T. Okajima

发表

O-Linked N-Acetylglucosamine Is Present on the Extracellular Domain of Notch Receptors*

K. Furukawa, Kosuke Murakami, Makiko Ito, 2008, Journal of Biological Chemistry.

Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions

H. Takeuchi, T. Okajima, Wataru Saiki, 2021, Biomolecules.

Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking

H. Takeuchi, T. Okajima, Wataru Saiki, 2020, Cells.

O-Fucose Monosaccharide of Drosophila Notch Has a Temperature-sensitive Function and Cooperates with O-Glucose Glycan in Notch Transport and Notch Signaling Activation*

K. Matsuno, T. Okajima, Takeshi Sasamura, 2014, The Journal of Biological Chemistry.

Modulation of Notch-Ligand Binding by Protein O-Fucosyltransferase 1 and Fringe*

A. Xu, K. Irvine, T. Okajima, 2003, Journal of Biological Chemistry.

Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling

K. Irvine, T. Matsuda, T. Okajima, 2008, BMC Biology.

O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1.

K. Furukawa, Makiko Ito, T. Matsuda, 2012, Biochemical and biophysical research communications.

Structural Divergence in O-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1

K. Ikeda, H. Takeuchi, T. Okajima, 2018, Molecules.

Allergenic potential of rice-pollen proteins: expression, immuno-cross reactivity and IgE-binding.

S. Hino, T. Matsuda, D. Nadano, 2013, Journal of biochemistry.

Comprehensive O-GlcNAc glycoproteomics on NOTCH1 EGF repeats implicated unique Lewis X epitopes in mammals

H. Takeuchi, Kentaro Yogi, T. Okajima, 2021 .

Structure and function of extracellular O-GlcNAc.

T. Okajima, Mitsutaka Ogawa, 2019, Current opinion in structural biology.

N-acetylglucosamine modification in the lumen of the endoplasmic reticulum.

K. Furukawa, T. Okajima, Mitsutaka Ogawa, 2015, Biochimica et biophysica acta.

Extracellular O-linked β-N-acetylglucosamine: Its biology and relationship to human disease.

K. Furukawa, T. Okajima, Mitsutaka Ogawa, 2014, World journal of biological chemistry.

Extracellular O-GlcNAcylation

K. Furukawa, T. Okajima, Mitsutaka Ogawa, 2014 .

Impaired O-linked N -Acetylglucosaminylation in the Endoplasmic Reticulum by Mutated EGF domain-specific O-linked N-acetylglucosamine transferase Found in Adams-Oliver Syndrome*

Yagi, Koichi Kato, H. Yagi, 2014 .

Impaired O-Linked N-Acetylglucosaminylation in the Endoplasmic Reticulum by Mutated Epidermal Growth Factor (EGF) Domain-specific O-Linked N-Acetylglucosamine Transferase Found in Adams-Oliver Syndrome*

Koichi Kato, H. Yagi, K. Furukawa, 2014, The Journal of Biological Chemistry.

Notch signaling: A sweet strategy.

T. Okajima, 2017, Nature chemical biology.

St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity

Kazuro Furukawa, T. Wakabayashi, K. Furukawa, 2021, Nagoya journal of medical science.

pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen.

Kazuro Furukawa, T. Urano, H. Nakada, 2012, Biochemical and biophysical research communications.

N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization

K. Ikeda, Yuko Tashima, H. Takeuchi, 2020, The Journal of Biological Chemistry.

Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes.

Kazuro Furukawa, Y. Yamauchi, K. Furukawa, 2016, Glycobiology.

Molecular Cloning of Brain-specific GD1α Synthase (ST6GalNAc V) Containing CAG/Glutamine Repeats*

Kazuro Furukawa, Hiromi Ito, T. Urano, 1999, The Journal of Biological Chemistry.

Molecular Cloning and Expression of Mouse GD1α/GT1aα/GQ1bα Synthase (ST6GalNAc VI) Gene*

Hiromi Ito, T. Urano, M. Kiso, 2000, The Journal of Biological Chemistry.

Expression Cloning of Human Globoside Synthase cDNAs

Kazuro Furukawa, T. Urano, M. Uchikawa, 2000, The Journal of Biological Chemistry.

Congenital diseases caused by defective O-glycosylation of Notch receptors

Yuko Tashima, T. Okajima, 2018, Nagoya journal of medical science.

Roles of O-fucosyltransferase 1 and O-linked fucose in notch receptor function.

T. Matsuda, T. Okajima, 2006, Methods in enzymology.

Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice.

Kazuro Furukawa, H. Kiyama, R. Banno, 2016, Biochemical and biophysical research communications.

Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells*

Kazuro Furukawa, K. Honke, K. Furukawa, 2016, The Journal of Biological Chemistry.

Association of chicken zona pellucida glycoprotein (ZP) B1 with ZPC induces formation of ZPB1-ZPC fibrous aggregates containing disulfide-bridged ZPB1 dimer.

T. Matsuda, D. Nadano, T. Okajima, 2007, Biochemical and biophysical research communications.

Galactosyltransferase I is a gene responsible for progeroid variant of Ehlers-Danlos syndrome: molecular cloning and identification of mutations.

K. Furukawa, T. Okajima, 2002, Biochimica et biophysica acta.

Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation.

Yuko Tashima, T. Okajima, Yohei Tsukamoto, 2022, Analytical biochemistry.

Molecular Cloning of Globotriaosylceramide/CD77 Synthase, a Glycosyltransferase That Initiates the Synthesis of Globo Series Glycosphingolipids*

Kazuro Furukawa, T. Urano, K. Furukawa, 2000, The Journal of Biological Chemistry.

Transfection of the human IGFBP-3 gene into Balb/c fibroblasts: a model for the cellular functions of IGFBPs.

T. Okajima, R. Rosenfeld, P. Cohen, 1993, Growth regulation.

Identification of a Drosophila Gene Encoding Xylosylprotein β4-Galactosyltransferase That Is Essential for the Synthesis of Glycosaminoglycans and for Morphogenesis*

Kazuro Furukawa, P. Stanley, T. Urano, 2002, The Journal of Biological Chemistry.

cells Xylosyl Extension of O -Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Tra ﬃ cking

H. Takeuchi, T. Okajima, Wataru Saiki, 2020 .

STRONG ANTIBODY REACTION AGAINST GLYCOSPHINGOLIPIDS INJECTED IN LIPOSOME-EMBEDDED FORMS IN β3GN-T5 KNOCKOUT MICE

Kazuro Furukawa, Qing Zhang, K. Furukawa, 2011, Nagoya journal of medical science.

Binding of Norovirus Virus-Like Particles (VLPs) to Human Intestinal Caco-2 Cells and the Suppressive Effect of Pasteurized Bovine Colostrum on This VLP Binding

N. Aoki, T. Oka, Kosuke Murakami, 2010, Bioscience, biotechnology, and biochemistry.

Molecular Basis for the p Phenotype

Kazuro Furukawa, T. Urano, M. Uchikawa, 2000, The Journal of Biological Chemistry.

Suppressive expression of the glutelin A1-collagen peptide fusion gene in hybrid rice lines with the mutant line, Low Glutelin Content-1 (LGC-1)

N. Aoki, S. Hino, T. Matsuda, 2008 .

Development and evaluation of transgenic rice seeds accumulating a type II-collagen tolerogenic peptide

N. Aoki, S. Hino, T. Matsuda, 2008, Transgenic Research.

Discharge of solubilized and Dectin-1-reactive β-glucan from macrophage cells phagocytizing insoluble β-glucan particles: involvement of reactive oxygen species (ROS)-driven degradation.

K. Uchida, S. Hino, T. Morita, 2012, Biochemical and biophysical research communications.

Synthesis of Disialyl Lewis a (Lea) Structure in Colon Cancer Cell Lines by a Sialyltransferase, ST6GalNAc VI, Responsible for the Synthesis of α-Series Gangliosides*

T. Ando, Kazuro Furukawa, R. Kannagi, 2003, Journal of Biological Chemistry.

b-series Ganglioside Deficiency Exhibits No Definite Changes in the Neurogenesis and the Sensitivity to Fas-mediated Apoptosis but Impairs Regeneration of the Lesioned Hypoglossal Nerve*

Kazuro Furukawa, S. Aizawa, Y. Matsuda, 2002, The Journal of Biological Chemistry.

Post-weaning increases in the milk-fat globule EGF-factor VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells.

D. Flint, T. Matsuda, D. Nadano, 2013, Journal of biochemistry.

Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice

Kazuro Furukawa, Pu Zhang, K. Furukawa, 2019, Neuroscience.

Serum and monoclonal immunoglobulin E antibodies from NC/Nga mice with severe atopic‐like dermatitis recognize an auto‐antigen, histone H3

N. Aoki, S. Hino, T. Matsuda, 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins

Kazuro Furukawa, K. Honke, K. Furukawa, 2021, International journal of molecular sciences.

Sensitive colorimetric bioassays for insulin-like growth factor (IGF) stimulation of cell proliferation and glucose consumption: use in studies of IGF analogs.

N. Ling, H. Zhang, K. Nakamura, 1992, Endocrinology.

Absorption, Migration and Kinetics in Peripheral Blood of Orally Administered Ovalbumin in a Mouse Model

N. Aoki, J. Kurisaki, T. Matsuda, 2008, Bioscience, biotechnology, and biochemistry.

Molecular Basis for the Progeroid Variant of Ehlers-Danlos Syndrome

Kazuro Furukawa, T. Urano, S. Fukumoto, 1999, The Journal of Biological Chemistry.

Human Homolog of Caenorhabditis elegans sqv-3 Gene Is Galactosyltransferase I Involved in the Biosynthesis of the Glycosaminoglycan-Protein Linkage Region of Proteoglycans*

K. Yoshida, Kazuro Furukawa, K. Furukawa, 1999, The Journal of Biological Chemistry.

O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions.

E. Suzuki, K. Furukawa, Kosuke Murakami, 2011, Nature communications.

O-GlcNAc Modification of the Extracellular Domain of Notch Receptors

K. Furukawa, Yuta Sakaidani, T. Okajima, 2010 .

O-GlcNAc modification of the extracellular domain of Notch receptors.

K. Furukawa, Yuta Sakaidani, T. Okajima, 2010, Methods in enzymology.

Roles of glycosylation in Notch signaling.

P. Stanley, T. Okajima, 2010, Current topics in developmental biology.

Molecular Cloning of a Novel α2,3-Sialyltransferase (ST3Gal VI) That Sialylates Type II Lactosamine Structures on Glycoproteins and Glycolipids*

Kazuro Furukawa, H. Miyazaki, T. Urano, 1999, The Journal of Biological Chemistry.

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

P. Stanley, T. Murohara, Koichi Kato, 2017, eLife.

Biological functions of glycosyltransferase genes involved in O-fucose glycan synthesis.

T. Matsuda, Aiko Matsuura, T. Okajima, 2008, Journal of biochemistry.

Significant Roles of Notch O-Glycosylation in Cancer

H. Takeuchi, T. Okajima, Weiwei Wang, 2022, Molecules.

Microsoft Word-JBC revised final

K. Matsuno, T. Okajima, Takeshi Sasamura, 2014 .

Regulation of Notch Signaling by O-Linked Fucose

K. Irvine, T. Okajima, Kenneth D. Irvine, 2002, Cell.

Proteomic analysis of rodent ribosomes revealed heterogeneity including ribosomal proteins L10-like, L22-like 1, and L39-like.

S. Hino, T. Matsuda, D. Nadano, 2010, Journal of proteome research.

Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth.

T. Okajima, R. Rosenfeld, P. Cohen, 1993, Molecular endocrinology.

Chaperone Activity of Protein O-Fucosyltransferase 1 Promotes Notch Receptor Folding

A. Xu, K. Irvine, T. Okajima, 2005, Science.

Nonurea sodium dodecyl sulfate-polyacrylamide gel electrophoresis with high-molarity buffers for the separation of proteins and peptides.

T. Okajima, T. Yasuda, T. Tanabe, 1993, Analytical biochemistry.

Establishment of a Mammary Stromal Fibroblastic Cell Line for In Vitro Studies in Mice of Mammary Adipocyte Differentiation1

D. Flint, N. Aoki, T. Matsuda, 2010, Biology of reproduction.

Intracellular and extracellular O-linked N-acetylglucosamine in the nervous system

T. Okajima, K. Kamemura, Mitsutaka Ogawa, 2015, Experimental Neurology.

GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine epitopes reactive with CTD110.6 antibody.

K. Furukawa, T. Endo, T. Okajima, 2013, Biochemical and biophysical research communications.

Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis.

T. Matsuda, D. Nadano, T. Okajima, 2007, The Biochemical journal.

Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing

Kazuro Furukawa, Y. Yamauchi, Qing Zhang, 2016, Scientific Reports.

Majority of alpha2,6-sialylated glycans in adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.

Kazuro Furukawa, F. Sugiyama, Yoshimasa Takahashi, 2020, Glycobiology.

Trimeric Tn Antigen on Syndecan 1 Produced by ppGalNAc-T13 Enhances Cancer Metastasis via a Complex Formation with Integrin α5β1 and Matrix Metalloproteinase 9*

Kazuro Furukawa, T. Urano, H. Nakada, 2013, The Journal of Biological Chemistry.

Aminoglycosides are efficient reagents to induce readthrough of premature termination codon in mutant B4GALNT1 genes found in families of hereditary spastic paraplegia.

Kazuro Furukawa, T. Okajima, Y. Ohkawa, 2020, Journal of biochemistry.

Glycoproteomic analysis identifies cryptdin-related sequence 1 as O-glycosylated protein modified with α1,2-fucose in the small intestine.

M. Fujishiro, Yuko Tashima, Masanao Nakamura, 2020, Archives of biochemistry and biophysics.

Dephosphorylation reduces passage of ovalbumin antigen through intestinal epithelial Caco-2 cell monolayers.

T. Matsuda, Y. Akiyama, D. Nadano, 2013, Journal of biochemistry.

Contribution of extracellular O-GlcNAc to the stability of folded epidermal growth factor-like domains and Notch1 trafficking.

Yuko Tashima, H. Takeuchi, T. Okajima, 2020, Biochemical and biophysical research communications.

Glycoconjugate glycosyltransferases

K. Furukawa, K. Furukawa, T. Okajima, 2008, Glycoconjugate Journal.

The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid–binding lectin SIGLEC7 on the cell surface

Kazuro Furukawa, T. Okajima, A. Tsuchida, 2019, The Journal of Biological Chemistry.

ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5,6 (ST6GALNAC5,6)

Koichi Furukawa, K. Furukawa, K. Furukawa, 2014 .

IgG2 dominancy and carbohydrate recognition specificity of C3H/He mouse antibodies directed to cross-reactive carbohydrate determinants (CCDs) bearing beta-(1,2)-xylose and alpha-(1,3)-fucose.

N. Aoki, C. Sato, S. Hino, 2010, Immunology letters.

Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin.

T. Matsuda, D. Nadano, T. Okajima, 2011, Archives of biochemistry and biophysics.

Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA‐binding protein in early involution of the mouse mammary gland

Y. Taga, T. Matsuda, D. Nadano, 2010, Cell biochemistry and function.

Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers

Yuko Tashima, A. Taguchi, H. Takeuchi, 2021, Molecules.

Evidence that only EWS among the FET proteins acquires a low partitioning property for the hyperosmotic stress response by O-GlcNAc glycosylation on its low-complexity domain.

T. Okajima, K. Kamemura, Mitsutaka Ogawa, 2023, Experimental cell research.

ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6 (ST3GAL6)

K. Furukawa, T. Okajima, 2014 .

Differential Labeling of Glycoproteins with Alkynyl Fucose Analogs

Yasuhiko Kizuka, K. Nakajima, M. Nagae, 2020, International journal of molecular sciences.

Material For : Chaperone Activity of Protein O-fucosyltransferase 1 Promotes Notch Receptor Folding

A. Xu, T. Okajima, Kenneth D. Irvine, 2005 .

Engineering of a mammalian O-glycosylation pathway in the yeast Saccharomyces cerevisiae: production of O-fucosylated epidermal growth factor domains.

Y. Jigami, T. Okajima, T. Oka, 2008, Glycobiology.

Impaired O-linked N -Acetylglucosaminylation in the Endoplasmic Reticulum by Mutated EGF domain-specific O-linked N-acetylglucosamine transferase Found in Adams-Oliver Syndrome*

Yagi, Koichi Kato, K. Furukawa, 2014 .

Glycosyltransferases Involved in O-fucose Glycan Synthesis

T. Matsuda, T. Okajima, 2008 .