Aloysius T. Nchinda

发表

Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme.

K. Chibale, E. Sturrock, Aloysius T. Nchinda, 2006, Bioorganic & medicinal chemistry letters.

Novel ketomethylene inhibitors of angiotensin I-converting enzyme (ACE): inhibition and molecular modelling

K. Chibale, E. Sturrock, Aloysius T. Nchinda, 2006, Biological chemistry.

Characterization of angiotensin I-converting enzyme N-domain selectivity using positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides

Ross G. Douglas, M. Juliano, E. Sturrock, 2012, Biological chemistry.

Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides for defining substrate specificity of the angiotensin I-converting enzyme and development of selective C-domain substrates.

L. Juliano, M. Juliano, E. Sturrock, 2004, Biochemistry.

1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.

T. Myers, C. Eyermann, K. Chibale, 2021, Journal of medicinal chemistry.

Synthesis, Structure–Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity

K. Chibale, Dale Taylor, T. Ioerger, 2020, ACS infectious diseases.

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies

G. Drewes, C. Harris, Markus Boesche, 2017, Journal of medicinal chemistry.

Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.

K. Chibale, M. Witty, S. Charman, 2012, Journal of Medicinal Chemistry.

Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure–Activity Relationship Studies, and Biological Assessment

C. Eyermann, K. Chibale, Dale Taylor, 2020, ACS omega.

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.

E. Winzeler, S. Meister, K. Chibale, 2016, Journal of medicinal chemistry.

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.

K. Chibale, Dale Taylor, M. Witty, 2014, Journal of medicinal chemistry.

Residue L143 of the Foot-and-Mouth Disease Virus Leader Proteinase Is a Determinant of Cleavage Specificity

R. Cencic, D. Neubauer, Christina Mayer, 2008, Journal of Virology.

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.

K. Chibale, Dale Taylor, K. Wicht, 2018, Journal of medicinal chemistry.

Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.

K. Chibale, M. Witty, S. Charman, 2013, Journal of medicinal chemistry.

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.

David M. Shackleford, K. Chibale, M. Witty, 2012, Journal of medicinal chemistry.

Chromone Studies. Part 11.1 Synthesis and Electron-Impact Mass Spectrometric Study of Granulosin and Side-Chain Analogues †

C. A. Gray, P. T. Kaye, Aloysius T. Nchinda, 2002 .

Novel Heterocyclic Analogues of the HIV‐1 Protease Inhibitor, Ritonavir

P. T. Kaye, M. Musa, Aloysius T. Nchinda, 2004 .

Novel Heterocyclic Analogues of the HIV-1 Protease Inhibitor, Ritonavir.

P. T. Kaye, M. Musa, Aloysius T. Nchinda, 2004 .

2,4-Diaminothienopyrimidines as orally active antimalarial agents.

K. Chibale, Dale Taylor, M. Witty, 2014, Journal of medicinal chemistry.

Novel orally active antimalarial thiazoles.

K. Chibale, M. Witty, S. Charman, 2011, Journal of medicinal chemistry.

Chromone studies. Part 15. Formation and condensation of Baylis–Hillman adducts in DABCO-catalysed reactions of chromone-3-carbaldehydes with acrylonitrile

P. T. Kaye, Aloysius T. Nchinda, D. Molefe, 2004 .

Chromone Studies. Part 14.1 Unprecedented Dimerisation of Chromone-3-Carbaldehyde-Derived Baylis–Hillman Adducts

P. T. Kaye, J. Bacsa, Aloysius T. Nchinda, 2003 .

Development of Domain‐Selective Angiotensin I‐Converting Enzyme Inhibitors

E. Sturrock, Aloysius T. Nchinda, Pierre Redelinghuys, 2005, Annals of the New York Academy of Sciences.

Chromone studies. Part 13. Synthesis and electron-impact mass spectrometric studies of 5-hydroxy-2-isopropyl-7-methoxychromone, a constituent of the medicinal plant Baeckea frutescens, and side-chain analogues.

C. A. Gray, P. T. Kaye, Aloysius T. Nchinda, 2003, Journal of natural products.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

R. Price, K. Chibale, Dale Taylor, 2018, Antimicrobial Agents and Chemotherapy.

Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.

K. Chibale, E. Sturrock, Aloysius T. Nchinda, 2006, Bioorganic & medicinal chemistry letters.

Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design.

K Ravi Acharya, H. Corradi, E. Sturrock, 2006, Journal of molecular biology.

Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.

C. Eyermann, K. Chibale, Dale Taylor, 2018, Journal of medicinal chemistry.

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.

K. Chibale, T. Egan, Dale Taylor, 2020, Journal of medicinal chemistry.

Catalytic properties of recombinant dipeptidyl carboxypeptidase from Escherichia coli: a comparative study with angiotensin I-converting enzyme

M. Juliano, E. Sturrock, T. Paschoalin, 2009, Biological chemistry.

Novel orally active antimalarial thiazoles.

K. Chibale, M. Witty, S. Charman, 2011, Journal of medicinal chemistry.