L. Aurelio

发表

New methodology for the N-alkylation of 2-amino-3-acylthiophenes.

P. Scammells, L. Aurelio, B. Flynn, 2011, Organic & biomolecular chemistry.

Synthetic Preparation of N-Methyl-α-amino Acids

R. Brownlee, L. Aurelio, A. B. Hughes, 2004 .

Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain.

R. Latorre, J. Quinn, T. P. Davis, 2022, Biomaterials.

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

B. Schmidt, C. Morissette, S. Vanner, 2019, Scientific Reports.

The Role of the Second Extracellular Loop of the Adenosine a 1 Receptor on Allosteric Modulator Binding, Signaling and Cooperativity

A. T. Nguyen, Trayder Thomas, Toan D. Nguyen, 2022 .

A molecular sensor to quantify the localization of proteins, DNA and nanoparticles in cells

Joshua J. Rennick, A. Johnston, L. Aurelio, 2020, Nature Communications.

SNAPSwitch: A Molecular Sensor to Quantify the Localization of Proteins, DNA and Nanoparticles in Cells

Joshua J. Rennick, A. Johnston, L. Aurelio, 2019, bioRxiv.

Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor.

Shane M. Devine, P. Sexton, A. Christopoulos, 2012, Journal of medicinal chemistry.

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation.

N. Bunnett, L. Aurelio, B. Graham, 2017, Bioorganic & medicinal chemistry letters.

The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.

P. Sexton, A. Christopoulos, P. Scammells, 2011, Bioorganic & medicinal chemistry letters.

Quantifying Cellular Internalization with a Fluorescent Click Sensor.

A. Johnston, Laura I. Selby, L. Aurelio, 2018, ACS sensors.

Granzyme A in Chikungunya and Other Arboviral Infections

P. Zanotto, A. Suhrbier, P. Bird, 2020, Frontiers in Immunology.

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.

P. Sexton, A. Christopoulos, J. Linden, 2009, Bioorganic & medicinal chemistry.

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers.

J. Linden, P. Scammells, L. Aurelio, 2008, Bioorganic & medicinal chemistry.

Chemical Tagging with tert-Butyl and Trimethylsilyl Groups for Measuring Intermolecular Nuclear Overhauser Effects in a Large Protein-Ligand Complex.

G. Otting, L. Aurelio, B. Graham, 2017, Chemistry.

Pulse EPR-enabled interpretation of scarce pseudocontact shifts induced by lanthanide binding tags

G. Otting, D. Goldfarb, A. Feintuch, 2015, Journal of Biomolecular NMR.

Determination of the Complete Absolute Configuration of Petriellin A

Jason W. Dang, R. Brownlee, L. Aurelio, 2006 .

Mapping the Interactions of I2 , I(.) , I(-) , and I(+) with Alkynes and Their Roles in Iodocyclizations.

E. Krenske, L. Aurelio, B. Flynn, 2015, Chemistry.

Synthesis of Thieno‐Fused Heterocycles through Reiterative Iodocyclization

P. Scammells, L. Aurelio, B. Flynn, 2014 .

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents.

Shane M. Devine, R. Callaghan, C. Pouton, 2018, Journal of medicinal chemistry.

Scaffold-divergent synthesis of ring-fused indoles, quinolines, and quinolones via iodonium-induced reaction cascades.

P. Scammells, L. Aurelio, B. Flynn, 2013, The Journal of organic chemistry.

Synthesis of N‐Alkyl Amino Acids

L. Aurelio, A. B. Hughes, A. Hughes, 2010 .

An efficient synthesis of N-methyl amino acids by way of intermediate 5-oxazolidinones.

R. Brownlee, L. Aurelio, A. B. Hughes, 2003, The Journal of organic chemistry.

Solution structures by NMR of a novel antifungal drug: Petriellin A.

Jason W. Dang, R. Brownlee, L. Aurelio, 2006, Organic & biomolecular chemistry.

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Pierangelo Geppetti, Martin J. Scanlon, Christopher J. H. Porter, 2017, Science Translational Medicine.

From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).

L. Furic, D. Creek, S. Pitson, 2016, Journal of medicinal chemistry.

Selective Distance Measurements Using Triple Spin Labeling with Gd3+, Mn2+, and a Nitroxide.

G. Otting, D. Goldfarb, A. Feintuch, 2017, The journal of physical chemistry letters.

Protein conformation by EPR spectroscopy using gadolinium tags clicked to genetically encoded p-azido-L-phenylalanine.

G. Otting, D. Goldfarb, A. Feintuch, 2015, Chemical communications.

Pulse EPR-enabled interpretation of scarce pseudocontact shifts induced by lanthanide binding tags

G. Otting, D. Goldfarb, A. Feintuch, 2016, Journal of biomolecular NMR.

Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2009, Journal of medicinal chemistry.

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Brian L. Schmidt, Rocco Latorre, Christopher J. H. Porter, 2018, Proceedings of the National Academy of Sciences.

Synthetic preparation of N-methyl-alpha-amino acids.

R. Brownlee, L. Aurelio, A. Hughes, 2004, Chemical reviews.

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Pierangelo Geppetti, Christopher J. H. Porter, Zhijian Cai, 2017, Proceedings of the National Academy of Sciences.

Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist

Joanne Baltos, P. White, P. Sexton, 2014, Proceedings of the National Academy of Sciences.

Application of a sulfoxonium ylide electrophile to generate cathepsin X-selective activity-based probes.

M. Hoang, N. Bunnett, P. Thompson, 2020, ACS chemical biology.

A novel synthesis of N-methyl asparagine, arginine, histidine, and tryptophan.

R. Brownlee, L. Aurelio, A. Hughes, 2002, Organic letters.

Delineating the Mode of Action of Adenosine A1 Receptor Allosteric Modulators

P. White, P. Sexton, A. Christopoulos, 2010, Molecular Pharmacology.

Legumain is activated in macrophages during pancreatitis.

M. Bogyo, T. Reinheckel, P. Storz, 2016, American journal of physiology. Gastrointestinal and liver physiology.

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

S. Hill, S. Briddon, T. P. Davis, 2021, The Journal of biological chemistry.

Decomposition of protonated threonine, its stereoisomers, and its homologues in the gas phase: evidence for internal backside displacement.

Kangling Zhang, L. Aurelio, T. Morton, 2004, Organic letters.

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P. White, P. Sexton, A. Christopoulos, 2010 .

Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A(1) adenosine receptor modulation.

P. Sexton, A. Christopoulos, J. White, 2010, Journal of Medicinal Chemistry.

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

J. Baell, Zhong-Chang Wang, T. Peat, 2018, Chemistry.