P. Harran

发表

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death.

Xiaodong Wang, Lin Li, R. Thomas, 2004, Science.

Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity

S. McKnight, Xiaodong Wang, N. Williams, 2007, Proceedings of the National Academy of Sciences.

Exploring the Boundaries of "Practical": De Novo Syntheses of Complex Natural Product-Based Drug Candidates.

P. Harran, Tyler K. Allred, F. Manoni, 2017, Chemical reviews.

The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity

M. Steinmetz, M. Wieczorek, J. Arezzo, 2016, Science Translational Medicine.

Electrolytic macrocyclizations: scalable synthesis of a diazonamide-based drug development candidate.

Hui Ding, Patrick G. Harran, A. Siddiqui, 2015, Angewandte Chemie.

A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

Xiaodong Wang, Patrick G. Harran, Xiaodong Wang, 2004, Science.

Concerning the phakellin substructure of palau’amine

P. Harran, Masakazu Nakadai, 2006 .

Synthesis of the First Members of a New Class of Biologically Active Bryostatin Analogues

Makoto Shiozaki, P. Wender, M. Koehler, 1998 .

Title page

P. Harran, N. Garg, S. D. Ramgren, 2017, 2017 International Conference on Electrical Engineering (ICEE).

Syntheses of atypically fluorinated peptidyl macrocycles via sequential vinylic substitutions.

Christopher G. Jones, P. Harran, Angel Mendoza, 2020, Angewandte Chemie.

Modular access to complex prodiginines: total synthesis of (+)-roseophilin via its 2-azafulvene prototropisomer.

P. Harran, James H. Frederich, 2013, Journal of the American Chemical Society.

Synthesis and biological evaluation of fully synthetic bryostatin analogues

K. Hinkle, P. Wender, P. Harran, 1998 .

Synthetic seco Forms of (-)-Diazonamide A.

P. Harran, Anthony W. G. Burgett, Xin Chen, 2001, Angewandte Chemie.

Stereocontrol in Pinacol Ring‐Contraction of Cyclopeptidyl Glycols: The Diazonamide C10 Problem

L. Esser, P. Harran, Xin Chen, 2000 .

Callyspongiolide Is a Potent Inhibitor of the Vacuolar ATPase.

J. Rutter, H. Rane, P. Harran, 2020, Journal of natural products.

Catalytic Synthesis of PEGylated EGCG Conjugates that Disaggregate Alzheimer’s Tau

D. Eisenberg, P. Harran, P. Seidler, 2021, Synthesis.

Anomalous Chromophore Disruption Enables an Eight-Step Synthesis and Stereochemical Reassignment of (+)-Marineosin A.

P. Harran, Tyler K. Allred, Zhengao Feng, 2019, Journal of the American Chemical Society.

Total Synthesis of Nominal Diazonamides—Part 1: Convergent Preparation of the Structure Proposed for (−)-Diazonamide A

Jing Li, Patrick G. Harran, L. Esser, 2001 .

Substituted 2,2'-bipyrroles and pyrrolylfurans via intermediate isoxazolylpyrroles.

P. Harran, James H. Frederich, J. K. Matsui, 2013, Tetrahedron letters.

A concise and flexible total synthesis of (-)-diazonamide A.

P. Harran, Qi Wei, Anthony W. G. Burgett, 2003, Angewandte Chemie.

Re-visiting the diastereoselectivity of organocatalytic conjugate addition of 2-trimethylsiloxyfuran to trans-crotonaldehyde

P. Harran, Liubo Li, Anton El Khoury, 2021 .

Synthetic (±)-axinellamines deficient in halogen.

P. Harran, H. Ding, A. G. Roberts, 2012, Angewandte Chemie.

Total Synthesis of Ageliferin via Acyl N-amidinyliminium Ion Rearrangement.

P. Harran, H. Ding, A. G. Roberts, 2013, Chemical science.

Spirocycloisomerization of tethered alkylidene glycocyamidines: synthesis of a base template common to the palau'amine family of alkaloids.

P. Harran, Masakazu Nakadai, Thomas Doundoulakis, 2005, Angewandte Chemie.

Synthesis of a designed sesquiterpenoid that forms useful composites with peptides and related oligomers

P. Harran, T. Rose, K. Lawson, 2011 .

A route to chiral epoxypyrroloindoles via oxiranyl radical cyclization

P. Harran, F. Ziegler, 1993 .

Exploring symmetry-based logic for a synthesis of palau'amine.

R. Akella, P. Harran, H. Ding, 2009, The Journal of organic chemistry.

Methods to initiate synthetic re-structuring of peptides

P. Harran, Qi Wei, Susan Harran, 2003 .

Synthetic Application of the Alder-Bong Reaction: Stereoselective Construction of the Methanohydroazulene Framework

P. Harran, R. J. Giguere, Blanca O. Lopez, 1990 .

Syntheses of hybrid cyclopeptidyl [n]sulfanes by internal alkyl group exchange

P. Harran, Luke J. Sisto, 2020, Tetrahedron Letters.

Template-constrained macrocyclic peptides prepared from native, unprotected precursors

Patrick G. Harran, P. Harran, Kenneth V. Lawson, 2013, Proceedings of the National Academy of Sciences.

Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan.

P. Harran, Tristan E. Rose, T. Rose, 2013, Tetrahedron.

Syntheses of Atypically Fluorinated Peptidyl Macrocycles through Sequential Vinylic Substitutions

Christopher G. Jones, P. Harran, Angel Mendoza, 2019, Angewandte Chemie.

Large ring-forming alkylations provide facile access to composite macrocycles† †Electronic supplementary information (ESI) available: Fig. S1–S4, list of macrocycles prepared, experimental procedures, and spectroscopic data. CCDC 1023942. For ESI and crystallographic data in CIF or other electronic

P. Harran, Tristan E. Rose, T. Rose, 2015, Chemical science.

SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner.

J. Minna, L. Girard, M. Peyton, 2011, Cancer research.

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis.

J. Minna, M. Peyton, Xiaodong Wang, 2007, Cancer cell.

Small-molecule activation of the TRAIL receptor DR5 in human cancer cells.

Xiaodong Wang, She Chen, Xiaoguang Lei, 2013, Nature chemical biology.

Photorearrangement of [8]-2,6-Pyridinophane N-Oxide.

Janice B. Lin, K. Houk, Selbi Nuryyeva, 2020, Journal of the American Chemical Society.

Intramolecular addition of a dioxolanyl radical to the indole nucleus: preparation of enantiomerically pure, oxygenated perhydro-3H-pyrrolo[1,2-a]indoles

P. Harran, F. Ziegler, 1993 .

Independent Manner − α to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-Small Cell Lung Cancers − SMAC Mimetic ( JP 1201 ) Sensitizes Non

J. Minna, L. Girard, M. Peyton, 2011 .

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.

P. Wender, M. Koehler, P. Harran, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.

E. Hamel, P. Harran, Z. Cruz-Monserrate, 2003, European journal of biochemistry.

A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance

M. Roth, P. Harran, Iryna Zubovych, 2006, Proceedings of the National Academy of Sciences.

Computational generation of an annotated gigalibrary of synthesizable, composite peptidic macrocycles

Dennis Svatunek, Kendall N Houk, Ishika Saha, 2020, Proceedings of the National Academy of Sciences.

Total Synthesis of Nominal Diazonamides. Part 2. On the True Structure and Origin of Natural Isolates.

Jing Li, Patrick G. Harran, L. Esser, 2002 .

Unconventional Fragment Usage Enables a Concise Total Synthesis of (-)-Callyspongiolide.

P. Harran, F. Manoni, Liubo Li, 2018, Journal of the American Chemical Society.

On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan† †Electronic supplementary information (ESI) available: Supplementary Fig. S1–S17: comparison of Tf2NH versus MeSO3H, structures of additional macrocycle isomers obtained from reactions of 12

K. Houk, P. Harran, Adam Simon, 2016, Chemical science.

Total Synthesis of Nominal Diazonamides—Part 2: On the True Structure and Origin of Natural Isolates

Jing Li, Patrick G. Harran, L. Esser, 2001 .

Diazonamide toxins reveal an unexpected function for ornithine δ-amino transferase in mitotic cell division

Xiaodong Wang, P. Harran, Anthony W. G. Burgett, 2007, Proceedings of the National Academy of Sciences.

In Search of Small Molecules That Selectively Inhibit MBOAT4

P. Tontonoz, Hui Ding, P. Harran, 2021, Molecules.

Abstract 5423: New diazonamide analogs demonstrate remarkably larger therapeutic window compared to taxanes and vinca alkaloids in rodents

M. Zhou, Xiaodong Wang, Xiaoming Xu, 2011 .

Macrocyclic Triarylethylenes via Heck Endocyclization: A System Relevant to Diazonamide Synthesis

P. Harran, Xin Chen, Susan Jeong, 1998 .

Acid promoted cinnamyl ion mobility within peptide derived macrocycles.

Lidet K. Negash, S. Estill, P. Harran, 2008, Journal of the American Chemical Society.

Sulfane transalkylations and metal catalyzed allylic substitutions for the synthesis of composite macrobicyclic peptides

P. Harran, Luke J. Sisto, 2020 .

Assembly of Complex Macrocycles by Incrementally Amalgamating Unprotected Peptides with a Designed Four-Armed Insert.

A. Roulston, Jiyong Park, P. Harran, 2018, The Journal of organic chemistry.

Asymmetric Organocatalysis Enables Rapid Assembly of Portimine Precursor Chains.

P. Harran, Liubo Li, Anton El Khoury, 2022, Organic letters.

Molecular pathogenesis of lung cancer with translation to the clinic: M10-01

K. Coombes, S. Lam, J. Minna, 2007 .

Exploring the Boundaries of "Practical": De Novo Syntheses of Complex Natural Product-Based Drug Candidates.

P. Harran, F. Manoni, Tyler K Allred, 2017, Chemical reviews.