W. Breuer

发表

Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulation.

A. Munnich, Z. Cabantchik, O. Kakhlon, 2010, Canadian journal of physiology and pharmacology.

Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting

M. Brandeis, T. Ravid, W. Breuer, 2013, Molecular biology of the cell.

Intracellular and extracellular labile iron pools.

Or Kakhlon, William Breuer, Z Ioav Cabantchik, 2002, Advances in experimental medicine and biology.

Labile iron in parenteral iron formulations and its potential for generating plasma nontransferrin‐bound iron in dialysis patients

I. Slotki, W. Breuer, Z. Cabantchik, 2002, European journal of clinical investigation.

of ferroportin up-regulation iron absorption mediated by down-regulation of hepcidin and -thalassemia is characterized by increased β Ineffective erythropoiesis in

Z. Cabantchik, N. Amariglio, G. Rechavi, 2013 .

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.

Yi Fang Liu, S. Rivella, N. Andrews, 2006, Blood.

On the mode of action of phlorizin as an antimalarial agent in in vitro cultures of Plasmodium falciparum.

H. Ginsburg, W. Breuer, Z. Cabantchik, 1987, Biochemical pharmacology.

ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture.

G. Link, W. Breuer, Z. Cabantchik, 2001, Blood.

Effects of a health promotion program on sustaining health behaviors in older adults.

W. Breuer, P. Fox, J. Wright, 1997, American journal of preventive medicine.

Effect of substrate structure on the activity of Man9-mannosidase from pig liver involved in N-linked oligosaccharide processing.

R. Roeser, R. Geyer, W. Breuer, 1992, European journal of biochemistry.

Redox active plasma iron in C282Y/C282Y hemochromatosis.

M. Pouchard, Z. Cabantchik, P. Brissot, 2005, Blood.

Redox active plasma iron in C 282 Y / C 282 Y hemochromatosis

M. Pouchard, P. Brissot, O. Loréal, 2005 .

Investigation of the active site of oligosaccharyltransferase from pig liver using synthetic tripeptides as tools.

W. Breuer, E. Bause, S. Peters, 1995, The Biochemical journal.

Epoxyethylglycyl peptides as inhibitors of oligosaccharyltransferase: double-labelling of the active site.

W. Breuer, E. Bause, A. Bartoschek, 1997, The Biochemical journal.

drug-mediated iron relocation Cell functions impaired by frataxin deficiency are restored by

A. Munnich, G. Cortopassi, N. Melamed-Book, 2013 .

Transport of iron and other transition metals into cells as revealed by a fluorescent probe.

I. Cabantchik, W. Breuer, S. Epsztejn, 1995, The American journal of physiology.

chelation Labile plasma iron in iron overload: redox activity and susceptibility to

I. Cabantchik, P. Pootrakul, W. Breuer, 2013 .

Serum chelatable redox-active iron is an independent predictor of mortality after myocardial infarction in individuals with diabetes.

A. Levy, D. Aronson, W. Breuer, 2004, Diabetes care.

A fluorescence-based one-step assay for serum non-transferrin-bound iron.

W. Breuer, Z. Cabantchik, 2001, Analytical biochemistry.

The importance of non-transferrin bound iron in disorders of iron metabolism.

W. Breuer, Z. Cabantchik, C. Hershko, 2000, Transfusion science.

Chelation and mobilization of cellular iron by different classes of chelators.

P. Milgram, J. Libman, A. Shanzer, 1997, Molecular pharmacology.

The role of endocytic pathways in cellular uptake of plasma non-transferrin iron

Y. Sohn, G. Weiss, W. Breuer, 2012, Haematologica.

Identification of endogenous binding proteins for the lectin discoidin-I in Dictyostelium discoideum.

W. Breuer, C. Siu, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Non–Transferrin-Bound Iron and Risk of Coronary Heart Disease in Postmenopausal Women

D. van der A, D. Grobbee, Y. T. van der Schouw, 2006, Circulation.

Oligosaccharyltransferase is highly specific for the hydroxy amino acid in Asn‐Xaa‐Thr/Ser

R. A. Klein, W. Breuer, R. Klein, 2001, FEBS letters.

Iron Acquired from Transferrin by K562 Cells Is Delivered into a Cytoplasmic Pool of Chelatable Iron(II) (*)

Z. Cabantchik, W. Breuer, Z. Cabantchik, 1995, The Journal of Biological Chemistry.

Flow cytometric quantification and characterization of intracellular protein aggregates in yeast

T. Ravid, W. Breuer, A. Shiber, 2014, Prion.

Characterization of chloride channels in membrane vesicles from the kidney outer medulla

W. Breuer, 2005, The Journal of Membrane Biology.

LPI-labile plasma iron in iron overload.

Z. Cabantchik, P. Cianciulli, W. Breuer, 2005, Best practice & research. Clinical haematology.

Newly delivered transferrin iron and oxidative cell injury

E. Greenberg, W. Breuer, Z. Cabantchik, 1997, FEBS letters.

therapeutic implications Redistribution of accumulated cell iron: a modality of chelation with

A. Munnich, Y. Sohn, W. Breuer, 2013 .

Exploring the "iron shuttle" hypothesis in chelation therapy: effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture.

G. Link, W. Breuer, Z. Cabantchik, 2001, The Journal of laboratory and clinical medicine.

EspH interacts with the host active Bcr related (ABR) protein to suppress RhoGTPases

D. Reichmann, T. Danieli, W. Breuer, 2022, Gut microbes.

Dynamics of the cytosolic chelatable iron pool of K562 cells

W. Breuer, S. Epsztejn, Z. Ioav Cabantchik, 1996, FEBS letters.

Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia/HbE patients treated with an oral chelator.

Z. Cabantchik, M. Sametband, P. Pootrakul, 2004, Blood.

Daily labile plasma iron as an indicator of chelator activity in Thalassaemia major patients

G. Zanninelli, W. Breuer, Z. Cabantchik, 2009, British journal of haematology.

A fluorescence assay for assessing chelation of intracellular iron in a membrane model system and in mammalian cells.

P. Milgram, W. Breuer, Z. Cabantchik, 1996, Analytical biochemistry.

Down Regulation of Hepcidin and Haemojuvelin Expression in the Hepatocyte Cell-Line HepG2 Induced by Thalassaemic Sera.

S. Rivella, K. Adamsky, N. Amariglio, 2006 .

The assessment of serum nontransferrin-bound iron in chelation therapy and iron supplementation.

Z. Cabantchik, I. Slotki, W. Breuer, 2000, Blood.

oral chelator -thalassemia/HbE patients treated with an β activity in iron-overloaded Labile plasma iron (LPI) as an indicator of chelatable plasma redox

I. Cabantchik, M. Sametband, P. Pootrakul, 2013 .

Synthesis of tritiated 4,4′-diisothiocyano-2,2′-stilbene disulfonic acid ([3H]DIDS) and its covalent reaction with sites related to anion transport in human red blood cells

W. Breuer, A. Rothstein, S. Ship, 1977, The Journal of Membrane Biology.

The molecular and cellular basis of iron toxicity in Iron Overload (IO) disorders. Diagnostic and therapeutic approaches

Y. Sohn, W. Breuer, Z. Cabantchik, 2013 .

Non‐transferrin bound iron in Thalassemia: Differential detection of redox active forms in children and older patients

Z. Cabantchik, W. Breuer, E. Rachmilewitz, 2012, American journal of hematology.

Non-transferrin-bound serum iron (NTBI) in megaloblastic anemia: effect of vitamin B(12) treatment.

I. Cabantchik, A. Gafter-Gvili, M. Prokocimer, 2004, The hematology journal : the official journal of the European Haematology Association.

Increased Non-Transferrin-Bound Serum Iron in Megaloblastic Anaemia

I. Cabantchik, A. Gafter-Gvili, W. Breuer, 2002, Acta Haematologica.

Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences.

G. Link, W. Breuer, Z. Cabantchik, 2006, Blood.

Effects of Combined Chelation Treatment with Pyridoxal Isonicotinoyl Hydrazone (PIH) Analogs and Deferoxamine in Hypertransfused Rats and in Iron-Loaded Rat Heart Cells Running Head: Combined PIH analog and DFO Chelation Treatment Heading: Red Cells

G. Link, P. Ponka, W. Breuer, 2017 .

iron-loaded rat heart cells hydrazone analogs and deferoxamine in hypertransfused rats and in Effects of combined chelation treatment with pyridoxal isonicotinoyl

P. Ponka, W. Breuer, Z. Cabantchik, 2013 .

Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells.

Z. Cabantchik, G. Link, P. Ponka, 2003, Blood.

Activation of K+ and Cl− channels by Ca2+ and cyclic AMP in dissociated kidney epithelial (MDCK) cells

W. Breuer, A. Rothstein, E. Mack, 1988, Pflügers Archiv.

Pyridoxal phosphate. An anionic probe for protein amino groups exposed on the outer and inner surfaces of intact human red blood cells.

I. Cabantchik, W. Breuer, A. Rothstein, 1975, The Journal of biological chemistry.

A comparison of intact human red blood cells and resealed and leaky ghosts with respect to their interactions with surface labelling agents and proteolytic enzymes.

W. Breuer, A. Rothstein, Z. Cabantchik, 1975, Biochimica et biophysica acta.

Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation.

Or Kakhlon, Hila Manning, William Breuer, 2008, Blood.

Differential cytotoxicity of iron chelators on malaria-infected cells versus mammalian cells.

A. Shanzer, Z. Cabantchik, W. Breuer, 1996, Blood.

versus mammalian cells Differential cytotoxicity of iron chelators on malaria-infected cells

A. Shanzer, Z. Cabantchik, W. Breuer, 2011 .

labile iron and functional consequences Action of chelators in iron-loaded cardiac cells : accessibility to intracellular

G. Link, W. Breuer, Z. Cabantchik, 2006 .

A review of fluorescence methods for assessing labile iron in cells and biological fluids.

W. Breuer, Z. Cabantchik, S. Epsztejn, 2002, Analytical biochemistry.

Labile plasma iron in iron overload: redox activity and susceptibility to chelation.

Z. Cabantchik, P. Pootrakul, W. Breuer, 2003, Blood.

How the malaria parasite invades its host cell, the erythrocyte.

W. Breuer, 1985, International review of cytology.

Results of an international round robin for the quantification of serum non-transferrin-bound iron: Need for defining standardization and a clinically relevant isoform.

D. Swinkels, J. Hendriks, R. Hider, 2005, Analytical biochemistry.

Asymmetry of the red cell anion exchange system. Different mechanisms of reversible inhibition by N-(4-azido-2-nitrophenyl)-2- aminoethylsulfonate (NAP-taurine) at the inside and outside of the membrane

W. Breuer, L. McCulloch, P. Knauf, 1978, The Journal of general physiology.

The interaction of an anionic photoreactive probe with the anion transport system of the human red blood cell.

W. Breuer, P. Knauf, A. Rothstein, 1976, Biochimica et biophysica acta.

N-(4-azido-2-nitrophenyl)-2-aminoethylsulfonate (NAP-taurine) as a photoaffinity probe for identifying membrane components containing the modifier site of the human red blood cell anion exchange system

W. Breuer, L. McCulloch, P. Knauf, 1978, The Journal of general physiology.

Transferrin therapy ameliorates disease in β-thalassemic mice

Charles B. Hall, Z. Cabantchik, E. Bouhassira, 2010, Nature Medicine.

Characterization of permeation pathways in the plasma membrane of human erythrocytes infected with early stages of Plasmodium falciparum: Association with parasite development

W. Breuer, Z. Cabantchik, S. Aley, 1985, Journal of cellular physiology.

Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell‐line HepG2 induced by thalassaemic sera

S. Rivella, K. Adamsky, N. Amariglio, 2006, British journal of haematology.

Fluorescence analysis of the labile iron pool of mammalian cells.

I. Cabantchik, O. Kakhlon, W. Breuer, 1997, Analytical biochemistry.

Role of internal domains of glycophorin in Plasmodium falciparum invasion of human erythrocytes

H. Ginsburg, W. Breuer, Z. Cabantchik, 1983, Infection and immunity.

An assay of malaria parasite invasion into human erythrocytes. The effects of chemical and enzymatic modification of erythrocyte membrane components.

H. Ginsburg, W. Breuer, Z. Cabantchik, 1983, Biochimica et biophysica acta.

H-ferritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance properties.

C. Beaumont, I. Slotki, W. Breuer, 1999, Blood.

Design and applications of methods for fluorescence detection of iron in biological systems.

W. Breuer, Z. Cabantchik, B. Espósito, 2001, Biochemical Society transactions.

Desferrioxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy.

Z. Cabantchik, P. Pootrakul, W. Breuer, 2001, Blood.

Exogenous iron increases hemoglobin in beta-thalassemic mice.

Charles B. Hall, R. Nagel, Z. Cabantchik, 2009, Experimental hematology.

Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown of surface polarity

A. Weiss, D. Reichmann, L. Lapierre, 2019, PLoS pathogens.

Long-term cAMP activation of Na(+)-K(+)-2Cl- cotransporter activity in HT-29 human adenocarcinoma cells.

R. Greger, I. Slotki, W. Breuer, 1993, The American journal of physiology.

Induction of multidrug resistance downregulates the expression of CFTR in colon epithelial cells.

D. Ausiello, I. Cabantchik, I. Slotki, 1993, The American journal of physiology.

Hepcidin Expression in Cultured Liver Cells Responds Differently to Iron Overloaded Sera Derived from Patients with Thalassemia and Hemochromatosis.

S. Rivella, K. Adamsky, N. Amariglio, 2004 .

Inhibition of prostaglandin E2 synthesis by a blocker of epithelial chloride channels.

K. Skorecki, W. Breuer, 1989, Biochemical and Biophysical Research Communications - BBRC.

Vasoconstrictor hormones depolarize renal glomerular mesangial cells by activating chloride channels

K. Skorecki, W. Breuer, Sidney G. Kremer, 1989, Journal of cellular physiology.

Induction of expression of the cystic fibrosis transmembrane conductance regulator.

J. Riordan, W. Breuer, Z. Cabantchik, 1992, The Journal of biological chemistry.

Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications.

A. Munnich, Y. Sohn, W. Breuer, 2008, Blood.

Intracellular labile iron.

Maya Shvartsman, W. Breuer, Z. Cabantchik, 2008, The international journal of biochemistry & cell biology.

Rescuing iron‐overloaded macrophages by conservative relocation of the accumulated metal

Y. Sohn, G. Weiss, W. Breuer, 2011, British journal of pharmacology.

Reconstitution of a kidney chloride channel and its identification by covalent labeling.

W. Breuer, 1990, Biochimica et biophysica acta.

Covalent modification of the permeability pathways induced in the human erythrocyte membrane by the malarial parasite Plasmodium falciparum

H. Ginsburg, Z. Cabantchik, W. Breuer, 1987, Journal of cellular physiology.

Temporal profiling of redox-dependent heterogeneity in single cells

N. Friedman, M. Schuldiner, D. Reichmann, 2017, bioRxiv.

Processing of N-linked carbohydrate chains in a patient with glucosidase I deficiency (CDG type IIb).

W. Breuer, R. Van Coster, E. Bause, 2002, Glycobiology.

Oligosaccharyl transferase is a constitutive component of an oligomeric protein complex from pig liver endoplasmic reticulum.

W. Breuer, E. Bause, 1995, European journal of biochemistry.

Stress Response and Induces Multidrug Resistance Properties H-Ferritin Subunit Overexpression in Erythroid Cells Reduces the Oxidative

C. Beaumont, I. Slotki, W. Breuer, 1999 .

Hydrophobic interactions in Plasmodium falciparum invasion into human erythrocytes.

H. Ginsburg, W. Breuer, Z. Cabantchik, 1984, Molecular and biochemical parasitology.

RoleofInternal Domains ofGlycophorin inPlasmodium falciparum Invasion ofHumanErythrocytes

H. Ginsburg, I. Cabantchik, W. Breuer, 1983 .

Objectives and Methods of Iron Chelation Therapy

I. Cabantchik, P. Pootrakul, W. Breuer, 2003, Bioinorganic chemistry and applications.

Flow cytometric quantification and characterization of intracellular protein aggregates in yeast

T. Ravid, W. Breuer, A. Shiber, 2014, Prion.