Jan Bevernage

发表

Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues.

M. Brewster, P. Augustijns, J. Brouwers, 2013, International journal of pharmaceutics.

IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Amitava Mitra, Jian Lin, Mai Anh Nguyen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Amitava Mitra, Jian Lin, Mai Anh Nguyen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

IMI – oral biopharmaceutics tools project – evaluation of bottom‐up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Xavier Pepin, Leon Aarons, Hans Lennernäs, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies.

M. Jamei, L. Aarons, M. Bolger, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Preclinical and Clinical Studies

G. Verreck, M. Brewster, J. Brouwers, 2015 .

Drug precipitation-permeation interplay: supersaturation in an absorptive environment.

P. Annaert, P. Augustijns, J. Brouwers, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Exploring food effects on indinavir absorption with human intestinal fluids in the mouse intestine.

J. Tack, P. Annaert, P. Augustijns, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Drug supersaturation in simulated and human intestinal fluids representing different nutritional states.

J. Tack, P. Annaert, P. Augustijns, 2010, Journal of pharmaceutical sciences.

Excipient-mediated supersaturation stabilization in human intestinal fluids.

Patrick Augustijns, Jan Bevernage, Jan Tack, 2011, Molecular pharmaceutics.

Linking In Vitro Intrinsic Dissolution Rate and Thermodynamic Solubility with Pharmacokinetic Profiles of Bedaquiline Long-Acting Aqueous Microsuspensions in Rats.

A. Vermeulen, C. Tistaert, Jan Bevernage, 2021, Molecular pharmaceutics.

Biorelevant dissolution testing of a weak base: Interlaboratory reproducibility and investigation of parameters controlling in vitro precipitation.

J. Dressman, P. Augustijns, J. Butler, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs.

Thomas Rades, Anette Müllertz, Jan Bevernage, 2016, Journal of pharmaceutical sciences.

Usefulness of the BioGIT system in screening for differences in early exposure in the fasted state on an a priori basis.

C. Reppas, M. Vertzoni, Jan Bevernage, 2023, International journal of pharmaceutics.

Screening for differences in early exposure in the fasted state with in vitro methodologies can be challenging: Experience with the BioGIT system.

C. Reppas, M. Vertzoni, Jan Bevernage, 2023, Journal of pharmaceutical sciences.

Current status and future opportunities for incorporation of dissolution data in pbpk modeling for pharmaceutical development and regulatory applications: orbito consortium commentary.

Filippos Kesisoglou, Tycho Heimbach, Xavier Pepin, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method.

Thomas Rades, Anette Müllertz, Jan Bevernage, 2017, Molecular pharmaceutics.

Supersaturation in human gastric fluids.

J. Tack, B. Hens, P. Annaert, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Small oligomeric micelles based on end group modified mPEG : Oligocaprolactone with monodisperse hydrophobic blocks

W. Hennink, D. Crommelin, R. Verrijk, 2007 .

Preclinical Bioavailability Strategy for Decisions on Clinical Drug Formulation Development: An In Depth Analysis.

M. Brewster, C. Mackie, E. Mannaert, 2018, Molecular pharmaceutics.

Enzymatic prodrug degradation in the fasted and fed small intestine: in vitro studies and interindividual variability in human aspirates.

Z. Vinarov, Jan Bevernage, Christophe Tistaert, 2023, International journal of pharmaceutics.