Xin Xie

发表

Structure of the CCR5 Chemokine Receptor–HIV Entry Inhibitor Maraviroc Complex

Hualiang Jiang, R. Stevens, Jian Li, 2013, Science.

Bifunctional Chimera That Coordinately Targets Human Immunodeficiency Virus 1 Envelope gp120 and the Host-Cell CCR5 Coreceptor at the Virus-Cell Interface.

M. Kutzler, I. Chaiken, Y. Long, 2018, Journal of medicinal chemistry.

Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents.

J. Deadman, Miao Wang, G. Pei, 2010, Bioorganic & medicinal chemistry letters.

Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents.

J. Deadman, Miao Wang, G. Pei, 2010, Bioorganic & medicinal chemistry letters.

Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors.

F. Nan, Ming-bo Su, Jia Li, 2014, ACS medicinal chemistry letters.

Design, syntheses, structure-activity relationships and docking studies of coumarin derivatives as novel selective ligands for the CB2 receptor.

Xin Xie, Xin Xie, Hai-Yan Qian, 2015, European journal of medicinal chemistry.

Glucagon receptor mediates calcium signaling by coupling to Gαq/11 and Gαi/o in HEK293 cells

Xin Xie, Yazhen Xu, 2009, Journal of receptor and signal transduction research.

[6,7]‐Heterocycle‐Fused 14‐Hydroxymorphinan Derivatives: Design, Synthesis, and Opioid Receptor Activity

A. Zhang, Xin Xie, Jie Chen, 2009, ChemMedChem.

Introducing nitrogen atoms to amidoalkylindoles: potent and selective cannabinoid type 2 receptor agonists with improved aqueous solubility.

Jie Tang, Xin Xie, Fan Yang, 2019, MedChemComm.

Structural basis of ligand recognition and self-activation of orphan GPR52

Yong Chen, M. Lei, Fei Xu, 2020, Nature.

Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents

Yongzhou Hu, Xiaowu Dong, J. Che, 2018, Royal Society Open Science.

Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining

Liu Wang, Qi Zhou, Xiao Han, 2018, Cancer communications.

Functional interplay between the RK motif and linker segment dictates Oct4–DNA recognition

Hualiang Jiang, X. Kong, C. Luo, 2015, Nucleic acids research.

Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis.

F. Nan, Xin Xie, Qing Zhang, 2022, Journal of medicinal chemistry.

Structural basis of GPBAR activation and bile acid recognition

F. Nan, Yuemao Shen, Changtao Jiang, 2020, Nature.

Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy

F. Nan, Xin Xie, Xiaoyang Wang, 2014, Acta Pharmacologica Sinica.

Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists.

Hualiang Jiang, J. Li, Liang-zhong Chen, 2018, Journal of medicinal chemistry.

Amidoalkylindoles as Potent and Selective Cannabinoid Type 2 Receptor Agonists with in Vivo Efficacy in a Mouse Model of Multiple Sclerosis.

Y. Duan, Jie Tang, Xin Xie, 2017, Journal of medicinal chemistry.

Development of Quinoline-2,4(1H,3H)-diones as Potent and Selective Ligands of the Cannabinoid Type 2 Receptor.

Xin Xie, Haiyan Qian, Jian-zhong Chen, 2015, Journal of medicinal chemistry.

Serine 363 of the δ-opioid receptor is crucial for adopting distinct pathways to activate ERK1/2 in response to stimulation with different ligands

Lan Ma, Xin Xie, Z. Chi, 2010, Journal of Cell Science.

Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1 Selective Antagonists.

F. Nan, Xin Xie, Hua-yan Chen, 2016, ACS medicinal chemistry letters.

Design, synthesis, and biological evaluation of a new class of MT2-selective agonists

Xuan Zhang, Xin Xie, Qingqing Huang, 2014 .

Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein–Coupled Receptor 84

Xin Xie, Qing Zhang, Hui Yang, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C.

Xin Xie, Jing Li, Li-li Cui, 2012, Journal of natural products.

A robust homogeneous binding assay for α4β2 nicotinic acetylcholine receptor

Ming-Wei Wang, Xin Xie, Jie Gao, 2005, Acta Pharmacologica Sinica.

GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes.

Youhong Hu, B. Lu, Shimeng Guo, 2020, Journal of medicinal chemistry.

Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder

Biao Yu, Xin Xie, Yuyong Ma, 2014, Proceedings of the National Academy of Sciences.

Design, Synthesis, and SAR Studies of Heteroarylpyrimidines and Heteroaryltriazines as CB2R Ligands

Xin Xie, Haiyan Qian, Jian-zhong Chen, 2018, ChemMedChem.

Development of Quinazoline/Pyrimidine-2,4(1H,3H)-diones as Agonists of Cannabinoid Receptor Type 2.

Xin Xie, Haiyan Qian, Jian-zhong Chen, 2017, ACS medicinal chemistry letters.

Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists.

Jing-kang Shen, Xin Wang, T. Meng, 2011, European journal of medicinal chemistry.

Development of a universal high-throughput calcium assay for G-protein-coupled receptors with promiscuous G-protein Gα15/16

Xin Xie, Ting Zhu, Li-yan Fang, 2008, Acta Pharmacologica Sinica.

Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists.

F. Nan, Xin Xie, Qing Zhang, 2020, Journal of medicinal chemistry.

Physiological oxygen tension reduces hepatocyte dedifferentiation in in vitro culture

Xin Xie, Xinxiu Xu, R. Guo, 2017, Scientific Reports.

Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies.

Xin Xie, Haiyan Qian, Jian-zhong Chen, 2017, European journal of medicinal chemistry.

Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2.

Yongzhou Hu, Huazhou Ying, Xiaowu Dong, 2021, ACS medicinal chemistry letters.

Design, Synthesis and Biological Evaluation of (2′,5′ and 3′5′-Linked) cGAMP Analogs that Activate Stimulator of Interferon Genes (STING)

Junyi Liu, Xin Xie, Xiaowei Wang, 2020, Molecules.

Synthesis and SAR Study of Opioid Receptor Ligands: Mono‐ and Bis‐Indolomorphinans

A. Zhang, Xin Xie, Jie Chen, 2009, Chemical biology & drug design.

Synthesis and opioid receptor activity of indolopropellanes.

A. Zhang, Xin Xie, Jie Chen, 2009, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α1A-Adrenoceptor Antagonists.

Hong Liu, Yu Zhou, Jiang Wang, 2016, Journal of medicinal chemistry.

Podophyllotoxin induces CREB phosphorylation and CRE-driven gene expression via PKA but not MAPKs

Xin Xie, Ya Chen, 2010, Molecules and cells.

The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity

Xin Xie, T. Ulven, H. Forsman, 2021, Journal of Innate Immunity.

The two formyl peptide receptors differently regulate GPR84-mediated neutrophil NADPH-oxidase activity

Xin Xie, T. Ulven, H. Forsman, 2020, bioRxiv.

Gold(I)-catalyzed cascade approach for the synthesis of tryptamine-based polycyclic privileged scaffolds as α1-adrenergic receptor antagonists.

Hong Liu, Zeng Li, Yu Zhou, 2013, The Journal of organic chemistry.

Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach.

Xin Eric Wang, B. Xiong, Jing-kang Shen, 2010, European journal of medicinal chemistry.

Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrido[4,3-c]azepin-5-one-based novel chemotype CCR2 antagonists via scaffold hopping strategy.

Y. Long, Xin Xie, Zhilong Wang, 2018, Bioorganic & medicinal chemistry.

AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.

G. Liao, Xuejun Jiang, D. Ye, 2019, Developmental cell.

Chemical reprogramming and transdifferentiation.

Xin Xie, Jian Liu, Yan-bin Fu, 2017, Current opinion in genetics & development.

Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists.

F. Nan, Wei Lu, Xin Xie, 2016, ACS medicinal chemistry letters.

The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog

Cizhong Jiang, Lingqiang Zhang, Xin Xie, 2016, Nature Communications.

TRPA1 channel mediates organophosphate-induced delayed neuropathy

B. Attali, Zhaobing Gao, Q. Ding, 2017, Cell Discovery.

Development of a quantitative, cell-based, high-content screening assay for epidermal growth factor receptor modulators

Xin Xie, Jue Wang, 2007, Acta Pharmacologica Sinica.

Selaginellin M, a new selaginellin derivative from Selaginella pulvinata

Xin Xie, Kang-ping Xu, Guishan Tan, 2011, Journal of Asian natural products research.

Testosterone-induced benign prostatic hyperplasia rat and dog as facile models to assess drugs targeting lower urinary tract symptoms

Shimeng Guo, Xin Xie, Qianting Yuan, 2018, PloS one.

Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids †

E. Hernández-Núñez, Xin Xie, M. Cappiello, 2018, Molecules.

Structural basis of bile acid receptor activation and Gs coupling

F. Nan, Yuemao Shen, Changtao Jiang, 2020, bioRxiv.

Design , synthesis and in combo antidiabetic 2 bioevaluation of multitarget phenylpropanoic acids ¥ 3

Emanuel, Xin Xie, M. Cappiello, 2018 .

Synthesis and biological evaluation of novel piperidin-4-ol derivatives

Yongzhou Hu, Xiaowu Dong, Wei Wei, 2012, Monatshefte für Chemie - Chemical Monthly.

Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis

Wei Li, G. Pei, Xin Xie, 2015, Cell Discovery.

Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell self-renewal and somatic cell reprogramming

Xin Xie, Min Wang, Li-hong Zhang, 2014, Cell Research.

Design, synthesis, biological evaluation, and comparative docking study of 1,2,4-triazolones as CB1 receptor selective antagonists.

Xin Xie, Jian-zhong Chen, Shuang Han, 2014, European journal of medicinal chemistry.

Role of Src in ligand‐specific regulation of δ‐opioid receptor desensitization and internalization

Xin Xie, Yu-Jun Wang, Z. Chi, 2009, Journal of neurochemistry.

Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective α1A-Adrenoceptor Antagonists.

Hualiang Jiang, B. Shoichet, Honglin Li, 2016, Journal of medicinal chemistry.

Design , Synthesis , and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives ( THPBs ) as Selective α 1 A-Adrenoceptor Antagonists

Hualiang Jiang, B. Shoichet, Honglin Li, 2016 .

Targeting Gpr52 lowers mutant HTT levels and rescues Huntington’s disease-associated phenotypes

S. Luo, Youhong Hu, B. Lu, 2018, Brain : a journal of neurology.

Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5H88Y Mutant Mice.

M. Gu, Jianpeng Yin, Shimeng Guo, 2021, Journal of medicinal chemistry.

Physiological oxygen tension reduces hepatocyte dedifferentiation in in vitro culture

Xin Xie, Xinxiu Xu, R. Guo, 2017, Scientific Reports.

Design, synthesis, and biological evaluation of novel piperidine-4-carboxamide derivatives as potent CCR5 inhibitors.

Yongzhou Hu, Xiaowu Dong, Tao Liu, 2014, European journal of medicinal chemistry.

Bicyclo[2.2.1]heptane containing N,N′-diarylsquaramide CXCR2 selective antagonists as anti-cancer metastasis agents

Yongzhou Hu, J. Che, Youhong Hu, 2018, RSC advances.

Structural optimization and biological evaluation of substituted bisphenol A derivatives as beta-amyloid peptide aggregation inhibitors.

Cheng Luo, Zhongjie Liang, Xin Xie, 2010, Journal of medicinal chemistry.

Targeting β2 subunit of Na+/K+-ATPase induces glioblastoma cell apoptosis through elevation of intracellular Ca2.

Xin Xie, Xiuyun Liu, Bin Sun, 2019, American journal of cancer research.

Discovery of a Novel CCR5 Antagonist Lead Compound Through Fragment Assembly

Yu Zhang, Kunqian Yu, Jin Zhu, 2008, Molecules.

The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog

Cizhong Jiang, Lingqiang Zhang, Xin Xie, 2016, Nature Communications.

Discovery of Novel 5,6-Dihydro-1,2,4-triazine Derivatives as Efficacious Glucagon-Like Peptide-1 Receptor Agonists.

Jianhua Shen, Ting Zhao, Shimeng Guo, 2023, Journal of medicinal chemistry.

Synthetic Analogues of Betulinic Acid as Potent Inhibitors of PS1/BACE1 Interaction to Reduce Aβ Generation

F. Nan, Wei Li, G. Pei, 2017 .

Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C.

Xin Xie, Jing Li, Li-li Cui, 2012, Journal of natural products.

Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine.

Shimeng Guo, Yushe Yang, Xin Xie, 2019, Bioorganic & medicinal chemistry letters.

Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles.

Shimeng Guo, Yushe Yang, Xin Xie, 2018, Bioorganic & medicinal chemistry.

Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into β-position to the carboxylic acid.

Nan Hu, Shimeng Guo, Y. Long, 2023, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel 2-methylpiperazine derivatives as potent CCR5 antagonists.

Xiaodong Ma, Tingjun Hou, Tao Liu, 2015, Bioorganic & medicinal chemistry.

Discovery and characterization of novel smallmolecule agonists of G protein-coupled receptor 119

Xin Xie, Jing Li, Shu-yong Zhang, 2014, Acta Pharmacologica Sinica.