M. Zak

发表

Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase.

D. Sampath, P. Dragovich, T. O'Brien, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Karl H. Clodfelter, P. Bauer, N. Kley, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.

Adam R. Johnson, N. C. Ray, Rohan V Mendonca, 2019, Bioorganic & medicinal chemistry letters.

Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

Adam R. Johnson, N. C. Ray, G. Cain, 2018, Science Translational Medicine.

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities

Xingrong Liu, L. Di, K. Nagapudi, 2019, Drug Metabolism and Disposition.

Preclinical disposition and pharmacokinetics-pharmacodynamic modeling of biomarker response and tumour growth inhibition in xenograft mouse models of G-573, a MEK inhibitor

M. Belvin, K. Hoeflich, J. Chan, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Inhaled Janus Kinase (JAK) inhibitors for the treatment of asthma.

M. Zak, N. Rajapaksa, Hart S. Dengler, 2019, Bioorganic & medicinal chemistry letters.

A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide.

K. Nicolaou, M. Zak, Anthony A Estrada, 2005, Angewandte Chemie.

Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Brandon J. Bravo, Qiang Zhao, N. Skelton, 2013, Journal of medicinal chemistry.

Revealed by Novel TYK2-Selective Inhibitors Activity in Human Cytokine Responses A Restricted Role for TYK2 Catalytic

Adam R. Johnson, N. Lewin-Koh, Lawren C. Wu, 2013 .

Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis.

K. Nicolaou, M. Zak, Anthony A Estrada, 2005, Journal of the American Chemical Society.

A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton.

K. Nicolaou, M. Zak, M. Nevalainen, 2002, Angewandte Chemie.

Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks.

Sang Hyup Lee, K C Nicolaou, Mark Zak, 2005, Journal of the American Chemical Society.

Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2005, Angewandte Chemie.

Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.

Bohdan Waszkowycz, Jane R Kenny, Charles Eigenbrot, 2012, Journal of medicinal chemistry.

Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2004, Angewandte Chemie.

Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2004, Angewandte Chemie.

Discovery of a biologically active thiostrepton fragment.

M. Ghadiri, K. Nicolaou, P. Giannakakou, 2005, Journal of the American Chemical Society.

Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle.

K. Nicolaou, M. Zak, M. Bella, 2003, Angewandte Chemie.

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

Adam R. Johnson, Jun Liang, N. Lewin-Koh, 2013, The Journal of Immunology.

Universal solid-phase approach for the immobilization, derivatization, and resin-to-resin transfer reactions of boronic acids.

D. Hall, M. Zak, M. Gravel, 2002, The Journal of organic chemistry.

Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2005, Angewandte Chemie.

Total Synthesis of Thiostrepton. Part 1. Construction of the Dehydropiperidine/Thiazoline-Containing Macrocycle.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2004 .

Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2004, Angewandte Chemie.

Stereocontrolled synthesis of the quinaldic acid macrocyclic system of thiostrepton.

K. Nicolaou, F. Zécri, M. Zak, 2002, Angewandte Chemie.

Highly asymmetric dihydroxylation of 1-aryl-1′-pyridyl alkenes

Matthew L. Maddess, M. Zak, P. Reider, 2000 .

Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase

Xukun Chen, Mark Zak, Yongbo Liu, 2014, Chembiochem : a European journal of chemical biology.

Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.

Karl H. Clodfelter, Zhongguo Wang, Mark Zak, 2013, Journal of medicinal chemistry.

Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors.

Jane R Kenny, Charles Eigenbrot, Micah Steffek, 2013, Bioorganic & medicinal chemistry letters.

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.

Adam R. Johnson, H. Dyke, Rohan V Mendonca, 2013, Bioorganic & medicinal chemistry letters.

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Ariana Peck, Shiuh-Ming Luoh, Steve Price, 2013, Nature.

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.

Jane R Kenny, Philippe Bergeron, Ignacio Aliagas, 2013, Journal of medicinal chemistry.

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.

Jane R Kenny, Philippe Bergeron, Tian Jin, 2012, Journal of medicinal chemistry.

Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: a randomized, controlled, proof-of-activity trial.

J. Galanter, Hubert C. Chen, R. Beasley, 2021, The Journal of allergy and clinical immunology.

Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.

Yang Xiao, Lei Zhang, Karl H. Clodfelter, 2013, Bioorganic & medicinal chemistry letters.

Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.

N. Skelton, D. Sampath, K. Bair, 2016, Journal of medicinal chemistry.

Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.

Karl H. Clodfelter, N. Skelton, D. Sampath, 2015, Bioorganic & medicinal chemistry letters.

Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS.

P. Dragovich, B. Liederer, C. Hop, 2014, Bioanalysis.

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Yang Xiao, Lei Zhang, Deepak Sampath, 2013, Bioorganic & medicinal chemistry letters.

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.

Jane R Kenny, Philippe Bergeron, Charles Eigenbrot, 2012, Bioorganic & medicinal chemistry letters.

Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.

Karl H. Clodfelter, Zhongguo Wang, Mark Zak, 2013, Bioorganic & medicinal chemistry letters.

Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.

Karl H. Clodfelter, P. Bauer, N. Kley, 2013, Journal of medicinal chemistry.

Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Brandon J. Bravo, Qiang Zhao, N. Skelton, 2014, Bioorganic & medicinal chemistry letters.

High throughput screening identifies novel, cell cycle‐arresting small molecule enhancers of transient protein expression

Athena W Wong, Juan Li, D. Reilly, 2017, Biotechnology progress.

A probabilistic method to report predictions from a human liver microsomes stability QSAR model: a practical tool for drug discovery

Man-Ling Lee, Ignacio Aliagas, Timothy Heffron, 2015, Journal of Computer-Aided Molecular Design.

Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Brandon J. Bravo, Qiang Zhao, N. Skelton, 2013, Journal of medicinal chemistry.

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.

Adam R. Johnson, Rohan V Mendonca, M. Ultsch, 2012, Bioorganic & medicinal chemistry letters.

Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2004, Angewandte Chemie.

A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton.

K. Nicolaou, M. Zak, M. Nevalainen, 2002, Angewandte Chemie.