J. Tilley

发表

Identification of a Small Molecule Inhibitor of the IL-2/IL-2Rα Receptor Interaction Which Binds to IL-2

G. Powers, D. Fry, L. Chen, 1997 .

Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1.

Y. Li, N. Fotouhi, Romyr Dominique, 2010, Journal of medicinal chemistry.

A convenient palladium-catalyzed coupling approach to 2,5-disubstituted pyridines

J. Tilley, S. Zawoiski, 1988 .

Potent, selective MCH-1 receptor antagonists.

S. Berthel, S. Mischke, Y. Qian, 2008, Bioorganic & medicinal chemistry letters.

Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs.

S. So, Y. Qian, Yonglin Ren, 2013, Bioorganic & medicinal chemistry letters.

1 Aminoadamantane Derivatives

J. Tilley, M. J. Kramer, 1981 .

Focused library approach for identification of new N-acylphenylalanines as VCAM/VLA-4 antagonists.

R. Campbell, D. Fry, L. Chen, 2002, Bioorganic & medicinal chemistry letters.

VLA-4 antagonists

J. Tilley, 2002 .

N-benzylpyroglutamyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists.

J. Tilley, R. Trilles, R. Guthrie, 2000, Bioorganic & medicinal chemistry letters.

N-Aroyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists.

R. Campbell, L. Chen, A. Sidduri, 2002, Bioorganic & medicinal chemistry letters.

CCK satiety is differentially mediated by high- and low-affinity CCK receptors in mice and rats.

G. Schwartz, T. Moran, J. Tilley, 1993, The American journal of physiology.

Recent Advances in Therapeutic Approaches to Type 2 Diabetes

J. Tilley, R. Sarabu, 2004 .

Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.

C. Rondinone, Yingsi Chen, Y. Qian, 2011, Journal of medicinal chemistry.

Novel glucokinase activators: a patent review (2008 – 2010)

S. Berthel, J. Tilley, R. Kester, 2011, Expert opinion on therapeutic patents.

Chapter 20. The Pharmacological Treatment of Obesity

J. Tilley, S. Hogan, J. Triscari, 1988 .

Antagonists of slow-reacting substance of anaphylaxis. 1. Pyrido[2,1-b]quinazolinecarboxylic acid derivatives.

J. Tilley, A. Welton, H. Crowley, 1983, Journal of medicinal chemistry.

N-acyl-L-phenylalanine derivatives as potent VLA-4 antagonists that mimic a cyclic peptide conformation.

R. Campbell, D. Fry, L. Chen, 2002, Bioorganic & medicinal chemistry letters.

The discovery of VLA-4 antagonists.

N. Fotouhi, L. Chen, A. Sidduri, 2004, Current topics in medicinal chemistry.

Imide and lactam derivatives of N-benzylpyroglutamyl-L-phenylalanine as VCAM/VLA-4 antagonists.

J. Tilley, G. Kaplan, B. Wolitzky, 2001, Bioorganic & medicinal chemistry letters.

N-acyl phenylalanine analogues as potent small molecule VLA-4 antagonists.

K. Luk, J. Tilley, R. Trilles, 2000, Bioorganic & medicinal chemistry letters.

Identification of N-acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives and their orally active prodrug esters as dual-acting alpha4-beta1 and alpha4-beta7 receptor antagonists.

A. Railkar, A. Sidduri, J. Lou, 2013, Bioorganic & medicinal chemistry letters.

Identification of N-acyl 4-(3-pyridonyl)phenylalanine derivatives and their orally active prodrug esters as dual acting α4β1 and α4β7 receptor antagonists.

A. Railkar, A. Sidduri, J. Lou, 2013, Bioorganic & medicinal chemistry letters.

The Securitisation of Catastrophic Property Risks

J. Tilley, 1998 .

Structure activity of C-terminal modified analogs of Ac-CCK-7.

J. Tilley, W. Danho, J. Swistok, 2009, International journal of peptide and protein research.

N-Aroyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists.

R. Campbell, L. Chen, A. Sidduri, 2002, Bioorganic & medicinal chemistry letters.

Antihypertensive (2-aminoethyl)thiourea derivatives. 2.

J. Tilley, H. Ramuz, F. Hefti, 1980, Journal of medicinal chemistry.

Carboxylic acids and tetrazoles as isosteric replacements for sulfate in cholecystokinin analogues.

J. Tilley, W. Danho, J. Swistok, 1991, Journal of medicinal chemistry.

Preparation of carboalkoxyalkylphenylalanine derivatives from tyrosine

J. Tilley, R. Wagner, R. Sarabu, 1990 .

Palladium-catalyzed carbonyl insertion route to pyrido[2-1-b]quinazoline derivatives

J. Tilley, D. L. Coffen, B. Schaer, 1987 .

Practical, catalytic synthesis of anthranilic acids

J. Tilley, R. LeMahieu, D. Valentine, 1981 .

Prodrugs of Benzamidines

J. Tilley, 2007 .

Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists.

J. Tilley, S. Zawoiski, T. Mowles, 1988, Journal of medicinal chemistry.

Miscellaneous Functional Groups

J. Tilley, N. Shimma, 2007 .

Asymmetric synthesis of a novel phenylogous amino acid mimicking an extended dipeptide

J. Tilley, R. Trilles, Lijing Chen, 1995 .

The design and synthesis of potent cyclic peptide VCAM-VLA-4 antagonists incorporating an achiral Asp-Pro mimetic.

N. Fotouhi, D. Fry, J. Tilley, 2000, Bioorganic & medicinal chemistry letters.

Pyrido[2,1-b]quinazolinecarboxylic acids as orally active antiallergy agents.

J. Tilley, R. LeMahieu, M. Carson, 1980, Journal of medicinal chemistry.

Antihypertensive (2-aminoethyl)thiourea derivatives. 1.

J. Tilley, R. W. Kierstead, M. Cohen, 1980, Journal of medicinal chemistry.

Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia.

S. So, I. Klein, Y. Qian, 2014, Journal of medicinal chemistry.

Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29.

J. Tilley, W. Danho, J. Swistok, 1992, Journal of medicinal chemistry.

Adamantylthiourea derivatives as antiviral agents.

J. Tilley, M. J. Kramer, P. Levitan, 1979, Journal of medicinal chemistry.

The direct preparation of protected hydrazines from alcohols via Mitsunobu chemistry

J. Tilley, M. Grandi, 1996 .

Synthesis of heterocyclic analogs of α-methyldopa

J. Tilley, R. W. Kierstead, P. Levitan, 1979 .

Preparation of a protected (2S,3S)-.beta.-hydroxyaspartic acid suitable for solid-phase peptide synthesis

J. Tilley, R. Wagner, 1990 .

Functionalized Organozinc Reagents in Medicinal Chemistry: Discovery of Novel Drug Candidates

N. Fotouhi, A. Sidduri, J. Tilley, 2014 .

Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.

L. Presta, N. Skelton, S. Bodary, 2002, Science.

Analogs of CCK incorporating conformationally constrained replacements for Asp32.

D. Fry, V. Madison, J. Tilley, 1992, Journal of medicinal chemistry.

Structure activity studies of tryptophan30 modified analogs of Ac-CCK-7.

J. Tilley, W. Danho, J. Swistok, 2009, International journal of peptide and protein research.

Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists.

N. Fotouhi, J. Tilley, B. Wolitzky, 2000, Bioorganic & medicinal chemistry letters.

Total synthesis of terpenes. XIX. Synthesis of 8-methoxy-4a.beta., 10b.beta., 12a.alpha.-trimethyl-3,4,4a,4b.alpha.,5,6,10b,11,12,12a-decahydrochrysen-1(2H)-one, a key intermediate in the total synthesis of (+-)-shionone

B. Trus, C. Lipinski, M. Dawson, 1975 .

EXPERIMENTS DIRECTED TOWARD THE TOTAL SYNTHESIS OF TERPENES PART 19, SYNTHESIS OF 8-METHOXY-4A BETA,10B BETA,12A ALPHA-TRIMETHYL-3,4,4A,4B ALPHA,5,6,10B,11,12A-DECAHYDROCHRYSEN-1(2H)-ONE, A KEY INTERMEDIATE IN THE TOTAL SYNTHESIS OF (

B. Trus, C. Lipinski, M. Dawson, 1975 .

A Palladium-Catalyzed Carbonyl Insertion Route to Pyrido(2,1-b)quinazoline Derivatives.

J. Tilley, D. L. Coffen, B. Schaer, 1987 .

Preparation of Carboalkoxyalkylphenylalanine Derivatives from Tyrosine.

J. Tilley, R. Wagner, R. Sarabu, 1990 .

Very late antigen-4 integrin antagonists

J. Tilley, 2008 .

Faculty Opinions recommendation of Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties.

Jefferson Tilley, J. Tilley, 2010 .

Diabetes Drugs: Present and Emerging

Berthel Steven Joseph, S. Erickson, J. Tilley, 2010 .

The Synthesis of 3,5‐Diamino‐1,2,4‐oxadiazoles. 1st Communication

J. Blount, J. Tilley, H. Ramuz, 1980 .

Glucokinase activators as new type 2 diabetes therapeutic agents

S. Berthel, J. Tilley, Ramakanth Sarabu, 2008 .

THE SYNTHESIS OF 3,5-DIAMINO-1,2,4-OXADIAZOLES. PART 1

J. Tilley, H. Ramuz, 1980 .

NMR characterization of interleukin‐2 in complexes with the IL‐2Rα receptor component, and with low molecular weight compounds that inhibit the IL‐2/IL‐Rα interaction

D. Fry, L. Chen, R. Palermo, 2003, Protein science : a publication of the Protein Society.

Total synthesis of dl-shionone, a tetracyclic triterpene

C. Lipinski, D. Walba, J. Tilley, 1974 .

The metabolism of 14C-cibenzoline in dogs and rats.

J. Tilley, V. Toome, T. Williams, 1986, Drug metabolism and disposition: the biological fate of chemicals.

Structure-Activity of TRP Modified Analogs of Ac-CCK-7,

J. Tilley, W. Danho, J. Swistok, 1992 .

Preparation of a Protected (2S,3S)-β-Hydroxyaspartic Acid Suitable for Solid-Phase Peptide Synthesis.

J. Tilley, R. Wagner, 1991 .

Aminoadamantane derivatives.

J. Tilley, M. J. Kramer, 1981, Progress in medicinal chemistry.

Propenyl carboxamide derivatives as antagonists of platelet activating factor.

J. Tilley, R. Guthrie, F. Mennona, 1989, Journal of medicinal chemistry.

Recent Advances in Therapeutic Approaches to Type 2 Diabetes

J. Tilley, R. Sarabu, 2004 .