D. Reynolds

发表

Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Karl H. Clodfelter, P. Bauer, N. Kley, 2013, Bioorganic & medicinal chemistry letters.

The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

Qiang Zhou, Peter G. Smith, P. Zhu, 2018, Genes & development.

2.03 – Alkyl Chalcogenides: Sulfur-based Functional Groups

R. Wilkes, D. Reynolds, P. C. Page, 1995 .

Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3.

B. Caleb, N. Larsen, Tuong-Vi Nguyen, 2020, ACS medicinal chemistry letters.

Estrogen Receptor Covalent Antagonists: The Best Is Yet to Come.

M. Hao, M. Korpal, P. Zhu, 2019, Cancer research.

Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of furanyl (γ)- and pyranyl (δ)-lactols

S. Ley, D. Dixon, R. I. Storer, 2004 .

Development of selective MELK kinase inhibitors for breast cancer treatment

D. Ito, P. Zhu, N. Larsen, 2016 .

Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).

Courtney A. Cullis, Mansoureh Rezaei, M. Sintchak, 2012, Journal of medicinal chemistry.

Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1.

P. Zhu, Lihua Yu, N. Larsen, 2020, ACS medicinal chemistry letters.

Preparation of desymmetrised meso-tartrate derivatives—synthesis and utility of (R′,R′,R,S)-2,3-butane diacetal protected dimethyl tartrate

S. Ley, D. Dixon, D. Reynolds, 1999 .

The total synthesis of the annonaceous acetogenin, muricatetrocin C.

S. Ley, D. Dixon, D. Reynolds, 2000, Chemistry.

Enantioselective synthesis of oasomycin A, part II: synthesis of the C29-C46 subunit.

Davidr . Evans, D. Reynolds, P. Nagorny, 2007, Angewandte Chemie.

Enantioselective synthesis of oasomycin a, part I: synthesis of the C1-C12 and C13-C28 subunits.

Davidr . Evans, Louis-Sebastian Sonntag, D. Reynolds, 2007, Angewandte Chemie.

A general and efficient procedure for the preparation of enantiopure anti-1,2-diols—synthesis and utility of (R′,R′,S,R)-2,3-butane diacetal protected butane tetrol

S. Ley, D. Dixon, D. Reynolds, 1999 .

Engineering diversity into dynamic combinatorial libraries by use of a small flexible building block

Philip S. Lukeman, S. Rowan, J. Sanders, 1998 .

1,2-diacetals: a new opportunity for organic synthesis.

S. Ley, D. Dixon, D. Reynolds, 2001, Chemical reviews.

New building blocks for efficient and highly diastereoselective polyol production—synthesis and utility of (R ′,R ′,S,S ) and (S′,S′,R,R)-2,3-butane diacetal protected butane tetrol derivatives

S. Ley, D. Dixon, D. Reynolds, 1999 .

Effects of Shape on Thermodynamic Cyclizations of Cinchona Alkaloids

S. Rowan, J. Sanders, D. Reynolds, 1999 .

Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.

Karl H. Clodfelter, Zhongguo Wang, Mark Zak, 2013, Journal of medicinal chemistry.

A Short and Efficient Stereoselective Synthesis of the Potent 5-Lipoxygenase Inhibitor CMI-977

S. Ley, D. Dixon, M. Chorghade, 2000 .

H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.

M. Hao, M. Warmuth, V. Subramanian, 2017, Cancer research.

Identification of a novel inositol phosphate recognition site: specific [3H]inositol hexakisphosphate binding to brain regions and cerebellar membranes.

P. Hawkins, D. Poyner, M. Hanley, 1990, Biochemical and biophysical research communications.

Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.

M. Hao, M. Warmuth, B. Caleb, 2018, Cancer discovery.

Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.

Yang Xiao, Lei Zhang, Karl H. Clodfelter, 2013, Bioorganic & medicinal chemistry letters.

Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.

Karl H. Clodfelter, N. Skelton, D. Sampath, 2015, Bioorganic & medicinal chemistry letters.

Characterization of metal ion-induced [3H]inositol hexakisphosphate binding to rat cerebellar membranes.

P. Hawkins, D. Poyner, M. Hanley, 1993, The Journal of biological chemistry.

Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.

Karl H. Clodfelter, Zhongguo Wang, Mark Zak, 2013, Bioorganic & medicinal chemistry letters.

Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.

Karl H. Clodfelter, P. Bauer, N. Kley, 2013, Journal of medicinal chemistry.

Reprogramming RNA processing: an emerging therapeutic landscape.

M. Seiler, A. Agrawal, D. Reynolds, 2022, TIPS - Trends in Pharmacological Sciences.

The Characterization of 3,4‐Dimethylmethcathinone (3,4‐DMMC)

D. Reynolds, O. Locos, 2012, Journal of forensic sciences.

Enantioselective synthesis of oasomycin A, part III: fragment assembly and confirmation of structure.

Louis-Sebastian Sonntag, D. Reynolds, P. Nagorny, 2007, Angewandte Chemie.

The Characterization of 3,4‐Dimethylmethcathinone (3,4‐DMMC)

D. Reynolds, Oliver B. Locos, 2012, Journal of forensic sciences.

The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C We thank the EPSRC (D.J.D. and D.J.R.), the Novartis Research Fellowship (S.V.L.), and the BP Research Endowment (S.V.L.) for generous financial support for this work.

Dixon, Ley, S. Ley, 2002, Angewandte Chemie.