P. Yuen

发表

Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Karl H. Clodfelter, P. Bauer, N. Kley, 2013, Bioorganic & medicinal chemistry letters.

Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis.

R. Gilbertsen, K. Wang, R. Talanian, 1996, The Biochemical journal.

Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.

Benjamin D. Sellers, Rohan V Mendonca, Sanjeev Kumar, 2020, ACS medicinal chemistry letters.

Calpain inhibition: an overview of its therapeutic potential.

K. Wang, P. Yuen, Yuen Po-Wai, 1994, Trends in pharmacological sciences.

Development and therapeutic potential of calpain inhibitors.

K. Wang, P. Yuen, Kevin K. W. Wang, 1997, Advances in pharmacology.

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.

Adam R. Johnson, N. C. Ray, Rohan V Mendonca, 2019, Bioorganic & medicinal chemistry letters.

An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.

E. Lunney, K. Wang, M. Maki, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

Benjamin D. Sellers, K. Scearce-Levie, M. Volgraf, 2016, Journal of medicinal chemistry.

Section Review: Central & Peripheral Nervous Systems: Therapeutic potential of calpain inhibitors in neurodegenerative disorders

P. Yuen, Kevin K W Wang, K. Wang, 1996 .

Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Brandon J. Bravo, Qiang Zhao, N. Skelton, 2013, Journal of medicinal chemistry.

Calpain : pharmacology and toxicology of calcium-dependent protease

P. Yuen, Kevin K W Wang, K. Wang, 1999 .

Enantioselective synthesis of PD144723: A potent stereospecific anticonvulsant

P. Yuen, M. Vartanian, G. Kanter, 1994 .

Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.

P. McEwan, J. DeVoss, A. Zarrin, 2015, Journal of medicinal chemistry.

Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers.

K. Tarczy-Hornoch, P. Yuen, B. Szoke, 1999, Bioorganic & medicinal chemistry letters.

Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor.

P. Yuen, Kevin K W Wang, Masayuki Nakamura, 2003, Journal of medicinal chemistry.

Highly reduced organometallics. 35. Synthesis and chemistry of the first isolable bis(naphthalene)titanium complexes. Structural characterization of [Ti(.eta.4-C10H8)2(SnMe3)2]2-

P. Yuen, J. Ellis, M. Jang, 1993 .

Polyfunctional, structurally defined catalysts for the enantioselective addition of dialkylzinc reagents to aldehydes

E. Corey, P. Yuen, D. A. Wierda, 1990 .

Chemistry and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile.

D. Brunner, R. Lukas, A. Kozikowski, 2012, Journal of medicinal chemistry.

Enantioselective vicinal hydroxylation of terminal and E-1,2-disubstituted olefins by a chiral complex of osmium tetraoxide. An effective controller system and a rational mechanistic model

R. D. Connell, E. Corey, P. Yuen, 1989 .

Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists.

E. R. Whittemore, P. Yuen, S. Cai, 1999, Journal of medicinal chemistry.

New classes of zerovalent zirconium carbonyls and related species. Structural characterizations of [Zr(CO)5(SnMe3)2]2− and [Zr(CO)4(dppe)SnMe3]−, dppe = Ph2PCH2CH2PPh2

P. Yuen, J. Ellis, M. Jang, 1996 .

Enantioselective Vicinal Hydroxylation of Terminal and E-1,2-Disubstituted Olefins by a Chiral Complex of Osmium Tetraoxide. An Effective Controller System and a Rational Mechanistic Model.

R. D. Connell, E. Corey, P. Yuen, 1990 .

Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase

Xukun Chen, Mark Zak, Yongbo Liu, 2014, Chembiochem : a European journal of chemical biology.

Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.

Karl H. Clodfelter, Zhongguo Wang, Mark Zak, 2013, Journal of medicinal chemistry.

Novel Use of Substituted 1,4-Dihydrobenz[d][1,3]oxazin-2-ones in the Synthesis of Important Aminomethyl o-Nitroanilines

P. Yuen, S. Nikam, M. Rafferty, 1997 .

Crystal structure of calcium bound domain VI of calpain at 1.9 Å resolution and its role in enzyme assembly, regulation, and inhibitor binding

L. DeLucas, M. Carson, G. Lin, 1997, Nature Structural Biology.

Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.

Adam R. Johnson, P. McEwan, A. Zarrin, 2014, Journal of medicinal chemistry.

AURINTRICARBOXYLIC ACm IS AN INHIBITOR OF 11- AND m-CALPAIN

P. Yuen, K. Raser, A. Posner, 1995 .

Aurintricarboxylic acid is an inhibitor of mu- and m-calpain.

K. Wang, P. Yuen, K. Raser, 1995, Biochemistry and molecular biology international.

Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2).

Benjamin D. Sellers, Rohan V Mendonca, G. Hatzivassiliou, 2018, ACS medicinal chemistry letters.

Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.

Yang Xiao, Lei Zhang, Karl H. Clodfelter, 2013, Bioorganic & medicinal chemistry letters.

Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.

N. Skelton, D. Sampath, K. Bair, 2016, Journal of medicinal chemistry.

Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.

Karl H. Clodfelter, N. Skelton, D. Sampath, 2015, Bioorganic & medicinal chemistry letters.

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Yang Xiao, Lei Zhang, Deepak Sampath, 2013, Bioorganic & medicinal chemistry letters.

Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.

Karl H. Clodfelter, Zhongguo Wang, Mark Zak, 2013, Bioorganic & medicinal chemistry letters.

Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.

Karl H. Clodfelter, P. Bauer, N. Kley, 2013, Journal of medicinal chemistry.

Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Brandon J. Bravo, Qiang Zhao, N. Skelton, 2014, Bioorganic & medicinal chemistry letters.

The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury.

E. Hall, K. Wang, P. Yuen, 2001, Journal of neurotrauma.

Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.

C. Brotherton-Pleiss, M. Volgraf, Jun Chen, 2018, Journal of medicinal chemistry.

GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.

Benjamin D. Sellers, K. Scearce-Levie, M. Volgraf, 2017, ACS medicinal chemistry letters.

Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI

J. Neale, Jia Zhou, G. Gurkoff, 2011, Brain Research.

Subtype-selective N-methyl-D-aspartate receptor antagonists: benzimidazalone and hydantoin as phenol replacements.

L. Wise, E. R. Whittemore, P. Yuen, 2000, Journal of medicinal chemistry.

NOVEL ALKOXO- AND ARYLOXOTITANIUM CARBONYLS. STRUCTURAL CHARACTERIZATION OF TI(CO)4(MU -OPH)22-1

P. Yuen, V. Young, J. Ellis, 1997 .

N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: a novel antagonist at the 1A/2B NMDA receptor subtype.

E. R. Whittemore, P. Yuen, S. Cai, 1998, Bioorganic & Medicinal Chemistry Letters.

Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Brandon J. Bravo, Qiang Zhao, N. Skelton, 2013, Journal of medicinal chemistry.

CALPAIN INHIBITORS : NOVEL NEUROPROTECTANTS AND POTENTIAL ANTI CATARACT AGENTS

K. Wang, P. Yuen, 1998 .