J. Roy

发表

Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives.

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2016, Bioorganic & medicinal chemistry letters.

A New Nonestrogenic Steroidal Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type I Blocks the Estrogen-Dependent Breast Cancer Tumor Growth Induced by Estrone

D. Poirier, J. Roy, D. Ayan, 2012, Molecular Cancer Therapeutics.

Therapeutic Discovery A New Nonestrogenic Steroidal Inhibitor of 17 b-Hydroxysteroid Dehydrogenase Type I Blocks the Estrogen-Dependent Breast Cancer TumorGrowth Induced by Estrone

D. Poirier, J. Roy, D. Ayan, 2012 .

Chemical Synthesis of (S)‐Spiro(estradiol‐17,2′‐[1,4]oxazinan)‐6′‐one Derivatives Bearing Two Levels of Molecular Diversity

D. Poirier, J. Roy, François Rouillard, 2008 .

Comparison of the effects of EM‐652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW‐5638 and raloxifene on the growth of human ZR‐75‐1 breast tumors in nude mice

C. Labrie, F. Labrie, M. Gutman, 2002, International journal of cancer.

Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines

C. Doillon, D. Poirier, J. Roy, 2012, Anti-cancer drugs.

Turning a Quinoline-based Steroidal Anticancer Agent into Fluorescent Dye for its Tracking by Cell Imaging.

D. Poirier, J. Roy, R. Maltais, 2021, ACS medicinal chemistry letters.

Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-Ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity, and Selectivity.

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2018, Journal of medicinal chemistry.

Structure-Based Design and Synthesis of New Estrane-Pyridine Derivatives as Cytochrome P450 (CYP) 1B1 Inhibitors.

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2017, ACS medicinal chemistry letters.

Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen.

D. Poirier, J. Roy, R. Maltais, 2019, Bioorganic & medicinal chemistry letters.

Impact of androstane A- and D-ring inversion on 17β-hydroxysteroid dehydrogenase type 3 inhibitory activity, androgenic effect and metabolic stability.

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2017, Bioorganic & medicinal chemistry.

Synthesis, NMR Characterization, and Antileukemic Activity of N-Nonanoylpiperazinyl-5α-Androstane-3α,17β-Diol A-Ring Derivatives

D. Poirier, J. Roy, R. Maltais, 2020, Magnetochemistry.

Chemical synthesis, NMR analysis and evaluation on a cancer xenograft model (HL-60) of the aminosteroid derivative RM-133

D. Poirier, J. Roy, R. Maltais, 2014, Steroids.

Chemical synthesis of fluorinated and iodinated 17β-HSD3 inhibitors and evaluation for imaging prostate cancer tumors and tissue biodistribution.

J. Rousseau, R. Lecomte, D. Poirier, 2022, Bioorganic chemistry.

A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models

D. Poirier, J. Roy, R. Maltais, 2021, Cancers.

Pharmacokinetic profile of PBRM in rodents, a first selective covalent inhibitor of 17β-HSD1 for breast cancer and endometriosis treatments

D. Poirier, J. Roy, D. Ayan, 2017, The Journal of Steroid Biochemistry and Molecular Biology.

Antisulfatase, Osteogenic, and Anticancer Activities of Steroid Sulfatase Inhibitor EO-33 in Mice.

D. Poirier, J. Roy, D. Ayan, 2019, Journal of medicinal chemistry.

Synthesis of 5α-Androstane-17-spiro-δ-lactones with a 3-Keto, 3-Hydroxy, 3-Spirocarbamate or 3-Spiromorpholinone as Inhibitors of 17β-Hydroxysteroid Dehydrogenases

D. Poirier, J. Roy, B. T. Ngatcha, 2013, Molecules.

Solid-phase chemical synthesis and in vitro biological evaluation of novel 2β-piperazino-(20R)-5α-pregnane-3α,20-diol N-derivatives as anti-leukemic agents

D. Poirier, J. Roy, R. Maltais, 2012, Steroids.

Impact of estradiol structural modifications (18-methyl and/or 17-hydroxy inversion of configuration) on the in vitro and in vivo estrogenic activity

D. Poirier, J. Roy, D. Ayan, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models

F. Pouliot, D. Poirier, B. Neveu, 2017, PloS one.

Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility.

D. Poirier, J. Roy, R. Maltais, 2019, European journal of medicinal chemistry.

Copper(II) and uranyl(II) complexes with acylthiosemicarbazide: synthesis, characterization, antibacterial activity and effects on the growth of promyelocytic leukemia cells HL-60.

T. Roșu, J. Roy, G. Almajan, 2009, European journal of medicinal chemistry.

In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis and structure – activity relationships

V. Stavila, D. Poirier, J. Roy, 2008 .

Crystal structures of copper(II) chloride, copper(II) bromide, and copper(II) nitrate complexes with pyridine-2-carbaldehyde thiosemicarbazone

D. Poirier, E. Jeanneau, J. Roy, 2008 .

Chemical synthesis of 2beta-amino-5alpha-androstane-3alpha,17beta-diol N-derivatives and their antiproliferative effect on HL-60 human leukemia cells.

D. Poirier, J. Roy, Patrick DeRoy, 2008, Bioorganic & medicinal chemistry.

Sulfanilamide-containing coordination compounds of Cu(II) with isatin and N-methylisatin thiosemicarbazones

D. Poirier, J. Roy, A. Gulea, 2006 .

The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers

D. Poirier, J. Roy, D. Ayan, 2015, PloS one.

Solid-phase synthesis of libraries of ethynylated aminosteroid derivatives as potential antileukemic agents

D. Poirier, J. Roy, R. Maltais, 2016, Steroids.

A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells

D. Poirier, S. Desnoyers, J. Roy, 2012, Investigational New Drugs.

Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes

D. Poirier, J. Roy, R. Maltais, 2011, Molecular Diversity.

Chemical synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 1

D. Poirier, J. Roy, R. Maltais, 2018, Steroids.

Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase

D. Poirier, J. Roy, R. Maltais, 2013, Molecular and Cellular Endocrinology.

Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3.

D. Poirier, J. Roy, R. Maltais, 2015, Bioorganic & medicinal chemistry.

Synthesis of 16β-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17β-ol as inhibitors of 17β-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases

D. Poirier, J. Roy, R. Maltais, 2021, Steroids.

Synthesis of 3-spiromorpholinone androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3.

D. Poirier, J. Roy, L. Kenmogne, 2013, Bioorganic & medicinal chemistry letters.

Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel

D. Poirier, J. Roy, R. Maltais, 2021, International journal of molecular sciences.

Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model

D. Poirier, J. Roy, R. Maltais, 2018, Investigational New Drugs.

A Novel Pure SERM Achieves Complete Regression of the Majority of Human Breast Cancer Tumors in Nude Mice

F. Labrie, J. Roy, Mathieu Gutman, 2003, Breast Cancer Research and Treatment.

Chemical Synthesis and Biological Evaluation of 3-Substituted Estrone/Estradiol Derivatives as 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Acting via a Reverse Orientation of the Natural Substrate Estrone

D. Poirier, J. Roy, R. Maltais, 2023, Molecules.

Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency.

D. Poirier, J. Roy, R. Maltais, 2020, European journal of medicinal chemistry.

Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging.

Jean-Philippe Lambert, D. Poirier, J. Roy, 2020, Bioorganic & medicinal chemistry.

Synthesis and pharmacokinetic study of poly(ethylene oxide) triazole dendrimers decorated with aminosteroids as anticancer agent

D. Poirier, Jean‐François Morin, J. Roy, 2020 .

Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17&bgr;‐hydroxysteroid dehydrogenase type 1

P. Lagüe, D. Poirier, J. Roy, 2017, Biochemical pharmacology.

Chemical synthesis and biological activities of 16α-derivatives of 5α-androstane-3α,17β-diol as antiandrogens

D. Poirier, R. Breton, F. Labrie, 2007 .

An Aminosteroid Derivative Shows Higher In Vitro and In Vivo Potencies than Gold Standard Drugs in Androgen-Dependent Prostate Cancer Models

D. Poirier, J. Roy, R. Maltais, 2023, Cancers.

Aminosteroid RM-581 Decreases Cell Proliferation of All Breast Cancer Molecular Subtypes, Alone and in Combination with Breast Cancer Treatments

D. Poirier, J. Roy, R. Maltais, 2023, Journal of clinical medicine.

Design of a Mestranol 2‐N‐Piperazino‐Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF‐7 Breast Cancer Models

D. Poirier, J. Roy, Raphaël Dutour, 2017, ChemMedChem.

Chemical synthesis, NMR characterization, and anticancer activity of androstene derivatives with a C17-side chain

D. Poirier, J. Roy, Adrien Djiemeny Ngueta, 2022, Steroids.

16-Picolyl-androsterone derivative exhibits potent 17β-HSD3 inhibitory activity, improved metabolic stability and cytotoxic effect on various cancer cells: Synthesis, homology modeling and docking studies

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2021, The Journal of Steroid Biochemistry and Molecular Biology.

A- and D-ring structural modifications of an androsterone derivative inhibiting 17β-hydroxysteroid dehydrogenase type 3: Chemical synthesis and structure-activity relationships.

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2019, Journal of medicinal chemistry.

Parallel Solid-Phase Synthesis using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines.

D. Poirier, J. Roy, Raphaël Dutour, 2019, Anti-cancer agents in medicinal chemistry.

Reprint of “In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3”

D. Poirier, J. Roy, M. Fournier, 2014, The Journal of Steroid Biochemistry and Molecular Biology.

In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3

D. Poirier, J. Roy, M. Fournier, 2014, The Journal of Steroid Biochemistry and Molecular Biology.

A Potent Inhibitor of Steroid Sulfatase (EM-1913) Blocks Tumor Growth in Nude Mice (MCF-7 Xenograft)

D. Poirier, J. Roy, D. Ayan, 2015 .

Synthesis and Biologic Properties of Some 1-(Alchyl)Phenyl-3-(4-(3-(Pyridin-2-Il)Acryloyl)Phenylthiourea

D. Poirier, J. Roy, A. Gulea, 2013 .

Chemical synthesis of 2beta-amino-5alpha-androstane-3alpha,17beta-diol N-derivatives and their antiproliferative effect on HL-60 human leukemia cells.

D. Poirier, J. Roy, Patrick DeRoy, 2008, Bioorganic & medicinal chemistry.

2β-(N-Substituted Piperazino)-5α-Androstane-3α,17β-Diols: Parallel Solid-Phase Synthesis and Antiproliferative Activity on Human Leukemia HL-60 Cells

D. Poirier, J. Roy, Patrick DeRoy, 2007 .