P. Goldfarb

发表

Investigating human P450s involved in drug metabolism via homology with high-resolution P450 crystal structures of the CYP2C subfamily.

D. Lewis, Yuko Ito, P. Goldfarb, 2006, Current drug metabolism.

Structural determinants of cytochrome P450 substrate specificity, binding affinity and catalytic rate.

M H Tarbit, D. Lewis, M. Tarbit, 1998, Chemico-biological interactions.

Assessment of the impact of organic pollutants on goby (Zosterisessor ophiocephalus) and mussel (Mytilus galloprovincialis) from the Venice Lagoon, Italy: Biochemical studies

Peter S. Goldfarb, Philippe Lemaire, Cinta Porte, 1995 .

Primary cell-culture of the digestive gland of the marine mussel Mytilus edulis: a time-course study of antioxidant- and biotransformation-enzyme activity and ultrastructural changes

D. Livingstone, R. Pipe, P. Goldfarb, 1999 .

Characterization of the presence and seasonal variation of a CYP1A-like enzyme in digestive gland of the common mussel, Mytilus edulis

D. Livingstone, P. Goldfarb, P. Lemaire, 1996 .

Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102.

D. Lewis, B. Lake, A. Beresford, 1999, Toxicology.

Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro

E. Ullerås, A. Oskarsson, P. Goldfarb, 2006, Journal of applied toxicology : JAT.

A MOLECULAR MODEL OF CYP2D6 CONSTRUCTED BY HOMOLOGY WITH THE CYP2C5 CRYSTALLOGRAPHIC TEMPLATE: INVESTIGATION OF ENZYME-SUBSTRATE INTERACTIONS

D. Lewis, B. Lake, P. Goldfarb, 2003, Drug metabolism and drug interactions.

Homology modelling of human CYP1A2 based on the CYP2C5 crystallographic template structure

D. Lewis, B. Lake, P. Goldfarb, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems

L. Corcos, D. Lewis, M. Ingelman-Sundberg, 2001, Xenobiotica; the fate of foreign compounds in biological systems.

Isolation and expression of a cDNA coding for rat kidney cytosolic cysteine conjugate beta-lyase.

E. Lock, L. J. King, M. MacFarlane, 1993, Molecular pharmacology.

Investigation of Enzyme Selectivity in the Human CYP2C Subfamily: Homology Modelling of CYP2C8, CYP2C9 and CYP2C19 from the CYP2C5 Crystallographic Template

D. Lewis, B. Lake, P. Goldfarb, 2003, Drug metabolism and drug interactions.

Glutathione peroxidase and other antioxidant enzyme function in marine invertebrates (Mytilus edulis, Pecten maximus, Carcinus maenas and Asterias rubens)

S. Gamble, D. Livingstone, C. Porte, 1995 .

Influence of single and concurrent clofibrate and phenobarbital administration on cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation in male rat liver.

D. Howes, G. Gibson, R. Sharma, 1992, Journal of biochemical toxicology.

Characterization of the hepatic responses to the short-term administration of ciprofibrate in several rat strain. Co-induction of microsomal cytochrome P-450 IVA1 and peroxisome proliferation.

C. Anders, G. Gibson, P. Goldfarb, 1990, Biochemical pharmacology.

Differential splicing in the 3′ non‐coding region of rat cytochrome P‐452 (P450 IVA1) mRNA

G. Gibson, J. W. Dale, P. Goldfarb, 1988, FEBS letters.

Evidence for the existence of cytochrome P450 gene families (CYP1A, 3A, 4A, 11A) and modulation of gene expression (CYP1A) in the mussel Mytilus spp.

A. Wiseman, C. Herring, D. Livingstone, 1995 .

Developmental modulation of cysteine conjugate β-lyase/glutamine transaminase K/kynurenine aminotransferase mRNA in rat brain

N. Plant, G. Gibson, I. Kitchen, 1997, European Journal of Drug Metabolism and Pharmacokinetics.

Enzyme effects and metabolism of fenitrothion in primary cell culture of the red swamp crayfish Procambarm clarkii

D. Livingstone, C. Porte, P. Goldfarb, 1998 .

Are food and environmental toxicants 'overdetected' by bioassay?

A. Wiseman, P. Goldfarb, T. Ridgway, 2002, Trends in biotechnology.

Xenoestrogens and phytoestrogens: bioremediation or biomonitoring?

A. Wiseman, P. Goldfarb, H. Wiseman, 1999, Trends in biotechnology.

Selenium‐Dependent Glutathione Peroxidase and other Selenoproteins: Their Synthesis and Biochemical Roles

A. Wiseman, S. Gamble, P. Goldfarb, 1997 .

Characterisation of biotransformation enzyme activities and DNA integrity in isolated cells of the digestive gland of the common mussel, Mytilus edulis L.

D. Livingstone, P. Goldfarb, C. Mitchelmore, 1998 .

Mutation analysis of the human CYP3A4 gene 5' regulatory region: population screening using non-radioactive SSCP.

P. Goldfarb, H. Hamzeiy, H. J. Edwards, 2002, Mutation research.

Differing features of proteins in membranes may result in antioxidant or prooxidant action: opposite effects on lipid peroxidation of alcohol dehydrogenase and albumin in liposomal systems.

A. Wiseman, P. Goldfarb, Z. Shamsi, 1996, Redox report : communications in free radical research.

Molecular cloning of a cDNA for rat diabetes-inducible cytochrome P450RLM6: hormonal regulation and similarity to the cytochrome P4502E1 gene.

T. Richardson, J. Schenkman, G. Gibson, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

INvestigation of the basis of reduced metabolic cooperation in mec- cells.

J. Subak-Sharpe, P. Goldfarb, C. Slack, 1976, Experimental cell research.

Isolation and characterisation of Chinese hamster cells resistant to 5-fluorodeoxyuridine.

P. Goldfarb, M. Hooper, B. Carritt, 1976, Experimental cell research.

The role of bound potassium ions in the hydrolysis of low concentrations of adenosine triphosphate by preparations of membrane fragments from ox brain cerebral cortex.

R. Rodnight, P. Goldfarb, 1970, The Biochemical journal.

In vitro biological systems: (Methods in Toxicology, Vol. 1, Pt A) edited by C. A. Tyson and J. M. Frazier, Academic Press, 1993. £56.00 (xxi + 568 pages) ISBN 0 12 461202 4

P. Goldfarb, 1994 .

Transcriptional regulation of cytochrome P4503A4 gene expression: effects of inherited mutations in the 5′-flanking region

N. Plant, G. Gibson, P. Goldfarb, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Molecular cloning and expression of a cDNA for human kidney cysteine conjugate β‐lyase

L. J. King, G. Gibson, C. Scholfield, 1995 .

Can Greener Technology Sustain Downstream Processing in Novel Food Bioprocessing by Elimination of Reactive Oxygen Species

A. Wiseman, P. Goldfarb, L. Woods, 2005 .

Variant Chinese hamster cells resistant to the proline analogl-azetidine 2-carboxylic acid

P. Goldfarb, M. Hooper, B. Carritt, 1977, Somatic cell genetics.

The isolation and characterization of asparagine-requiring mutants of Chinese hamster cells.

P. Goldfarb, M. Hooper, B. Carritt, 1977, Experimental cell research.

The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the ‘termination’ codon, TGA.

P. Harrison, J. Frampton, I. Chambers, 1986, The EMBO journal.

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism.

M H Tarbit, D. Lewis, M. Tarbit, 1997, Xenobiotica; the fate of foreign compounds in biological systems.

Analysis of red blood cell differentiation.

J. O'prey, P. Harrison, E. Black, 1982, Advances in experimental medicine and biology.

Chromosome assignment of a human gene for argininosuccinate synthetase expression in Chinese hamsterxhuman somatic cell hybrids.

P. Goldfarb, M. Hooper, B. Carritt, 1977, Experimental cell research.

Applications of recombinant DNA technology to diagnostics

P. Goldfarb, 2007 .

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.

M. Tarbit, J. Williams, M. Ogg, 1999, Xenobiotica; the fate of foreign compounds in biological systems.

Cloning of a new mouse foetal beta-globin mRNA sequence

Alan Lyons, Nabeel A. Affara, Peter S. Goldfarb, 1981, Nucleic Acids Res..

Detection of mRNA sequences homologous to the human glutathione peroxidase and rat cytochrome P-450IVA1 genes in Mytilus edulis

A. Wiseman, G. Gibson, D. Livingstone, 1989 .

Dose-dependent induction or depression of cysteine conjugate beta-lyase in rat kidney by N-acetyl-S-(1,2,3,4,4-pentachloro-1,3-butadienyl)-L-cysteine.

E. Lock, L. J. King, M. MacFarlane, 1993, Toxicology.

Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4.

M H Tarbit, D. Lewis, B. Lake, 1999, Xenobiotica; the fate of foreign compounds in biological systems.

Homology modelling of CYP2A6 based on the CYP2C5 crystallographic template: enzyme-substrate interactions and QSARs for binding affinity and inhibition.

D. Lewis, B. Lake, P. Goldfarb, 2003, Toxicology in vitro : an international journal published in association with BIBRA.

Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity.

M H Tarbit, D. Lewis, B. Lake, 1999, Toxicology.

Apparent induction of a cytochrome P450 with immunochemical similarities to CYP1A in digestive gland of the common mussel (Mytilus galloprovincialis L.) with exposure to 2,2′,3,4,4′,5′-hexachlorobiphenyl and Arochlor 1254

D. Livingstone, M. Solé, P. Goldfarb, 1997 .

Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform.

M H Tarbit, D. Lewis, B. Lake, 2000, Xenobiotica; the fate of foreign compounds in biological systems.

Cytochrome P450 Substrate Specificities, Substrate Structural Templates and Enzyme Active Site Geometries

D. Lewis, M. Tarbit, P. Goldfarb, 1999, Drug metabolism and drug interactions.

Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily.

M H Tarbit, D. Lewis, R. Weaver, 1998, Xenobiotica; the fate of foreign compounds in biological systems.

Adenine nucleotides and magnesium ions in relation to control of mammalian cerebral-cortex hexokinase.

H. Bachelard, P. Goldfarb, 1969, The Biochemical journal.

Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: investigation of enzyme-substrate and enzyme-inhibitor interactions.

D. Lewis, B. Lake, G. Loizou, 2003, Toxicology in vitro : an international journal published in association with BIBRA.

A human cDNA sequence for a novel glutathione peroxidase-related selenopeptide, GPRP.

J. Richardson, P. Goldfarb, D. Howells, 1989, Nucleic acids research.

Homology modelling of CYP3A4 from the CYP2C5 crystallographic template: analysis of typical CYP3A4 substrate interactions

D. Lewis, B. Lake, P. Goldfarb, 2004, Xenobiotica; the fate of foreign compounds in biological systems.

An evaluation of ondansetron binding interactions with human cytochrome P450 enzymes CYP3A4 and CYP2D6.

D. Lewis, Yuko Ito, P. Goldfarb, 2010, Drug metabolism letters.

Applications of protein engineering in bioanalysis

A. Wiseman, P. Goldfarb, 1986 .

Analysis of CYP2D6 substrate interactions by computational methods.

Yuko Ito, D. Lewis, H. Kondo, 2008, Journal of molecular graphics & modelling.

Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems.

Alan R Boobis, Laurent Corcos, Magnus Ingelman-Sundberg, 2003, Drug metabolism and disposition: the biological fate of chemicals.

An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant.

R J Edwards, A R Boobis, K J Hoffmann, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Isolation of variant cells with defective metabolic cooperation (mec-) from polyoma virus transformed Syrian hamster cells.

J. Subak-Sharpe, P. Goldfarb, E. D. Wright, 1976, Experimental cell research.

Biomarkers, bioindicators or ecotranslators to biomonitor oestrogen mimics?

A. Wiseman, P. Goldfarb, H. Wiseman, 2000, Trends in biotechnology.

Cytochrome P450 structures and their substrate interactions

Yuko Ito, D. Lewis, Yuko Ito, 2005 .

Molecular modelling of CYP3A4 from an alignment with CYP102: identification of key interactions between putative active site residues and CYP3A-specific chemicals.

M H Tarbit, D. Lewis, M. Tarbit, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase.

G. Gibson, C. Scholfield, P. Goldfarb, 1995, FEBS Letters.

Cell Engineering of the Rat and Human Cysteine Conjugate Beta Lyase Genes and Applications to Nephrotoxicity Assessment

N. Plant, L. J. King, G. Gibson, 1999 .

Metabolic co-operation between cells in tissue culture.

J. Subak-Sharpe, P. Goldfarb, C. Slack, 1974, Symposia of the Society for Experimental Biology.

Molecular Modelling of CYP2B6 Based on Homology with the CYP2C5 Crystal Structure: Analysis of Enzyme-Substrate Interactions

D. Lewis, P. Goldfarb, M. Dickins,, 2002, Drug metabolism and drug interactions.

Biomonitoring in the aquatic environment: use of molecular biomarkers.

D. Livingstone, P. Goldfarb, C. Birmelin, 1998, Biochemical Society transactions.

Enzyme-Substrate Binding Interaction Energies and Their Application to the Cytochrome P450 System

D. Lewis, Yuko Ito, P. Goldfarb, 2008 .