D. Light

发表

Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.

M. Adler, M. Whitlow, C. Mallari, 2018, Bioorganic & medicinal chemistry letters.

Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA).

M. Adler, M. Whitlow, R. Pulk, 2009, Bioorganic & medicinal chemistry letters.

A novel synthetic inhibitor of factor Xa decreases early reocclusion and improves 24-h patency after coronary fibrinolysis in dogs.

D. Abendschein, P. Eisenberg, P. Verhallen, 2001, The Journal of pharmacology and experimental therapeutics.

Amplified anticoagulant activity of tissue factor-targeted thrombomodulin

D. Light, B. Martin-McNulty, Yi-xin Wang, 2006, Thrombosis and Haemostasis.

Fasudil , a Rho -

M. Halks-Miller, Xiangru Lu, Q. Feng, 2005 .

Fasudil, a Rho-Kinase Inhibitor, Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm in Apolipoprotein E–Deficient Mice by Inhibiting Apoptosis and Proteolysis

M. Halks-Miller, Xiangru Lu, Q. Feng, 2005, Circulation.

The Shape of Thrombomodulin and Interactions with Thrombin as Determined by Electron Microscopy*

J. Weisel, T. A. Young, D. Light, 1996, The Journal of Biological Chemistry.

VLA‐4 blockade by natalizumab inhibits sickle reticulocyte and leucocyte adhesion during simulated blood flow

S. Sarnaik, D. Light, S. Krishnamoorthy, 2016, British journal of haematology.

The short loop between epidermal growth factor-like domains 4 and 5 is critical for human thrombomodulin function.

E. Blasko, C. Glaser, J. Parkinson, 1993, The Journal of biological chemistry.

An inhibitor of activated thrombin-activatable fibrinolysis inhibitor potentiates tissue-type plasminogen activator-induced thrombolysis in a rabbit jugular vein thrombolysis model.

P. Verhallen, M. Nagashima, J. Morser, 2000, Thrombosis research.

Rubber elongation factor from Hevea brasiliensis. Identification, characterization, and role in rubber biosynthesis.

M. Dennis, D. Light, 1989, The Journal of biological chemistry.

Amino acid sequence of rubber elongation factor protein associated with rubber particles in Hevea latex.

W. Kohr, M. Dennis, W. Henzel, 1989, The Journal of biological chemistry.

Studies on the chirality of sulfoxidation catalyzed by bacterial flavoenzyme cyclohexanone monooxygenase and hog liver flavin adenine dinucleotide containing monooxygenase.

C. Walsh, D. Waxman, D. Light, 1982, Biochemistry.

Chiral sulfoxidations catalyzed by rat liver cytochromes P-450.

C. Walsh, D. Waxman, D. Light, 1982, Biochemistry.

FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834.

J. Morser, A. Johns, D. Light, 2001, Thrombosis research.

Steroid binding properties of beef adrenal cortical cytochrome P-450 which catalyzes the conversion of cholesterol into pregnenolone.

W. Orme-Johnson, N. Orme-Johnson, D. Light, 1979, The Journal of biological chemistry.

Beef adrenal cortical cytochrome P-450 which catalyzes the conversion of cholesterol to pregnenolone. Oxidation-reduction potentials of the free, steroid-complexed, and adrenodoxin-complexed P-450.

N. Orme-Johnson, D. Light, 1981, The Journal of biological chemistry.

Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.

M. Halks-Miller, W. Dole, A. Johns, 2005, European journal of pharmacology.

Can natural variation in erythroid microRNA‐29b be translated to sickle cell disease severity?

D. Light, 2019, British journal of haematology.

Obligate Multivalent Recognition of Cell Surface Tomoregulin following Selection from a Multivalent Phage Antibody Library

B. Müller-Tiemann, Ying-hua Zhu, R. Cobb, 2006, Journal of biomolecular screening.

Characteristics of the cofactor requirements for the superoxide-generating NADPH oxidase of human polymorphonuclear leukocytes.

C. Walsh, E. Goetzl, A. Tauber, 1981, Biochemistry.

Effects of ZK-807834, a novel inhibitor of factor Xa, on arterial and venous thrombosis in rabbits.

D. Abendschein, P. Eisenberg, R. Vergona, 2000, Journal of cardiovascular pharmacology.

Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture.

M. Whitlow, Ying-hua Zhu, M. Polokoff, 2006, Cancer research.

In Vivo Biodistribution, PET Imaging, and Tumor Accumulation of 86Y- and 111In-Antimindin/RG-1, Engineered Antibody Fragments in LNCaP Tumor–Bearing Nude Mice

Tara Heitner, Jason S. Lewis, Jeongsoo Yoo, 2009, Journal of Nuclear Medicine.

Intravenous recombinant soluble human thrombomodulin prevents venous thrombosis in a rat model.

J. Eidt, J. Morser, D. Light, 1991, Journal of vascular surgery.

Rubber elongation by farnesyl pyrophosphate synthases involves a novel switch in enzyme stereospecificity.

M. Dennis, R. Lazarus, D. Light, 1989, The Journal of biological chemistry.

Purification of a prenyltransferase that elongates cis-polyisoprene rubber from the latex of Hevea brasiliensis.

M. Dennis, D. Light, 1989, The Journal of biological chemistry.

Development of a Homogeneous Time-Resolved Fluorescence Leukotriene B4 Assay for Determining the Activity of Leukotriene A4 Hydrolase

J. Parkinson, R. Snider, D. Light, 2007, Journal of biomolecular screening.

Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031).

D. Abendschein, D. Light, M. Sullivan, 2002, Thrombosis research.

Recombinant soluble human thrombomodulin: a randomized, blinded assessment of prevention of venous thrombosis and effects on hemostatic parameters in a rat model.

J. Morser, D. Light, M. Solis, 1994, Thrombosis research.

Modulation of glycosaminoglycan addition in naturally expressed and recombinant human thrombomodulin.

J. Lin, J. Morser, D. Light, 1994, Journal of Biological Chemistry.

The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.

M. Adler, M. Whitlow, E. Zhang, 2006, Bioorganic & Medicinal Chemistry Letters.

Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors.

M. Morrissey, M. McCarrick, D. Light, 2005, Bioorganic & medicinal chemistry letters.

Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.

M. Whitlow, D. Davey, K. Eagen, 1998, Journal of medicinal chemistry.

Discovery and characterization of a potent and selective non-amidine inhibitor of human factor Xa.

J. Morser, D. Light, M. Kochanny, 2003, Biochemical pharmacology.

Evaluation of the toxicology and pharmacokinetics of recombinant factor VIII Fc fusion protein in animals.

J. Dumont, G. Pierce, Haiyan Jiang, 2015, Thrombosis research.

Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors.

Bin Ye, David Light, Marc Adler, 2007, Journal of medicinal chemistry.

Crystal structures of two potent nonamidine inhibitors bound to factor Xa.

Bin Ye, Marc Adler, M. Adler, 2002, Biochemistry.

Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa.

Sung-Hou Kim, M. Adler, S. Kim, 2000, Biochemistry.

Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin.

M. Whitlow, D. Davey, M. Morrissey, 1999, Acta crystallographica. Section D, Biological crystallography.

Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation.

J. Lin, E. Blasko, C. Glaser, 1992, The Journal of clinical investigation.

Evaluation of the toxicology, pharmacokinetics, and local tolerance of recombinant factor IX Fc fusion protein in animals.

J. Dumont, G. Pierce, Haiyan Jiang, 2015, Thrombosis research.

FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes

Haiyan Jiang, D. Light, A. van der Flier, 2015, PloS one.

The interaction of thrombomodulin with Ca2+.

M. Betts, M. Mccaman, E. Blasko, 1999, European journal of biochemistry.

Conformations of trypsin-bound amidine inhibitors of blood coagulant factor Xa by double REDOR NMR and MD simulations.

M. Whitlow, M. McCarrick, J. Schaefer, 1999, Journal of medicinal chemistry.

Synthesis, characterization, and structure-activity relationships of amidine-substituted (bis)benzylidene-cycloketone olefin isomers as potent and selective factor Xa inhibitors.

M. Whitlow, M. Morrissey, M. McCarrick, 1999, Journal of medicinal chemistry.

A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase

S. Srinivasan, M. Whitlow, R. Mintzer, 2004, Protein science : a publication of the Protein Society.

based on its remote structural homolog purple acid phosphatase A model of the acid sphingomyelinase phosphoesterase domain data

S. Srinivasan, M. Whitlow, R. Mintzer, 2004 .

(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.

M. Morrissey, M. McCarrick, D. Light, 1998, Journal of medicinal chemistry.

Alpha-isoenzyme of alcohol dehydrogenase from monkey liver. Cloning, expression, mechanism, coenzyme, and substrate specificity.

C. Liu, D. Green, M. Dennis, 1992, The Journal of biological chemistry.

Analytical and preparative high-performance liquid chromatography separation of flavin and flavin analog coenzymes.

C. Walsh, M. Marletta, D. Light, 1980, Analytical Biochemistry.

Flavin analogs as mechanistic probes of adrenodoxin reductase-dependent electron transfer to the cholesterol side chain cleavage cytochrome P-450 of the adrenal cortex.

C. Walsh, D. Light, 1980, The Journal of biological chemistry.

The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain.

S. Bass, G. Fuh, M. Mulkerrin, 1990, The Journal of biological chemistry.

MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease.

D. K. Wood, E. Schonbrun, F. Musayev, 2019, Blood advances.

Structural basis for the anticoagulant activity of the thrombin–thrombomodulin complex

Robert Huber, R. Huber, W. Bode, 2000, Nature.

Cloning and Sequencing of the cDNA Encoding the Rubber Elongation Factor of Hevea brasiliensis.

N. Chua, M. Dennis, D. Light, 1991, Plant physiology.

Amino acid sequence similarity of Hev b 3 to two previously reported 27‐ and 23‐kDa latex proteins allergenic to spina bifida patients

M. Dennis, H. Yeang, D. Light, 1998, Allergy.

Studies on the autoinactivation behavior of pure, reconstituted phenobarbital-induced cytochrome P-450 isozyme from rat liver.

C. Walsh, D. Light, M. Loosemore, 1980, The Journal of biological chemistry.

Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.

B. Pace, Biaoru Li, Levi H C Makala, 2017, JCI insight.

Human factor Xa bound amidine inhibitor conformation by double rotational-echo double resonance nuclear magnetic resonance and molecular dynamics simulations.

M. Adler, M. McCarrick, J. Schaefer, 2003, Journal of medicinal chemistry.

Conformation of a bound inhibitor of blood coagulant factor Xa.

M. Adler, A. Mehta, J. Schaefer, 2003, Biochemistry.

A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) – Part I: Pharmacological characterization

R. Vergona, M. Nagashima, J. Morser, 2006, Thrombosis and Haemostasis.

Dimethyl Fumarate Induces Fetal Hemoglobin in Sickle Cell Disease

B. Pace, Biaoru Li, D. Light, 2015 .

The Structure of a 19-Residue Fragment from the C-loop of the Fourth Epidermal Growth Factor-like Domain of Thrombomodulin (*)

M. Adler, J. Morser, D. Light, 1995, The Journal of Biological Chemistry.

Anti-EphA2 antibodies decrease EphA2 protein levels in murine CT26 colorectal and human MDA-231 breast tumors but do not inhibit tumor growth.

W. Xia, R. Cobb, S. Roffler, 2006, Neoplasia.

Different Contribution of Hematopoietic and Somatic Cell Types Expressing FcRn to the Prolonged Half-Life of Recombinant Factor VIII Fc and Recombinant FIX Fc

Haiyan Jiang, K. Wharton, D. Light, 2012 .

THERMODYNAMIC AND KINETIC PROPERTIES OF THE ADRENOCORTICAL MITOCHONDRIAL CYTOCHROME P450 WHICH CONVERTS CHOLESTEROL INTO PREGNENOLONE

N. Orme-Johnson, D. Light, 1980 .

111In-Antimindin/RG-1, Engineered Antibody Fragments in LNCaP Tumor–Bearing Nude Mice

Jeongsoo Yoo, B. Alicke, D. Light, 2009 .

Discovery of the factor Xa inhibitor, ZK 807834 (CI-1031).

D. Light, W. Guilford, 2001, Current topics in medicinal chemistry.

Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.

B. Pace, Biaoru Li, Levi H C Makala, 2017, JCI insight.

Effect of vascular injury on inhibition of venous thrombosis with ZK‐807834, a direct inhibitor of factor Xa

D. Abendschein, J. Morser, D. Light, 2003, Journal of thrombosis and haemostasis : JTH.

The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex--Part 2.

M. Adler, M. Whitlow, E. Zhang, 2005, Bioorganic & medicinal chemistry letters.