J. Maclean

发表

A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies.

Z. Rankovic, C. Jamieson, S. Basten, 2010, Bioorganic & medicinal chemistry letters.

Identification of potent, soluble, and orally active TRPV1 antagonists.

Peter Littlewood, J. Maclean, O. Nimz, 2011, Bioorganic & medicinal chemistry letters.

Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.

M. Ohlmeyer, Peter Littlewood, J. Maclean, 2011, Bioorganic & medicinal chemistry letters.

Estimating the affinity of protein-ligand complex from changes to the charge-state distribution of a protein in electrospray ionization mass spectrometry.

Elizabeth A. Blackburn, M. Walkinshaw, J. Maclean, 2010, Biochemical and biophysical research communications.

Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications.

Duan Liu, M. Altman, Ruojing Yang, 2015, Bioorganic & medicinal chemistry letters.

Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in allergic bronchopulmonary aspergillosis.

A. Hamosh, R. Slavin, M. Macek, 1996, American journal of human genetics.

Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 1.

C. Charrier, M. Craighead, J. Maclean, 2020, RSC medicinal chemistry.

Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.

C. Charrier, M. Craighead, D. Hughes, 2016, Bioorganic & medicinal chemistry letters.

Structure based evolution of a novel series of positive modulators of the AMPA receptor.

Z. Rankovic, C. Jamieson, Robert A. Campbell, 2011, Bioorganic & medicinal chemistry letters.

Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.

Z. Rankovic, C. Jamieson, J. Maclean, 2010, Journal of medicinal chemistry.

A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.

Z. Rankovic, C. Jamieson, Robert A. Campbell, 2010, Bioorganic & medicinal chemistry letters.

Structure-activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists.

M. Ohlmeyer, J. Maclean, Koc-Kan Ho, 2011, Bioorganic & medicinal chemistry letters.

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

T. Fischmann, M. Altman, Ruojing Yang, 2015, ACS medicinal chemistry letters.

Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.

C. Moskaluk, J. Aster, B. Bernstein, 2014, Cancer discovery.

Triple-Negative Breast Cancer and Adenoid Cystic Carcinoma Discovery of Biomarkers Predictive of GSI Response in

C. Moskaluk, J. Aster, B. Bernstein, 2014 .

Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases.

M. van der Stelt, S. Nagpal, J. Maclean, 2020, ACS medicinal chemistry letters.

Design, synthesis and antibacterial properties of pyrimido[4,5-b]indol-8-amine inhibitors of DNA gyrase.

C. Charrier, J. Maclean, W. Kerr, 2018, Bioorganic & medicinal chemistry letters.

Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers.

G. Naumov, U. Philippar, A. Petrocchi, 2016, Journal of medicinal chemistry.

AMPA receptor positive modulators

C. Jamieson, J. Maclean, J. Morrow, 2012 .

Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy

M. Benveniste, K. Partin, C. Jamieson, 2013, Neuropharmacology.

Recent advances in positive allosteric modulators of the AMPA receptor.

C. Jamieson, J. Maclean, J. Morrow, 2006, Current opinion in drug discovery & development.

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Michael E. Lassman, Jeffrey T. Kuethe, M. Struthers, 2015, ACS medicinal chemistry letters.

Inhibitors of phosphopantetheine adenylyltransferase.

J. Barker, J. Maclean, W. U. Primrose, 2003, European journal of medicinal chemistry.

Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors.

A. Kral, B. Haines, Thomas A. Miller, 2014, Biochemistry.