E. Stewart

发表

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

T. Willson, M. Lambert, K. Pearce, 2002, Cell.

Selection, application, and validation of a set of molecular descriptors for nuclear receptor ligands.

T. Willson, P. Brown, E. Stewart, 2004, Combinatorial chemistry & high throughput screening.

Biological and Structural Characterization of Rotamers of C-C Chemokine Receptor Type 5 (CCR5) Inhibitor GSK214096.

W. Kazmierski, E. Stewart, R. Ferris, 2014, ACS medicinal chemistry letters.

Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes.

M. Lambert, I. McLay, Shawn P. Williams, 2004, Journal of medicinal chemistry.

X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.

I. McLay, L. Shewchuk, A. Hassell, 2008, Journal of medicinal chemistry.

A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta.

L. Moore, M. Lambert, G. B. Wisely, 2002, Journal of medicinal chemistry.

Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Liping Wang, R. Nolte, E. Stewart, 2012, Journal of medicinal chemistry.

Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists.

C. M. Yates, I. Uings, E. Stewart, 2010, Journal of medicinal chemistry.

The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist.

I. McLay, Shawn P. Williams, I. Uings, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

R. Hamatake, Z. Hong, Shawn P. Williams, 2014, Journal of medicinal chemistry.

Ab Initio and Molecular Mechanics Calculations on the Inversion of Cs to C2 Conformations of 1,3-Cycloheptadiene

N. L. Allinger, J. P. Bowen, E. Stewart, 1994 .

Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

David Frederick, Andrea Nuzzo, D. Sévin, 2020, Skeletal muscle.

The evolution of progesterone receptor ligands

Shawn P. Williams, E. Stewart, K. Madauss, 2007, Medicinal research reviews.

Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38.

J. D. Stuart, L. Shewchuk, B. Shearer, 2015, Journal of medicinal chemistry.

2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships.

J. D. Stuart, B. Henke, B. Shearer, 2018, Bioorganic & medicinal chemistry.

2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor.

D. Drewry, B. Henke, R. Wiethe, 2001, Bioorganic & medicinal chemistry letters.

Discovery of tertiary sulfonamides as potent liver X receptor antagonists.

Paul R Reid, Timothy M Willson, William J Zuercher, 2010, Journal of medicinal chemistry.

Molecular modeling studies of some choline acetyltransferase inhibitors.

G. McGaughey, J. P. Bowen, M. Kontoyianni, 1994, Journal of medicinal chemistry.

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors.

J. D. Stuart, W. Harrington, B. Henke, 2015, Journal of medicinal chemistry.

Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists.

Shawn P. Williams, S. Thompson, E. Stewart, 2005, Bioorganic & medicinal chemistry letters.

Molecular mechanics studies of ketene derivatives and related structures

J. P. Bowen, E. Stewart, 1992 .

Ab initio and molecular mechanics (MM2 and MM3) calculations of nonconjugated positively charged nitrogen‐containing compounds

J. Phillip Bowen, Eugene L. Stewart, Georgia B. McGaughey, 1995, J. Comput. Chem..

Computer‐Assisted Molecular Modeling: Indispensable Tools for Molecular Pharmacology

Dora Schnur, Maria Kontoyianni, Peter C. Fox, 1993, Journal of clinical pharmacology.

Novel secondary mutations C56S and G149A confer resistance to HIV‐1 integrase strand transfer inhibitors

T. Seki, T. Miyamoto, T. Fujiwara, 2018, Antiviral research.

Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance.

Bin He, E. Wilson, R. Gampe, 2004, Molecular cell.

A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157.

L. Shewchuk, E. Stewart, D. J. Porter, 2014, Archives of biochemistry and biophysics.

Integrase Inhibitor Resistance Mechanisms and Structural Characteristics in Antiretroviral Therapy-Experienced, Integrase Inhibitor-Naive Adults with HIV-1 Infection Treated with Dolutegravir plus Two Nucleoside Reverse Transcriptase Inhibitors in the DAWNING Study

Keith Nangle, Kimberly Smith, M. Aboud, 2021, Antimicrobial agents and chemotherapy.

A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor*[boxs]

Timothy M Willson, Shawn P Williams, Kenneth H Pearce, 2005, Journal of Biological Chemistry.

A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.

Shawn P Williams, N. Laping, Shawn P. Williams, 2007, Molecular endocrinology.

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines.

D. Drewry, R. Wiethe, E. Stewart, 2006, Bioorganic & medicinal chemistry letters.

Structure and function of the glucocorticoid receptor ligand binding domain.

K. Pearce, R. Bledsoe, E. Stewart, 2004, Vitamins and hormones.

The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.

Paul N. Mortenson, D. J. Price, L. Shewchuk, 2020, Bioorganic & medicinal chemistry.

Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.

Angela Smallwood, Ping Wang, Timothy M Willson, 2008, Journal of medicinal chemistry.

Design and synthesis of an array of selective androgen receptor modulators.

T. Willson, M. Caivano, D. W. Gray, 2007, Journal of combinatorial chemistry.

Ab initio and molecular mechanics (MM2 and MM3) calculations of positively charged conjugated nitrogen‐containing compounds

G. McGaughey, J. Bowen, E. Stewart, 1996 .

AB INITIO AND MOLECULAR MECHANICS (MM3) CALCULATIONS ON PROPARGYL ALCOHOL AND DERIVATIVES

J. P. Bowen, E. Stewart, U. Mazurek, 1996 .

Improving the developability profile of pyrrolidine progesterone receptor partial agonists.

C. Duraiswami, N. Laping, Shawn P. Williams, 2010, Bioorganic & medicinal chemistry letters.

The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.

I. E. Smith, Paul N. Mortenson, D. J. Price, 2019, Bioorganic & medicinal chemistry.

Hartree−Fock and Møller−Plesset (MP2) Treatment of Oxygen-Containing Phosphorus Compounds

J. P. Bowen, E. Stewart, N. Nevins, 1997 .

Ab initio calculations with electronic correlation (MP2) on the nucleic acid bases and their methyl derivatives

N. L. Allinger, J. P. Bowen, E. Stewart, 1994 .