I. Barsukov

发表

Protein-ligand interactions: exchange processes and determination of ligand conformation and protein-ligand contacts.

M. Sutcliffe, G. Roberts, L. Lian, 1994, Methods in enzymology.

D. Rigden, J. Coulson, M. J. Clague, 2013, Physiological reviews.

Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain.

Clive R. Bagshaw, P. De Camilli, G. Roberts, 2003, The Journal of biological chemistry.

Phosphatidylinositol Phosphate Kinase Type 1γ and β1-Integrin Cytoplasmic Domain Bind to the Same Region in the Talin FERM Domain*

Clive R. Bagshaw, P. Camilli, G. Roberts, 2003, Journal of Biological Chemistry.

The Inhibitor Thiomandelic Acid Binds to Both Metal Ions in Metallo-β-lactamase and Induces Positive Cooperativity in Metal Binding*

Lars Olsen, Gordon C K Roberts, Mikael Jensen, 2003, Journal of Biological Chemistry.

The Activity of the Vinculin Binding Sites in Talin Is Influenced by the Stability of the Helical Bundles That Make Up The Talin Rod*

R. Liddington, G. Roberts, J. Emsley, 2006, Journal of Biological Chemistry.

Mechanism of the Ca2+-Dependent Interaction between S100A4 and Tail Fragments of Nonmuscle Myosin Heavy Chain IIA

Clive R. Bagshaw, P. R. Elliott, H. Jung, 2011, Journal of molecular biology.

Vinculin controls talin engagement with the actomyosin machinery

Pengbo Wang, B. Goult, N. Bate, 2015, Nature Communications.

Role of vinculin in regulating focal adhesion turnover.

R. Liddington, A. Bobkov, G. Dunn, 2006, European journal of cell biology.

A further unique chondroitin sulfate from the shrimp Litopenaeus vannamei with antithrombin activity that modulates acute inflammation.

James A. London, E. Yates, H. Nader, 2019, Carbohydrate polymers.

Further characterization of the interaction between the cytoskeletal proteins talin and vinculin

D. Critchley, I. Barsukov, M. Bass, 2002 .

Atomic Resolution Structures and Solution Behavior of Enzyme-Substrate Complexes of Enterobacter cloacae PB2 Pentaerythritol Tetranitrate Reductase

N. Scrutton, A. Munro, Richard J. Harris, 2004, Journal of Biological Chemistry.

A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.

G. Roberts, J. Emsley, D. Critchley, 2005, Structure.

Relief of talin autoinhibition triggers a force-independent association with vinculin

Alexandre F. Carisey, A. Gilmore, D. Critchley, 2019, The Journal of cell biology.

Structural variability of the ubiquitin specific protease DUSP‐UBL double domains

P. R. Elliott, D. Rigden, M. J. Clague, 2011, FEBS letters.

Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death

O. Sansom, I. Vattulainen, Guillaume Jacquemet, 2022, bioRxiv.

NMR solution structure of gramicidin A complex with caesium cations

A. Arseniev, I. Barsukov, V. Bystrov, 1985 .

2D-NMR FOR 3D-STRUCTURE OF MEMBRANE SPANNING POLYPEPTIDES: Gramacidin A and Fragments of Bacteriorhodopsin

A. Arseniev, A. Lomize, A. Golovanov, 1991 .

NMR assignment of the C-terminal actin-binding domain of talin

G. Roberts, B. Goult, N. Bate, 2008, Biomolecular NMR assignments.

Combined COSY-NOESY experiment

A. Arseniev, I. Barsukov, V. Bystrov, 1984 .

A stereodivergent asymmetric approach to difluorinated aldonic acids.

J. Fawcett, C. Audouard, J. Percy, 2004, Chemical communications.

Structural and dynamic characterization of a vinculin binding site in the talin rod.

H. Steinhoff, G. Roberts, J. Emsley, 2006, Biochemistry.

1H‐NMR study of gramicidin A transmembrane ion channel

Y. Ovchinnikov, A. Arseniev, A. Lomize, 1985, FEBS letters.

Model for the complex between protein G and an antibody Fc fragment in solution.

G. Roberts, L. Lian, I. Shimada, 1995, Structure.

Mapping the interactions between streptococcal protein G and the Fab fragment of IgG in solution

G. Roberts, L. Lian, J. Derrick, 1994, Nature Structural Biology.

Interactions of bacterial cell-surface proteins with antibodies: a ersatile set of protein-protein interactions

G. Roberts, L. Lian, J. Derrick, 1995 .

Mutations affecting the N-terminal domains of SHANK3 point to different pathomechanisms in neurodevelopmental disorders

M. Larsen, C. Fagerberg, I. Barsukov, 2021, bioRxiv.

The intracellular Ig fold: a robust protein scaffold for the engineering of molecular recognition.

O. Mayans, S. Barbieri, I. Barsukov, 2012, Protein engineering, design & selection : PEDS.

Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion

Richard Smith, P. Rudland, I. Barsukov, 2020, The Biochemical journal.

New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

D. Drewry, W. Zuercher, P. Eyers, 2018, The Biochemical journal.

New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors

D. Drewry, W. Zuercher, P. Eyers, 2018, bioRxiv.

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm.

G. Roberts, L. Lian, R. Badii, 1997, Structure.

Asymmetric Mode of Ca2+-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling

Clive R. Bagshaw, P. R. Elliott, P. Rudland, 2012, Structure.

Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI.

C. Dermardirossian, G. Bokoch, G. Roberts, 2001, Journal of molecular biology.

Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1.

G. Bokoch, G. Roberts, L. Lian, 2000, Structure.

Structure-activity Relationships in Flexible Protein Domains : Regulation of rho GTPases by RhoGDI and D 4 GDI

C. Dermardirossian, G. Bokoch, G. Roberts, 2000 .

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

O. Mayans, D. Rigden, S. Labeit, 2016, FEBS letters.

Anion binding to a cationic europium(iii) probe enables the first real-time assay of heparan sulfotransferase activity

D. Fernig, E. Yates, I. Barsukov, 2021, Organic & biomolecular chemistry.

Reaction of Morphinone Reductase with 2-Cyclohexen-1-one and 1-Nitrocyclohexene

N. Scrutton, A. Munro, N. Bruce, 2005, Journal of Biological Chemistry.

SHANK3 Gene Mutations Associated with Autism Facilitate Ligand Binding to the Shank3 Ankyrin Repeat Region*

T. Boeckers, C. Verpelli, E. Dvoretskova, 2013, The Journal of Biological Chemistry.

Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions

E. Manser, M. Ptushkina, J. Gunaratne, 2021, bioRxiv.

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras

T. Boeckers, J. Pouwels, Guillaume Jacquemet, 2017, Nature Cell Biology.

Force-independent interactions of talin and vinculin govern integrin-mediated mechanotransduction

Alexandre F. Carisey, A. Gilmore, D. Critchley, 2019, bioRxiv.

Mapping and Consensus Sequence Identification for Multiple Vinculin Binding Sites within the Talin Rod*

Alexandre R Gingras, Gordon C K Roberts, Igor L Barsukov, 2005, Journal of Biological Chemistry.

The Structure of an Interdomain Complex That Regulates Talin Activity

Neil Bate, Igor L. Barsukov, Iain D. Campbell, 2009, Journal of Biological Chemistry.

A Conserved Lipid-binding Loop in the Kindlin FERM F1 Domain Is Required for Kindlin-mediated αIIbβ3 Integrin Coactivation*

B. Goult, N. Bate, D. Critchley, 2012, The Journal of Biological Chemistry.

Structural Determinants of Integrin Binding to the Talin Rod

R. Liddington, M. Joyce, G. Roberts, 2009, Journal of Biological Chemistry.

Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.

Gordon C K Roberts, Igor L Barsukov, David R Critchley, 2008, Journal of molecular biology.

Activation of a vinculin‐binding site in the talin rod involves rearrangement of a five‐helix bundle

Neil Bate, Ronald Frank, Bipin Patel, 2004 .

S100A4 regulates the Src-tyrosine kinase dependent differentiation of Th17 cells in rheumatoid arthritis.

M. Bokarewa, I. Barsukov, M. Brisslert, 2014, Biochimica et biophysica acta.

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras

J. Pouwels, Guillaume Jacquemet, Hellyeh Hamidi, 2017, Nature Cell Biology.

A study of the membrane association and regulatory effect of the phospholemman cytoplasmic domain.

D. Middleton, I. Barsukov, M. Esmann, 2011, Biochimica et biophysica acta.

The solution structure of the complex of Lactobacillus casei dihydrofolate reductase with methotrexate.

T. Frenkiel, J. Feeney, C. Bauer, 1998, Journal of molecular biology.

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

P. R. Elliott, G. Roberts, B. Goult, 2010, Structure.

LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex

Christoph Ballestrem, Igor L. Barsukov, Benjamin T. Goult, 2016, Structure.

The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation

I. Campbell, G. Roberts, Nicholas J Anthis, 2009, Journal of molecular biology.

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

P. R. Elliott, G. Roberts, B. Goult, 2010, The EMBO journal.

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.

Niels Volkmann, Alexandre R Gingras, Neil Bate, 2013, Journal of structural biology.

Domain Motion in Cytochrome P450 Reductase

A. Gutiérrez, G. Roberts, I. Barsukov, 2009, The Journal of Biological Chemistry.

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.

A. Strasser, L. Lian, M. Hinds, 2004, The Biochemical journal.

Pressure-Dependent Chemical Shifts in the R3 Domain of Talin Show that It Is Thermodynamically Poised for Binding to Either Vinculin or RIAM.

N. J. Baxter, M. Williamson, I. Barsukov, 2017, Structure.

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover*

Neil Bate, Ricky Tsang, Christoph Ballestrem, 2013, The Journal of Biological Chemistry.

Targeting SxIP-EB1 interaction: An integrated approach to the discovery of small molecule modulators of dynamic binding sites

N. Berry, I. Barsukov, T B Almeida, 2017, Scientific Reports.

The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling

I. Barsukov, H. Kreienkamp, V. Martens, 2023, bioRxiv.

The structure of the C-terminal actin-binding domain of talin

Niels Volkmann, Alexandre R Gingras, Neil Bate, 2007, The EMBO journal.

Three-dimensional structure of proteolytic fragment 163-231 of bacterioopsin determined from nuclear magnetic resonance data in solution.

D. Nolde, A. Arseniev, A. Lomize, 1992, European journal of biochemistry.

Crystal structure of pentaerythritol tetranitrate reductase: "flipped" binding geometries for steroid substrates in different redox states of the enzyme.

N S Scrutton, P C Moody, N. Scrutton, 2001, Journal of molecular biology.

1H, 15N and 13C NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450

C. Wolf, L. Lian, G. Roberts, 1997, Journal of biomolecular NMR.

The domain structure of talin: Residues 1815–1973 form a five-helix bundle containing a cryptic vinculin-binding site

Neil Bate, Igor L. Barsukov, Benjamin T. Goult, 2010, FEBS letters.

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.

Alexandre R Gingras, Neil Bate, Gordon C K Roberts, 2004, The EMBO journal.

Base-plane correction in 2D NMR

A. Arseniev, I. Barsukov, I. L Barsukov, 1987 .

Structural consequences of site-directed mutagenesis in flexible protein domains: NMR characterization of the L(55,56)S mutant of RhoGDI.

A P Golovanov, D Hawkins, I Barsukov, 2001, European journal of biochemistry.

Sequence-specific 1H-NMR assignment and conformation of proteolytic fragment 163-231 of bacterioopsin.

A. Arseniev, I. Barsukov, V. Bystrov, 1990, European journal of biochemistry.

Parallel evolution or purifying selection, not introgression, explains similarity in the pyrethroid detoxification linked GSTE4 of Anopheles gambiae and An. arabiensis

M. Donnelly, D. Weetman, C. Wilding, 2015, Molecular Genetics and Genomics.

The 2D NMR of Single and Double Stranded Helixes of Gramicidin A in Micelles and Solutions

A. Arseniev, A. Lomize, I. Barsukov, 1987 .

Parallel evolution or purifying selection, not introgression, explains similarity in the pyrethroid detoxification linked GSTE4 of Anopheles gambiae and An. arabiensis

M. Donnelly, D. Weetman, C. Wilding, 2014, Molecular Genetics and Genomics.

The divalent cation‐binding sites of gramicidin A transmembrane ion‐channel

S. V. Sukhanov, A. Arseniev, L. I. Barsukov, 1991, Biopolymers.

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

G. Roberts, J. Emsley, B. Goult, 2010, The Journal of Biological Chemistry.

Crystal structure of the Ca2+‐form and Ca2+‐binding kinetics of metastasis‐associated protein, S100A4

Clive R. Bagshaw, I. Barsukov, A. Gingras, 2008, FEBS Letters.

to in KAR

B. Hutchinson, B. Goult, N. Bate, 2022 .