C. McCurdy

发表

In vitro and in vivo sigma 1 receptor imaging studies in different disease states.

Hebaalla Agha, C. McCurdy, 2020, RSC medicinal chemistry.

New positron emission tomography (PET) radioligand for imaging σ-1 receptors in living subjects.

S. Gambhir, C. H. Nielsen, M. James, 2012, Journal of medicinal chemistry.

Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme.

Nidhi Singh, Christopher R McCurdy, Nidhi Singh, 2007, Current pharmaceutical design.

Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity.

J. Poupaert, Yan-tong Xu, Nidhi Kaushal, 2008, Journal of medicinal chemistry.

A Novel Substituted Piperazine, CM156, Attenuates the Stimulant and Toxic Effects of Cocaine in Mice

Yan-tong Xu, Nidhi Kaushal, C. McCurdy, 2010, Journal of Pharmacology and Experimental Therapeutics.

Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine

B. Avery, E. Boyer, C. McCurdy, 2016, Journal of Medical Toxicology.

Evaluation of 18F-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue

D. Mann, M. Kassiou, A. Jacobs, 2020, Theranostics.

Exploring 1-adamantanamine as an alternative amine moiety for metabolically labile azepane ring in newly synthesized benzo[d]thiazol-2(3H)one σ receptor ligands

B. Avery, Hebaalla Agha, C. McCurdy, 2020, Medicinal Chemistry Research.

Benzimidazolone-based selective σ2 receptor ligands: Synthesis and pharmacological evaluation.

N. Fazio, Yan-tong Xu, C. McCurdy, 2019, European journal of medicinal chemistry.

Quantification of highly selective sigma-1 receptor antagonist CM304 using liquid chromatography tandem mass spectrometry and its application to a pre-clinical pharmacokinetic study.

B. Avery, F. Chin, C. McCurdy, 2017, Drug testing and analysis.

Evaluation of σ-1 Receptor Radioligand 18F-FTC-146 in Rats and Squirrel Monkeys Using PET

D. M. Lyons, S. Gambhir, C. H. Nielsen, 2014, The Journal of Nuclear Medicine.

Structure activity relationship study of benzo[d]thiazol-2(3H)one based σ receptor ligands.

J. Poupaert, C. McCurdy, James A. Fishback, 2013, Bioorganic & medicinal chemistry letters.

A 96-well filtration method for radioligand binding analysis of σ receptor ligands.

C. McCurdy, James A. Fishback, R. Matsumoto, 2012, Journal of pharmaceutical and biomedical analysis.

Synthesis and pharmacological evaluation of indole-based sigma receptor ligands.

J. Poupaert, C. McCurdy, E. Amata, 2011, European journal of medicinal chemistry.

Sigma Receptor Agonists: Receptor Binding and Effects on Mesolimbic Dopamine Neurotransmission Assessed by Microdialysis

G. Tanda, C. McCurdy, C. Mesangeau, 2011, Biological Psychiatry.

The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats

S. Amara, T. Su, W. Hong, 2017, The Journal of Biological Chemistry.

Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro.

Nidhi Kaushal, C. McCurdy, R. Matsumoto, 2014, European journal of pharmacology.

The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice.

Rolf T Hansen, Han-Ting Zhang, Nidhi Kaushal, 2013, The international journal of neuropsychopharmacology.

Herbal Medicines for the Management of Opioid Addiction

E. Boyer, C. McCurdy, C. Rosenbaum, 2011, CNS drugs.

DESIGN AND SYNTHESIS OF SIGMA-1 PROBE FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING

C. McCurdy, 2015 .

CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice

Nidhi Kaushal, C. McCurdy, C. Mesangeau, 2011, Neuropharmacology.

Oral Pharmacokinetics in Beagle Dogs of the Mitragynine Metabolite, 7-Hydroxymitragynine

C. McCurdy, F. León, Abhisheak Sharma, 2021, European journal of drug metabolism and pharmacokinetics.

Pharmacokinetics and Safety of Mitragynine in Beagle Dogs

B. Avery, C. McCurdy, F. León, 2020, Planta Medica.

Highly selective hydrolysis of kinins by recombinant prolylcarboxypeptidase.

J Mallela, Z Shariat-Madar, D. Watson, 2011, Biochemical and biophysical research communications.

Clinical Toxicology

Edward W Boyer, Christopher R McCurdy, E. Boyer, 2018 .

Kratom (Mitragyna speciosa Korth.): A description on the ethnobotany, alkaloid chemistry, and neuropharmacology

S. Ramanathan, V. Murugaiyah, C. McCurdy, 2021 .

Kratom (Mitragyna speciosa): worldwide issues.

S. Ramanathan, C. McCurdy, 2020, Current opinion in psychiatry.

Kratom policy: The challenge of balancing therapeutic potential with public safety

B. Avery, J. Henningfield, E. Boyer, 2019, The International journal on drug policy.

Development and validation of a UPLC-MS/MS method for the determination of 7-hydroxymitragynine, a μ-opioid agonist, in rat plasma and its application to a pharmacokinetic study.

B. Avery, C. McCurdy, P. Vuppala, 2013, Biomedical chromatography : BMC.

Simple, Sensitive, High-Throughput Method for the Quantification of Mitragynine in Rat Plasma Using UPLC-MS and Its Application to an Intravenous Pharmacokinetic Study

B. Avery, C. McCurdy, P. Vuppala, 2011 .

Computational Study on the Conformations of Mitragynine and Mitragynaline.

R. J. Doerksen, C. McCurdy, Haining Liu, 2010, Theochem.

Inhibition of choline uptake by N-cyclohexylcholine, a high affinity ligand for the choline transporter at the blood–brain barrier

W. Geldenhuys, P. Lockman, C. McCurdy, 2005, Journal of drug targeting.

Evaluation of the rewarding effects of mitragynine and 7-hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats.

Adriaan W. Bruijnzeel, C. McCurdy, F. León, 2020, Drug and alcohol dependence.

Synthesis and Pharmacological Characterization of a Novel Sigma Receptor Ligand with Improved Metabolic Stability and Antagonistic Effects Against Methamphetamine

B. Avery, A. Abdelazeem, C. McCurdy, 2011, The AAPS Journal.

Chemical function-based pharmacophore development for novel, selective kappa opioid receptor agonists.

Nidhi Singh, C. McCurdy, T. Nolan, 2008, Journal of molecular graphics & modelling.

Visualizing Nerve Injury in a Neuropathic Pain Model with [18F]FTC-146 PET/MRI

S. Gambhir, A. B. Lutz, M. James, 2017, Theranostics.

(E)-Methyl 2-[(2S,3S,12bR)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyacrylate ethanol solvate

C. McCurdy, P. Carvalho, Edward B. Furr III, 2009, Acta crystallographica. Section E, Structure reports online.

Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma

W. Bowen, C. McCurdy, C. Mesangeau, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain

T. Cirino, Amy R Alleyne, S. Eans, 2022, Molecules.

Pharmacological evaluation of SN79, a sigma (σ) receptor ligand, against methamphetamine-induced neurotoxicity in vivo

Nidhi Kaushal, C. McCurdy, R. Matsumoto, 2013, European Neuropsychopharmacology.

Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor.

D. Ferguson, Brian E Kane, C. McCurdy, 2008, Journal of medicinal chemistry.

Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1β mRNA expression in the hypothalamus.

C. McCurdy, R. Matsumoto, M. Seminerio, 2012, European journal of pharmacology.

Brain Magnetic Resonance Imaging of Regular Kratom (Mitragyna speciosa Korth.) Users: A preliminary study

Eric Tatt Wei Ho, M. Yücel, Y. Chye, 2018 .

The hallucinogen derived from Salvia divinorum, salvinorin A, has κ-opioid agonist discriminative stimulus effects in rats

C. McCurdy, D. Kinder, Catherine B. Willmore-Fordham, 2007, Neuropharmacology.

Plant growth and phytoactive alkaloid synthesis in kratom [Mitragyna speciosa (Korth.)] in response to varying radiance

B. Pearson, B. Avery, R. Kjelgren, 2022, PloS one.

Plant growth and phytoactive alkaloid synthesis in Mitragyna speciosa (kratom) in response to varying radiance

B. Pearson, B. Avery, R. Kjelgren, 2021, bioRxiv.

Opioid receptor-like 1 (ORL1) molecular "road map" to understanding ligand interaction and selectivity.

J. Poupaert, C. McCurdy, Ashok E. Philip, 2005, Current topics in medicinal chemistry.

Ultra-performance liquid chromatography tandem mass spectrometry method for the determination of AZ66, a sigma receptor ligand, in rat plasma and its application to in vivo pharmacokinetics.

B. Avery, A. Abdelazeem, C. McCurdy, 2013, Biomedical chromatography : BMC.

Activity of Mitragyna speciosa ("Kratom") Alkaloids at Serotonin Receptors.

C. McCurdy, Clinton E. Canal, T. Hiranita, 2021, Journal of medicinal chemistry.

Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats

Tobias Braun, J. Wilkerson, J. Fortner, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists

K. Rice, A. Abdelazeem, C. McCurdy, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Blockade of Cocaine or Sigma Receptor Agonist Self-Administration by Subtype- Selective Sigma Receptor Antagonists

K. Rice, A. Abdelazeem, C. McCurdy, 2016 .

Characterization of a mouse neuropathic pain model caused by the highly active antiviral therapy (HAART) Stavudine

J. Wilkerson, C. McCurdy, L. McMahon, 2021, Pharmacological Reports.

Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo

B. Avery, F. Chin, J. McLaughlin, 2020, The AAPS Journal.

Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone: modeling an abuse-deterrent opioid analgesic in rats

Shelley R. Edwards, K. Freeman, S. Negus, 2017, Psychopharmacology.

Acute Renal Insufficiency Associated With Consumption of Hydrocodone- and Morphine-Adulterated Kratom (Mitragyna Speciosa).

B. Avery, C. McCurdy, Abhisheak Sharma, 2022, The Journal of emergency medicine.

SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation

J. Huber, C. McCurdy, R. Matsumoto, 2013, Experimental Neurology.

Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence.

B. Avery, E. Boyer, T. Cirino, 2020, Drug and alcohol dependence.

Electronic and steric effects in the control of the Anilinium chloride catalyzed condensation reaction between Aldones and 4-Phenylthiosemicarbazide

Urbain C. Kasséhin, J. Poupaert, C. McCurdy, 2013 .

Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7‐hydroxymitragynine

S. Cutler, S. Hemby, C. McCurdy, 2018, Addiction biology.

Opioid Receptor Ligands

T. Prisinzano, C. McCurdy, 2022, Burger's Medicinal Chemistry and Drug Discovery.

Regulatory sampling of industrial hemp plant samples (Cannabis sativa L.) using UPLC-MS/MS method for detection and quantification of twelve cannabinoids

B. Avery, J. Freeman, C. McCurdy, 2020, Journal of Cannabis Research.

Development of Cannabinoids in Flowers of Industrial Hemp (Cannabis sativa L.)-a Pilot Study.

J. Freeman, C. McCurdy, Z. Brym, 2020, Journal of agricultural and food chemistry.

Is cocaine a social drug? Exploration of the stereo-structure of cocaine’s pharmacophore

J. Poupaert, C. McCurdy, F. Gbaguidi, 2012, Medicinal Chemistry Research.

Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats.

B. Avery, C. McCurdy, F. León, 2021, Journal of natural products.

Variations in mitragynine content in the naturally growing Kratom (Mitragyna speciosa) population of Thailand

B. Pearson, R. Kjelgren, N. Leksungnoen, 2022, Frontiers in Plant Science.

Novel pyrazolopyrimidine derivatives targeting COXs and iNOS enzymes; design, synthesis and biological evaluation as potential anti-inflammatory agents.

Samir M. El-Moghazy, Shabana I. Khan, A. Abdelazeem, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy

W. Kaufmann, L. Oberman, R. Deacon, 2021, Scientific Reports.

Beta-triketone inhibitors of plant p-hydroxyphenylpyruvate dioxygenase: modeling and comparative molecular field analysis of their interactions.

Nidhi Singh, F. Dayan, R. T. Weavers, 2009, Journal of agricultural and food chemistry.

p-Hydroxyphenylpyruvate dioxygenase is a herbicidal target site for beta-triketones from Leptospermum scoparium.

S. Duke, Nidhi Singh, F. Dayan, 2007, Phytochemistry.

Early development of sigma-receptor ligands.

J. Poupaert, C. McCurdy, C. Mesangeau, 2011, Future medicinal chemistry.

Anomalous reactivity of benzopinacolone towards 4-phenylthiosemicarbazide, a nucleophile endowed with alpha-effect

Urbain C. Kasséhin, J. Poupaert, J. Quetin-Leclercq, 2019, Journal of Medicinal and Chemical Sciences.

Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: application to opioid receptor affinity labels with greatly improved fluorogenic properties.

P. Law, P. Portoghese, T. Metzger, 2002, Journal of medicinal chemistry.

WILLGERODT-KINDLER'S MICROWAVE-ENHANCED SYNTHESIS OF THIOAMIDE DERIVATIVES

P. Depreux, J. Poupaert, E. Colacino, 2004 .

Flavanones from Miconia prasina.

S. Cutler, C. McCurdy, F. León, 2014, Phytochemistry letters.

o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label.

P. Portoghese, C. McCurdy, B. Le Bourdonnec, 2007, Journal of medicinal chemistry.

N, N-dimethylformamide.diiodine complex (DMF.I2) as an innovative efficient green catalyst in the synthesis of thiosemicarbazones by condensation of ketones with thiosemicarbazides

Urbain C. Kasséhin, J. Poupaert, C. McCurdy, 2015 .

Synthesis and characterization of [³H]-SN56, a novel radioligand for the σ₁ receptor.

J. Poupaert, C. McCurdy, C. Mesangeau, 2011, European journal of pharmacology.

Molecular and Cellular Pharmacology Synthesis and characterization of ( 3 H)-SN56, a novel radioligand for the σ1 receptor

J. Poupaert, C. McCurdy, C. Mesangeau, 2011 .

Design and synthesis of 3-acyl-2(3H)-benzoxazolone and 3-acyl-2(3H)-benzothiazolone derivatives

J. Poupaert, C. McCurdy, D. Lambert, 2011 .

Heteroatom analogues of hydrocodone: synthesis and biological activity.

T. Hudlický, S. Cutler, C. McCurdy, 2013, The Journal of organic chemistry.

Structure–activity relationship of phenytoinergic antiepileptic drugs related to ameltolide

J. Poupaert, C. McCurdy, G. Chevé, 2007, Medicinal Chemistry Research.

Analgesic substances derived from natural products (natureceuticals).

C. McCurdy, Stephenie Scully, 2005, Life sciences.

Phytochemistry of Mitragyna speciosa

B. Avery, S. Cutler, C. McCurdy, 2014 .

Structure-Based Identification of Potent Natural Product Chemotypes as Cannabinoid Receptor 1 Inverse Agonists

R. J. Doerksen, S. Cutler, J. Rimoldi, 2018, Molecules.

Phytochemical Characterization of the Leaves of Mitragyna Speciosa Grown in USA

S. Cutler, C. McCurdy, F. León, 2009, Natural product communications.

Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist

Christopher R. McCurdy, J. E. Warnick, C. McCurdy, 2006, Pharmacology Biochemistry and Behavior.

In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower.

S. Cutler, M. Elsohly, C. McCurdy, 2015, Journal of ethnopharmacology.

Lobeline: A Natural Product with High Affinity for Neuronal Nicotinic Receptors and a Vast Potential for Use in Neurological Disorders*

C. McCurdy, Reagan L. Miller, W. Beach, 1999 .

Ligand macromolecule interactions: theoretical principles of molecular recognition.

Tammy Nolan, Nidhi Singh, Christopher R McCurdy, 2009, Methods in molecular biology.

Structure–activity relationships of neuropeptide FF and related peptidic and non-peptidic derivatives

C. Mollereau, C. McCurdy, G. Chevé, 2006, Peptides.

Nonpeptide Small Molecule Agonist and Antagonist Original Leads for Neuropeptide FF1 and FF2 Receptors

S. Cutler, C. Mollereau, S. Eans, 2014, Journal of medicinal chemistry.

Exploration of Cytochrome P450 Inhibition Mediated Drug-Drug Interaction Potential of Kratom Alkaloids.

B. Avery, C. McCurdy, F. León, 2019, Toxicology letters.

Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells

F. Vizeacoumar, Kalpana K Bhanumathy, D. Falzarano, 2021, Pathogens.

Synthesis and pharmacological evaluation of antioxidant chalcone derivatives of 2 ( 3 H )-benzoxazolones

J. Poupaert, C. McCurdy, D. Lambert, 2009 .

Synthesis and pharmacological evaluation of antioxidant chalcone derivatives of 2(3H)-benzoxazolones

J. Poupaert, C. McCurdy, D. Lambert, 2009, Medicinal Chemistry Research.

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

A. Ferrando, M. Konopleva, P. Houghton, 2019, Nature Medicine.

Sigma-1 Receptor Changes Observed in Chronic Pelvic Pain Patients: A Pilot PET/MRI Study

C. Mari Aparici, Daehyun Yoon, S. Biswal, 2021, Frontiers in Pain Research.

Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation

B. Pattnaik, C. McCurdy, T. Mavlyutov, 2022, Genes.

Bioanalytical method development and validation of corynantheidine, a kratom alkaloid, using UPLC-MS/MS, and its application to preclinical pharmacokinetic studies.

B. Avery, C. McCurdy, F. León, 2019, Journal of pharmaceutical and biomedical analysis.

Investigation of phenolic bioisosterism in opiates: 3-sulfonamido analogues of naltrexone and oxymorphone.

R. M. Jones, P. Portoghese, C. McCurdy, 2000, Organic letters.

A Role for Sigma Receptors in Stimulant Self-Administration and Addiction.

W. Hong, C. McCurdy, J. Katz, 2017, Handbook of experimental pharmacology.

Novel Approaches, Drug Candidates, and Targets in Pain Drug Discovery.

C. McCurdy, F. León, T. Hiranita, 2021, Journal of medicinal chemistry.

Slow conformational dynamics of the human A2A adenosine receptor are temporally ordered

H. Gutiérrez‐de‐Terán, M. Eddy, C. McCurdy, 2021, Structure.

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

A. Ferrando, M. Konopleva, P. Houghton, 2019, Nature Medicine.

SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation

J. O'Callaghan, J. Huber, C. McCurdy, 2014, Experimental Neurology.

CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain

D. Patel, Yan-tong Xu, C. McCurdy, 2012, Pharmacology Biochemistry and Behavior.

σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation

A. Coop, C. McCurdy, R. Matsumoto, 2013, Pharmacological reports : PR.

Synthesis and Pharmacological Evaluation of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a Cocaine Antagonist, in Rodents

B. Avery, Nidhi Kaushal, C. McCurdy, 2011, The AAPS Journal.

Patterns and reasons for kratom (Mitragyna speciosa) use among current and former opioid poly-drug users.

B. Avery, S. Narayanan, C. McCurdy, 2019, Journal of ethnopharmacology.

The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats

B. Avery, J. Wilkerson, C. McCurdy, 2019, Psychopharmacology.

N-naphthoyl-β-naltrexamine (NNTA), a highly selective and potent activator of μ/κ-opioid heteromers

P. Portoghese, C. McCurdy, S. Roerig, 2011, Proceedings of the National Academy of Sciences.

The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats.

C. McCurdy, T. Hiranita, L. McMahon, 2021, Journal of pharmacological and toxicological methods.

Acute morphine blocks spinal respiratory motor plasticity via long‐latency mechanisms that require toll‐like receptor 4 signalling

D. Bolser, C. McCurdy, G. Mitchell, 2021, The Journal of physiology.

Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors.

K. Abboud, S. Ramanathan, C. McCurdy, 2021, Journal of natural products.

Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine

B. Avery, E. Boyer, C. McCurdy, 2016, Journal of Medical Toxicology.

Evaluation of phytocannabinoids from high-potency Cannabis sativa using in vitro bioassays to determine structure–activity relationships for cannabinoid receptor 1 and cannabinoid receptor 2

S. Cutler, Safwat Ahmed, M. Elsohly, 2014, Medicinal Chemistry Research.

Specific cross-linking of Lys233 and Cys235 in the mu opioid receptor by a reporter affinity label.

Yan Zhang, Christopher R McCurdy, P. Portoghese, 2005, Biochemistry.

Studies on diketopiperazine and dipeptide analogs as opioid receptor ligands.

V. Neugebauer, T. Abbruscato, C. McCurdy, 2023, European journal of medicinal chemistry.

Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel

B. Pattnaik, C. McCurdy, T. Mavlyutov, 2017, Oncotarget.

Motives for using Kratom (Mitragyna speciosa Korth.) among regular users in Malaysia.

S. Narayanan, M. Swogger, C. Müller, 2019, Journal of ethnopharmacology.

Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity.

E. Boyer, C. McCurdy, J. Adkins, 2011, Current topics in medicinal chemistry.

UPLC-MS/MS method for the quantification of MCI-77, a novel sigma-1 receptor ligand, and its application to pharmacokinetic studies.

C. McCurdy, Sebastiano Intagliata, Abhisheak Sharma, 2022, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives

W. Bowen, C. McCurdy, C. Mesangeau, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Further validation to support clinical translation of [18F]FTC-146 for imaging sigma-1 receptors

S. Gambhir, M. James, Bin Shen, 2015, EJNMMI Research.

Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity

W. Bowen, C. McCurdy, C. Mesangeau, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Further validation to support clinical translation of ( 18 F)FTC-146 for imaging

S. Gambhir, M. James, F. Chin, 2015 .

Radiosynthesis and First-In-Human PET/MRI Evaluation with Clinical-Grade [18F]FTC-146

S. Gambhir, B. Avery, Daehyun Yoon, 2017, Molecular Imaging and Biology.

Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain

T. Cirino, S. Eans, J. M. Medina, 2019, Front. Pharmacol..

Successful treatment of chronic knee pain following localization by a sigma-1 receptor radioligand and PET/MRI: a case report

J. Dragoo, M. James, V. Tawfik, 2018, Journal of pain research.

Biodistribution and Radiation Dosimetry of 18F-FTC-146 in Humans

G. Zaharchuk, E. Mittra, S. Gambhir, 2017, The Journal of Nuclear Medicine.

The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes

C. McCurdy, T. Mavlyutov, A. Ruoho, 2015, EBioMedicine.

Bioanalytical method development and pharmacokinetics of MCI-92, a sigma-1 receptor ligand.

C. McCurdy, Sebastiano Intagliata, Abhisheak Sharma, 2020, Journal of pharmaceutical and biomedical analysis.

Novel 2(3H)-Benzothiazolones as Highly Potent and Selective Sigma-1 Receptor Ligands

J. Poupaert, S. Yous, C. McCurdy, 2005, Medicinal Chemistry Research.

Identification and characterization of MAM03055A: a novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity.

W. Bowen, C. McCurdy, Hilary E. Nicholson, 2021, European journal of pharmacology.

Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy.

B. Avery, C. McCurdy, F. León, 2020, ACS pharmacology & translational science.

Oral Pharmacokinetics in Beagle Dogs of the Mitragynine Metabolite, 7-Hydroxymitragynine

C. McCurdy, Abhisheak Sharma, L. McMahon, 2021, European Journal of Drug Metabolism and Pharmacokinetics.

Assessing the therapeutic potential and toxicity of Mitragyna speciosa in opioid use disorder

C. McCurdy, Abhisheak Sharma, 2020, Expert opinion on drug metabolism & toxicology.

Investigation of the Adrenergic and Opioid Binding affinities, Metabolic Stability, Plasma Protein Binding Properties and Functional Effects of Selected Indole-based Kratom Alkaloids.

B. Avery, S. Ramanathan, C. McCurdy, 2019, Journal of medicinal chemistry.

Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)

B. Avery, C. McCurdy, F. León, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth).

Edward W Boyer, Christopher R McCurdy, E. Boyer, 2008, Addiction.

The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats

B. Avery, J. Wilkerson, C. McCurdy, 2019, Psychopharmacology.

Searching for a Signal: Self-Reported Kratom Dose-Effect Relationships Among a Sample of US Adults With Regular Kratom Use Histories

D. Epstein, J. Rogers, O. Grundmann, 2022, Frontiers in Pharmacology.

Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra-performance liquid chromatography-tandem mass spectrometry.

B. Avery, S. Ramanathan, C. McCurdy, 2019, Drug testing and analysis.

In Vitro and In Vivo Pharmacological Comparison of Mu‐Opioid Receptor Activity of the Kratom (Mitragyna speciosa) Alkaloid Mitragynine and its Metabolite 7‐Hydroxymitragynine

C. McCurdy, T. Hiranita, L. McMahon, 2021, Alzheimer's & Dementia.

The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study

C. McCurdy, T. Hiranita, Abhisheak Sharma, 2021, Drug Metabolism and Disposition.

Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method.

B. Avery, C. McCurdy, F. León, 2020, Journal of pharmaceutical and biomedical analysis.

Effects of Nutrient Fertility on Growth and Alkaloidal Content in Mitragyna speciosa (Kratom)

B. Pearson, B. Avery, R. Kjelgren, 2020, Frontiers in Plant Science.

Determination of mitragynine in rat plasma by LC-MS/MS: application to pharmacokinetics.

C. McCurdy, V. Lanchote, Edward B. Furr, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Adolescent nicotine and tobacco smoke exposure enhances nicotine self-administration in female rats

Adriaan W. Bruijnzeel, C. McCurdy, Abhisheak Sharma, 2020, Neuropharmacology.

Sigma receptors and cocaine abuse.

J. Poupaert, C. McCurdy, C. Mesangeau, 2011, Current topics in medicinal chemistry.

Mephedrone (4-methylmethcathinone), a principal constituent of psychoactive bath salts, produces behavioral sensitization in rats.

A. Reitz, C. McCurdy, S. Rawls, 2013, Drug and alcohol dependence.

Clinical pharmacokinetics of kavalactones after oral dosing of standardized kava extract in healthy volunteers.

C. McCurdy, Abhisheak Sharma, Robyn Nelson, 2022, Journal of ethnopharmacology.

Characterization of different forms of kava (Piper methysticum) products by UPLC-MS/MS

C. McCurdy, Abhisheak Sharma, K. S. Raju, 2021, Planta Medica.

In vitro and in vivo pharmacology of kratom.

J. Wilkerson, C. McCurdy, T. Hiranita, 2022, Advances in pharmacology.

Comparative Pharmacokinetics of Mitragynine after Oral Administration of Mitragyna speciosa (Kratom) Leaf Extracts in Rats

B. Avery, S. Cutler, C. McCurdy, 2018, Planta Medica.

Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations

Mitchell A. Avery, Christopher R. McCurdy, Nidhi Singh, 2007, J. Comput. Aided Mol. Des..

A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist

David M. Ferguson, Christopher R. McCurdy, Nidhi Singh, 2006, J. Comput. Aided Mol. Des..

Comparative Protein Modeling of 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Enzyme from Plasmodium falciparum: A Potential Target for Antimalarial Drug Discovery

Mitchell A. Avery, Christopher R. McCurdy, Nidhi Singh, 2006, J. Chem. Inf. Model..

Antidepressive effects of the &kgr;-opioid receptor agonist salvinorin A in a rat model of anhedonia

C. McCurdy, Jennifer Niehoff, G. Taylor, 2012, Behavioural pharmacology.

Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics.

B. Avery, C. McCurdy, C. Mesangeau, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Opioid receptor function in social attachment in young domestic fowl

J. E. Warnick, C. McCurdy, K. Sufka, 2005, Behavioural Brain Research.

SAR analysis of new dual targeting fluoroquinolones. Implications of the benzenesulfonyl group.

Nidhi Singh, R. Manzo, A. B. Pierini, 2012, Medicinal chemistry (Shariqah (United Arab Emirates)).

Solvent effect and catalysis in the synthesis of thiosemicarbazone derivatives from ketones and 4-phenylthiosemicarbazide

J. Poupaert, C. McCurdy, F. Gbaguidi, 2014 .

A unique binding epitope for salvinorin A, a non‐nitrogenous kappa opioid receptor agonist

Christopher R McCurdy, D. Ferguson, Brian E Kane, 2006, The FEBS journal.

Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone: modeling an abuse-deterrent opioid analgesic in rats

Shelley R. Edwards, K. Freeman, S. Negus, 2017, Psychopharmacology.

Inhibition of brain choline uptake by isoarecolone and lobeline derivatives: implications for potential vector-mediated brain drug delivery

A. Terry, C. McCurdy, D. D. Allen, 1998, Neuroscience Letters.

Synthesis and Pharmacological Characterization of a Novel Sigma Receptor Ligand with Improved Metabolic Stability and Antagonistic Effects Against Methamphetamine

B. Avery, A. Abdelazeem, C. McCurdy, 2012, The AAPS Journal.

Pharmacy education: from Prescott to pharmacogenomics.

C. McCurdy, 2002, Journal of the American Pharmaceutical Association.

Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.

Shabana I. Khan, S. White, A. Abdelazeem, 2015, Bioorganic & medicinal chemistry.

Computationally Assisted Lead Optimization of Novel Potent and Selective MAO-B Inhibitors

Khaled M. Elokely, B. Tekwani, S. Cutler, 2021, Biomedicines.

Pharmacokinetics of delta-9-tetrahydrocannabinol following acute cannabis smoke exposure in mice; effects of sex, age, and strain

B. Setlow, J. Bizon, Jada Lewis, 2023, Frontiers in pharmacology.

Insight into the Willgerodt-Kindler Reaction of ω-Haloacetophenone Derivatives: Mechanistic Implication

Urbain C. Kasséhin, J. Poupaert, C. McCurdy, 2014 .

Correction to "Novel Approaches, Drug Candidates, and Targets in Pain Drug Discovery".

C. McCurdy, T. Hiranita, L. McMahon, 2021, Journal of medicinal chemistry.

Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study.

B. Avery, C. McCurdy, C. Mesangeau, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.