K. Sugahara

发表

Abstract C244: Development of the BET bromodomain inhibitor OTX015.

J. Noel, K. Iwata, Shinsuke Ooike, 2013 .

Amiselimod, a novel sphingosine 1‐phosphate receptor‐1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk

K. Sugahara, H. Kataoka, H. Kumagai, 2016, British journal of pharmacology.

Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate.

K. Adachi, K. Sugahara, Y. Maeda, 2005, Bioorganic & medicinal chemistry.

Y-24180, an antagonist of platelet-activating factor, suppresses interleukin 5 production in cultured murine th(2)cells and human peripheral blood mononuclear cells.

H. Matsuyuki, H. Kusuhara, K. Sugahara, 2000, Cytokine.

FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo.

K. Sugahara, H. Kataoka, Y. Yanagawa, 1998, Journal of immunology.

Lymphadenopathy in IgG4-related disease: a phenotype of severe activity and poor prognosis, with eotaxin-3 as a new biomarker.

T. Takeuchi, J. Kikuchi, M. Akiyama, 2020, Rheumatology.

Inhibition of activation of human peripheral blood eosinophils by Y-24180, an antagonist to platelet-activating factor receptor.

K. Sugahara, H. Komatsu, M. Amano, 1999, Life sciences.

A phenotypic drug discovery study on thienodiazepine derivatives as inhibitors of T cell proliferation induced by CD28 co-stimulation leads to the discovery of a first bromodomain inhibitor.

H. Sumichika, K. Adachi, K. Iwata, 2016, Bioorganic & medicinal chemistry letters.

Migration of CD4 T Cells and Dendritic Cells toward Sphingosine 1-Phosphate (S1P) Is Mediated by Different Receptor Subtypes: S1P Regulates the Functions of Murine Mature Dendritic Cells via S1P Receptor Type 3

H. Matsuyuki, K. Sugahara, H. Kataoka, 2007, The Journal of Immunology.

Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models

K. Sugahara, T. Kakimoto, H. Utsumi, 2019, Journal of immunology research.

Edaravone inhibits collagen-induced arthritis possibly through suppression of nuclear factor-kappa B.

Y. Ikeda, T. Suehiro, Y. Kumon, 2008, Molecular immunology.

Role of sphingosine 1-phosphate (S1P) and effects of fingolimod, an S1P receptor 1 functional antagonist in lymphocyte circulation and autoimmune diseases

N. Seki, K. Sugahara, H. Kataoka, 2014 .

S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1.

T. Masuko, K. Sugahara, A. Fukunari, 2014, International immunology.

Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P.

H. Matsuyuki, Y. Igarashi, Takayuki Kohno, 2006, Cellular & molecular immunology.

FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.

M. Koyama, K. Sugahara, A. Fukunari, 2005, Cellular & molecular immunology.

Sphingosine 1-phosphate receptor modulator, fingolimod (FTY720), provides a new therapeutic approach for autoimmune diseases

N. Seki, K. Sugahara, H. Kataoka, 2010 .

Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus.

H. Matsuyuki, K. Sugahara, Y. Maeda, 2006, Cellular & molecular immunology.

FTY720, a novel immunosuppressant, prolongs rat skin allograft survival by decreasing T-cell infiltration into grafts.

K. Sugahara, H. Kataoka, Y. Yanagawa, 1999, Transplantation proceedings.

Fingolimod (FTY720), the Sphingosine 1-Phosphate Receptor Modulator, as a New Therapeutic Drug in Multiple Sclerosis

N. Seki, K. Sugahara, H. Kataoka, 2011 .

Fingolimod (FTY720) ameliorates experimental autoimmune encephalomyelitis (EAE): I. Oral administration of FTY720 effectively inhibits re- lapse of EAE

M. Koyama, N. Seki, K. Sugahara, 2010 .

Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells

K. Sugahara, H. Utsumi, H. Kataoka, 2019, PloS one.

Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow.

N. Seki, K. Sugahara, Y. Maeda, 2010, International immunology.

Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate.

K. Adachi, K. Sugahara, Mahoko Asayama, 2010, Journal of medicinal chemistry.

A Murine Monoclonal Antibody that Recognizes an Extracellular Domain of the Human c‐erbB‐2 Protooncogene Product

T. Akiyama, T. Masuko, Y. Hashimoto, 1989, Japanese journal of cancer research : Gann.

Role of Sphingosine 1-Phosphate (S1P) Receptor 1 in Experimental Autoimmune Encephalomyelitis —I

N. Seki, K. Sugahara, H. Kataoka, 2013 .

Production In Vivo Infiltration into Grafts But Not Cytokine Allograft Survival by Decreasing T Cell Homing in Rats. II. FTY720 Prolongs Skin Lymphocytes by Acceleration of Lymphocyte Sequestration of Circulating Mature FTY720, a Novel Immunosuppressant, Induces

K. Sugahara, H. Kataoka, Y. Yanagawa, 1998 .

FTY720 induces the sequestration of circulating lymphocytes into the bone marrow in alymphoplasia mice

M. Koyama, N. Seki, K. Sugahara, 2010 .

Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: II. Effect of FTY720 and FTY720-phosphate on host-versus-graft and graft-versus-host reaction in mice.

K. Sugahara, H. Kataoka, N. Sato, 2005, Transplantation proceedings.

Reactive oxygen species are involved in the apoptosis induced by nonsteroidal anti-inflammatory drugs in cultured gastric cells.

H. Kusuhara, H. Sumichika, K. Sugahara, 1999, European journal of pharmacology.

A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys

K. Adachi, N. Seki, K. Sugahara, 2013, Pharmaceuticals.

Role of Sphingosine 1-Phosphate ( S 1 P ) Receptor 1 in Experimental Autoimmune Encephalomyelitis — I . S 1 PS 1 P 1 Axis Induces Migration of Th 1 and Th 17 Cells

N. Seki, K. Sugahara, H. Kataoka, 2013 .

Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells 2. IFN-α and IFN-λ1 cooperatively contribute to the expansion of Tph cells in systemic lupus erythematosus.

T. Takeuchi, J. Kikuchi, Katsuya Suzuki, 2022, International immunology.

Production and characterization of monoclonal antibodies against Trypanosoma cruzi-associated antigens.

T. Masuko, Y. Hashimoto, K. Sugahara, 1989, The Tohoku journal of experimental medicine.

Altered expression of immunohistochemically detected cytochrome P-450 component(s) in nitrosamine-induced rat urinary bladder lesion.

T. Masuko, Y. Hashimoto, K. Sugahara, 1987, Japanese journal of cancer research : Gann.

Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis.

M. Koyama, N. Seki, K. Sugahara, 2011, International immunopharmacology.

Therapeutic Effects of the Sphingosine 1-Phosphate Receptor Modulator, Fingolimod (FTY720), on Experimental Autoimmune Encephalomyelitis

N. Seki, K. Sugahara, H. Kataoka, 2012 .

IL-17–Producing Vγ4+ γδ T Cells Require Sphingosine 1-Phosphate Receptor 1 for Their Egress from the Lymph Nodes under Homeostatic and Inflammatory Conditions

N. Seki, K. Sugahara, A. Fukunari, 2015, The Journal of Immunology.

Increase in murine monoclonal‐antibody‐defined urinary antigens in patients with bladder cancer and benign urogenital disease

T. Masuko, Y. Hashimoto, K. Sugahara, 1989, International journal of cancer.

Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate.

H. Matsuyuki, K. Sugahara, H. Kataoka, 2005, Transplantation proceedings.

Multiple sclerosis (PP-038)

D. Arnold, F. Najafi, A. Bar-Or, 2010 .

Fingolimod (FTY720) ameliorates experimental autoimmune encephalomyelitis (EAE)

M. Koyama, N. Seki, K. Sugahara, 2010 .

Fingolimod (FTY720) ameliorates experimental autoimmune encephalomyelitis (EAE) : II. FTY720 decreases infiltration of Th17 and Th1 cells into the central nervous system in EAE

N. Seki, K. Sugahara, H. Kataoka, 2010 .

Th17/IL-17A axis is critical for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc): SSc patients with high levels of serum IL-17A exhibit reduced lung functions and increased prevalence of PAH.

M. Akiyama, N. Seki, K. Sugahara, 2024, Cytokine.

Cytotoxic Tph subset with low B-cell helper functions and its involvement in systemic lupus erythematosus

M. Akiyama, N. Seki, K. Sugahara, 2024, Communications biology.