preparation containing sodium laurate and taurine that can safely improve rectal absorption of rebamipide.

M. Odomi, Naoki Kamada, M. Miyake, 2006, Biological & pharmaceutical bulletin.

Involvement of intracellular Ca2+ dynamics in cytoprotective action by amino acids and cytotoxicity by sodium laurate, an absorption enhancer.

T. Okuda, K. Higaki, Toshikiro Kimura, 2006, Journal of pharmaceutical sciences.

Development of suppository formulation safely improving rectal absorption of rebamipide, a poorly absorbable drug, by utilizing sodium laurate and taurine.

M. Odomi, Naoki Kamada, M. Miyake, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Combinatorial use of sodium laurate with taurine or L-glutamine enhances colonic absorption of rebamipide, poorly absorbable antiulcer drug, without any serious histopathological mucosal damages.

M. Odomi, M. Miyake, H. Toguchi, 2003, Journal of pharmaceutical sciences.

Mechanisms of cytoprotective effect of amino acids on local toxicity caused by sodium laurate, a drug absorption enhancer, in intestinal epithelium.

Y. Endo, M. Miyake, K. Higaki, 2002, Journal of pharmaceutical sciences.

Estimation of Intradermal Disposition Kinetics of Drugs: I. Analysis by Compartment Model with Contralateral Tissues

K. Higaki, Toshikiro Kimura, K. Ogawara, 2004, Pharmaceutical Research.

Interaction of polyphenolic metabolites with human serum albumin: a circular dichroism study.

Hideyuki Ito, T. Hatano, Toshikiro Kimura, 2009, Chemical & pharmaceutical bulletin.

Poly(vinyl alcohol) gel sphere as GI transit-time controlling dosage form.

Toshikiro Kimura, Y. Kurosaki, T. Murakami, 1992 .

Interaction of percutaneous absorption enhancer with stratum corneum of hamster cheek pouch; an electrophysiological study

S. Yamashita, T. Nadai, Toshikiro Kimura, 1992 .

Functional inhibition of NF-kappa B signal transduction in alpha v alpha beta 3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant I kappa B

M. Rots, C. Trautwein, B. Kroesen, 2018 .

University of Groningen Functional inhibition of NF-kappa B signal transduction in alpha v alpha beta 3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant I kappa B gene Ogawara,

M. Rots, C. Trautwein, B. Kroesen, 2015 .

A novel approach to overcome multidrug resistance: utilization of P-gp mediated efflux of paclitaxel to attack neighboring vascular endothelial cells in tumors.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice: Involvement of cytotoxic effect on vascular endothelial cells.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene

M. Rots, C. Trautwein, B. Kroesen, 2006, Arthritis research & therapy.

Hepatic uptake of negatively charged particles in rats: possible involvement of serum proteins in recognition by scavenger receptor.

M. Hashida, Y. Takakura, K. Higaki, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Effect of coupling of albumin onto surface of PEG liposome on its in vivo disposition.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2007, International journal of pharmaceutics.

Development of transdermal therapeutic formulation of CNS5161, a novel NMDA receptor antagonist, by utilizing pressure-sensitive adhesives II: improved transdermal absorption and evaluation of efficacy and safety.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Development of transdermal therapeutic formulation of CNS5161, a novel N-methyl-D-aspartate receptor antagonist, by utilizing pressure-sensitive adhesives I.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2012, Biological & pharmaceutical bulletin.

Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2005, International journal of pharmaceutics.

Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles.

K. Higaki, Toshikiro Kimura, Susumu Nagayama, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Important role of serum proteins associated on the surface of particles in their hepatic disposition.

M. Hashida, Y. Takakura, K. Higaki, 2002, Journal of controlled release : official journal of the Controlled Release Society.

Sex differences in pharmacokinetics of cilostazol in rats

M. Odomi, Naoki Kamada, Keigo Yamada, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2008, International journal of pharmaceutics.

In vitro evaluation of the ciliary beat frequency of the rat nasal epithelium using a high-speed digital imaging system.

H. Katsumi, A. Yamamoto, K. Higaki, 2013, Biological & pharmaceutical bulletin.

Correlation between Cyclosporine Blood Concentration-Dose Ratio and Biochemical Parameters in Living-Donor Lung Transplant Patients

H. Date, T. Sendo, K. Higaki, 2008 .

Effects of surfactants on the absorption of salicylic acid from hamster cheek pouch as a model of keratinized oral mucosa

Toshikiro Kimura, Y. Kurosaki, T. Nakayama, 1988 .

Enhancing effect of 1-dodecylazacycloheptan-2-one (Azone) on the absorption of salicylic acid from keratinized oral mucosa and the duration of enhancement in vivo

Toshikiro Kimura, Y. Kurosaki, T. Nakayama, 1989 .

Determinants for in vivo antitumor effect of angiogenesis inhibitor SU5416 formulated in PEGylated emulsion.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2014, Journal of pharmaceutical sciences.

Interaction of polyphenols with proteins: binding of (-)-epigallocatechin gallate to serum albumin, estimated by induced circular dichroism.

M. Hori, Hideyuki Ito, T. Hatano, 2009, Chemical & pharmaceutical bulletin.

Interaction of 1-dodecylazacycloheptan-2-one (Azone) with erythrocyte membrane

T. Katsu, Toshikiro Kimura, Y. Kurosaki, 1989 .

Quantitative Evaluation of PEPT1 Contribution to Oral Absorption of Cephalexin in Rats

K. Higaki, Toshikiro Kimura, K. Ogawara, 2008, Pharmaceutical Research.

CARRIER-MEDIATED TRANSPORT SYSTEMS FOR AMINOPENICIL-LINS IN RAT SMALL INTESTINE

Toshikiro Kimura, S. Muranishi, H. Sezaki, 1978 .

Transmucosal Passage of Liposomally-Entrapped Drugs in Rat Small Intestine

K. Higaki, Toshikiro Kimura, H. Sezaki, 1984, Pharmaceutical Research.

Transport of D‐glucose across cultured stratified cell layer of human oral mucosal cells

H. Yamano, T. Matsumura, M. Ueda, 2002, The Journal of pharmacy and pharmacology.

Effect of adrenergic stimulation on drug absorption via passive diffusion in Caco-2 cells.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2009, International journal of pharmaceutics.

Regulation of drug absorption from small intestine by enteric nervous system I: a poorly absorbable drug via passive diffusion.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2004, Drug metabolism and pharmacokinetics.

Determinants for in vivo anti-tumor effects of PEG liposomal doxorubicin: importance of vascular permeability within tumors.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2008, International journal of pharmaceutics.

Gastrointestinal transit and drug absorption.

Kazutaka Higaki, K. Higaki, Toshikiro Kimura, 2000, Biological & pharmaceutical bulletin.

[Analysis of factors governing drug absorption and their improvement].

Toshikiro Kimura, 2009, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model: utilization of a more suitable medium for in-vitro dissolution study.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Animal models for predicting potency of oral sustained-release adhesive microspheres in humans.

K. Higaki, Toshikiro Kimura, Y. Akiyama, 2007, International journal of pharmaceutics.

Analysis and prediction of absorption behavior of colon-targeted prodrug in rats by GI-transit-absorption model.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Analysis and prediction of absorption behavior for theophylline orally administered as powders based on gastrointestinal-transit-absorption (Gita) model.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2002, Drug metabolism and pharmacokinetics.

Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): in vivo evaluation.

R. Ibuki, K. Higaki, Toshikiro Kimura, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine.

A. Ohike, R. Ibuki, K. Higaki, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Comparative studies on the absorption mechanism of p-aminobenzoic acid and p-acetamidobenzoic acid from the rat intestine

Hiroyuki Kobayashi, M. Yasuhara, Toshikiro Kimura, 1979 .

Establishment of new preparation method for solid dispersion formulation of tacrolimus.

Atsuo Ohike, Yuji Tokunaga, Kazutaka Higaki, 2003, International journal of pharmaceutics.

Strategies for overcoming the stratum corneum

K. Higaki, Toshikiro Kimura, Chomchan Amnuaikit, 2003 .

Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers.

K. Higaki, Toshikiro Kimura, Tamer M. Shehata, 2008, International journal of pharmaceutics.

Use of lipid disperse systems in transdermal drug delivery: Comparative study of flufenamic acid permeation among rat abdominal skin, silicon rubber membrane and stratum corneum sheet isolated from hamster cheek pouch

T. Tanizawa, Toshikiro Kimura, Y. Kurosaki, 1991 .

Effects of diclofenac sodium and disodium ethylenediaminetetraacetate on electrical parameters of the mucosal membrane and their relation to the permeability enhancing effects in the rat jejunum

S. Yamashita, T. Nadai, Toshikiro Kimura, 1987, The Journal of pharmacy and pharmacology.

Evaluation of Inhibitory Activity of Casein on Proteases in Rat Intestine

K. Higaki, Toshikiro Kimura, K. Shirasu, 2003, Pharmaceutical Research.

Development of Safe and Potent Oil-in-Water Emulsion of Paclitaxel to Treat Peritoneal Dissemination.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2017, Journal of pharmaceutical sciences.

Importance of bile acids for novel oral absorption system containing polyamines to improve intestinal absorption.

M. Odomi, M. Miyake, H. Toguchi, 2006, Journal of Controlled Release.

Novel oral formulation safely improving intestinal absorption of poorly absorbable drugs: utilization of polyamines and bile acids.

M. Hirota, M. Odomi, M. Miyake, 2006, Journal of controlled release : official journal of the Controlled Release Society.

An assessment of indomethacin‐induced gastrointestinal mucosal damage in‐vivo: enhancement of urinary recovery after oral administration of phenolsulfonphthalein in rats

J. Nakamura, A. Yamamoto, Toshikiro Kimura, 1983, The Journal of pharmacy and pharmacology.

ABSORPTION AND METABOLISM OF p-AMINOBENZOIC ACID BY RAT INTESTINE IN VITRO

Hiroyuki Kobayashi, M. Yasuhara, Toshikiro Kimura, 1978 .

ABSORPTION AND METABOLISM OF p-AMINOBENZOIC ACID BY RAT SMALL INTESTINE IN SITU

Hiroyuki Kobayashi, M. Yasuhara, Toshikiro Kimura, 1978 .

Colonic mucosa-specific “pro-antedrugs” for oral treatment of ulcerative colitis: design, synthesis and fate of methyl 20-glucopyranosyloxyprednisolonates

Toshio Suzuki, Y. Fujiwara, Toshikiro Kimura, 1994 .

PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2011, International journal of pharmaceutics.

Regional Variation in Oral Mucosal Drug Absorption: Permeability and Degree of Keratinization in Hamster Oral Cavity

Toshikiro Kimura, Y. Kurosaki, T. Nakayama, 1991, Pharmaceutical Research.

Plasma protein binding of frusemide in renal failure rabbits: investigation of endogenous protein binding inhibitors

Toshikiro Kimura, H. Yoshitomi, T. Nakayama, 1984, The Journal of pharmacy and pharmacology.

Catalytic effect of cationic surfactants on degradation of cephalexin in aqueous solution

M. Yasuhara, Toshikiro Kimura, S. Muranishi, 1977, The Journal of pharmacy and pharmacology.

Formulation and evaluation of paclitaxel-loaded polymeric nanoparticles composed of polyethylene glycol and polylactic acid block copolymer.

T. Ono, K. Higaki, Toshikiro Kimura, 2012, Biological & pharmaceutical bulletin.

Nanoparticle-based passive drug targeting to tumors: considerations and implications for optimization.

Ken-ichi Ogawara, Kazutaka Higaki, Tomoya Araki, 2013, Biological & pharmaceutical bulletin.

Deeper penetration into tumor tissues and enhanced in vivo antitumor activity of liposomal paclitaxel by pretreatment with angiogenesis inhibitor SU5416.

G. Molema, K. Higaki, Toshikiro Kimura, 2012, Molecular pharmaceutics.

The use of liposomes as a model for drug absorption: β‐lactam antibiotics

M. Yasuhara, Toshikiro Kimura, H. Sezaki, 1980 .

Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats.

Makoto Sato, Ken-ichi Ogawara, Kazutaka Higaki, 2008, International journal of pharmaceutics.

Appearance of Double Peaks in Plasma Concentration–time Profile after Oral Administration Depends on Gastric Emptying Profile and Weight Function

Yoshihiro Miyaji, Ken-ichi Ogawara, Kazutaka Higaki, 2008, Pharmaceutical Research.

In vitro evaluation of nasal mucociliary clearance using excised rat nasal septum.

H. Katsumi, A. Yamamoto, K. Higaki, 2012, Biological & pharmaceutical bulletin.

Perfusion Cells for Studying Regional Variation in Oral-Mucosal Permeability in Humans. I: Kinetic Aspects in Oral-Mucosal Absorption of Alkylparabens

Toshikiro Kimura, Y. Kurosaki, K. Vano, 1997, Pharmaceutical Research.

In vivo distribution characteristics and anti-tumor effects of doxorubicin encapsulated in PEG-modified niosomes in solid tumor-bearing mice

K. Higaki, Toshikiro Kimura, Tamer M. Shehata, 2023, Journal of Drug Delivery Science and Technology.

Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layer.

Takayuki Suyama, Ken-ichi Ogawara, Kazutaka Higaki, 2002, International journal of pharmaceutics.

Prediction of the Plasma Concentration Profiles of Orally Administered Drugs in Rats on the Basis of Gastrointestinal Transit Kinetics and Absorbability

K. Higaki, Toshikiro Kimura, T Kimura, 1997, The Journal of pharmacy and pharmacology.

Existence of a specialized absorption mechanism for cefadroxil, an aminocephalosporin antibiotic, in the human oral cavity

Toshikiro Kimura, Y. Kurosaki, T. Nakayama, 1992 .

Design of controlled-release morphine suppositories containing polyglycerol ester of fatty acid.

Toshikazu Yamaguchi, K. Higaki, Toshikiro Kimura, 2005, Biological and Pharmaceutical Bulletin.

Evaluation of sustained release suppositories prepared with fatty base including solid fats with high melting points.

K. Higaki, Toshikiro Kimura, N. Shimono, 2004, International journal of pharmaceutics.

Major determinants in hepatic disposition of polystyrene nanospheres: implication for rational design of particulate drug carriers.

K. Higaki, Toshikiro Kimura, K. Ogawara, 2002, Critical reviews in therapeutic drug carrier systems.

What is the lowest acceptable temperature for liquid preservation of red blood cells

Toshikiro Kimura, M. Miyahara, T. Nishizaki, 1991 .

Prediction of plasma concentration-time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteers.

S. Jinnouchi, R. Nishii, S. Tamura, 2002, International journal of pharmaceutics.

In-vivo disposition characteristics of PEG niosome and its interaction with serum proteins.

K. Higaki, Toshikiro Kimura, Tamer M. Shehata, 2016, International journal of pharmaceutics.

Analysis of Hepatic Transport of Cefpiramide in Rats with Obstructive Jaundice by Using Isolated Hepatocytes

Toshikiro Kimura, Y. Kurosaki, T. Nakayama, 1990, Pharmaceutical Research.

The relationship between in vivo nasal drug clearance and in vitro nasal mucociliary clearance: Application to the prediction of nasal drug absorption

A. Kiriyama, H. Katsumi, A. Yamamoto, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Biopharmaceutical studies on drug/conjugated-metabolite interactions. II. Effect of acetaminophen sulfate on pharmacokinetics of acetaminophen in rats

Toshikiro Kimura, T. Sawamoto, Y. Kurosaki, 1997 .

Biopharmaceutical studies on drug/conjugated-metabolite interactions. I. Fate of acetaminophen sulfate, a major conjugated metabolite of acetaminophen, in rats

Toshikiro Kimura, T. Sawamoto, Y. Kurosaki, 1995 .

Up-Regulation of P-Glycoprotein Expression in Small Intestine under Chronic Serotonin-Depleted Conditions in Rats

K. Higaki, Toshikiro Kimura, K. Ogawara, 2005, Journal of Pharmacology and Experimental Therapeutics.

an Anti-NeoplasticAgent,in Plasma

T. Higuchi, Toshikiro Kimura, L. Sternson, 1976 .

Pharmacokinetics of recombinant human insulin-like growth factor-I in diabetic rats.

K. Higaki, Toshikiro Kimura, Yukihiro Matsumoto, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Gastrointestinal absorption of recombinant human insulin-like growth factor-I in rats.

K. Higaki, Toshikiro Kimura, T. Kimura, 1996, The Journal of pharmacology and experimental therapeutics.

Short Communication Pharmacokinetics of Recombinant Human Insulin-Like Growth Factor-I in Diabetic Rats

K. Higaki, Toshikiro Kimura, T. Kimura, 1997 .

Pharmacokinetics of tolbutamide following intravenous and oral administrations in rats with obstructive jaundice.

Toshikiro Kimura, Y. Kurosaki, T. Nakayama, 1994, Biological & pharmaceutical bulletin.

Biliary excretion of polystyrene microspheres depends on the type of receptor-mediated uptake in rat liver.

M. Hashida, Y. Takakura, K. Higaki, 2001, Biochimica et biophysica acta.

Pharmacokinetic analysis of factors determining elimination pathways for sulfate and glucuronide metabolites of drugs. I: Studies by in vivo constant infusion

H. Esumi, K. Higaki, Toshikiro Kimura, 2002, Xenobiotica; the fate of foreign compounds in biological systems.

Intestinal absorption of dolichol from emulsions and liposomes in rats.

Toshikiro Kimura, T. Kimura, Y. Kurosaki, 1989, Chemical & pharmaceutical bulletin.