H. P. Morgan

发表

An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase.

Kun-Yi Hsin, M. Walkinshaw, P. Michels, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Trypanosomatid phosphoglycerate mutases have multiple conformational and oligomeric states.

M. Walkinshaw, Elizabeth A Blackburn, P. Michels, 2014, Biochemical and biophysical research communications.

The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site*

D. Auld, M. Walkinshaw, P. Michels, 2011, The Journal of Biological Chemistry.

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies

M. Walkinshaw, P. Michels, L. Fothergill-Gilmore, 2014, Royal Society Open Science.

Pyruvate kinases have an intrinsic and conserved decarboxylase activity.

J. Bella, M. Walkinshaw, P. Michels, 2014, The Biochemical journal.

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

M. Walkinshaw, T. Hupp, J. R. O'Neill, 2013, Proceedings of the National Academy of Sciences.

The division potential of cells in continuous growth as compared to cells subcultivated after maintenance in stationary phase.

B. Strehler, H. P. Morgan, R. Hay, 1968, Experimental gerontology.

Crystallization and X-ray structure of cold-shock protein E from Salmonella typhimurium.

M. P. Gallagher, M. Walkinshaw, M. Wear, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.

Montserrat G. Vásquez-Valdivieso, A. Simeonov, D. Auld, 2014, ACS medicinal chemistry letters.

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation

T. Le Bihan, M. Walkinshaw, G. Loake, 2018, The Biochemical journal.

Sulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline state.

M. Walkinshaw, P. Michels, V. Hannaert, 2008, Journal of molecular biology.

Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo.

M. Walkinshaw, P. Michels, L. J. Eades, 2011, Metallomics : integrated biometal science.

Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass.

M. Walkinshaw, P. Michels, L. Fothergill-Gilmore, 2009, Journal of molecular biology.

Structural basis for engagement by complement factor H of C3b on a self surface

Dmitri I. Svergun, Paul N. Barlow, Christoph Q. Schmidt, 2011, Nature Structural &Molecular Biology.

Structural Analysis of the C-Terminal Region (Modules 18–20) of Complement Regulator Factor H (FH)

D. Svergun, H. Mertens, D. Soares, 2012, PloS one.

Structural and functional characterization of the product of disease-related factor H gene conversion.

D. Uhrín, P. Barlow, J. Hannan, 2012, Biochemistry.

Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.

D. Uhrín, P. Barlow, J. Hannan, 2011, Acta crystallographica. Section D, Biological crystallography.

Allosteric Mechanism of Pyruvate Kinase from Leishmania mexicana Uses a Rock and Lock Model*

M. Walkinshaw, P. Michels, V. Hannaert, 2010, The Journal of Biological Chemistry.

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

D. Auld, M. Boxer, M. Walkinshaw, 2012, The Biochemical journal.

Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach

Malcolm D. Walkinshaw, Peter J. Sadler, Udo Heinemann, 2007, Nucleic acids research.

Molecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteins.

M. Walkinshaw, Y. Yuthavong, S. Kamchonwongpaisan, 2014, Molecular and biochemical parasitology.

`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.

M. Walkinshaw, P. Michels, L. Fothergill-Gilmore, 2013, Acta crystallographica. Section D, Biological crystallography.

EDULISS: a small-molecule database with data-mining and pharmacophore searching capabilities

Kun-Yi Hsin, Paul Taylor, Andrew C. Hinton, 2010, Nucleic Acids Res..