R. Leatherbarrow

发表

Comparing experimental and computational alanine scanning techniques for probing a prototypical protein-protein interaction.

Richard T. Bradshaw, I. Gould, E. Tate, 2011, Protein engineering, design & selection : PEDS.

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

Edward W. Tate, A. Holder, A. Wilkinson, 2012, PLoS neglected tropical diseases.

Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs?

S. Curry, R. Leatherbarrow, P. Zunszain, 2007, Biochemical Society transactions.

Analysis of Protein–Protein Interactions by Using Droplet‐Based Microfluidics

Jongin Hong, Soo-Ik Chang, Monpichar Srisa-Art, 2009, Chembiochem : a European journal of chemical biology.

Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease.

S. Curry, R. Leatherbarrow, P. Zunszain, 2014, Bioorganic & medicinal chemistry letters.

Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate

S. Curry, G. Belsham, R. Leatherbarrow, 2009, Journal of Molecular Biology.

Ligand loading at the surface of an optical biosensor and its effect upon the kinetics of protein–protein interactions

P. R. Edwards, P. Lowe, P. Edwards, 1997, Journal of molecular recognition : JMR.

Analysis of calibration methodologies for solvent effects in drug discovery studies using evanescent wave biosensors.

N. Karp, P. Edwards, R. Leatherbarrow, 2005, Biosensors & bioelectronics.

The role of threonine in the P2 position of Bowman-Birk proteinase inhibitors: studies on P2 variation in cyclic peptides encompassing the reactive site loop.

R. Leatherbarrow, J. McBride, A. Brauer, 1998, Journal of molecular biology.

GraFit User's Guide

R. Leatherbarrow, 1998 .

Diversification of the IgG molecule by oligosaccharides.

R. Dwek, T. Rademacher, P. Rudd, 1991, Molecular immunology.

Binding of complement subcomponent C1q to mouse IgG1, IgG2a and IgG2b: a novel C1q binding assay.

R. Dwek, R. Leatherbarrow, 1984, Molecular immunology.

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

Edward W. Tate, A. Wilkinson, J. Brannigan, 2014, IUCrJ.

A tri-functional vanadium(iv) complex to detect cysteine oxidation.

R. Woscholski, Marina Fedorova, R. Vilar, 2017, Dalton transactions.

N-Myristoyl transferase-mediated protein labelling in vivo.

Edward W. Tate, E. Tate, R. Leatherbarrow, 2008, Organic & biomolecular chemistry.

Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution.

A. Beavil, B. Sutton, F. Saab, 2011, Organic & biomolecular chemistry.

The effect of aglycosylation on the binding of mouse IgG to staphylococcal protein A

R. Dwek, R. Leatherbarrow, Raymond A. Dwek, 1983, FEBS letters.

Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes

Edward W. Tate, Deborah F. Smith, E. Tate, 2014, PLoS neglected tropical diseases.

Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation.

R. Woscholski, E. Tate, P. Gaffney, 2008, Chemical communications.

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

E. Tate, R. Leatherbarrow, N. Roqué-Rosell, 2008, Organic & biomolecular chemistry.

Immobilized Protease‐Assisted Synthesis of Engineered Cysteine‐Knot Microproteins

Edward W. Tate, E. Tate, R. Leatherbarrow, 2007, Chembiochem : a European journal of chemical biology.

Analysis of kinetic data of antibody-antigen interaction from an optical biosensor by exponential curve fitting.

M. Hoare, D. Pollard-Knight, R. Leatherbarrow, 1996, Journal of biotechnology.

ENHANCED PROSPECTS FOR FMDV ANTI-VIRALS TARGETED TO THE 3C PROTEASE

S. Curry, R. Leatherbarrow, P. Zunszain, 2008 .

Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease

P. Brick, S. Curry, R. Leatherbarrow, 2005, Journal of Biological Chemistry.

Use of nonlinear regression to analyze enzyme kinetic data: application to situations of substrate contamination and background subtraction.

R. Leatherbarrow, 1990, Analytical biochemistry.

Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides: creation of a new tri-functional inhibitor.

R. Leatherbarrow, J. McBride, D. Scarpi, 2004, Bioorganic & medicinal chemistry.

Studies on the mechanism of binding of serum albumins to immobilized cibacron blue F3G A.

R. Leatherbarrow, P. Dean, 1980, The Biochemical journal.

Metal ion dependence of phosphorothioate ATP analogues in the Bacillus stearothermophilus tyrosyl-tRNA synthetase reaction.

A. Fersht, F. Eckstein, R. Leatherbarrow, 1990, Biochemistry.

Peptide mimics of the Bowman-Birk inhibitor reactive site loop.

R. Leatherbarrow, A. Jaulent, J. McBride, 2002, Biopolymers.

Synthetic peptide mimics of the Bowman-Birk inhibitor protein.

R. Leatherbarrow, J. McBride, 2001, Current Medicinal Chemistry.

The role of the P2' position of Bowman-Birk proteinase inhibitor in the inhibition of trypsin. Studies on P2' variation in cyclic peptides encompassing the reactive site loop.

R. Leatherbarrow, J. McBride, T. Gariani, 1999, Biochimica et biophysica acta.

Foot-and-mouth disease virus 3C protease: Recent structural and functional insights into an antiviral target

S. Curry, R. Leatherbarrow, P. Zunszain, 2006, The International Journal of Biochemistry & Cell Biology.

Synthesis and incorporation into cyclic peptides of tolan amino acids and their hydrogenated congeners: construction of an array of A-B-loop mimetics of the Cε3 domain of human IgE.

A. Beavil, B. Sutton, B. Helm, 2012, The Journal of organic chemistry.

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase

Edward W. Tate, A. Holder, A. Wilkinson, 2012, Journal of medicinal chemistry.

Enantioselective synthesis of (+)-aspercyclide A

A. Beavil, R. Leatherbarrow, A. Spivey, 2013 .

Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether.

A. Beavil, B. Sutton, A. White, 2010, Chemical communications.

Introduction of the new dipeptide isostere 7-endo-BtA as reverse turn inducer in a Bowman-Birk proteinase inhibitor: synthesis and conformational analysis.

R. Leatherbarrow, A. Trabocchi, A. Guarna, 2001, Bioorganic & medicinal chemistry.

Synthesis and bio-assay of RCM-derived Bowman-Birk inhibitor analogues.

S. Marsden, R. Leatherbarrow, W. J. Coates, 2004, Organic & biomolecular chemistry.

Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.

A. Holder, A. Wilkinson, A. Brzozowski, 2012, Journal of medicinal chemistry.

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase

A. Wilkinson, J. Brannigan, E. Tate, 2016, MedChemComm.

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.

Edward W. Tate, M. Grainger, A. Holder, 2014, Nature chemistry.

Structural and Mutagenic Analysis of Foot-and-Mouth Disease Virus 3C Protease Reveals the Role of the β-Ribbon in Proteolysis

S. Curry, R. Leatherbarrow, J. Birtley, 2006, Journal of Virology.

Using linear and non-linear regression to fit biochemical data.

R. Leatherbarrow, 1990, Trends in biochemical sciences.

Mouse + micro = molecular model: Alchemy™ Molecular modelling software for the IBM (PC, AT, XT or compatible) Tripos Associates Inc., 1986. US$750 commercial/$450 educational users

Robin J. Leatherbarrow, R. Leatherbarrow, 1988 .

Bovine dopamine beta-hydroxylase, primary structure determined by cDNA cloning and amino acid sequencing.

R J Leatherbarrow, C. Southan, R. Leatherbarrow, 1990, Biochemistry.

Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry.

Edward W. Tate, A. Holder, Deborah F. Smith, 2008, Chemical communications.

Structural studies on DNP binding antibodies

R. Leatherbarrow, 1983 .

Effector functions of a monoclonal aglycosylated mouse IgG2a: binding and activation of complement component C1 and interaction with human monocyte Fc receptor.

D R Burton, R J Leatherbarrow, A. Feinstein, 1985, Molecular immunology.

Expression and kinetic characterization of barley chymotrypsin inhibitors 1a and 1b.

R. Leatherbarrow, A. Brauer, M. A. Greagg, 1994, Biochimica et biophysica acta.

Identification of chymotrypsin inhibitors from a second‐generation template assisted combinatorial peptide library

H. N. Freeman, R. Leatherbarrow, J. McBride, 2000, Journal of peptide science : an official publication of the European Peptide Society.

Selection of human elastase inhibitors from a conformationally constrained combinatorial peptide library.

H. N. Freeman, R. Leatherbarrow, J. McBride, 1999, European journal of biochemistry.

The 1H-NMR Solution Structure of the Antitryptic Core Peptide of Bowman-Birk Inhibitor Proteins: A Minimal ‘Canonical Loop’

S. Matthews, R. Leatherbarrow, G. Kelly, 2002, Journal of biomolecular structure & dynamics.

Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds.

S. Matthews, R. Leatherbarrow, G. Kelly, 2007, Bioorganic & medicinal chemistry.

A Two-step Mechanism for the Folding of Actin by the Yeast Cytosolic Chaperonin

K. Willison, R. Leatherbarrow, Sarah F. Stuart, 2010, The Journal of Biological Chemistry.

N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

Edward W. Tate, A. Wilkinson, A. Brzozowski, 2010, Journal of molecular biology.

Synchronized optical and electronic detection of biomolecules using a low noise nanopore platform.

William H. Pitchford, Ki-Bum Kim, A. Ivanov, 2015, ACS nano.

Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering.

A. Fersht, G. Winter, R. Leatherbarrow, 1985, Proceedings of the National Academy of Sciences of the United States of America.

The use of osmolytes to facilitate protein NMR spectroscopy

S. Matthews, R. Leatherbarrow, 1993 .

Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II.

Edward W. Tate, E. Tate, R. Leatherbarrow, 2006, Chemical communications.

N‐Myristoyltransferase: a Prospective Drug Target for Protozoan Parasites

A. Holder, K. Brown, Deborah F. Smith, 2008, ChemMedChem.

Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major.

K. Brown, Deborah F. Smith, R. Leatherbarrow, 2006, The Biochemical journal.

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

S. Johnston, A. Wilkinson, J. Brannigan, 2018, Nature Chemistry.

A combined proton and phosphorus-31 nuclear magnetic resonance investigation of the combining site of M603, a phosphocholine-binding myeloma protein.

R. Dwek, R. Leatherbarrow, P. Gettins, 1982, Biochemistry.

Structure of immunoglobulin G by scanning tunnelling microscopy.

R. Leatherbarrow, T. Wells, M. Stedman, 1991, Journal of molecular biology.

On to the second generation

Robin J. Leatherbarrow, R. Leatherbarrow, 1990, Nature.

13C NMR study of the effects of mutation on the tryptophan dynamics in chymotrypsin inhibitor 2: correlations with structure and stability.

S. Matthews, R. Leatherbarrow, S. K. Jandu, 1993, Biochemistry.

Carbon‐13 nuclear magnetic resonance relaxation study of chymotrypsin inhibitor 2 (CI‐2)

S. Matthews, R. Leatherbarrow, 1992 .

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes

Edward W. Tate, M. Wright, A. Wilkinson, 2020, Journal of medicinal chemistry.

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)

Edward W. Tate, S. Meister, A. Holder, 2014, Journal of medicinal chemistry.

Structure-Based Design of Potent and Selective LeishmaniaN-Myristoyltransferase Inhibitors

Edward W. Tate, Robin J. Leatherbarrow, Anthony J. Wilkinson, 2014, Journal of medicinal chemistry.

A fluorescence-based assay for N-myristoyltransferase activity.

Emmanuelle Thinon, A. Wilkinson, J. Brannigan, 2012, Analytical biochemistry.

The Bowman-Birk inhibitor reactive site loop sequence represents an independent structural beta-hairpin motif.

S. Matthews, R. Cooke, R. Leatherbarrow, 2001, Journal of molecular biology.

Binding energy and catalysis: a lesson from protein engineering of the tyrosyl-tRNA synthetase

Alan R. Fersht, Robin J. Leatherbarrow, Timothy N. C. Wells, 1986 .

THE STUDY AND REDESIGN OF ENZYMES BY PROTEIN ENGINEERING

A. Fersht, R. Leatherbarrow, T. Wells, 1986 .

Solution Structure of a Novel C2-Symmetrical Bifunctional Bicyclic Inhibitor Based on SFTI-1

S. Matthews, R. Leatherbarrow, A. Jaulent, 2005, Journal of biomolecular NMR.

The conserved P1' Ser of Bowman-Birk-type proteinase inhibitors is not essential for the integrity of the reactive site loop.

R. Leatherbarrow, A. Brauer, 2003, Biochemical and biophysical research communications.

The Structural Basis of a Conserved P2 Threonine in Canonical Serine Proteinase Inhibitors

R. Leatherbarrow, J. McBride, A. Brauer, 2003, Journal of biomolecular structure & dynamics.

Inhibition of human β-tryptase by Bowman–Birk inhibitor derived peptides

R. Leatherbarrow, J. McBride, D. Scarpi, 2002 .

Selection of chymotrypsin inhibitors from a conformationally-constrained combinatorial peptide library.

R J Leatherbarrow, R. Leatherbarrow, J D McBride, 1996, Journal of molecular biology.

Role of arginine 67 in the stabilization of chymotrypsin inhibitor 2: examination of amide proton exchange rates and denaturation thermodynamics of an engineered protein.

R J Leatherbarrow, R. Leatherbarrow, L. Brooks, 1990, Biochemistry.

A conserved cis peptide bond is necessary for the activity of Bowman-Birk inhibitor protein.

Robert M Cooke, S. Matthews, R. Cooke, 2002, Biochemistry.

Stability of protease inhibitors based on the Bowman-Birk reactive site loop to hydrolysis by proteases.

R. Leatherbarrow, T. Gariani, 2009, The journal of peptide research : official journal of the American Peptide Society.

Synthesis of a mixture of cyclic peptides based on the Bowman-Birk reactive site loop to screen for serine protease inhibitors.

S. Patel, M. Weir, R. Leatherbarrow, 2009, International journal of peptide and protein research.

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold.

E. Tate, R. Leatherbarrow, Camille Bonomelli, 2009, Journal of medicinal chemistry.

Design of a small peptide-based proteinase inhibitor by modeling the active-site region of barley chymotrypsin inhibitor 2.

R. Leatherbarrow, H. Salacinski, 1991, Biochemistry.

Design, synthesis and analysis of novel bicyclic and bifunctional protease inhibitors.

R. Leatherbarrow, A. Jaulent, 2004, Protein engineering, design & selection : PEDS.

Peptide‐based inhibitors of N‐myristoyl transferase generated from a lipid/combinatorial peptide chimera library

A. Holder, K. Brown, Deborah F. Smith, 2006 .

Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships.

R J Leatherbarrow, A. Fersht, R. Leatherbarrow, 1987, Biochemistry.

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

M. Grainger, A. Holder, K. Brown, 2007, The Biochemical journal.

Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.

Edward W. Tate, A. Holder, A. Wilkinson, 2012, Journal of medicinal chemistry.

A study of the specificity of barley chymotrypsin inhibitor 2 by cysteine engineering of the P1 residue.

R. Leatherbarrow, Z. Hasan, 1998, Biochimica et biophysica acta.

Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II

Edward W. Tate, V. Ellis, T. Bugge, 2014, Thrombosis and Haemostasis.

Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors Structure-Based of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors.

M. Wright, A. Wilkinson, J. Brannigan, 2018 .

Structure and activity of the tyrosy1-tRNA synthetase: the hydrogen bond in catalysis and specificity

Alan R. Fersht, Robin J. Leatherbarrow, Timothy N. C. Wells, 1986, Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences.

Organic Solvent Nanofiltration: A New Paradigm in Peptide Synthesis

Andrew G. Livingston, Edward W. Tate, Robin J. Leatherbarrow, 2010 .

Membrane enhanced peptide synthesis.

A. Livingston, E. Tate, R. Leatherbarrow, 2010, Chemical communications.

Reagent-controlled stereoselective synthesis of lignan-related tetrahydrofurans.

S. Marsden, R. Leatherbarrow, Stephen P Marsden, 2004, The Journal of organic chemistry.

Analysis of molecular recognition using optical biosensors.

R J Leatherbarrow, P. Edwards, R. Leatherbarrow, 1999, Current opinion in chemical biology.

Investigation of transition-state stabilization by residues histidine-45 and threonine-40 in the tyrosyl-tRNA synthetase.

A. Fersht, R. Leatherbarrow, 1987, Biochemistry.

Kinetics of protein-protein interactions at the surface of an optical biosensor.

R J Leatherbarrow, A Gill, M. Hoare, 1995, Analytical biochemistry.

A novel, stereoselective and convergent synthesis of aryltetralins.

S. Marsden, R. Leatherbarrow, W. J. Coates, 2004, Chemical communications.

Cover Picture: Analysis of Protein–Protein Interactions by Using Droplet‐Based Microfluidics (ChemBioChem 10/2009)

A. deMello, J. Edel, M. Srisa-Art, 2009 .

Synthesis and Activity of a Small Cyclic Protease Inhibitor from Sunflower Seeds, SFTI-1

R. Leatherbarrow, A. Jaulent, J. McBride, 2001 .

Second-order kinetic analysis of IAsys biosensor data: its use and applicability.

R J Leatherbarrow, D. Winzor, P. Edwards, 1998, Analytical biochemistry.

Development of small molecules to target the IgE:FcεRI protein-protein interaction in allergies.

R. Leatherbarrow, A. Spivey, Lucy D. Smith, 2013, Future medicinal chemistry.

Quantitative analysis of structure–activity relationships in engineered proteins by linear free-energy relationships

Alan R. Fersht, Robin J. Leatherbarrow, A. Fersht, 1986, Nature.

A continuous assay for foot-and-mouth disease virus 3C protease activity.

S. Curry, R. Leatherbarrow, J. Birtley, 2007, Analytical biochemistry.

Mutational Locally Enhanced Sampling (MULES) for quantitative prediction of the effects of mutations at protein–protein interfaces

Ian R. Gould, Richard T. Bradshaw, Pietro G. A. Aronica, 2012 .

Effect of osmolytes on the exchange rates of backbone amide protons in proteins.

R. Leatherbarrow, R. Foord, 1998, Biochemistry.

Vanadyl complexes with dansyl-labelled di-picolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies.

R. Woscholski, Marina Fedorova, R. Vilar, 2016, Dalton transactions.

The Parasol Protocol for computational mutagenesis.

P G A Aronica, C Verma, B Popovic, 2016, Protein engineering, design & selection : PEDS.

title : The Parasol Protocol for computational mutagenesis First Author :

R. Leatherbarrow, Corr, P. Aronica, 2016 .

Total Synthesis of (.+-.)-Aspercyclide A and Its C19 Methyl Ether.

A. Beavil, B. Sutton, R. Leatherbarrow, 2010 .

Antibody specificity: a 270-MHz hydrogen-1 nuclear magnetic resonance study of the binding of dinitrophenyl compounds to the VL dimer of protein 315.

R. Dwek, M. Gavish, D. Givol, 1981, Biochemistry.

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

Edward W. Tate, A. Wilkinson, J. Brannigan, 2015, MedChemComm.

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

Edward W. Tate, A. Wilkinson, J. Brannigan, 2014, Organic & biomolecular chemistry.

N‐Myristoyltransferase: a Prospective Drug Target for Protozoan Parasites

A. Holder, K. Brown, Deborah F. Smith, 2008, ChemMedChem.

Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.

Edward W. Tate, A. Holder, A. Wilkinson, 2012, Journal of medicinal chemistry.

Determination of association rate constants by an optical biosensor using initial rate analysis.

P. Edwards, R. Leatherbarrow, 1997, Analytical biochemistry.

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

Edward W. Tate, R. Leatherbarrow, P. Thongyoo, 2008, Organic & biomolecular chemistry.

Comparing experimental and computational alanine scanning techniques for probing a prototypical protein-protein interaction.

Richard T. Bradshaw, Edward W. Tate, I. Gould, 2011, Protein engineering, design & selection : PEDS.