H. Uppal

发表

Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase.

D. Sampath, P. Dragovich, T. O'Brien, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Improving Risk Assessment

D. Dambach, H. Uppal, 2012, Science Translational Medicine.

Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice

M. Jiang, Wenxin Qin, S. Poloyac, 2011, Hepatology.

Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

Thomas J. Jones, W. Xie, H. Uppal, 2005, Hepatology.

Direct Reprogramming of Human Fibroblasts to Hepatocyte-Like Cells by Synthetic Modified mRNAs

H. Uppal, K. Simeonov, 2014, PloS one.

Mechanism of subendocardial cell proliferation in the rat and relevance for understanding drug-induced valvular heart disease in humans.

M. Fielden, K. Kolaja, Rosario Garrido, 2010, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice

S. Poloyac, W. Xie, H. Uppal, 2005, Hepatology.

Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism.

W. Xie, H. Uppal, S. Saini, 2004, Drug discovery today.

Results from a phase 2 study of enzalutamide (ENZA), an androgen receptor (AR) inhibitor, in advanced AR+ triple-negative breast cancer (TNBC).

C. Hudis, M. Blaney, I. C. Tudor, 2015 .

Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization

Yonggong Zhai, W. Xie, H. Uppal, 2007, Hepatology.

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.

R. Evans, D. Moore, W. Xie, 2004, Molecular pharmacology.

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer

D. Danilenko, J. DeVoss, A. Zarrin, 2019, Front. Immunol..

In Vitro Cardiotoxicity Investigation Using High Content Analysis and Human Stem Cell-Derived Models

N. Thomas, M. Kauss, H. Uppal, 2017 .

Chronic Activation of LXR Sensitizes Mice to High Cholesterol Diet Induced Gut Toxicity

D. Stolz, H. Uppal, Meishu Xu, 2018 .

Cardiotoxicity Associated with Nicotinamide Phosphoribosyltransferase Inhibitors in Rodents and in Rat and Human-Derived Cells Lines

A. Bruening-Wright, D. Sampath, P. Dragovich, 2017, Cardiovascular Toxicology.

1802 Overall survival (OS) from the phase 2 study of enzalutamide (ENZA), an androgen receptor (AR) signaling inhibitor, in AR+ advanced triple-negative breast cancer (aTNBC)

C. Hudis, M. Blaney, I. C. Tudor, 2015 .

Drug discovery perspective of chemical-driven mouse mutagenesis.

H. Uppal, Wen Xie, 2003, Drug discovery today.

Enzalutamide for the Treatment of Androgen Receptor-Expressing Triple-Negative Breast Cancer.

Peter Schmid, Rita Nanda, Hirdesh Uppal, 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway*

R. Evans, Jie Zhou, Yonggong Zhai, 2006, Journal of Biological Chemistry.

Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1)

M. Sliwkowski, S. Girish, V. Ramakrishnan, 2014, Clinical Cancer Research.

REGULATORY NETWORKS OF PXR, CAR AND LXR IN CHOLESTEROL AND BILE ACID METABOLISM

H. Uppal, 2007 .

Identification of a Kinase Profile that Predicts Chromosome Damage Induced by Small Molecule Kinase Inhibitors

Hans Bitter, David Goldstein, Andrew J. Olaharski, 2009, PLoS Comput. Biol..

Activation of LXRs prevents bile acid toxicity and cholestasis in female mice

D. Mangelsdorf, G. Michalopoulos, Jie Zhou, 2007, Hepatology.

Characterization of rat liver proteins adducted by reactive metabolites of menthofuran.

S. Nelson, H. Uppal, Kevin A. Ford, 2012, Chemical research in toxicology.

Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor.

Jie Zhou, M. J. Jarzynka, Shi-Yuan Cheng, 2007, Molecular endocrinology.

A novel biomarker to predict sensitivity to enzalutamide (ENZA) in TNBC.

J. Parker, I. C. Tudor, H. Uppal, 2015 .

Phase I/II trial of a dendritic cell vaccine transfected with DNA encoding melan A and gp100 for patients with metastatic melanoma

L. Billingham, L. Young, S. Berhane, 2011, Gene Therapy.

Chronic Activation of Liver X Receptor Sensitizes Mice to High Cholesterol Diet–Induced Gut Toxicity

D. Stolz, W. Xie, H. Uppal, 2018, Molecular Pharmacology.

In vitro to in vivo concordance of a high throughput assay of bone marrow toxicity across a diverse set of drug candidates.

Hirdesh Uppal, K. Kolaja, A. Olaharski, 2009, Toxicology letters.

Androgen Receptor Immunohistochemistry as a Companion Diagnostic Approach to Predict Clinical Response to Enzalutamide in Triple-Negative Breast Cancer.

I. C. Tudor, Jianjun Yu, Vernon T. Phan, 2017, JCO precision oncology.

Evaluation of the GreenScreen GADD45alpha-GFP indicator assay with non-proprietary and proprietary compounds.

Silvio Albertini, Stephan Kirchner, Hirdesh Uppal, 2009, Mutation research.

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid

Dolores Diaz, Deepak Sampath, Hirdesh Uppal, 2015, Toxicology mechanisms and methods.

Abstract A135: T-DM1-induced thrombocytopenia results from impaired platelet production in a HER2-independent manner.

M. Sliwkowski, S. Girish, V. Ramakrishnan, 2011 .

Abstract OT3-02-02: ENDEAR: A randomized international phase 3 study comparing the efficacy and safety of enzalutamide in combination with paclitaxel chemotherapy or as monotherapy vs placebo with paclitaxel in patients with advanced diagnostic-positive triple-negative breast cancer

F. Cardoso, F. André, I. C. Tudor, 2017 .

Abstract P3-07-25: Improved clinical outcomes on enzalutamide observed in patients with PREDICT AR+ triple-negative breast cancer: prognosis or prediction?

J. Parker, W. Gradishar, K. Gelmon, 2016 .

Direct Reprogramming of Human Fibroblasts to Hepatocyte-Like Cells by Synthetic Modified mRNAs

H. Uppal, K. Simeonov, 2014, PloS one.

Activation of LXRs prevents bile acid toxicity and cholestasis in female mice

D. Mangelsdorf, G. Michalopoulos, Jie Zhou, 2007, Hepatology.