J. Sommadossi

发表

Nevirapine, Zidovudine, and Didanosine Compared with Zidovudine and Didanosine in Patients with HIV-1 Infection

M. Niu, S. Liou, V. Johnson, 1996, Annals of Internal Medicine.

Linear single‐dose pharmacokinetics of ganciclovir in newborns with congenital cytomegalovirus infections

S. Soong, W. Gruber, G. Storch, 1993, Clinical pharmacology and therapeutics.

1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.

J. Starrett, W. Prusoff, T. Lin, 1989, Journal of medicinal chemistry.

Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro

J. Sommadossi, R. Carlisle, 1987, Antimicrobial Agents and Chemotherapy.

Evaluation of the mutagenic and genotoxic activities of anti-hepatitis B analogs of beta-L-adenosine by the Ames test and the Comet assay.

G. Duménil, J. Imbach, J. Sommadossi, 2001, Antiviral research.

Inhibition of beta-globin gene expression by 3'-azido-3'-deoxythymidine in human erythroid progenitor cells.

D. Weidner, J. Sommadossi, R. D. Leboeuf, 1999, Antiviral research.

Indinavir, nevirapine, stavudine, and lamivudine for human immunodeficiency virus-infected, amprenavir-experienced subjects: AIDS Clinical Trials Group protocol 373.

D. Kuritzkes, R. D’Aquila, E. Acosta, 2001, Journal of Infectious Diseases.

Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

E. Decroly, B. Canard, J. Vasseur, 2021, bioRxiv.

Reduction of 3′‐azido‐3′‐deoxythymidine to 3′‐amino‐3′‐deoxythymidine in human liver microsomes and its relationship to cytochrome P450

J. Sommadossi, M. Placidi, L. Placidi, 1993, Clinical pharmacology and therapeutics.

In vivo antagonism with zidovudine plus stavudine combination therapy.

D. Richman, D. Havlir, H. Kessler, 2000, The Journal of infectious diseases.

Plasma population pharmacokinetics and penetration into cerebrospinal fluid of indinavir in combination with zidovudine and lamivudine in HIV-1-infected patients

D. Richman, D. Havlir, A. Collier, 2000, AIDS.

Human liver microsomal cytochrome P450 and B5 act as reductases in the reductive metabolism of 3′‐azido‐3′‐deoxythymidine to 3′‐amino‐3′deoxythymidine

J. Sommadossi, J. Lasker, Xiao-jian Zhou, 1996 .

Pharmacokinetics of β-l-2′,3′-Dideoxy-5-Fluorocytidine in Rhesus Monkeys

H. McClure, R. Schinazi, J. Imbach, 1997, Antimicrobial Agents and Chemotherapy.

Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses

B. Canard, P. la Colla, J. Sommadossi, 2021, Antimicrobial agents and chemotherapy.

AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19

B. Canard, P. la Colla, J. Westover, 2021, Antimicrobial Agents and Chemotherapy.

Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs

J. Wakefield, R. Schinazi, C. Morrow, 1994, Antimicrobial Agents and Chemotherapy.

Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells.

R. Diasio, J. Schuetz, J. Sommadossi, 1985, Cancer research.

Cellular and Molecular Events Leading to Mitochondrial Toxicity of 1-( 2-Deoxy-2-Fluoro-1-, fD-Arabinofuranosyl )-5-lodouracil in Human Liver Cells

R. Schinazi, J. Sommadossi, L. Cui, 2013 .

Liver Cells

R. Schinazi, J. Sommadossi, L. Cui, 2022 .

Anti-human immunodeficiency and anti-hepatitis B virus activities of β-l-2′,3′-dideoxy purine nucleosides

R. Schinazi, C. K. Chu, Ju-sheng Lin, 1996 .

Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro

R. Schinazi, J. Imbach, J. Sommadossi, 1994, Antimicrobial Agents and Chemotherapy.

3'-Azido-3'-deoxythymidine inhibition of human lymphocyte cytolytic function in vitro.

J. Sommadossi, D. Shaw, D. Knight, 1991, Biochemical pharmacology.

Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1

R. Schinazi, V. Saalmann, D. Cannon, 1990, Antimicrobial Agents and Chemotherapy.

Toxicological study of the anti-HBV agent β-L-thymidine

B. Tennant, J. Imbach, J. Sommadossi, 2003 .

Quantitation of 3'-amino-3'-deoxythymidine (AMT), a toxic catabolite of 3'-azido-3'-deoxythymidine (AZT), by competitive ELISA.

J. Grassi, J. Sommadossi, R. Garraffo, 1996, Journal of immunoassay.

Effect of recombinant human hemoglobin on human bone marrow progenitor cells: protection and reversal of 3'-azido-3'-deoxythymidine-induced toxicity.

G. Rosenthal, J. Sommadossi, D. Fowler, 1996, Toxicology letters.

Selective protection of toxicity of 2',3'-dideoxypyrimidine nucleoside analogs by beta-D-uridine in human granulocyte-macrophage progenitor cells.

R. Schinazi, J. Imbach, J. Sommadossi, 1996, Antiviral research.

Comparative pharmacokinetics of zidovudine and its toxic catabolite 3'-amino-3'-deoxythymidine in HIV-infected patients.

J. Sommadossi, Xiao-jian Zhou, 1996 .

Effects of 3'-azido-3'-deoxythymidine on erythroid inducible gene expression in human K-562 leukemia cells.

D. Weidner, J. Sommadossi, D. Fowler, 1995, Toxicology Letters.

Comparison of metabolism and in vitro antiviral activity of stavudine versus other 2',3'-dideoxynucleoside analogues.

J. Sommadossi, 1995, The Journal of infectious diseases.

Quantification of 3'-amino-3'-deoxythymidine, a toxic catabolite of 3'-azido-3'-deoxythymidine (zidovudine) in human plasma by high-performance liquid chromatography using precolumn derivatization with fluorescamine and fluorescence detection.

X. J. Zhou, J. Sommadossi, 1994, Journal of chromatography. B, Biomedical applications.

Antiretroviral Activity, Biochemistry, and Pharmacokinetics of 3′‐Azido‐2′,3′‐Dideoxy‐5‐Methylcytidine a

H. McClure, R. Schinazi, C. K. Chu, 1990, Annals of the New York Academy of Sciences.

Pharmacologic Studies of Nucleosides Active against the Human Immunodeficiency Virus a

D. Weidner, J. Sommadossi, M. Xie, 1990, Annals of the New York Academy of Sciences.

Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity

R. Schinazi, J. Sommadossi, R. Carlisle, 1988, Antimicrobial Agents and Chemotherapy.

AT-527 is a potent in vitro replication inhibitor of SARS-CoV-2, the virus responsible for the COVID-19 pandemic

B. Canard, P. la Colla, J. Westover, 2020, bioRxiv.

Kinetics and Metabol i sm of a New Fluoropyrimidine , 5 '-Deoxy-5f luorour

G. Mathé, J. Sommadossi, J. Cano, 2007 .

Kinetics and metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine, in humans.

G. Mathé, J. Sommadossi, J. Cano, 1983, Cancer research.

Evidence from rat hepatocytes of an unrecognized pathway of 5-fluorouracil metabolism with the formation of a glucuronide derivative.

R. Diasio, D. Gewirtz, I. Goldman, 1985, Cancer research.

Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high performance liquid chromatography.

R. Diasio, D. Gewirtz, I. Goldman, 1982, The Journal of biological chemistry.

ANTI-HBV SPECIFIC β-L-2′-DEOXYNUCLEOSIDES

R. Schinazi, B. Tennant, J. Imbach, 2001 .

Antiviral effect and pharmacokinetic interaction between nevirapine and indinavir in persons infected with human immunodeficiency virus type 1.

R. Murphy, M. Myers, J. Sommadossi, 1999, The Journal of infectious diseases.

Thiazolo[4,5-d]Pyrimidines. Part II. Synthesis and Anti-Human Cytomegalovirus Activity in Vitro of Certain Acyclonucleosides and Acyclonucleotides Derived from the Guanine Analogue 5-Aminothiazolo[4,5-d]Pyrimidine-2,7(3H,6H)-Dione

E. De Clercq, J. Ojwang, J. Sommadossi, 1998, Antiviral chemistry & chemotherapy.

Population pharmacokinetics of ganciclovir in newborns with congenital cytomegalovirus infections. NIAID Collaborative Antiviral Study Group

W. Gruber, R. Jacobs, G. Demmler, 1996, Antimicrobial agents and chemotherapy.

Population pharmacokinetics of ganciclovir in newborns with congenital cytomegalovirus infections

W. Gruber, R. Jacobs, G. Demmler, 1996 .

Clinical pharmacokinetics of ganciclovir in patients with normal and impaired renal function.

R. Bevan, J. Sommadossi, William Buhles, 1988, Reviews of infectious diseases.

Therapies for Viral Hepatitis

H. Thomas, R. Schinazi, J. Sommadossi, 1998 .

Determination of Zidovudine Triphosphate Intracellular Concentrations in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus-Infected Individuals by Tandem Mass Spectrometry

O. Rosario, J. Sommadossi, J. Santana, 1999, Antimicrobial Agents and Chemotherapy.

, Individuals by Tandem Mass Spectrometry Immunodeficiency Virus-Infected Blood Mononuclear Cells from Human Intracellular Concentrations in Peripheral Determination of Zidovudine Triphosphate

O. Rosario, J. Sommadossi, J. Santana, 1999 .

Comparative kinetic analyses of interaction of inhibitors with Rauscher murine leukemia virus and human immunodeficiency virus reverse transcriptases

R. Schinazi, J. Cherrington, J. Sommadossi, 1996, Antimicrobial agents and chemotherapy.

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

E. Decroly, A. Delpal, B. Canard, 2021, Nature Communications.

Simultaneous quantitation of the 5′-triphosphate metabolites of zidovudine, lamivudine, and stavudine in peripheral mononuclear blood cells of HIV infected patients by high-performance liquid chromatography tandem mass spectrometry

Jeff D. Moore, J. Sommadossi, Xiao-jian Zhou, 2000, Journal of the American Society for Mass Spectrometry.

Cellular nucleoside pharmacokinetics and pharmacology: a potentially important determinant of antiretroviral efficacy.

J. Sommadossi, 1998, AIDS.

Reduction of 3'-azido-2',3'-dideoxynucleosides to their 3'-amino metabolite is mediated by cytochrome P-450 and NADPH-cytochrome P-450 reductase in rat liver microsomes.

J. Sommadossi, E. M. Cretton, 1993, Drug metabolism and disposition: the biological fate of chemicals.

In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine

H. McClure, S. Kaul, J. Sommadossi, 1993, Antimicrobial Agents and Chemotherapy.

Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus

J. Sommadossi, A. Moussa, S. Good, 2020, PloS one.

Cellular pharmacology of 3'-azido-3'-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells.

J. Sommadossi, R. Carlisle, Z. Zhou, 1989, Molecular pharmacology.

Safety, Pharmacokinetics, and Antiviral Activity of AT-527, a Novel Purine Nucleotide Prodrug, in Hepatitis C Virus-Infected Subjects with or without Cirrhosis

R. Murphy, J. Sommadossi, A. Moussa, 2019, Antimicrobial Agents and Chemotherapy.

In Vitro Activities of Methylenecyclopropane Analogues of Nucleosides and Their Phosphoralaninate Prodrugs against Cytomegalovirus and Other Herpesvirus Infections

R. Rybak, J. Sommadossi, E. Kern, 2000, Antimicrobial Agents and Chemotherapy.

In vitro and in vivo evaluation of 6-azido-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosylpurine and N6-methyl-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosyladenine as prodrugs of the anti-HIV nucleosides 2'-F-ara-ddA and 2'-F-ara-ddI.

L. Kotra, R. Schinazi, C. K. Chu, 1996, Journal of Medicinal Chemistry.

Comparison of Cytotoxicity of Mononucleoside Phosphotriester Derivatives Bearing Biolabile Phosphate Protecting Groups in Normal Human Bone Marrow Progenitor Cells

J. Imbach, J. Sommadossi, A. Aubertin, 1996 .

Rapid quantification of indinavir in human plasma by high-performance liquid chromatography with ultraviolet detection.

J. Sommadossi, M. Foisy, Michele L. Foisy, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Safety Assessment, In Vitro and In Vivo, and Pharmacokinetics of Emivirine, a Potent and Selective Nonnucleoside Reverse Transcriptase Inhibitor of Human Immunodeficiency Virus Type 1

K. Borroto-Esoda, G. Painter, M. Yamamoto, 2000, Antimicrobial Agents and Chemotherapy.

Synthesis and antiviral evaluation of some β-l-2′,3′-dideoxy-5-chloropyrimidine nucleosides and pronucleotides☆

E. De Clercq, P. Herdewijn, A. Aerschot, 2000 .

Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus

Y. Cheng, C. K. Chu, J. Sommadossi, 1995, Antimicrobial agents and chemotherapy.

Determination of Theophylline in Plasma by High Performance Liquid Chromatography

J. Sommadossi, J. Cano, C. Aubert, 1981 .

Synthesis and Antiviral Evaluation of SATE-Foscarnet Prodrugs and New Foscarnet—AZT Conjugates

J. Imbach, J. Sommadossi, A. Aubertin, 1998, Antiviral chemistry & chemotherapy.

Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

R F Schinazi, R. Schinazi, G. Painter, 1992, Antimicrobial Agents and Chemotherapy.

2′-C-Methyl Branched Pyrimidine Ribonucleoside Analogues: Potent Inhibitors of RNA Virus Replication

M. Tausek, S. Bergelson, V. Bichko, 2007, Antiviral chemistry & chemotherapy.

Substrate specificity of Escherichia coli thymidine phosphorylase for pyrimidine nucleosides with anti-human immunodeficiency virus activity.

R. Schinazi, J. Sommadossi, A. Peck, 1992, Biochemical pharmacology.

Stereospecific synthesis and biological evaluations of beta-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine.

E. De Clercq, J. Balzarini, J. Sommadossi, 2001, European journal of medicinal chemistry.

5-(Trifluoromethyl)-beta-l-2'-deoxyuridine, the L-enantiomer of trifluorothymidine: stereospecific synthesis and antiherpetic evaluations.

A. Marchand, M. Pregnolato, J. Sommadossi, 2001, Bioorganic & medicinal chemistry.

Intracellular Nucleoside Triphosphate Concentrations in HIV-Infected Patients on Dual Nucleoside Reverse Transcriptase Inhibitor Therapy

V. Johnson, D. Kuritzkes, M. Fischl, 2007, Antiviral therapy.

Intracellular Nucleotides of (−)-2′,3′-Deoxy-3′-Thiacytidine in Peripheral Blood Mononuclear Cells of a Patient Infected with Human Immunodeficiency Virus

C. Solas, J. Sommadossi, Yufeng Li, 1998, Antimicrobial Agents and Chemotherapy.

Synthesis, biotransformation, and pharmacokinetic studies of 9-(beta-D-arabinofuranosyl)-6-azidopurine: a prodrug for ara-A designed to utilize the azide reduction pathway.

L. Kotra, R. Schinazi, C. K. Chu, 1996, Journal of medicinal chemistry.

Unnatural β-L-Enantiomers of Nucleoside Analogues as Potent Anti-Hepatitis B Virus Agents

J. Imbach, J. Sommadossi, G. Gosselin, 1998 .

Antiviral Activities of β-Enantiomers of 3′-Substituted-3′-deoxythymidine Analogs

R. Schinazi, J. Imbach, J. Sommadossi, 1997 .

New Unnatural L-Nucleoside Enantiomers:From Their Stereospecific Synthesis to Their Biological Activities

R. Schinazi, J. Imbach, J. Sommadossi, 1997 .

Inhibition of Hepatitis B Virus Replication by Nucleoside Enantiomers of β-2′,3′-Dideoxypurine Analogues

R. Schinazi, J. Imbach, J. Sommadossi, 1996 .

Effects of nucleotide analogues on human immunodeficiency virus type 1 integrase.

Y. Pommier, N. Neamati, R. Schinazi, 1996, Molecular pharmacology.

2′-and/or 3Y-Deoxy-β-L-pentofuranosyl Nucleoside Derivatives: Stereospecific Synthesis and Antiviral Activities

R. Schinazi, J. Imbach, J. Sommadossi, 1995 .

Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro

R. Schinazi, D. Liotta, J. Imbach, 1994, Antimicrobial Agents and Chemotherapy.

Synthesis and biological properties of 5-o-carboranyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil.

R. Schinazi, K. Watanabe, J. Sommadossi, 1994, Journal of medicinal chemistry.

Antiviral nucleoside analogues and their bioactive phosphorylated metabolites: state of the art review of their detection and tissue monitoring applied to the anti-HIV drug AZT

J. Imbach, J. Sommadossi, G. Gosselin, 1994 .

1-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine. A Highly Potent and Selective Anti-HIV Agent.

J. Starrett, W. Prusoff, J. Sommadossi, 1989 .

Comparison of cytotoxicity of the (-)- and (+)-enantiomer of 2',3'-dideoxy-3'-thiacytidine in normal human bone marrow progenitor cells.

R. Schinazi, C. K. Chu, J. Sommadossi, 1992, Biochemical pharmacology.

Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low-dose ritonavir

P. Portegies, G. Weverling, S. Jurriaans, 2000, AIDS.

HIV protease inhibitors: pharmacologic and metabolic distinctions.

J. Sommadossi, 1999, AIDS.

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile.

R. Diasio, J. Sommadossi, W. Huster, 1987, Cancer research.

Population Pharmacokinetics of Nevirapine, Zidovudine, and Didanosine in Human Immunodeficiency Virus-Infected Patients

Lewis B. Sheiner, Martin S. Hirsch, Victoria A. Johnson, 1999, Antimicrobial Agents and Chemotherapy.

Nucleoside analogs: similarities and differences.

J. Sommadossi, 1993, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Synthesis of [4-(hydroxy)tetrahydrofuran-2-yl]nucleosides as a novel class of uridine phosphorylase inhibitors

L. Kotra, C. K. Chu, Q. Teng, 1995 .

Clinical pharmacokinetics of 3′‐azido‐3′‐deoxythymidine (zidovudine) and catabolites with formation of a toxic catabolite, 3′‐amino‐3′‐deoxythymidine

R. Diasio, J. Sommadossi, L. Kidd, 1992, Clinical pharmacology and therapeutics.

Pharmacokinetics and metabolism of O-(chloroacetyl-carbamoyl) fumagillol (TNP-470, AGM-1470) in rhesus monkeys

H. McClure, D. Anderson, J. Sommadossi, 1996, Cancer Chemotherapy and Pharmacology.

Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes.

G. de Sousa, R. Rahmani, J. Sommadossi, 1995, Cancer research.

Metabolic drug interactions between angiogenic inhibitor, TNP-470 and anticancer agents in primary cultured hepatocytes and microsomes.

J. Sommadossi, L. Placidi, S. Bynon, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Interspecies variability of TNP-470 metabolism, using primary monkey, rat, and dog cultured hepatocytes.

G. de Sousa, R. Rahmani, J. Sommadossi, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys

H. McClure, R. Schinazi, D. Anderson, 1991, Antimicrobial Agents and Chemotherapy.

Phase I dose escalation pharmacokinetics of O-(chloroacetylcarbamoyl) fumagillol (TNP-470) and its metabolites in AIDS patients with Kaposi's sarcoma

E. Acosta, B. Dezube, Jeff D. Moore, 2000, Cancer Chemotherapy and Pharmacology.

Fumagillin analog in the treatment of Kaposi's sarcoma: a phase I AIDS Clinical Trial Group study. AIDS Clinical Trial Group No. 215 Team.

J. V. Von Roenn, J. Holden-Wiltse, S. Shriver, 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

High-performance liquid chromatographic method for the determination of 9-(1,3-dihydroxy-2-propoxymethyl)guanine in human plasma.

R. Bevan, J. Sommadossi, 1987, Journal of chromatography.

Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase II study. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group.

J. Fitzgerald, S. Spector, W. Britt, 1997, The Journal of infectious diseases.

Effects of 5-benzylacyclouridine, an inhibitor of uridine phosphorylase, on the pharmacokinetics of uridine in rhesus monkeys: implications for chemotherapy

H. McClure, J. Sommadossi, Daniel C. Anderson, 2004, Cancer Chemotherapy and Pharmacology.

Role of human liver P450s and cytochrome b5 in the reductive metabolism of 3'-azido-3'-deoxythymidine (AZT) to 3'-amino-3'-deoxythymidine.

X. J. Zhou, J. Sommadossi, J. Lasker, 1998, Biochemical pharmacology.

Catabolic disposition of 3'-azido-2',3'-dideoxyuridine in hepatocytes with evidence of azido reduction being a general catabolic pathway of 3'-azido-2',3'-dideoxynucleosides.

R. Schinazi, C. K. Chu, J. Sommadossi, 1992, Biochemical pharmacology.

Modulation of 3'-azido-3'-deoxythymidine catabolism by probenecid and acetaminophen in freshly isolated rat hepatocytes.

J. Sommadossi, E. M. Cretton, 1991, Biochemical pharmacology.

Glucuronidation of 3'-azido-3'-deoxythymidine by rat and human liver microsomes.

R. Bevan, J. Sommadossi, D. V. Waterhous, 1990, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis of the first example of a nucleoside analogue bearing a 5'-deoxy-beta-D-allo-septanose as a seven-membered ring sugar moiety.

R. Storer, J. Sommadossi, J. Meillon, 2009, Carbohydrate research.

Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

R. Schinazi, P. Marion, B. Tennant, 2001, Antimicrobial Agents and Chemotherapy.

Arabinogalactan (9kDa)-9-β-D-Arabinofuranosyladenine-5′-Monophosphate, A Novel Liver-Targeted Conjugate that Selectively Inhibits Hepatitis B virus Replication in Vitro

L. Josephson, J. Sommadossi, E. Groman, 1997 .

Synthesis and antiviral evaluation of a seven-membered sugar ring nucleoside analog, 9-(5-deoxy-beta-D-allo-septanosyl)-adenine.

R. Storer, M. Liuzzi, J. Sommadossi, 2008, Nucleic acids symposium series.

Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.

John Mao, R. Storer, J. Sommadossi, 2006, Journal of medicinal chemistry.

Synthesis of β‐L‐2′‐Deoxythymidine (L‐dT)

J. Sommadossi, C. Pierra, D. Dukhan, 2006, Current protocols in nucleic acid chemistry.

Broad specificity of human phosphoglycerate kinase for antiviral nucleoside analogs.

Michel Véron, Edward Seclaman, M. Véron, 2004, Biochemical pharmacology.

Synthesis, Physicochemical and Pharmacokinetic Studies of Potential Prodrugs of β-L-2′-Deoxycytidine, a Selective and Specific Anti-HBV Agent

P. la Colla, J. Sommadossi, C. Pierra, 2004, Antiviral chemistry & chemotherapy.

Pharmacokinetics of β-L-thymidine and β-L-2′-deoxycytidine in woodchucks and monkeys

B. Tennant, J. Imbach, J. Sommadossi, 2003 .

Pharmacology of β-l-Thymidine and β-l-2′-Deoxycytidine in HepG2 Cells and Primary Human Hepatocytes: Relevance to Chemotherapeutic Efficacy against Hepatitis B Virus

J. Rodríguez-Orengo, J. Imbach, J. Sommadossi, 2002, Antimicrobial Agents and Chemotherapy.

Antiviral ß-L-Nucleosides Specific for Hepatitis B Virus Infection

J. Sommadossi, 2002 .

Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

R. Schinazi, J. Imbach, J. Sommadossi, 2000, Antimicrobial Agents and Chemotherapy.

Differential Effects of Antiretroviral Nucleoside Analogs on Mitochondrial Function in HepG2 Cells

V. Darley-Usmar, J. Sommadossi, Xiao-jian Zhou, 2000, Antimicrobial Agents and Chemotherapy.

Intracellular Metabolism of b - L -2 9 ,3 9 -Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

R. Schinazi, J. Imbach, J. Sommadossi, 2000 .

Effect of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil on mitochondrial functions in HepG2 cells.

J. Sommadossi, L. Cui, A. Faraj, 1999, Antiviral research.

Intracellular metabolism of beta-L-ddAMP-bis(tbutylSATE), a potent inhibitor of hepatitis B virus replication.

R. Schinazi, J. Imbach, J. Sommadossi, 1999, Nucleosides & nucleotides.

Effect of nucleoside analogs on neurite regeneration and mitochondrial DNA synthesis in PC-12 cells.

J. Sommadossi, L. Locatelli, M. Xie, 1997, The Journal of pharmacology and experimental therapeutics.

Effect of β-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells

R. Schinazi, C. K. Chu, G. R. Revankar, 1996 .

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.

E. Levine, K. Watanabe, K. O. Tankersley, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.

R. Schinazi, J. Sommadossi, L. Cui, 1995, The Journal of clinical investigation.

Effects of 2',3'-dideoxynucleosides on proliferation and differentiation of human pluripotent progenitors in liquid culture and their effects on mitochondrial DNA synthesis

J. Sommadossi, E. Bridges, A. Faraj, 1994, Antimicrobial Agents and Chemotherapy.

Enantiomeric 2',3'-dideoxycytidine derivatives are potent human immunodeficiency virus inhibitors in cell cultures.

R. Schinazi, J. Imbach, J. Sommadossi, 1994, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

Antiviral beta-L-nucleosides specific for hepatitis B virus infection.

R. Schinazi, M. Myers, B. Tennant, 2001, Antiviral chemistry & chemotherapy.

Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

K. Anderson, R. Schinazi, C. K. Chu, 2001, Antimicrobial Agents and Chemotherapy.

Pharmacology of beta-L-thymidine and beta-L-2'-deoxycytidine in HepG2 cells and primary human hepatocytes: relevance to chemotherapeutic efficacy against hepatitis B virus.

J. Rodríguez-Orengo, J. Imbach, J. Sommadossi, 2002, Antimicrobial Agents and Chemotherapy.

Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.

K. Anderson, R. Schinazi, C. K. Chu, 2001, Antimicrobial agents and chemotherapy.

Chapter 21 – Antiviral β-L-nucleosides specific for hepatitis B virus infection

R. Schinazi, M. Myers, B. Tennant, 2003 .

and Epstein-Barr virus. l as a novel antiviral agent for hepatitis B virus 2'-fluoro-5-methyl-beta-L-arabinofuranosyluraci Use of

C. K. Chu, J. Sommadossi, Y. Xiang, 2013 .

vitro. selective inhibitors of hepatitis B virus in beta-2',3'-dideoxycytidine analogs are Pure nucleoside enantiomers of

R. Schinazi, D. Liotta, J. Imbach, 2014 .

Effects of beta-L-3'-azido-3'-deoxythymidine 5'-triphosphate on host and viral DNA polymerases.

C. Morrow, J. Imbach, J. Sommadossi, 2000, Antiviral research.

Prototype trial design for rapid dose selection of antiretroviral drugs: an example using emtricitabine (Coviracil).

J. Kahn, D. Shepp, D. Mildvan, 2001, The Journal of antimicrobial chemotherapy.

Quantitation of Intracellular Triphosphate of Emtricitabine in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus-Infected Patients

J. Sommadossi, Xiao-jian Zhou, A. Darque, 1999, Antimicrobial Agents and Chemotherapy.

Synthesis and Antiviral Evaluation of 4′-C-Azidomethyl-β-D-Ribofuranosyl Purine and Pyrimidine Nucleosides

R. Storer, J. Sommadossi, G. Gosselin, 2009, Nucleosides, nucleotides & nucleic acids.

Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes

R. Schinazi, X. J. Zhou, R. Rahmani, 1997, Antimicrobial agents and chemotherapy.

Procedes de traitement de l'infection par le virus delta de l'hepatite par ?-l-2' deoxy-nucleosides

J. Sommadossi, M. Bryant, 2001 .

Synthesis and antiviral evaluation of thieno[3,4-d]pyrimidine C-nucleoside analogues of 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-adenosine and -inosine.

R. Storer, M. Liuzzi, J. Sommadossi, 2009, Bioorganic & medicinal chemistry.

Stereospecific Synthesis and Biological Evaluations of β‐L‐Pentofuranonucleoside Derivatives of 5‐Fluorouracil and 5‐Fluorocytosine.

J. Balzarini, E. Clercq, J. Sommadossi, 2001 .

Inhibition of human cytomegalovirus in culture by alkenyl guanine analogs of the thiazolo[4,5-d]pyrimidine ring system

R. Ptak, G. R. Revankar, J. Huffman, 1994, Antimicrobial Agents and Chemotherapy.

Treatment of hepatitis B by nucleoside analogs: still a reality

J. Sommadossi, 1994 .

NM 283 has potent antiviral activity against genotype 1 chronic hepatitis C virus (HCV-1) infection in the chimpanzee

M. Tausek, R. Chung, R. Lanford, 2003 .

Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection: a report of 12 cases.

V. Johnson, M. Saag, N. Jhala, 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Radioimmunoassay for quantitation of 2',3'-didehydro-3'-deoxythymidine (D4T) in human plasma

X. J. Zhou, J. Sommadossi, B. Ferruà, 1996, Antimicrobial agents and chemotherapy.

In Vitro and In Vivo Metabolism and Pharmacokinetics of bis [(T-Butyl)-S-acyl-2-thioethyl]-β-L-2′,3′-dideoxy-5-fluorocytidine Monophosphate

H. McClure, R. Schinazi, J. Imbach, 2000, Nucleosides, nucleotides & nucleic acids.

NDP kinase reactivity towards 3TC nucleotides.

M. Véron, J. Sommadossi, A. Kreimeyer, 2001, Antiviral research.

Determination of a novel fluoropyrimidine, 5'-deoxy-5-fluorouridine, in plasma by high-performance liquid chromatography.

J. Sommadossi, J. Cano, 1981, Journal of Chromatography A.

Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.

E. De Clercq, J. Balzarini, J. Imbach, 1997, Journal of medicinal chemistry.

Treatment with amprenavir alone or amprenavir with zidovudine and lamivudine in adults with human immunodeficiency virus infection. AIDS Clinical Trials Group 347 Study Team.

D. Kuritzkes, A. Caliendo, R. D’Aquila, 1999, The Journal of infectious diseases.

Lamivudine in combination with zidovudine, stavudine, or didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial. National Institute of Allergy and Infectious Disease AIDS Clinical Trials Group Protocol 306 Investigators.

C. Pettinelli, I. Marschner, V. Johnson, 1999, AIDS.

Cellular pharmacology of 2',3'-didehydro-2',3'-dideoxythymidine (D4T) in human peripheral blood mononuclear cells.

H. Ho, J. Sommadossi, M. Hitchcock, 1990, Biochemical pharmacology.

Advances in Chemotherapy of AIDS

R. Diasio, J. Sommadossi, 1990 .

Synthesis, Anti-Hiv Activity, and Biological Properties of 2′,3′-Didehydro-2′,3′-Dideoxythwidine (d4T)

J. Starrett, H. Ho, J. Sommadossi, 1989 .

Modulation of 5-fluorouracil catabolism in isolated rat hepatocytes with enhancement of 5-fluorouracil glucuronide formation.

R. Diasio, D. Gewirtz, I. Goldman, 1985, Cancer research.

Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry.

J. Sommadossi, J. Cano, C. Aubert, 1982, Biomedical mass spectrometry.

Synthesis and studies of 3'-C-trifluoromethyl nucleoside analogues bearing adenine or cytosine as the base.

P. la Colla, J. Sommadossi, Martin Bryant, 2002, Bioorganic & medicinal chemistry.

Intravenous Infusion of Cereport Increases Uptake and Efficacy of Acyclovir in Herpes Simplex Virus-Infected Rat Brains

R. Rybak, J. Sommadossi, E. Kern, 2001, Antimicrobial Agents and Chemotherapy.

Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis

J. Sommadossi, D. Diop, R. Carlisle, 1989, Antimicrobial Agents and Chemotherapy.

Rapid quantitation of (-)-2'-deoxy-3'-thiacytidine in human serum by high-performance liquid chromatography with ultraviolet detection.

X. J. Zhou, J. Sommadossi, 1997, Journal of chromatography. B, Biomedical sciences and applications.

A randomized trial to study first-line combination therapy with or without a protease inhibitor in HIV-1-infected patients

M. Moroni, F. Antunes, J. Montaner, 2003, AIDS.

Stable Concentrations of Zidovudine, Stavudine, Lamivudine, Abacavir, and Nevirapine in Serum and Cerebrospinal Fluid during 2 Years of Therapy

S. Jurriaans, J. Prins, J. Sommadossi, 2002, Antimicrobial Agents and Chemotherapy.

Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells.

R. Bevan, R. Schinazi, J. Sommadossi, 1991, Molecular pharmacology.

Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives.

E. De Clercq, J. Balzarini, J. Imbach, 1999, Nucleosides & nucleotides.

Metabolism and DNA interaction of 2',3'-didehydro-2',3'-dideoxythymidine in human bone marrow cells.

J. Sommadossi, M. Hitchcock, Z. Zhu, 1991, Molecular pharmacology.

Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.

M. Liuzzi, J. Sommadossi, C. Musiu, 2015, Future medicinal chemistry.

3‘‐Azido‐ 3’‐deoxythymidine inhibits erythroid‐specific transcription factors in human erythroid K562 leukemia cells

J. Sommadossi, P. Jeannesson, C. Trentesaux, 2009, European journal of haematology.

A mathematical model of the kinetics of 5-fluorouracil and its metabolites in cancer patients

J. Steimer, R. Diasio, J. Sommadossi, 2004, Cancer Chemotherapy and Pharmacology.

The Cellular Metabolism of AzdU

R. Schinazi, J. Sommadossi, H. Mitsuya, 1990 .

Cellular metabolism of 3'-azido-2',3'-dideoxyuridine with formation of 5'-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2'-deoxyuridine analogs.

R. Schinazi, C. K. Chu, J. Sommadossi, 1990, Molecular pharmacology.

Pharmacological considerations in antiretroviral therapy.

J. Sommadossi, 1998, Antiviral therapy.

3'-(N-hydroxyimino)-2',3-dideoxynucleosides and their derivatives: synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues.

E. De Clercq, J. Balzarini, J. Imbach, 1999, Nucleosides & nucleotides.

Inhibition of mammalian DNA polymerase-associated 3' to 5' exonuclease activity by 5'-monophosphates of 3'-azido-3'-deoxythymidine and 3'-amino-3'-deoxythymidine.

J. Sommadossi, E. Bridges, A. Faraj, 1993, Biochemical pharmacology.

Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens.

M. Hirsch, D. Richman, C. Petropoulos, 2000, JAMA.

AT-752, a double prodrug of a guanosine nucleotide analog, inhibits yellow fever virus in a hamster model

J. Sommadossi, Kai Lin, J. Julander, 2021, bioRxiv.

Determination ofO-(chloroacetylcarbamoyl)fumagillol (TNP-470; AGM-1470) and two metabolites in plasma by high-performance liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization

Jeff D. Moore, J. Sommadossi, 1995 .

Protection and rescue from 2',3'-dideoxypyrimidine nucleoside analog toxicity by hemin in human bone marrow progenitor cells

J. Sommadossi, M. Xie, D. Fowler, 1996, Antimicrobial agents and chemotherapy.

Comparative effects of 3'-azido-3'-deoxythymidine and its metabolite 3'-amino-3'-deoxythymidine on hemoglobin synthesis in K-562 human leukemia cells.

D. Weidner, J. Sommadossi, E. Bridges, 1992, Molecular pharmacology.

AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5.

Priscila Sutto-Ortiz, E. Decroly, P. Shi, 2023, Antiviral research.

A combination of AT-527, a pan-genotypic guanosine nucleotide prodrug, and daclatasvir was well-tolerated and effective in HCV-infected subjects

S. Bourgeois, J. Sommadossi, N. Brown, 2020, Journal of Hepatology.

A mathematical model of the kinetics of 5-fluorouracil and its catabolites in freshly isolated rat hepatocytes.

R. Diasio, J. Steimer, J. Sommadossi, 1984, Biochemical pharmacology.

Evidencefrom Rat Hepatocytesof an UnrecognizedPathwayof 5-Fluorouracil Metabolismwith the Formationof a GlucuronideDerivative1

R. Diasio, D. Gewirtz, I. Goldman, 1985 .

Phase I Dose‐Escalation Pharmacokinetics of AZT‐P‐ddI (IVX‐E‐59) in Patients with Human Immunodeficiency Virus

K. Squires, J. Sommadossi, L. Agrofoglio, 1997, Journal of clinical pharmacology.

Continued lamivudine versus delavirdine in combination with indinavir and zidovudine or stavudine in lamivudine-experienced patients: results of Adult AIDS Clinical Trials Group protocol 370

C. Pettinelli, I. Marschner, V. Johnson, 2000, AIDS.

3'-Azido-3'-deoxythymidine inhibits globin gene transcription in butyric acid-induced K-562 human leukemia cells.

D. Weidner, J. Sommadossi, 1990, Molecular pharmacology.

Comparative metabolism of the antiviral dimer AZT-P-ddl and the monomers zidovudine and didanosine by rat, monkey and human hepatocytes

R. Schinazi, R. Rahmani, J. Sommadossi, 1997 .

High-performance liquid chromatographic method for the determination of plasma and urine metapramine after dansylation.

J. Necciari, J. Sommadossi, J. Cano, 1982, Journal of Chromatography A.

ANTI-HBV SPECIFIC β-L-2′-DEOXYNUCLEOSIDES

R. Schinazi, B. Tennant, J. Imbach, 2001 .

Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity.

R. Schinazi, G. R. Revankar, J. Imbach, 1996, Biochemical pharmacology.

Effect of stereoisomerism on the cellular pharmacology of beta-enantiomers of cytidine analogs in Hep-G2 cells.

R. Schinazi, J. Imbach, J. Sommadossi, 1997, Biochemical pharmacology.

Influence of template primary structure on 3'-azido-3'-deoxythymidine triphosphate incorporation into DNA.

D. Weidner, J. Sommadossi, E. Bridges, 1993, Antiviral Research.

Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

R. Schinazi, P. Marion, B. Tennant, 2001, Antimicrobial Agents and Chemotherapy.