Jian Wang

发表

Discovery of pulmonary fibrosis inhibitor targeting TGF-β RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy

Kefei Han, Jiameng Qu, Qing Li, 2020, Journal of pharmaceutical analysis.

Synthesis, structure analysis, antitumor evaluation and 3D-QSAR studies of 3,6-disubstituted-dihydro-1,2,4,5-tetrazine derivatives.

Wei-xiao Hu, Jian Wang, Guo-Wu Rao, 2013, Bioorganic & medicinal chemistry letters.

In vitro evaluation of the anti-digestion and antioxidant effects of grape seed procyanidins according to their degrees of polymerization

Jian Wang, Wei Li, Baoshan Sun, 2018, Journal of Functional Foods.

LC-0882 targets PAK4 and inhibits PAK4-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells.

Dong-mei Zhao, M. Cheng, Jian Wang, 2017, American journal of translational research.

Homology modeling, molecular dynamics and virtual screening of endothelin-A receptor for the treatment of pulmonary arterial hypertension

Han-xun Wang, Jian Wang, Ying Wang, 2020, Journal of biomolecular structure & dynamics.

The design, synthesis and in vitro immunosuppressive evaluation of novel isobenzofuran derivatives.

M. Cheng, Jian Wang, Feng Li, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis, and anti-tumor evaluation of novel symmetrical bis-benzimidazoles.

M. Cheng, Jian Wang, Hong Chen, 2009, European journal of medicinal chemistry.

Computational investigation of TGF-β receptor inhibitors for treatment of idiopathic pulmonary fibrosis: Field-based QSAR model and molecular dynamics simulation

Wei Li, Xue Liu, Jian Wang, 2018, Comput. Biol. Chem..

Advances in the 1-phenanthryl-tetrahydroisoquinoline series of PAK4 inhibitors: potent agents restrain tumor cell growth and invasion.

Xiaodong Li, M. Cheng, Jian Wang, 2016, Organic & biomolecular chemistry.

Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro

Jian Wang, Yue Hou, Ning Li, 2017, Scientific Reports.

Structure prediction and R115866 binding study of human CYP26A1: homology modelling, fold recognition, molecular docking and MD simulations

D. Zhao, M. Cheng, Jian Wang, 2008 .

Transdermal Cubic Phases of Metformin Hydrochloride: In Silico and in Vitro Studies of Delivery Mechanisms.

X. Zhang, P. Ding, Yiguang Jin, 2018, Molecular pharmaceutics.

Molecular mechanism of polymer-assisting supersaturation of poorly water-soluble loratadine based on experimental observations and molecular dynamic simulations

Jin Sun, Zhonggui He, Jian Wang, 2017, Drug Delivery and Translational Research.

Combination of l-Carnitine with Lipophilic Linkage-Donating Gemcitabine Derivatives as Intestinal Novel Organic Cation Transporter 2-Targeting Oral Prodrugs.

Jinhua Dong, Dongyang Zhao, Jin Sun, 2017, Journal of medicinal chemistry.

Dinucleotides docking to scorpion polypeptide toxins: a molecular modeling method for protein functional site recognition.

M. Cheng, Jian Wang, Jun Zhu, 2009, Biochemical and biophysical research communications.

Mechanism study on pH-responsive cyclodextrin capped mesoporous silica: effect of different stalk densities and the type of cyclodextrin

Qinfu Zhao, Donghua Di, Yikun Gao, 2015, Nanotechnology.

A Three‐Dimensional Pharmacophore Model for IMPDH Inhibitors

M. Cheng, Jian Wang, Na Yang, 2011, Chemical biology & drug design.

Synthesis, Antitumor Evaluation and Docking Study of Novel 4‐Anilinoquinazoline Derivatives as Potential Epidermal Growth Factor Receptor (EGFR) Inhibitors

Haibing Li, Jian Wang, Guo-Wu Rao, 2013, ChemMedChem.

Kukoamine B, an amide alkaloid, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro

Qingchun Zhao, Jian Wang, Qiao Zhang, 2015, Neurochemistry International.

Covalently mucoadhesive amphiphilic prodrug of 5-fluorouracil for enhanced permeation and improved oral absorption

Haotian Zhang, Yingli Wang, Dongyang Zhao, 2018, Drug Delivery and Translational Research.

In Silico Design of Human IMPDH Inhibitors Using Pharmacophore Mapping and Molecular Docking Approaches

Mao-Sheng Cheng, Jian Wang, Rui-Juan Li, 2015, Comput. Math. Methods Medicine.

Co-delivery of latanoprost and timolol from micelles-laden contact lenses for the treatment of glaucoma.

Xing Tang, Yu Zhang, Jian Wang, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors.

Ting-jian Zhang, Jian Wang, Mingxing Xue, 2010, European journal of medicinal chemistry.

Structure-based virtual screening of natural products as potential stearoyl-coenzyme a desaturase 1 (SCD1) inhibitors

Tianci Huang, Yuzhou Huang, Jian Wang, 2020, Comput. Biol. Chem..

Structure-based virtual screening and ADME/T-based profiling for low molecular weight chemical starting points as p21-activated kinase 4 inhibitors

M. Cheng, Jian Wang, Kai-Bo Wang, 2015 .

GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways

Dong-mei Zhao, M. Cheng, Jian Wang, 2016, International journal of molecular sciences.

LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells.

M. Cheng, Jian Wang, Q. Guo, 2012, Cancer letters.

Development of 2, 4-diaminoquinazoline derivatives as potent PAK4 inhibitors by the core refinement strategy.

Meng Chen, Xiaodong Li, M. Cheng, 2017, European journal of medicinal chemistry.

Solvent-shift strategy to identify suitable polymers to inhibit humidity-induced solid-state crystallization of lacidipine amorphous solid dispersions.

Donghua Di, Xiao Kuang, Chao Wang, 2016, International journal of pharmaceutics.

NSCA-1-a novel N-substituted coumalamide derivative-increases Adriamycin sensitivity in HepG2/adriamycin cells through modulating Akt/GSK-3β signaling and p53-dependant apoptotic pathway.

Qingchun Zhao, Yongnan Xu, Yanhua Fan, 2017, Environmental toxicology and pharmacology.

Activated toll‐like receptor 4 is involved in oridonin‐induced phagocytosis via promotion of migration and autophagy‐lysosome pathway in RAW264.7 macrophages

T. Ikejima, S. Onodera, S. Tashiro, 2019, International immunopharmacology.

Graphene/Fe3O4 nanocomposite for effective removal of ten triazole fungicides from water solution: Tebuconazole as an example for investigation of the adsorption mechanism by experimental and molecular docking study

Xingjie Guo, Jian Wang, Baichun Hu, 2019, Journal of the Taiwan Institute of Chemical Engineers.

Molecular dynamics investigation of Cl(-) transport through the closed and open states of the 2α12β2γ2 GABA(A) receptor.

M. Cheng, Jian Wang, Yu Sha, 2013, Biophysical chemistry.

3D-QSAR study using CoMFA and CoMSIA methods for a series of histone H3 phosphorylation inhibitors

Jian Wang, Cheng-Hai Hu, Guo-Wu Rao, 2014, Medicinal Chemistry Research.

A Selective Pharmacophore Model for β2-Adrenoceptor Agonists

M. Cheng, Jian Wang, L. Pan, 2009, Molecules.

Synthesis and biological evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one derivatives as acetylcholinesterase inhibitors

Chun Hu, Zhe Jin, Huang-Quan Lin, 2010, Archives of pharmacal research.

Spectroscopic investigations and molecular docking analysis of ML115: A potential molecular probe of the signal transducer and activator of transcription

Jian Wang, Wei Li, Tiemin Sun, 2019, Journal of Molecular Structure.

Identification of ssDNA aptamers specific for anti-neuroexcitation peptide III and molecular modeling studies: Insights into structural interactions

M. Cheng, Jian Wang, Qin Li, 2008, Archives of pharmacal research.

Computational Insight into p21‐Activated Kinase 4 Inhibition: A Combined Ligand‐ and Structure‐Based Approach

Zhen Xu, Jia Li, Jian Wang, 2014, ChemMedChem.

Structure-based virtual screening of influenza virus RNA polymerase inhibitors from natural compounds: Molecular dynamics simulation and MM-GBSA calculation

Ying Wang, Chun Hu, Jian Wang, 2020, Comput. Biol. Chem..

In silico exploration of aryl sulfonamide analogs as voltage-gated sodium channel 1.7 inhibitors by using 3D-QSAR, molecular docking study, and molecular dynamics simulations

Ying Wang, Mingxing Wang, Hailun Jiang, 2018, Comput. Biol. Chem..

Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression

M. Cheng, Jian Wang, Fu Liu, 2009, Cancer biology & therapy.

Targeting PAK1 with the Small Molecule Drug AK963/40708899 Suppresses Gastric Cancer Cell Proliferation and Invasion by Downregulation of PAK1 Activity and PAK1‐Related Signaling Pathways

Dong-mei Zhao, M. Cheng, Jian Wang, 2019, Anatomical record.

Refined pharmacophore features for virtual screening of human thromboxane A2 receptor antagonists

Xinyue Liu, Yiheng Wu, Baichun Hu, 2020, Comput. Biol. Chem..

Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro

Jian Wang, Yue Hou, Ning Li, 2017, Scientific Reports.

Design, Synthesis, Molecular Docking Analysis, and Carbonic Anhydrase IX Inhibitory Evaluations of Novel N-Substituted-β-d-Glucosamine Derivatives that Incorporate Benzenesulfonamides

Zhanfang Fan, M. Cheng, Jian Wang, 2017, Molecules.

Some insights into the binding mechanism of the GABAA receptor: a combined docking and MM-GBSA study

M. Cheng, Jian Wang, Yu Sha, 2013, Journal of Molecular Modeling.

Isolation, structure elucidation, and synthesis of (±)-millpuline A with a suppressive effect in miR-144 expression

Gang Chen, Jian Wang, Ning Li, 2019, Organic Chemistry Frontiers.

Pharmacophore identification of PAK4 inhibitors

M. Cheng, Jian Wang, Feng Li, 2010 .

Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study.

M. Cheng, Jian Wang, Dongmei Zhao, 2017, Bioorganic & medicinal chemistry.

Molecular mechanism of polymer-assisting supersaturation of poorly water-soluble loratadine based on experimental observations and molecular dynamic simulations

Jin Sun, Zhonggui He, Jian Wang, 2017, Drug Delivery and Translational Research.

In Silicon Approach for Discovery of Chemopreventive Agents

M. Cheng, Jian Wang, Wei Li, 2017, Current Pharmacology Reports.

Natural Cancer Chemopreventive Reagents from Food and Herbals

Gang Chen, Jian Wang, Ning Li, 2017, Current Pharmacology Reports.

Structure-based functional site recognition for p21-activated kinase 4

Dong-mei Zhao, M. Cheng, Jian Wang, 2013, Archives of pharmacal research.

Structure-based functional site recognition for p21-activated kinase 4

Jian Wang, M. Cheng, Feng Li, 2013, Archives of Pharmacal Research.

Molecular determinants for ligand binding at Nav1.4 and Nav1.7 channels: Experimental affinity results analyzed by molecular modeling

Ying Wang, Jian Wang, De-Jiang Kong, 2019, Comput. Biol. Chem..

Experimental and theoretical investigations on the tautomerism of 1-phenyl-2-thiobarbituric acid and its methylation reaction

W. Shi, M. Cheng, Jian Wang, 2013 .

Molecular dynamics simulations of HIV‐1 protease monomer: Assembly of N‐terminus and C‐terminus into β‐sheet in water solution

M. Cheng, Jian Wang, Yu Sha, 2008, Proteins.