J. Ly

发表

Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Karl H. Clodfelter, P. Bauer, N. Kley, 2013, Bioorganic & medicinal chemistry letters.

Investigation of mechanism of drug‐induced cardiac injury and torsades de pointes in cynomolgus monkeys

K. Kolaja, L. Guo, M. Albassam, 2012, British journal of pharmacology.

Use of Transgenic Mouse Models to Understand the Oral Disposition and Drug-Drug Interaction Potential of Cobimetinib, a MEK Inhibitor

E. Choo, J. Ly, Ann Qin, 2015, Drug Metabolism and Disposition.

Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor

E. Choo, J. Ly, Kirsten Messick, 2015 .

Investigations into the Mechanisms of Pyridine Ring Cleavage in Vismodegib

J. Lyssikatos, H. Wong, C. Hop, 2014, Drug Metabolism and Disposition.

Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK).

Adam R. Johnson, S. Bromidge, Lawren C. Wu, 2013, Bioorganic & medicinal chemistry letters.

Differential Effects of Rifampin and Ketoconazole on the Blood and Liver Concentration of Atorvastatin in Wild-Type and Cyp3a and Oatp1a/b Knockout Mice

E. Plise, J. Cheong, J. Ly, 2014, Drug Metabolism and Disposition.

Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21*

D. Sutherlin, J. Ernst, Wei Zhou, 2016, The Journal of Biological Chemistry.

A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors.

Fei Wang, H. Jayaram, F. A. Romero, 2017, Journal of medicinal chemistry.

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.

A. Ebens, C. Noland, J. Lyssikatos, 2019, Journal of medicinal chemistry.

Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions.

E. Choo, J. Ly, Ann Qin, 2017, Molecular pharmaceutics.

Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs

E. Choo, J. Boggs, C. Hop, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.

Leslie B. Lee, D. Sampath, P. Jackson, 2013, Neoplasia.

Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.

Fei Wang, F. A. Romero, E. Choo, 2018, Bioorganic & medicinal chemistry letters.

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.

Karen E Gascoigne, Fei Wang, S. Kharbanda, 2016, Journal of medicinal chemistry.

Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor

D. Sampath, P. Dragovich, B. Liederer, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.

Matthew S. Johnson, M. Ultsch, J. Veal, 2022, Journal of medicinal chemistry.

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.

M. Volgraf, A. Ebens, John G. Moffat, 2017, Journal of medicinal chemistry.

In vitro and in vivo characterization of CYP inhibition by 1‐aminobenzotriazole in rats

J. Mao, J. Ly, S. Mukadam, 2016, Biopharmaceutics & drug disposition.

Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.

Karen E Gascoigne, Z. Modrušan, S. Kharbanda, 2017, Cancer research.

Disruption of IRE1α through its kinase domain attenuates multiple myeloma

M. Amiot, D. Lawrence, P. Walter, 2018, Proceedings of the National Academy of Sciences.

Application of genetically modified rodent models in drug discovery and development for translation of clinical ADME properties

J. Ly, Robert S Jones, Jae H Chang, 2020 .

Role of P-glycoprotein on the brain penetration and brain pharmacodynamic activity of the MEK inhibitor cobimetinib.

J. Chan, E. Choo, E. Plise, 2014, Molecular pharmaceutics.

Investigating the Utility of Humanized PXR-CAR-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction.

Liling Liu, J. Ly, Susan D. Wong, 2021, Drug metabolism and disposition: the biological fate of chemicals.

Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model

Liling Liu, J. Ly, Kirsten Messick, 2016, Drug Metabolism and Disposition.

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.

M. Volgraf, A. Rohou, Jun Chen, 2021, Journal of medicinal chemistry.

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).

Karen E Gascoigne, Y. Ran, G. Hatzivassiliou, 2017, Journal of medicinal chemistry.

Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole

Sarah J. Robinson, J. Ly, Susan D. Wong, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.

Karl H. Clodfelter, N. Skelton, D. Sampath, 2015, Bioorganic & medicinal chemistry letters.

Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS.

P. Dragovich, B. Liederer, C. Hop, 2014, Bioanalysis.

Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.

Karl H. Clodfelter, P. Bauer, N. Kley, 2013, Journal of medicinal chemistry.

Preclinical Disposition of GDC-0973 and Prospective and Retrospective Analysis of Human Dose and Efficacy Predictions

M. Belvin, K. Hoeflich, M. Merchant, 2012, Drug Metabolism and Disposition.

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Simon S. Gao, J. Elstrott, M. Volgraf, 2021, The Journal of experimental medicine.

Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts

R. Kim, E. Choo, B. Alicke, 2013, Breast Cancer Research and Treatment.

Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse

J. Cheong, J. Ly, E. Chen, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.

C. Brotherton-Pleiss, M. Volgraf, Jun Chen, 2018, Journal of medicinal chemistry.

Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs

F. A. Romero, G. Cain, E. Choo, 2020, Toxicologic pathology.