C. Lowell

发表

Distinct and overlapping functional roles of Src family kinases in mouse platelets

S. Watson, Y. Senis, C. Abram, 2012, Journal of thrombosis and haemostasis : JTH.

Efficiency and Specificity of Gene Deletion in Lung Epithelial Doxycycline‐Inducible Cre Mice

C. Lowell, M. Sinha, 2017, American journal of respiratory cell and molecular biology.

Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk

Rong Zhou, A. Guerriero, V. Ferrari, 2003, Science.

LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.

Mark S. Anderson, A. DeFranco, J. Moon, 2016, The Journal of clinical investigation.

Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors

R. Poincloux, I. Maridonneau-Parini, A. Gallois, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection

Jennifer Y. Zhang, M. Shinohara, Dong-hai Wang, 2020, Infection and Immunity.

Neutrophils mediate antibody-induced antitumor effects in mice.

L. Fiette, P. Bruhns, J. D. Di Santo, 2013, Blood.

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

A. Mócsai, T. Németh, Z. Helyes, 2014, The Journal of experimental medicine.

Neutrophils give us a shock.

C. Lowell, 2011, The Journal of clinical investigation.

Fresh and Stored Red Blood Cell Transfusion Equivalently Induce Subclinical Pulmonary Gas Exchange Deficit in Normal Humans

R. Weiskopf, David Shimabukuro, M. Looney, 2012, Anesthesia and analgesia.

MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase

Huafeng Wang, A. DeFranco, M. Suresh, 2016, PLoS pathogens.

Lipopolysaccharide (LPS)-induced Macrophage Activation and Signal Transduction in the Absence of Src-Family Kinases Hck, Fgr, and Lyn

F. Meng, C. Lowell, Clifford A. Lowell, 1997, The Journal of experimental medicine.

B cell autoimmunity at the extremes

J. Zikherman, C. Lowell, 2017, Nature Immunology.

Requirement for MyD88 Signaling in B Cells and Dendritic Cells for Germinal Center Anti-Nuclear Antibody Production in Lyn-Deficient Mice

A. DeFranco, Zhaolin Hua, B. Hou, 2014, The Journal of Immunology.

B Cell–Specific Loss of Lyn Kinase Leads to Autoimmunity

A. DeFranco, C. Lowell, C. Lamagna, 2014, The Journal of Immunology.

Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.

J. Cyster, Ying Xu, T. Yi, 2015, Immunity.

Lyn kinase promotes erythroblast expansion and late-stage development.

D. Wojchowski, V. Karur, C. Lowell, 2006, Blood.

Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.

C. Damsky, D. Ilić, C. Lowell, 1999, Journal of cell science.

Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement

D. Bowtell, F. Pixley, E. Stanley, 2003, Journal of cellular physiology.

Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr.

H. Gresham, C. Willman, R. Geahlen, 2001, Immunity.

Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells.

C. Divino, T. Takai, Ge Ma, 2011, Immunity.

The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.

Hong Zhang, T. Takai, C. Chu, 2005, Immunity.

The Inhibitory Receptor PIR-B Negatively Regulates Neutrophil and Macrophage Integrin Signaling1

Hong Zhang, T. Takai, C. Lowell, 2004, The Journal of Immunology.

Integrin Signaling Regulates Neutrophil and Macrophage The Inhibitory Receptor PIR-B Negatively

Hong Zhang, T. Takai, C. Lowell, 2004 .

Complement Activation and Intraventricular Rituximab Distribution inRecurrentCentral NervousSystemLymphoma

V. S. Wong, S. Cha, P. Munster, 2014 .

Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma

V. S. Wong, S. Cha, P. Munster, 2013, Clinical Cancer Research.

A CD22-Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity

K. Ley, C. Brandl, E. Butcher, 2021, Nature immunology.

Selective augmentation of intestinal immunity by CD22-dependent SHP-1 control of β7 integrin expression

K. Ley, C. Brandl, E. Butcher, 2020, bioRxiv.

Store‐operated calcium signaling in neutrophils

C. Lowell, R. Clemens, 2015, Journal of leukocyte biology.

Expression of the TEL-Syk Fusion Protein in Hematopoietic Stem Cells Leads to Rapidly Fatal Myelofibrosis in Mice

C. Abram, C. Lowell, Yongmei Hu, 2013, PloS one.

Dectin-1-triggered Recruitment of Light Chain 3 Protein to Phagosomes Facilitates Major Histocompatibility Complex Class II Presentation of Fungal-derived Antigens*

D. Underhill, C. Lowell, Jun Ma, 2012, The Journal of Biological Chemistry.

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

Philippe Soriano, C. Lowell, 1996, Genes & development.

Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr.

C. Lowell, G. Berton, Giorgio Berton, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Production in Lyn-Deficient Mast Cells RI Signaling and to Cytokine and Chemokine ε Increased Expression of Genes Linked to Fc

J. Oliver, C. Lowell, J. Wilder, 2013 .

Increased Expression of Genes Linked to FcεRI Signaling and to Cytokine and Chemokine Production in Lyn-Deficient Mast Cells1

B. Wilson, J. Oliver, C. A. Tarleton, 2005, The Journal of Immunology.

Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin.

T. Pestina, C. Lowell, T. K. Gartner, 2002, Blood.

PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen‐1 signalling

J. M. Bradshaw, A. Zarbock, A. Margraf, 2018, British journal of pharmacology.

Positive and negative roles of the tyrosine kinase Lyn in B cell function.

A. DeFranco, C. Lowell, V. W. Chan, 1998, Seminars in immunology.

Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

A. DeFranco, C. Lowell, V. W. Chan, 1998, Current Biology.

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.

M. Fujimoto, A. DeFranco, T. Tedder, 2000, Immunity.

Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport.

O. Olivieri, L. De Franceschi, R. Corrocher, 1997, The Journal of clinical investigation.

Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma.

R. Advani, T. Batchelor, E. Gerstner, 2011, Blood.

Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.

T. Mazel, Alexander J. Smith, B. Wilson, 2004, Journal of immunology.

Dysregulated FcεRI Signaling and Altered Fyn and SHIP Activities in Lyn-Deficient Mast Cells1

T. Mazel, Alexander J. Smith, B. Wilson, 2004, The Journal of Immunology.

Non-immunogenic murine hepatocellular carcinoma Hepa1-6 cells expressing the membrane form of macrophage colony stimulating factor are rejected in vivo and lead to CD8+ T-cell immunity against the parental tumor.

E. Jeffes, M. Jadus, C. Lowell, 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

Differentiating pulmonary transfusion reactions using recipient and transfusion factors

E. Murphy, O. Gajic, N. Roubinian, 2017, Transfusion.

Endothelial Growth Factor-A Mediated by Neutrophil-Derived Vascular Protein-2-Induced Angiogenesis In Vivo Is CXCL1/Macrophage Inflammatory

D. Noonan, A. Albini, M. Cassatella, 2004 .

CXCL1/Macrophage Inflammatory Protein-2-Induced Angiogenesis In Vivo Is Mediated by Neutrophil-Derived Vascular Endothelial Growth Factor-A1

D. Noonan, A. Albini, M. Cassatella, 2004, The Journal of Immunology.

Emergency Blood Drives During the Covid-19 Pandemic: A New Model of Collaboration among UCSF Leadership, Medical Students, and a Community Partner

C. Lowell, Anya L. Greenberg, Hope Schwartz, 2020, Nejm Catalyst Innovations in Care Delivery.

Shp1 function in myeloid cells

C. Abram, C. Lowell, 2017, Journal of leukocyte biology.

Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9

R. Locksley, S. Ghosh, A. DeFranco, 2016, PloS one.

Mitogen-Activated Protein Kinase Activated Neutrophils: The Role of p38 Chemoattractant-Induced Degranulation of Kinase Pathways in

A. Mócsai, E. Ligeti, C. Lowell, 2017 .

mast cells coupled receptor signaling in Syk-deficient neutrophils and - G-protein

A. Mócsai, Hong Zhang, T. Kawakami, 2013 .

Establishment of a Novel System for Studying the Syk Function in B Cells

T. Kurosaki, C. Lowell, 2012 .

and Spleen Tyrosine Kinase Function in Generation of a Novel System for Studying

Chao Zhang, K. Shokat, C. Lowell, 2008 .

Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr.

Y. Matsuzaki, K. Hayashi, D. Kitamura, 2006, Blood.

Src Family Kinases Mitogen-Activated Protein Kinase Activated Neutrophils : The Role of p 38 Chemoattractant-Induced Degranulation of Kinase Pathways in

A. Mócsai, E. Ligeti, C. Lowell, 2000 .

Independent and Opposing Roles For Btk and Lyn in B and Myeloid Signaling Pathways

F. Alt, A. Satterthwaite, O. Witte, 1998, The Journal of experimental medicine.

Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

M. Loh, T. Graeber, J. Coligan, 2015, Nature.

Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk.

C. Lowell, 2011, Cold Spring Harbor perspectives in biology.

Overview: studying integrins in vivo.

T. Mayadas, C. Lowell, 2012, Methods in molecular biology.

Skap2 is required for β2 integrin–mediated neutrophil recruitment and functions

A. Zarbock, Helena Block, J. Rossaint, 2017, The Journal of experimental medicine.

L-selectin shedding affects bacterial clearance in the lung - a new regulatory pathway for integrin-outside-in signaling.

A. Mellmann, A. Zarbock, A. Margraf, 2019, Blood.

Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling

T. Mayadas, X. Cullere, Cheng Zhu, 2021, Cell reports.

An Important Role of the Src Family Kinase Lyn in Stimulating Platelet Granule Secretion*

Aleksandra Stojanovic, Xiaoping Du, Junling Liu, 2010, The Journal of Biological Chemistry.

Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling

Junling Liu, C. Lowell, M. Berndt, 2008, Journal of thrombosis and haemostasis : JTH.

Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury.

D. Ferriero, Hong Zhang, D. Mu, 2004, The Journal of clinical investigation.

Neutrophil protein kinase Cδ as a mediator of stroke-reperfusion injury

D. Ferriero, Hong Zhang, D. Mu, 2004 .

Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading.

A. Mócsai, Hong Zhang, P. Allen, 2003, Immunity.

Fgr Deficiency Results in Defective Eosinophil Recruitment to the Lung During Allergic Airway Inflammation1

C. Lowell, G. Berton, L. Vicentini, 2002, The Journal of Immunology.

Minimum conditions of major histocompatibility complex compatibility and recipient immune compromise required to establish donor white blood cell persistence in a murine transfusion model

M. Busch, C. Lowell, Tzong-Hae Lee, 2005, Transfusion.

This information is current as Inhibit Colitis Sufficient To Induce Dendritic Cells That Pathway in Intestinal Dendritic Cells Is Downregulation of the Syk Signaling and

M. Mitreva, J. Weinstock, A. Blum, 2016 .

Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis

M. Mitreva, J. Weinstock, A. Blum, 2016, The Journal of Immunology.

Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy

David Chisanga, S. Nutt, L. Whitehead, 2022, Science advances.

Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis.

C. Mermel, D. Link, Fulu Liu, 2006, Blood.

Multiple roles of Lyn kinase in myeloid cell signaling and function

Hong Zhang, C. Lowell, P. Scapini, 2009, Immunological reviews.

Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice.

B. Neel, C. Abram, L. Pao, 2013, Immunity.

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages

A. Weiss, H. Goodridge, C. Lowell, 2015, eLife.

Enhanced Toll-like receptor responses in the absence of DAP12

L. Lanier, J. Hamerman, C. Lowell, 2005 .

Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12

L. Lanier, J. Hamerman, C. Lowell, 2005, Nature Immunology.

Phosphatidylinositol 3‐kinase and mTOR mediate lipopolysaccharide‐stimulated nitric oxide production in macrophages via interferon‐β

A. DeFranco, J. Sanghera, C. Lowell, 2000, Journal of leukocyte biology.

Reduced Dosage of Bruton’s Tyrosine Kinase Uncouples B Cell Hyperresponsiveness from Autoimmunity in lyn−/− Mice1

A. Satterthwaite, O. Witte, C. Lowell, 2003, The Journal of Immunology.

Scaffolding Adapter Grb 2-Associated Binder 2 Requires Syk to Transmit Signals from Fc RI 1

B. Neel, C. Lowell, Haihua Gu, 2006 .

ActivationTyrosine Kinases, Btk and Lyn, in Mast Cell Redundant and Opposing Functions of Two

A. Satterthwaite, O. Witte, D. Rawlings, 2000 .

TRALI--definition, mechanisms, incidence and clinical relevance.

P. Toy, C. Lowell, 2007, Best practice & research. Clinical anaesthesiology.

Macrophages require Skap2 and Sirp&agr; for integrin-stimulated cytoskeletal rearrangement

B. Neel, D. Golan, T. Matozaki, 2012, Journal of Cell Science.

The Absence of Hck, Fgr, and Lyn Tyrosine Kinases Augments Lung Innate Immune Responses to Pneumocystis murina

Shaoguang Li, C. Steele, C. Lowell, 2009, Infection and Immunity.

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia

R. Locksley, Hong Zhang, P. Wolters, 2006, The Journal of experimental medicine.

Regulation of Synthesis of Amyloid A‐Related Protein *

W. Pearson, C. Lowell, R. Stearman, 1982, Annals of the New York Academy of Sciences.

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.

M. Matthay, M. Looney, C. Lowell, 2009, The Journal of clinical investigation.

CARD9 mediates dendritic cell–induced development of Lyn deficiency–associated autoimmune and inflammatory diseases

C. Abram, C. Lowell, Yongmei Hu, 2019, Science Signaling.

Deletion of Syk in Neutrophils Prevents Immune Complex Arthritis

R. Locksley, C. Lowell, B. Sullivan, 2011, The Journal of Immunology.

Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.

M. Matthay, M. Looney, C. Lowell, 2006, The Journal of clinical investigation.

Neutrophils in animal models of autoimmune disease.

A. Mócsai, T. Németh, C. Lowell, 2016, Seminars in immunology.

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury

A. Zarbock, Helena Block, J. Rossaint, 2012, The Journal of experimental medicine.

Lyn Tyrosine Kinase Is Important for IL-5-Stimulated Eosinophil Differentiation1

S. Stafford, C. Lowell, S. Sur, 2002, The Journal of Immunology.

The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation.

A. Zarbock, Helena Block, C. Lowell, 2016, Immunity.

Tumor Cells Metalloproteinase-Independent Invasion by Promotes Matrix The Process of Macrophage Migration

Stéphanie Balor, I. Maridonneau-Parini, C. Lowell, 2011 .

The Pathogenicity of Human Immunodeficiency Virus (HIV) Type 1 Nef in CD4C/HIV Transgenic Mice Is Abolished by Mutation of Its SH3-Binding Domain, and Disease Development Is Delayed in the Absence of Hck

P. Jolicoeur, C. Lowell, D. Kay, 2001, Journal of Virology.

Title Neutrophil protein kinase C delta as a mediator of stroke-reperfusion injury

D. Ferriero, Hong Zhang, D. Mu, 2004 .

A critical role for Lyn kinase in strengthening endothelial integrity and barrier function.

Jingyan Han, Emily J. Welch, Xiaoping Du, 2013, Blood.

Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions

E. Murphy, O. Gajic, M. Matthay, 2015, Transfusion.

The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines

C. Lowell, G. Berton, E. Caveggion, 2015, The Journal of Immunology.

Their Ability To Secrete Chemokines Myeloid Cell Recruitment into the Lung and Regulate Early Lipopolysaccharide-Induced The Src-Family Kinases Hck and Fgr

C. Lowell, G. Berton, E. Caveggion, 2015 .

Early Divergence of Fcε Receptor I Signals for Receptor Up-Regulation and Internalization from Degranulation, Cytokine Production, and Survival1

T. Kawakami, M. Maeda-Yamamoto, J. Kitaura, 2004, The Journal of Immunology.

Neutrophils: Their Role in Innate and Adaptive Immunity

N. Demaurex, C. Lowell, E. Uribe-Querol, 2016, Journal of immunology research.

Anti-Nuclear Antibody Production in and Dendritic Cells for Germinal Center Requirement for MyD88 Signaling in B Cells

Zhaolin Hua, M. Ji, C. Lowell, 2014 .

The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase

A. Mócsai, L. Lanier, A. Burghardt, 2004 .

Integrin Affinity and Valency in Neutrophils, but Are Required for 2 Integrin-Mediated Outside-In Signaling Involved in Sustained Adhesion

C. Giagulli, G. Constantin, L. Ottoboni, 2006 .

B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice

A. DeFranco, C. Lowell, Karim Lee, 2011, Proceedings of the National Academy of Sciences.

Complement activation on endothelium initiates antibody-mediated acute lung injury.

H. Howie, J. Zimring, B. Mallavia, 2020, The Journal of clinical investigation.

c‐Abl and Src‐family kinases cross‐talk in regulation of myeloid cell migration

G. Martinelli, I. Iacobucci, S. Soverini, 2010, FEBS letters.

Early Targeting of L-Selectin on Leukocytes Promotes Recovery after Spinal Cord Injury, Implicating Novel Mechanisms of Pathogenesis

P. Weinstein, L. Noble-Haeusslein, C. Lowell, 2018, eNeuro.

Role of MyD88 signaling in the imiquimod‐induced mouse model of psoriasis: focus on innate myeloid cells

A. DeFranco, D. Bevilacqua, G. Girolomoni, 2017, Journal of leukocyte biology.

Sensitive to Rottlerin, and Depends on Lyn Parallel with the Classical Pathway, Is Pathway for BCR Signaling Operates in Cross-Talk: The IL-4-Induced Alternate Cutting Edge: B Cell Receptor (BCR)

T. Chiles, Derek Blair, T. Rothstein, 2007 .

Sensitive to Rottlerin , and Depends on Lyn Parallel with the Classical Pathway , Is Pathway for BCR Signaling Operates in Cross-Talk : The IL-4-Induced Alternate Cutting Edge : B Cell Receptor ( BCR )

T. Chiles, Derek Blair, T. Rothstein, 2007 .

Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung.

T. Hohl, Y. Iwakura, Xin Lin, 2012, Cell reports.

Dual function for the adaptor MIST in IFN- (cid:1) production by NK and CD4 (cid:2) NKT cells regulated by the Src kinase Fgr

Y. Matsuzaki, Katsuhiko Hayashi, D. Kitamura, 2006 .

Evidence of a Role for SHP-1 in Platelet Activation by the Collagen Receptor Glycoprotein VI*

S. Watson, A. Poole, L. Quek, 2000, The Journal of Biological Chemistry.

The Lyn Tyrosine Kinase Differentially Regulates Dendritic Cell Generation and Maturation1

C. Chu, C. Lowell, 2005, The Journal of Immunology.

MaturationRegulates Dendritic Cell Generation and The Lyn Tyrosine Kinase Differentially

C. Chu, C. Lowell, 2005 .

A role for PKCθ in outside‐in αIIbβ3 signaling

T. Kawakami, A. Altman, M. de Virgilio, 2006 .

A role for PKCh in outside-in a IIb b 3 signaling

T. Kawakami, A. Altman, K. Eto, 2006 .

ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use.

F. Sánchez‐Madrid, J. Enríquez, P. Fernández-Silva, 2014, Cell metabolism.

This information is current as Phagocytosis-Dependent Pathway Colony Stimulating Factor Through a Bearing the Membrane Isoform of Macrophage Macrophages Kill T9 Glioma Tumor Cells

M. Jadus, C. Lowell, Christopher C. Williams, 2012 .

Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway.

M. Jadus, C. Lowell, S. Kim, 1998, Journal of immunology.

Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma.

J. Kurhanewicz, P. Sneed, P. Munster, 2018, Blood advances.

of April 14 , 2017 . This information is current as Mice Regulates Autoimmunity in Lyn-Deficient A CD 19-Dependent Signaling Pathway

M. Fujimoto, T. Tedder, M. Hasegawa, 2001 .

Mice Regulates Autoimmunity in Lyn-Deficient A CD 19-Dependent Signaling Pathway

M. Fujimoto, T. Tedder, M. Hasegawa, 2001 .

Bacterial Infection to Degranulation and Host Defense Responses Pyk2 Is Required for Neutrophil

J. Schlessinger, C. Lowell, Lynn Kamen, 2022 .

IL-33 and M2a Alveolar Macrophages Promote Lung Defense against the Atypical Fungal Pathogen Pneumocystis murina

C. Steele, C. Lowell, J. Trevor, 2011, The Journal of Immunology.

Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis.

David Chisanga, M. Pajic, L. Boon, 2022, Cell reports.

A β1 integrin signaling pathway involving Src‐family kinases, Cbl and PI‐3 kinase is required for macrophage spreading and migration

C. Lowell, Fanying Meng, 1998, The EMBO journal.

The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.

A. Mócsai, L. Lanier, A. Burghardt, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A dominant function of LynB kinase in preventing autoimmunity

B. Moriarity, C. Lowell, B. Binstadt, 2022, Science advances.

Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells.

C. Lowell, M. Sinha, 2016, American journal of respiratory cell and molecular biology.

The Lyn Tyrosine Kinase Negatively Regulates Neutrophil Integrin Signaling 1

C. Lowell, Shalini Pereira, 2003, The Journal of Immunology.

Spleen tyrosine kinase facilitates neutrophil activation and worsens long-term neurologic deficits after spinal cord injury

C. Abram, C. Lowell, Yongmei Hu, 2021, Journal of neuroinflammation.

contributes to myeloid cell growth G-CSF induced reactive oxygen species involves Lyn-PI 3-kinase-Akt and

G. Mills, S. Corey, Quan-sheng Zhu, 2013 .

G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.

G. Mills, S. Corey, Quan-sheng Zhu, 2006, Blood.

SLP-76 Regulates Fcγ Receptor and Integrin Signaling in Neutrophils

A. Mócsai, G. Koretzky, C. Lowell, 2003 .

stimulated with secretion, Akt phosphorylation, and irreversible aggregation in platelets Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate

T. Pestina, C. Lowell, T. K. Gartner, 2013 .

Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.

Xiaoping Du, Junling Liu, C. Lowell, 2008, Blood.

Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells

J. Kellum, A. Zarbock, D. Vestweber, 2022, JCI insight.

Responses of Neutrophils to Anti-Integrin Antibodies Depends on Costimulation through Low Affinity FcγRs: Full Activation Requires Both Integrin and Nonintegrin Signals1

A. Mócsai, E. Ligeti, C. Lowell, 2004, The Journal of Immunology.

Recipient clinical risk factors predominate in possible transfusion‐related acute lung injury

P. Bacchetti, O. Gajic, M. Matthay, 2015, Transfusion.

Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection.

R. Reguera, S. Yamasaki, C. del Fresno, 2016, Immunity.

The Src kinase Lyn is a negative regulator of mast cell proliferation

J. Oliver, C. Lowell, G. Mackay, 2004, Journal of leukocyte biology.

Results in Defective Adhesion-dependent Neutrophil Functions

C. Lowell, G. Berton, L. Fumagalli, 2002 .

Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice

A. DeFranco, C. Chu, M. Cassatella, 2010, The Journal of experimental medicine.

HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels

P. Jolicoeur, J. Cáceres-Cortés, C. Lowell, 2021, Journal of Virology.

Prospective Study on the Clinical Course and Outcomes in Transfusion-Related Acute Lung Injury*

E. Murphy, P. Bacchetti, O. Gajic, 2014, Critical care medicine.

Title Prospective study on the clinical course and outcomes in transfusion-related acute lung injury

E. Murphy, P. Bacchetti, O. Gajic, 2014 .

The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.

T. Kawakami, C. Ra, J. Kitaura, 2007, Blood.

an inhibitory Src family kinase Lyn The Src family kinase Hck regulates mast cell activation by suppressing

T. Kawakami, C. Ra, J. Kitaura, 2007 .

Neutrophil activation by adhesion: mechanisms and pathophysiological implications

C. Lowell, G. Berton, L. Fumagalli, 1996, International journal of clinical & laboratory research.

Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells.

Karan Sharma, Yan Shi, W. Schoel, 2008, Immunity.

The Src Family Kinases Hck and Fgr Regulate Neutrophil Responses to N-Formyl-Methionyl-Leucyl-Phenylalanine1

Hong Zhang, C. Lowell, A. Baruzzi, 2007, The Journal of Immunology.

The Bruton's tyrosine kinase inhibitor PRN473 inhibits neutrophil recruitment via inhibition of Mac-1 signaling

A. Zarbock, A. Margraf, C. Lowell, 2017 .

Kinase Pathways in Chemoattractant-Induced Degranulation of Neutrophils: The Role of p38 Mitogen-Activated Protein Kinase Activated by Src Family Kinases1

A. Mócsai, E. Ligeti, C. Lowell, 2000, The Journal of Immunology.

Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis

D. Bevilacqua, G. Girolomoni, G. Constantin, 2022, Frontiers in Immunology.

The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4.

Danielle G. Lemay, J. Chung, S. Rhee, 2005, Biochemical pharmacology.

Cancer genes and hematopoiesis.

H. Varmus, C. Lowell, 1994, Blood.

Regulation of K–Cl cotransport by protein phosphatase 1α in mouse erythrocytes

E. Villa-Moruzzi, S. Alper, C. Brugnara, 2006, Pflügers Archiv.

SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin

J. Danska, D. Vinh, Inmoo Rhee, 2017, Nature.

The ins and outs of leukocyte integrin signaling.

C. Abram, C. Lowell, 2009, Annual review of immunology.

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages

A. DeFranco, V. Tybulewicz, C. Fitzer-Attas, 1997, The Journal of experimental medicine.

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.

S. Grinstein, K. Kain, B. Heit, 2013, Developmental cell.

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.

H. Varmus, Philippe Soriano, C. Lowell, 1994, Genes & development.

The multifaceted functions of neutrophils.

T. Mayadas, X. Cullere, C. Lowell, 2014, Annual review of pathology.

Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils.

S. Simon, Hong Zhang, Chad E. Green, 2006, Immunity.

ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense

Chen Kang, R. Sah, H. McBride, 2020, Proceedings of the National Academy of Sciences.

STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production.

C. Lowell, R. Clemens, Yongmei Hu, 2017, Blood.

STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense.

Hong Zhang, Y. Baba, T. Kurosaki, 2014, Blood.

PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS STIM 1 calcium sensor is required for activation of the phagocyte oxidase during in fl ammation and host defense

Hong Zhang, Y. Baba, T. Kurosaki, 2014 .

The Expanding Role for ITAM-Based Signaling Pathways in Immune Cells

C. Abram, C. Lowell, 2007, Science's STKE.

Src and Syk kinases: key regulators of phagocytic cell activation.

A. Mócsai, C. Lowell, G. Berton, 2005, Trends in immunology.

Src-family kinases: rheostats of immune cell signaling.

C. Lowell, 2004, Molecular immunology.

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.

Philippe Soriano, A. DeFranco, C. Lowell, 1997, Immunity.

Interferon-γ production by neutrophils during bacterial pneumonia in mice.

Pauline E. Chugh, M. Dinauer, D. Dittmer, 2011, American journal of respiratory and critical care medicine.

The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.

C. Liu, P. Utz, L. Rhee, 2010, Immunity.

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI

Toshiaki Kawakami, Stephen J. Galli, B. George Barisas, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Role of Src kinases and Syk in Fcγ receptor‐mediated phagocytosis and phagosome‐lysosome fusion

C. Lowell, G. Berton, E. Caveggion, 2001, Journal of leukocyte biology.

Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice.

C. Abram, C. Lowell, Yongmei Hu, 2014, Journal of immunological methods.

Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice

J. Hellman, C. Lowell, Ying-gang Zhu, 2015, Shock.

Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis.

H. Varmus, Philippe Soriano, C. Lowell, 1996, Blood.

The diverse functions of Src family kinases in macrophages.

C. Abram, C. Lowell, 2008, Frontiers in bioscience : a journal and virtual library.

Negative Regulation of Phagocytosis in Murine Macrophages by the Src Kinase Family Member, Fgr

C. Lagenaur, H. Gresham, C. Willman, 2000, The Journal of experimental medicine.

Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration

A. Mócsai, M. Sperandio, S. Klapproth, 2019, Haematologica.

Amplification of IFN-α-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors

P. Paik, L. Ivashkiv, Xiaoyu Hu, 2004, Nature Immunology.

R. Weiskopf, E. Murphy, P. Bacchetti, 2012, Blood.

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.

A. Tarakhovsky, H. Wu, L. Cantley, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Scaffolding Adapter Grb2-Associated Binder 2 Requires Syk to Transmit Signals from FcεRI1

B. Neel, C. Lowell, Haihua Gu, 2006, The Journal of Immunology.

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions

C. Lowell, G. Berton, L. Fumagalli, 1996, The Journal of cell biology.

Microarray kit analysis of cytokines in blood product units and segments

R. Weiskopf, P. Toy, C. Lowell, 2009, Transfusion.

Syk is required for integrin signaling in neutrophils.

A. Mócsai, V. Tybulewicz, F. Meng, 2002, Immunity.

Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice

L. Boon, L. Whitehead, F. Pixley, 2020, Cancer Immunology Research.

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.

O. Sieber, L. Whitehead, C. Tsui, 2017, Cancer cell.

Tec, and Protein Kinase C Family Kinases IgE-Induced Mast Cell Adhesion by Src, Syk, Regulation of Highly Cytokinergic

M. Leitges, K. Eto, C. Lowell, 2017 .

Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis.

J. Mege, G. Tabouret, I. Maridonneau-Parini, 2010, Blood.

Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase

H. Pfister, U. Koedel, C. Lowell, 2008, Journal of leukocyte biology.

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

K. Ley, A. Zarbock, A. Altman, 2008, The Journal of experimental medicine.

Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.

T. Kawakami, C. Lowell, W. Xiao, 2008, The Journal of clinical investigation.

Src family kinases mediate neutrophil adhesion to adherent platelets.

M. Rojas, S. Smyth, L. Federico, 2007, Blood.

The Src Family Kinases Hck and Fgr Are Dispensable for Inside-Out, Chemoattractant-Induced Signaling Regulating β2 Integrin Affinity and Valency in Neutrophils, but Are Required for β2 Integrin-Mediated Outside-In Signaling Involved in Sustained Adhesion1

Cinzia Giagulli, Carlo Laudanna, Gabriela Constantin, 2006, The Journal of Immunology.

Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin.

C. Cerletti, S. Smyth, L. Federico, 2006, The Biochemical journal.

Regulation of Highly Cytokinergic IgE-Induced Mast Cell Adhesion by Src, Syk, Tec, and Protein Kinase C Family Kinases1

T. Kawakami, M. Leitges, K. Eto, 2005, The Journal of Immunology.

The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.

C. Lowell, A. Baruzzi, G. Berton, 2005, Experimental cell research.

Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development

A. Tarakhovsky, M. Reth, T. Adachi, 2003, Nature Immunology.

Fcγ Receptor–Mediated Phagocytosis in Macrophages Lacking the Src Family Tyrosine Kinases Hck, Fgr, and Lyn

A. DeFranco, C. Fitzer-Attas, F. Meng, 2000, The Journal of experimental medicine.

Integrin signal transduction in myeloid leukocytes

C. Lowell, G. Berton, 1999, Journal of leukocyte biology.

Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck.

A. Mócsai, E. Ligeti, C. Lowell, 1999, Journal of immunology.

The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105

K. Rajewsky, A. Tarakhovsky, M. Leitges, 1998, The Journal of experimental medicine.

Fgr and Hck Neutrophils Requires the Src Family Kinases Adhesion-Dependent Degranulation of

A. Mócsai, E. Ligeti, C. Lowell, 1998 .

Class I Phosphoinositide-3-Kinases and Src Kinases Play a Nonredundant Role in Regulation of Adhesion-Independent and -Dependent Neutrophil Reactive Oxygen Species Generation

E. Hirsch, C. C. Campa, C. Lowell, 2013, The Journal of Immunology.

Species Generation-Dependent Neutrophil Reactive Oxygen Regulation of Adhesion-Independent and Kinases Play a Nonredundant Role in Class I Phosphoinositide-3-Kinases and Src

E. Hirsch, C. C. Campa, C. Lowell, 2013 .

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.

H. Varmus, P. Schwartzberg, L. Xing, 1997, Genes & development.

Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation

Mark S. Anderson, L. Philipson, A. Zarbock, 2021, Diabetes Care.

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.

C. Lowell, J. Van Ziffle, 2009, Blood.

Molecular Editing of Cellular Responses by the High-Affinity Receptor for IgE

E. Ralston, J. Rivera, C. Lowell, 2014, Science.

CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma.

V. S. Wong, S. Cha, J. Cyster, 2013, Blood.

Resting Murine Neutrophils Express Functional α4 Integrins that Signal Through Src Family Kinases1

A. Mócsai, C. Lowell, Meijuan Zhou, 2001, The Journal of Immunology.

Increased TLR responses in dendritic cells lacking the ITAM‐containing adapters DAP12 and FcRγ

L. Lanier, K. Shen, C. Chu, 2008, European journal of immunology.

Integrin signalling in neutrophils and macrophages.

C. Lowell, G. Berton, 1999, Cellular signalling.

Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.

D. Metcalfe, C. Lowell, C. Deberry, 2001, Blood.

NEF-INDUCED HIV-ASSOCIATED NEPHROPATHY THROUGH HCK/LYN.

S. Benichou, P. Chrobak, P. Jolicoeur, 2023, The American journal of pathology.

The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells

C. Chu, J. Hamerman, C. Lowell, 2009, Immunological reviews.

Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton

A. Mócsai, S. Moores, J. Brugge, 2002, The Journal of cell biology.

Redundant and Opposing Functions of Two Tyrosine Kinases, Btk and Lyn, in Mast Cell Activation1

A. Satterthwaite, O. Witte, D. Rawlings, 2000, The Journal of Immunology.

Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2

D. Fearon, R. Carter, J. Ahearn, 1989, The Journal of experimental medicine.

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.

D. Underhill, C. Lowell, Randi M. Simmons, 2005, Blood.

Leukocyte adhesion deficiency syndrome: a controversy solved

C. Abram, C. Lowell, 2009, Immunology and cell biology.

Flow cytometric detection of CD10 (cALLA) on peripheral blood B lymphocytes of neonates

C. Lowell, S. Atwater, K. Brady, 1999, British journal of haematology.

CRAC channel regulation of innate immune cells in health and disease.

C. Lowell, R. Clemens, 2019, Cell calcium.

The Process of Macrophage Migration Promotes Matrix Metalloproteinase-Independent Invasion by Tumor Cells

Stéphanie Balor, I. Maridonneau-Parini, C. Lowell, 2011, The Journal of Immunology.

Editorial Neutrophils : Their Role in Innate and Adaptive Immunity

N. Demaurex, C. Lowell, E. Uribe-Querol, 2016 .

Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity

M. Goldsmith, Mallika Singh, E. Quintana, 2020, Frontiers in Immunology.

Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation

A. DeFranco, C. Lowell, C. Lamagna, 2013, Proceedings of the National Academy of Sciences.

Positive and Negative Regulation of Mast Cell Activation by Lyn via the FcεRI1

T. Kawakami, C. Ra, S. Nunomura, 2005, The Journal of Immunology.

FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection

Michaela Wimmerova, Jonathan M. Palmer, Meenal Sinha, 2016, PLoS pathogens.

Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.

S. Watson, M. Hibbs, I. Hers, 2000, Blood.

Differential transformation capacity of Src family kinases during the initiation of prostate cancer

Sanaz Memarzadeh, Jonathan A. Cooper, S. Memarzadeh, 2011, Proceedings of the National Academy of Sciences.

Pathologic Correlates of Primary Central Nervous System Lymphoma Defined in an Orthotopic Xenograft Model

C. James, M. Shuman, Cigall Kadoch, 2009, Clinical Cancer Research.

Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils.

C. Lowell, Adam Blaisdell, Karim Mahiddine, 2019, The Journal of clinical investigation.

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

M. Colonna, W. Seaman, S. Branda, 2009, The Journal of cell biology.

Immunoreceptor-like signaling by β2 and β3 integrins

A. Mócsai, Szabina Fodor, C. Abram, 2007 .

Immunoreceptor-like signaling by beta 2 and beta 3 integrins.

A. Mócsai, Szabina Fodor, C. Abram, 2007, Trends in cell biology.

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

A. Mócsai, L. Lanier, C. Abram, 2006, Nature Immunology.

Integrins: Regulation of Adhesion and Downstream Signaling

C. Lowell, 2016 .

Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.

K. Ley, A. Zarbock, C. Lowell, 2007, Immunity.

Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus.

A. Weiss, Hong Zhang, Jason Park, 2011, Immunity.

Intracellular signalling during neutrophil recruitment

A. Mócsai, B. Walzog, C. Lowell, 2015, Cardiovascular research.

Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment

A. Zarbock, C. Abram, C. Lowell, 2015, The Journal of Immunology.

Title Cross-talk between Shp 1 and PIPKIγ controls leukocyte recruitment

A. Zarbock, C. Abram, C. Lowell, 2015 .

Convergence of immunoreceptor and integrin signaling

C. Abram, C. Lowell, 2007, Immunological reviews.

Isolation of Highly Pure Primary Mouse Alveolar Epithelial Type II Cells by Flow Cytometric Cell Sorting.

C. Lowell, M. Sinha, 2016, Bio-protocol.

A CD19-Dependent Signaling Pathway Regulates Autoimmunity in Lyn-Deficient Mice1

Jonathan C. Poe, Thomas F. Tedder, M. Fujimoto, 2001, The Journal of Immunology.

A Neutrophil Subset Defined by Intracellular Olfactomedin 4 is Associated with Mortality in Sepsis.

H. Wong, M. Matthay, Xiaohui Fang, 2020, American journal of physiology. Lung cellular and molecular physiology.

A CD22–Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity

K. Ley, C. Brandl, E. Butcher, 2021, Nature Immunology.

G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells.

A. Mócsai, Hong Zhang, T. Kawakami, 2003, Blood.

Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.

S. Hartman, T. Kawakami, J. Kitaura, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Critical role for Syk in responses to vascular injury.

S. Parikh, Yibing Yan, D. Simon, 2011, Blood.

Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn

A. DeFranco, T. Yen, C. Lowell, 2001, Current Biology.

Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.

T. Mayadas, D. Wagner, S. Shapiro, 2006, Immunity.

Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities

Mark S. Anderson, J. Derisi, M. Wilson, 2023, bioRxiv.

Neutrophils in acute inflammation: current concepts and translational implications

A. Zarbock, A. Margraf, C. Lowell, 2021, Blood.

Actin cytoskeleton reorganization by Syk regulates Fcγ receptor responsiveness by increasing its lateral mobility and clustering.

Raibatak Das, Khuloud Jaqaman, Valentin Jaumouillé, 2014, Developmental cell.

UC San Francisco UC San Francisco Previously Published Works Title Intracellular signalling during neutrophil recruitment

A. Mócsai, B. Walzog, C. Lowell, 2015 .

Transmigration of Neutrophils across Inflamed Endothelium Is Signaled through LFA-1 and Src Family Kinase1

Heather N. Hayenga, S. Simon, Hong Zhang, 2008, The Journal of Immunology.

Neutrophil-specific deletion of Syk results in recruitment-independent stabilization of the barrier and a long-term improvement in cognitive function after traumatic injury to the developing brain

J. Raber, L. Noble-Haeusslein, C. Lowell, 2021, Neurobiology of Disease.

B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K

J. Hamerman, C. Lowell, K. Campbell, 2011, Proceedings of the National Academy of Sciences.

Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.

T. Kawakami, C. Ra, S. Nunomura, 2005, Journal of immunology.

VASCULAR BIOLOGY A critical role for Lyn kinase in strengthening endothelial integrity and barrier function

Jingyan Han, Emily J. Welch, Xiaoping Du, 2013 .

Neutrophils: Their Role in Innate and Adaptive Immunity 2017

C. Lowell, M. Schnoor, E. Uribe-Querol, 2017, Journal of immunology research.

Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection

J. Schlessinger, C. Lowell, Lynn Kamen, 2011, The Journal of Immunology.

Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.

B. Neel, C. Lowell, Haihua Gu, 2006, Journal of immunology.

Generation of a Novel System for Studying Spleen Tyrosine Kinase Function in Macrophages and B Cells1

Chao Zhang, K. Shokat, C. Lowell, 2009, The Journal of Immunology.

IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion.

Dianqing Wu, T. Kawakami, M. Leitges, 2005, Blood.

Tumor necrosis factor- (cid:1) -induced leukocyte adhesion and microvessel permeability

Hong Zhang, C. Lowell, Pingnian He, 2022 .

A role for PKCtheta in outside-in alpha(IIb)beta3 signaling.

T. Kawakami, A. Altman, M. de Virgilio, 2006, Journal of thrombosis and haemostasis : JTH.

Rewiring phagocytic signal transduction.

C. Lowell, 2006, Immunity.

Strain‐dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa

Hong Zhang, S. Lynch, Yuanlin Song, 2012, Journal of leukocyte biology.

Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models.

A. Mócsai, T. Németh, Z. Helyes, 2023, The Journal of experimental medicine.

Tumor necrosis factor-alpha-induced leukocyte adhesion and microvessel permeability.

Hong Zhang, C. Lowell, Pingnian He, 2002, American journal of physiology. Heart and circulatory physiology.

Integrin signaling and immunodeficiency Leukocyte adhesion deficiency syndrome : a controversy solved

C. Abram, C. Lowell, 2009 .

Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice

K. Yau, D. Berson, A. Guerriero, 2003, Science.

Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes.

E. Villa-Moruzzi, S. Alper, L. De Franceschi, 2006, Pflügers Archiv: European Journal of Physiology.

Deletion of Syk in Neutrophils Prevents Immune Complex Arthritis

R. Locksley, C. Lowell, B. Sullivan, 2011, The Journal of Immunology.

Immune Complex Arthritis Deletion of Syk in Neutrophils Prevents

R. Locksley, C. Lowell, B. Sullivan, 2022 .

STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production.

C. Lowell, R. Clemens, Yongmei Hu, 2017, Blood.

LFA-1 and Src Family Kinase Inflamed Endothelium Is Signaled through Transmigration of Neutrophils across

Heather N. Hayenga, U. Schaff, C. Lowell, 2010 .