A. Marrazzo

Carmela Parenti, Giovanni Nastasi, Giuseppe Floresta, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors

L. Salerno, A. Rescifina, V. Pittalà, 2017, Data in brief.

Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions.

C. Di Giacomo, V. Sorrenti, L. Vanella, 2017, Current medicinal chemistry.

New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation.

V. Pittalà, C. Parenti, L. Pasquinucci, 2016, Bioorganic & medicinal chemistry.

Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells.

F. Drago, G. Lupo, G. Giurdanella, 2016, Journal of medicinal chemistry.

Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties.

N. Colabufo, C. Parenti, L. Pasquinucci, 2011, Journal of medicinal chemistry.

A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect.

C. Parenti, A. Marrazzo, O. Prezzavento, 2008, Life sciences.

In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia.

C. Parenti, A. Marrazzo, S. Ronsisvalle, 2006, Life sciences.

A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma1 receptors.

E. Mazzon, S. Cuzzocrea, F. Drago, 2006, European journal of pharmacology.

Synthesis of (+)- and (−)-cis-2-[(1-adamantylamino)-methyl]-1-phenylcyclopropane derivatives as high affinity probes for σ1 and σ2 binding sites

M. Iadanza, V. Pike, A. Marrazzo, 2002 .

Synthesis and pharmacological evaluation of potent and enantioselective σ1 and σ2 ligands

L. Pasquinucci, A. Marrazzo, O. Prezzavento, 2001 .

Synthesis and binding affinity of cis-(−)- and cis-(+)-N-ethyleneamino-N-nordeoxymetazocine and cis-(−)-N-normetazocine analogues at σ1, σ2 and κ opioid receptors

S. Spampinato, A. Marrazzo, O. Prezzavento, 2001 .

Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites.

L. Pasquinucci, S. Spampinato, A. Marrazzo, 2000, Bioorganic & medicinal chemistry.

Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review.

R. Parenti, R. Turnaturi, C. Parenti, 2018, European journal of medicinal chemistry.

Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5ʹ‐monophosphate glycosidase

A. Rescifina, G. Floresta, M. Dichiara, 2018, Chemical biology & drug design.

Synthesis and biological evaluation of new benzo-thieno[3,2-d]pyrimidin-4-one sulphonamide thio-derivatives as potential selective cyclooxygenase-2 inhibitors

V. Cardile, A. Marrazzo, A. Graziano, 2013, Molecular Diversity.

Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia

V. Sorrenti, L. Vanella, K. Greish, 2022, Molecules.

Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect.

V. Cardile, Aurore Fraix, S. Sortino, 2017, Journal of medicinal chemistry.

Haloperidol Metabolite II Valproate Ester (S)-(−)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma

G. Pitari, G. Lupo, G. Giurdanella, 2021, Journal of medicinal chemistry.

Specific κ opioid receptor agonists

A. Marrazzo, O. Prezzavento, G. Ronsisvalle, 2001 .

New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells

V. Sorrenti, L. Vanella, K. Greish, 2020, International journal of molecular sciences.

Novel sigma receptor ligands: synthesis and biological profile.

G. Li Volti, L. Vanella, A. Cagnotto, 2007, Journal of medicinal chemistry.

Crystal morphologies and polymorphs in tolbutamide microcrystalline powder.

A. Rescifina, A. Marrazzo, F. Punzo, 2013, Journal of pharmaceutical sciences.

The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling

R. Parenti, S. Chiechio, F. Caraci, 2021, Frontiers in Pharmacology.

Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation.

R. Acquaviva, C. Di Giacomo, R. Turnaturi, 2020, ACS medicinal chemistry letters.

Synthetic approaches to bridgehead nitrogen methanesulfonamide derivatives of 3-amino-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones, potential cox-2 selective inhibitors

V. Cardile, G. Granata, S. Barbagallo, 2006 .

Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects.

L. Salerno, V. Pittalà, A. Marrazzo, 2022, Bioorganic & medicinal chemistry.

(+)-Pentazocine attenuates SH-SY5Y cell death, oxidative stress and microglial migration induced by conditioned medium from activated microglia

L. Vanella, A. Marrazzo, O. Prezzavento, 2017, Neuroscience Letters.

(+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury

L. Vanella, E. Arena, A. Marrazzo, 2016, Neuroscience Letters.

Exploiting the power of stereochemistry in drug action: 3-[(2S,6S,11S)-8-hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as potent sigma 1 receptor antagonist.

S. Chiechio, R. Turnaturi, C. Parenti, 2020, ACS chemical neuroscience.

CCB, a novel specific κ opioid agonist, which discriminates between opioid and σ1 recognition sites

L. Carboni, L. Pasquinucci, J. A. Gómez-Vidal, 1995 .

Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma.

G. Li Volti, A. Russo, A. Marrazzo, 2017, Oncotarget.

4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes

N. Colabufo, Mauro Niso, A. Rescifina, 2015 .

(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects.

R. Turnaturi, C. Parenti, L. Pasquinucci, 2017, European journal of medicinal chemistry.

Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain

R. Parenti, G. Li Volti, S. Chiechio, 2022, International journal of molecular sciences.

Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.

C. Di Giacomo, V. Sorrenti, L. Vanella, 2015, European journal of medicinal chemistry.

Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents.

V. Cardile, R. Vitale, P. Amodeo, 2014, European journal of medicinal chemistry.

1-Phenyl-3-azabicyclo[3.1.0]hexane derivatives as new ligands for sigma receptors

A. Pappalardo, A. Marrazzo, O. Prezzavento, 2004 .

Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents.

L. Salerno, A. Rescifina, V. Pittalà, 2017, European journal of medicinal chemistry.

How molecular interactions affect crystal morphology: the case of haloperidol.

A. Rescifina, A. Marrazzo, F. Punzo, 2011, Journal of pharmaceutical sciences.

Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties

H. Stark, T. Karcz, K. Kieć‐Kononowicz, 2021, ACS chemical neuroscience.

Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors.

V. Sorrenti, L. Salerno, A. Rescifina, 2018, European journal of medicinal chemistry.

Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors.

L. Salerno, V. Pittalà, A. Marrazzo, 2019, European journal of medicinal chemistry.

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation

V. Sorrenti, K. Greish, L. Salerno, 2018, Molecules.

Simultaneous determination of amphetamine and one of its metabolites by HPLC with electrochemical detection.

N. A. Santagati, A. Marrazzo, G. Ronsisvalle, 2002, Journal of pharmaceutical and biomedical analysis.

Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.

L. Pasquinucci, A. Marrazzo, O. Prezzavento, 2011, European journal of medicinal chemistry.

Copper‐Catalyzed Coupling Reaction of 2‐Thioxo‐4‐quinazolinone and Thieno[3,2‐d]pyrimidin‐4‐one Methane Sulphonamide with Aryl Iodides: Preparation of Potential COX‐2 Selective Inhibitors

G. Granata, A. Marrazzo, A. Santagati, 2008 .

Copper-Catalyzed Coupling Reaction of 2-Thioxo-4-quinazolinone and Thieno[3,2-d]pyrimidin-4-one Methane Sulfonamide with Aryl Iodides: Preparation of Potential COX-2 Selective Inhibitors.

G. Granata, A. Marrazzo, A. Santagati, 2008 .

Synthesis and Effects on the COX‐1 and COX‐2 Activity in Human Whole Blood ex vivo of Derivatives Containing the [1]Benzothienol‐[3, 2‐d]pyrimidin‐4‐one Heterocyclic System

G. Granata, M. Santagati, A. Marrazzo, 2003, Archiv der Pharmazie.

Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands.

E. Arena, A. Marrazzo, O. Prezzavento, 2017, Colloids and surfaces. B, Biointerfaces.

Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.

A. Cataldi, A. Rescifina, C. Parenti, 2015, European journal of medicinal chemistry.

The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation

R. Parenti, C. Parenti, L. Pasquinucci, 2014, Inflammation Research.

Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective

L. Salerno, V. Pittalà, A. Marrazzo, 2021, Journal of medicinal chemistry.

Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain

S. Chiechio, R. Turnaturi, C. Parenti, 2022, Molecules.

Interaction of new sigma ligands with biomembrane models evaluated by differential scanning calorimetry and Langmuir-Blodgett studies.

F. Castelli, A. Marrazzo, E. Amata, 2021, Colloids and surfaces. B, Biointerfaces.

Synthesis and pharmacological evaluation of potent and enantioselective sigma 1, and sigma 2 ligands.

L. Pasquinucci, A. Marrazzo, O. Prezzavento, 2001, Farmaco.

Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain

G. Cantarella, C. Parenti, A. Marrazzo, 2013, Inflammation.

Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity

T. Su, A. Copani, F. Caraci, 2005, Neuroreport.

The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures

R. Turnaturi, C. Parenti, L. Pasquinucci, 2013, Neuropharmacology.

Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand.

R. Turnaturi, C. Parenti, L. Pasquinucci, 2012, Life sciences.

Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents

M. Gariboldi, R. Turnaturi, A. Rescifina, 2021, Journal of medicinal chemistry.

Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases

S. Collina, A. Rescifina, M. Dichiara, 2017, ChemMedChem.

Evaluation of N-substitution in 6,7-benzomorphan compounds.

C. Parenti, L. Pasquinucci, A. Marrazzo, 2010, Bioorganic & medicinal chemistry.

Opiate Receptors and Antagonists: From Bench to Clinic. Edited by R. Dean, E. J. Bilsky, and S. S. Negus.

A. Marrazzo, 2010 .

Opioid and sigma receptor studies. New developments in the design of selective sigma ligands

A. Cagnotto, C. Parenti, A. Marrazzo, 2001 .

Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands

A. Rescifina, G. Floresta, M. Dichiara, 2019, International journal of molecular sciences.

S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands

Giovanni Nastasi, Giuseppe Romeo, Carla Miceli, 2017, Journal of Cheminformatics.

Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion.

A. Marrazzo, O. Prezzavento, G. Leanza, 2011, Journal of Alzheimer's disease : JAD.

Anti‐amnesic properties of (±)‐PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats

E. Arena, A. Marrazzo, O. Prezzavento, 2009, Journal of neurochemistry.

Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands.

S. Chiechio, R. Turnaturi, L. Salerno, 2019, European journal of medicinal chemistry.

Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands

M. Salmona, A. Cagnotto, L. Salerno, 2020, Molecules.

Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists.

R. Turnaturi, L. Salerno, C. Parenti, 2020, ACS medicinal chemistry letters.

Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists

R. Turnaturi, C. Parenti, L. Pasquinucci, 2018, Molecules.

Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.

R. Turnaturi, L. Pasquinucci, M. Dichiara, 2022, European journal of medicinal chemistry.

Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review.

R. Turnaturi, C. Parenti, L. Pasquinucci, 2018, European journal of medicinal chemistry.

The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment.

R. Turnaturi, C. Parenti, L. Pasquinucci, 2012, Life sciences.

New benzomorphan derivatives of MPCB as MOP and KOP receptor ligands.

M. Iadanza, C. Parenti, L. Pasquinucci, 2007, Pharmazie.

Tuning Properties for Blood-Brain Barrier (BBB) Permeation: A Statistics-Based Analysis.

R. Turnaturi, M. Dichiara, A. Marrazzo, 2019, ACS chemical neuroscience.

Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands.

R. Turnaturi, L. Pasquinucci, Sara Fortuna, 2022, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of haloperidol metabolite II prodrugs as anticancer agents.

A. Rescifina, V. Pittalà, C. Parenti, 2017, Future medicinal chemistry.

MRJF4, a novel histone deacetylase inhibitor, induces p21 mediated autophagy in PC3 prostate cancer cells.

A. Cataldi, M. Rapino, D. Bosco, 2015, Cellular and molecular biology.

Preparation and characterization of polymeric micelles loaded with a potential anticancer prodrug

W. Hennink, A. Marrazzo, L. Marinelli, 2016 .

Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors

Giuseppe Romeo, Giovanni Nastasi, Valeria Pittalà, 2017, ChemMedChem.

Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands

C. Parenti, L. Pasquinucci, S. Alcaro, 2023, ACS chemical neuroscience.

Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands

S. Collina, Sara Fortuna, M. Dichiara, 2023, Molecules.

Synthesis and biological evaluation of new benzo-thieno[3,2-d]pyrimidin-4-one sulphonamide thio-derivatives as potential selective cyclooxygenase-2 inhibitors

V. Cardile, A. Marrazzo, A. Graziano, 2013, Molecular Diversity.

Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain

H. Stark, T. Karcz, K. Kieć‐Kononowicz, 2023, Journal of medicinal chemistry.

New Insights into the Opioid Analgesic Profile of cis-(−)-N-Normetazocine-derived Ligands

R. Turnaturi, C. Parenti, L. Pasquinucci, 2023, Molecules.

Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity.

A. Cataldi, M. Rapino, A. Rescifina, 2023, Bioorganic chemistry.

Nanostructured lipid carrier for the ophthalmic delivery of haloperidol metabolite II valproate ester (±)-MRJF22: A potential strategy in the treatment of uveal melanoma

G. Pitari, R. Pignatello, A. Marrazzo, 2023, Journal of Drug Delivery Science and Technology.

Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo

U. Spampinato, D. Moison, A. Cagnotto, 2003, Neuropharmacology.

Synthesis of potential selective cox‐2 enzyme inhibitors derived from ethyl ester of 2‐isothiocyanato‐5‐phenyl‐3‐thiophenecarboxylic acid

G. Granata, A. Marrazzo, A. Santagati, 2003 .

Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5‐Fluorouracil and Imidazole‐Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells

V. Sorrenti, L. Vanella, L. Salerno, 2023, ChemMedChem.

How molecular interactions affect crystal morphology: the case of haloperidol.

A. Rescifina, A. Marrazzo, F. Punzo, 2011, Journal of pharmaceutical sciences.

Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity

Jessica Lombino, L. Pasquinucci, S. Alcaro, 2023, Journal of medicinal chemistry.

Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity

R. Gitto, L. De Luca, A. Marrazzo, 2023, RSC medicinal chemistry.

Sigma-1 receptor targeting inhibits connexin 43 based intercellular communication in chronic neuropathic pain.

C. Parenti, L. Pasquinucci, A. Marrazzo, 2024, Inflammation research : official journal of the European Histamine Research Society ... [et al.].

Mechanisms of the Antineoplastic Effects of New Fluoroquinolones in 2D and 3D Human Breast and Bladder Cancer Cell Lines

M. Gariboldi, G. Perletti, A. Marrazzo, 2024, Cancers.

Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties.

N. Colabufo, C. Parenti, L. Pasquinucci, 2011, Journal of medicinal chemistry.

Designing drugs optimized for both blood–brain barrier permeation and intra-cerebral partition

L. Pasquinucci, A. Marrazzo, E. Amata, 2023, Expert opinion on drug discovery.