R. Honzatko

发表

The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.

H. Fromm, G. Bourenkov, H. Bartunik, 1998, Structure.

Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis*

Reuben J. Peters, R. Peters, J. A. Hoy, 2012, The Journal of Biological Chemistry.

Xyloglucan Xylosyltransferase 1 Displays Promiscuity Toward Donor Substrates During In vitro Reactions.

R. Jernigan, O. Zabotina, S. Shome, 2021, Plant & cell physiology.

Refined crystal structures of glucoamylase from Aspergillus awamori var. X100.

L. Firsov, A. Aleshin, R. Honzatko, 1994, Journal of molecular biology.

Environment of Tryptophan 57 in Porcine Fructose-1,6-bisphosphatase Studied by Time-resolved Fluorescence and Site-directed Mutagenesis¶

H. Fromm, J. Petrich, R. Honzatko, 2001, Photochemistry and photobiology.

Environment of Tryptophan 57 in Porcine Fructose‐1,6‐bisphosphatase Studied by Time‐resolved Fluorescence and Site‐directed Mutagenesis ¶

H. Fromm, J. Petrich, R. Honzatko, 2001 .

Gross quaternary changes in aspartate carbamoyltransferase are induced by the binding of N-(phosphonacetyl)-L-aspartate: A 3.5-A resolution study.

W. Lipscomb, H. Ke, A. Kalb, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Discrete disorder in protein crystals

W. Hendrickson, S. Sheriff, Janet L. Smith, 1984 .

Crystallization and preliminary X-ray analysis of the Plasmodium falciparum apicoplast DNA polymerase.

J. Choe, R. Honzatko, S. Nelson, 2015, Acta crystallographica. Section F, Structural biology communications.

Mutational analysis of the roles in catalysis and substrate recognition of arginines 54 and 305, aspartic acid 309, and tryptophan 317 located at subsites 1 and 2 in glucoamylase from Aspergillus niger.

B. Svensson, T. P. Frandsen, R. Honzatko, 1995, Biochemistry.

Crystal structure and evolution of a prokaryotic glucoamylase.

P. Reilly, A. Aleshin, R. Honzatko, 2003, Journal of molecular biology.

Crystal Structure of the Apicoplast DNA Polymerase from Plasmodium falciparum: The First Look at a Plastidic A-Family DNA Polymerase.

J. Choe, R. Honzatko, S. Nelson, 2016, Journal of molecular biology.

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

Z. Otwinowski, J. Nix, C. Basler, 2010, Nature Structural &Molecular Biology.

Refined structure for the complex of d‐gluco‐dihydroacarbose with glucoamylase from Aspergillus awamori var. X100 to 2.2 Å resolution: dual conformations for extended inhibitors bound to the active site of glucoamylase

B. Svensson, L. Firsov, A. Aleshin, 1995, FEBS letters.

Structure of xyloglucan xylosyltransferase 1 reveals simple steric rules that define biological patterns of xyloglucan polymers

O. Zabotina, J. Choe, R. Honzatko, 2018, Proceedings of the National Academy of Sciences.

Nucleotide Complexes of Escherichia coli Phosphoribosylaminoimidazole Succinocarboxamide

H. Fromm, R. Honzatko, N. Ginder, 2006 .

Cavitation as a mechanism of substrate discrimination by adenylosuccinate synthetases.

H. Fromm, T. Borza, C. V. Iancu, 2006, Biochemistry.

Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain.

J. Nix, C. Basler, D. Leung, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Glucose 6-Phosphate Release of Wild-type and Mutant Human Brain Hexokinases from Mitochondria*

H. Fromm, H. J. Tsai, Chang Sup Kim, 2005, Journal of Biological Chemistry.

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins.

Z. Otwinowski, J. Nix, C. Basler, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Interactions of metal-nucleotide complexes with aspartate carbamoyltransferase in the crystalline state.

W. Lipscomb, R. Honzatko, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Replacement of Asp333 with Asn by site-directed mutagenesis changes the substrate specificity of Escherichia coli adenylosuccinate synthetase from guanosine 5'-triphosphate to xanthosine 5'-triphosphate.

H. Fromm, N. Sun, R. Honzatko, 1994, The Journal of biological chemistry.

Cloning, expression and characterization of an extracellular enolase from Leuconostoc mesenteroides.

Doman Kim, Jinha Lee, J. Choe, 2006, FEMS microbiology letters.

Cloning, expression and characterization of an extracellular enolase from Leuconostocmesenteroides

Doman Kim, Jinha Lee, J. Choe, 2006 .

Crystallization and preliminary X‐ray analysis of human brain hexokinase

H. Fromm, A. Aleshin, C. Zeng, 1996, FEBS letters.

Preliminary X-ray crystallographic study of adenylosuccinate synthetase from Escherichia coli.

H. Fromm, M. Bass, R. Honzatko, 1988, Journal of molecular biology.

Identification of Arginine Residues in the Putative L-Aspartate Binding Site of Escherichiacoli Adenylosuccinate Synthetase (*)

H. Fromm, R. Honzatko, Wenyan Wang, 1995, The Journal of Biological Chemistry.

Crystal structure of glucoamylase from Aspergillus awamori var. X100 to 2.2-A resolution.

A. Golubev, L. Firsov, A. Aleshin, 1994, The Journal of biological chemistry.

Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75-A resolution.

D C Rees, W. Lipscomb, D. Rees, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Terpenoid synthase structures: a so far incomplete view of complex catalysis.

R. Peters, R. Honzatko, Yang Gao, 2012, Natural product reports.

Structures of Activated Fructose-1,6-bisphosphatase from Escherichia coli

H. Fromm, R. Honzatko, J. Hines, 2007, Journal of Biological Chemistry.

Novel Allosteric Activation Site in Escherichia coli Fructose-1,6-bisphosphatase*

H. Fromm, R. Honzatko, J. Hines, 2006, Journal of Biological Chemistry.

Protein sulfhydryls and their role in the antioxidant function of protein S-thiolation.

J. A. Thomas, R. Honzatko, B. Poland, 1995, Archives of biochemistry and biophysics.

Complex of N-phosphonacetyl-L-aspartate with aspartate carbamoyltransferase. X-ray refinement, analysis of conformational changes and catalytic and allosteric mechanisms.

W. Lipscomb, H. Ke, Yunje Cho, 1988, Journal of molecular biology.

Structural asymmetry in the CTP-liganded form of aspartate carbamoyltransferase from Escherichia coli.

K H Kim, W. Lipscomb, H. Ke, 1987, Journal of molecular biology.

Interactions of phosphate ligands with Escherichia coli aspartate carbamoyltransferase in the crystalline state.

W. Lipscomb, R. Honzatko, 1982, Journal of molecular biology.

Site-directed mutagenesis of the catalytic base glutamic acid 400 in glucoamylase from Aspergillus niger and of tyrosine 48 and glutamine 401, both hydrogen-bonded to the gamma-carboxylate group of glutamic acid 400.

B. Svensson, T. P. Frandsen, M. Sierks, 1994, Biochemistry.

Refined structure for the complex of 1-deoxynojirimycin with glucoamylase from Aspergillus awamori var. X100 to 2.4-A resolution.

L. Firsov, A. Aleshin, R. Honzatko, 1993, Biochemistry.

Effectors of the Stringent Response Target the Active Site ofEscherichia coli Adenylosuccinate Synthetase*

H. Fromm, M. Cashel, R. Honzatko, 1999, The Journal of Biological Chemistry.

Adenylosuccinate Syntheatase: Recent Developments

M. Stayton, R. Honzatko, H. J. Formm, 2006 .

Central Cavity of Fructose-1,6-bisphosphatase and the Evolution of AMP/Fructose 2,6-bisphosphate Synergism in Eukaryotic Organisms*

R. Honzatko, Yang Gao, Lu Shen, 2014, The Journal of Biological Chemistry.

Mechanism of displacement of a catalytically essential loop from the active site of mammalian fructose-1,6-bisphosphatase.

C. V. Iancu, J. Choe, R. Honzatko, 2006, Biochemistry.

Structures of Mammalian and Bacterial Fructose-1,6-bisphosphatase Reveal the Basis for Synergism in AMP/Fructose 2,6-Bisphosphate Inhibition*

H. Fromm, J. Nix, R. Honzatko, 2007, Journal of Biological Chemistry.

R-State AMP Complex Reveals Initial Steps of the Quaternary Transition of Fructose-1,6-bisphosphatase*

H. Fromm, C. V. Iancu, S. Mukund, 2005, Journal of Biological Chemistry.

Origin of Cooperativity in the Activation of Fructose-1,6-bisphosphatase by Mg2+*

H. Fromm, R. Honzatko, S. Nelson, 2004, Journal of Biological Chemistry.

Inhibition of Fructose-1,6-bisphosphatase by a New Class of Allosteric Effectors*

M. J. Newman, H. Fromm, D. Slee, 2003, Journal of Biological Chemistry.

Interaction of Tl+ with Product Complexes of Fructose-1,6-bisphosphatase*

H. Fromm, J. Choe, R. Honzatko, 2003, The Journal of Biological Chemistry.

Hybrid Tetramers of Porcine Liver Fructose-1,6-bisphosphatase Reveal Multiple Pathways of Allosteric Inhibition*

H. Fromm, R. Honzatko, S. Nelson, 2002, The Journal of Biological Chemistry.

The N-terminal Segment of Recombinant Porcine Fructose-1,6-bisphosphatase Participates in the Allosteric Regulation of Catalysis*

H. Fromm, R. Honzatko, S. Nelson, 2001, The Journal of Biological Chemistry.

Mutations in the Hinge of a Dynamic Loop Broadly Influence Functional Properties of Fructose-1,6-bisphosphatase*

H. Fromm, J. Choe, R. Honzatko, 2000, The Journal of Biological Chemistry.

Major Changes in the Kinetic Mechanism of AMP Inhibition and AMP Cooperativity Attend the Mutation of Arg49 in Fructose-1,6-bisphosphatase*

H. Fromm, R. Honzatko, L. Shyur, 1997, The Journal of Biological Chemistry.

Biochemical Properties of Mutant and Wild-type Fructose-1,6-bisphosphatases Are Consistent with the Coupling of Intra- and Intersubunit Conformational Changes in the T- and R-state Transition*

H. Fromm, A. Aleshin, R. Honzatko, 1996, The Journal of Biological Chemistry.

Metaphosphate in the Active Site of Fructose-1,6-bisphosphatase*

H. Fromm, C. V. Iancu, J. Choe, 2003, The Journal of Biological Chemistry.

Preliminary X-ray crystallographic study of cyanase from Escherichia coli.

R. M. Little, P. Anderson, R. Honzatko, 1987, Journal of molecular biology.

Structure of the Ebola VP35 interferon inhibitory domain

J. Nix, C. Basler, D. Leung, 2009, Proceedings of the National Academy of Sciences.

Structural heterogeneity in protein crystals.

J. L. Smith, W A Hendrickson, J L Smith, 1986, Biochemistry.

Structure of Inhibited Fructose-1,6-bisphosphatase from Escherichia coli

H. Fromm, R. Honzatko, J. Hines, 2007, Journal of Biological Chemistry.

Residues Essential for Catalysis and Stability of the Active Site of Escherichia coli Adenylosuccinate Synthetase as Revealed by Directed Mutation and Kinetics*

H. Fromm, N. Sun, R. Honzatko, 1997, The Journal of Biological Chemistry.

Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.

R. Joseph, A. Andreotti, J. Nix, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

The Roles of Glycine Residues in the ATP Binding Site of Human Brain Hexokinase*

H. Fromm, A. Aleshin, C. Zeng, 1998, The Journal of Biological Chemistry.

Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli.

J. L. Crawford, J L Crawford, J E Ladner, 1982, Journal of molecular biology.

Crystal structures of adenylosuccinate synthetase from Escherichia coli complexed with GDP, IMP hadacidin, NO3-, and Mg2+.

H J Fromm, H. Fromm, R. Honzatko, 1996, Journal of molecular biology.

Refined Crystal Structures of Guanine Nucleotide Complexes of Adenylosuccinate Synthetase from Escherichia coli*

H. Fromm, R. Honzatko, B. Poland, 1996, The Journal of Biological Chemistry.

Crystal structure of adenylosuccinate synthetase from Escherichia coli. Evidence for convergent evolution of GTP-binding domains.

K H Kim, Y. Cho, R. Honzatko, 1993, The Journal of biological chemistry.

Refinement of a molecular model for lamprey hemoglobin from Petromyzon marinus.

W A Hendrickson, W. Hendrickson, R. Honzatko, 1985, Journal of molecular biology.

Nucleotide Complexes of Escherichia coli Phosphoribosylaminoimidazole Succinocarboxamide Synthetase*

H. Fromm, R. Honzatko, N. Ginder, 2006, Journal of Biological Chemistry.

Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.

H. Fromm, H. Bartunik, A. Aleshin, 1998, Journal of molecular biology.

Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase

R. Honzatko, S. Nelson, Anuradha Roy, 2022, bioRxiv.

Promising Antimalarials targeting Apicoplast DNA Polymerase from Plasmodium falciparum

R. Honzatko, Supreet Kaur, J. M. Beck, 2022, bioRxiv.

Raman spectroscopy of avidin: secondary structure, disulfide conformation, and the environment of tyrosine.

R. Williams, R. Honzatko, 1982, Biochemistry.

Structure of unligated aspartate carbamoyltransferase of Escherichia coli at 2.6-A resolution.

W. Lipscomb, H. Ke, R. Honzatko, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.

H J Fromm, H. Fromm, G. Bourenkov, 2000, Journal of molecular biology.

Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase.

H. Fromm, R. Honzatko, S. Nelson, 2005, Biochemistry.

IMP, GTP, and 6-Phosphoryl-IMP Complexes of Recombinant Mouse Muscle Adenylosuccinate Synthetase*

H. Fromm, T. Borza, C. V. Iancu, 2002, The Journal of Biological Chemistry.

Refined structure for the complex of acarbose with glucoamylase from Aspergillus awamori var. X100 to 2.4-A resolution.

L. Firsov, A. Aleshin, R. Honzatko, 1994, The Journal of biological chemistry.

Variations in the Response of Mouse Isozymes of Adenylosuccinate Synthetase to Inhibitors of Physiological Relevance*

H. Fromm, T. Borza, C. V. Iancu, 2003, The Journal of Biological Chemistry.

Recombinant Mouse Muscle Adenylosuccinate Synthetase

H. Fromm, T. Borza, C. V. Iancu, 2001, The Journal of Biological Chemistry.

Relationship of Conserved Residues in the IMP Binding Site to Substrate Recognition and Catalysis in Escherichia coliAdenylosuccinate Synthetase*

H. Fromm, R. Honzatko, Wenyan Wang, 1997, The Journal of Biological Chemistry.

A Study of Escherichia coli Adenylosuccinate Synthetase Association States and the Interface Residues of the Homodimer*

H. Fromm, R. Honzatko, Wenyan Wang, 1997, The Journal of Biological Chemistry.

Tertiary Structure and Characterization of a Glycoside Hydrolase Family 44 Endoglucanase from Clostridium acetobutylicum

Christopher D Warner, J. A. Hoy, P. Reilly, 2009, Applied and Environmental Microbiology.

Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution.

H. Fromm, D. Svergun, M. Malfois, 1999, Biochemistry.

Spontaneous subunit exchange in porcine liver fructose‐1,6‐bisphosphatase

H. Fromm, R. Honzatko, S. Nelson, 2001, FEBS letters.

Crystal structures of fructose 1,6-bisphosphatase: mechanism of catalysis and allosteric inhibition revealed in product complexes.

H. Fromm, J. Choe, R. Honzatko, 2000, Biochemistry.

Role of a dynamic loop in cation activation and allosteric regulation of recombinant porcine fructose-1,6-bisphosphatase.

H J Fromm, H. Fromm, J. Choe, 1998, Biochemistry.

Adenylosuccinate synthetase: recent developments.

M. Stayton, H. Fromm, R. Honzatko, 1999, Advances in enzymology and related areas of molecular biology.

Calculation of structure factors from molecular models with anisotropic atoms

R. Honzatko, Z. Pan, A. Takaya, 1987 .

Crystal structure of S‐glutathiolated carbonic anhydrase III

R. Fisher, T. Chatterjee, R. J. Mallis, 2000, FEBS letters.

Dual Mechanisms for Glucose 6-Phosphate Inhibition of Human Brain Hexokinase*

H J Fromm, H. Fromm, R. Honzatko, 1999, The Journal of Biological Chemistry.

Single‐residue Determinants in the Binding of Recombinant Human Brain Hexokinase to the Mitochondrion

R. Honzatko, Lu Shen, N. Mehyar, 2011 .

Feedback Inhibition and Product Complexes of Recombinant Mouse Muscle Adenylosuccinate Synthetase*

H. Fromm, T. Borza, C. V. Iancu, 2002, The Journal of Biological Chemistry.

Structure-function studies of adenylosuccinate synthetase from Escherichia coli.

H. Fromm, R. Honzatko, 1999, Archives of biochemistry and biophysics.

Mechanistic implications from crystalline complexes of wild-type and mutant adenylosuccinate synthetases from Escherichia coli.

H. Fromm, J. Choe, R. Honzatko, 1999, Biochemistry.

Multiple crystal forms of hexokinase I: new insights regarding conformational dynamics, subunit interactions, and membrane association

H. Fromm, A. Aleshin, R. Honzatko, 1998, FEBS letters.

Entrapment of 6-Thiophosphoryl-IMP in the Active Site of Crystalline Adenylosuccinate Synthetase from Escherichia coli *

H. Fromm, R. Honzatko, B. Poland, 1997, The Journal of Biological Chemistry.

Terpenoid synthase structures: a so far incomplete view of complex catalysis.

R. Peters, R. Honzatko, Yang Gao, 2012, Natural product reports.

Mutations in the Hinge of a Dynamic Loop Broadly Influence Functional Properties of Fructose-1,6-bisphosphatase*

H. Fromm, J. Choe, R. Honzatko, 2000, The Journal of Biological Chemistry.

Determinants of l-Aspartate and IMP Recognition inEscherichia coli Adenylosuccinate Synthetase*

H. Fromm, R. Honzatko, Eric S. Underbakke, 2002, The Journal of Biological Chemistry.

IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli *

H. Fromm, R. Honzatko, Wenyan Wang, 2002, The Journal of Biological Chemistry.

The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase.

H. Fromm, M. Grütter, S. Cowan-Jacob, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Refined crystal structures of unligated adenylosuccinate synthetase from Escherichia coli.

H. Fromm, R. Honzatko, C. Hoffman, 1995, Journal of molecular biology.

Ambiguities in Mapping the Active Site of a Conformationally Dynamic Enzyme by Directed Mutation

H. Fromm, R. Honzatko, Wenyan Wang, 1998, The Journal of Biological Chemistry.

Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis*

R. Peters, J. A. Hoy, R. Honzatko, 2012, The Journal of Biological Chemistry.

Crystallographic complexes of glucoamylase with maltooligosaccharide analogs: relationship of stereochemical distortions at the nonreducing end to the catalytic mechanism.

B. Svensson, L. Firsov, A. Aleshin, 1996, Biochemistry.

Directed Mutations in the Poorly Defined Region of Porcine Liver Fructose-1,6-bisphosphatase Significantly Affect Catalysis and the Mechanism of AMP Inhibition*

H. Fromm, J. Choe, R. Honzatko, 1998, The Journal of Biological Chemistry.

Site-directed Mutagenesis of Residues at Subunit Interfaces of Porcine Fructose-1,6-bisphosphatase (*)

H. Fromm, A. Aleshin, R. Honzatko, 1996, The Journal of Biological Chemistry.

Identification of a Phosphate Regulatory Site and a Low Affinity Binding Site for Glucose 6-Phosphate in the N-terminal Half of Human Brain Hexokinase*

H. Fromm, T. Fang, A. Aleshin, 1998, The Journal of Biological Chemistry.

Crystal structure of S‐glutathiolated carbonic anhydrase III

R. Fisher, T. Chatterjee, R. J. Mallis, 2000, FEBS letters.

Structure of an actively exchanging complex between carboxypeptidase A and a substrate analogue.

W. Lipscomb, D. Rees, R. Honzatko, 1980, Proceedings of the National Academy of Sciences of the United States of America.