K. Foreman

发表

Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.

A. Moretto, D. Joseph-McCarthy, T. Mansour, 2007, Journal of medicinal chemistry.

Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors.

N. Gibson, K. Foreman, Hanqing Dong, 2008, Bioorganic & medicinal chemistry.

Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR.

D. Werner, P. Gokhale, E. May, 2010, ACS medicinal chemistry letters.

Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase

F. Barany, D. Werner, S. Giardina, 2018, ACS medicinal chemistry letters.

Substrate-dependent modulation of the leukotriene A4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation

Ezra M. Chung, M. Paige, S. Noble, 2022, Scientific Reports.

Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction.

T. Rush, L. Mosyak, Yuanhong Li, 2004, Bioorganic & medicinal chemistry letters.

A general model for predicting the binding affinity of reversibly and irreversibly dimerized ligands

K. Foreman, 2017, PloS one.

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.

A. Moretto, D. Joseph-McCarthy, D. P. Wilson, 2006, Bioorganic & medicinal chemistry.

Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction.

T. Rush, L. Mosyak, S. Haney, 2004, Bioorganic & medicinal chemistry.

Small‐molecule inhibition and activation‐loop trans‐phosphorylation of the IGF1 receptor

S. Hubbard, W. Miller, B. Craddock, 2008, The EMBO journal.

1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors.

M. Cox, Qinghua Weng, D. Werner, 2007, Bioorganic & medicinal chemistry letters.

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.

N. Gibson, L. Arnold, K. Foreman, 2009, Future medicinal chemistry.

Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3

S. Emtage, Mark A. Brown, L. Arnold, 2011, PloS one.

Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

F. Barany, Jutta Wanner, D. Werner, 2015, PloS one.

C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis

Haley O. Tucker, Mark A. Brown, K. Foreman, 2015, Oncotarget.

Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase.

F. Barany, D. Werner, S. Giardina, 2020, Journal of medicinal chemistry.

Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics.

P. Gokhale, D. Epstein, E. May, 2013, ACS medicinal chemistry letters.

Automated Architecture Search for Brain-inspired Hyperdimensional Computing

M. Paige, K. Foreman, Lei Yang, 2022, ArXiv.

Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy.

P. Gokhale, K. Foreman, Hanqing Dong, 2011, Bioorganic & medicinal chemistry letters.

Binding of Venezuelan Equine Encephalitis Virus Inhibitors to Importin-α Receptors Explored with All-Atom Replica Exchange Molecular Dynamics.

Bryan M. Delfing, K. Kehn-Hall, D. Klimov, 2023, The journal of physical chemistry. B.

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.

J. Alvarez, T. Rush, L. Mosyak, 2003, Organic & biomolecular chemistry.

Can Free Energy Perturbation Simulations Coupled with Replica-Exchange Molecular Dynamics Study Ligands with Distributed Binding Sites?

Bryan M. Delfing, K. Kehn-Hall, D. Klimov, 2023, J. Chem. Inf. Model..

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.

N. Gibson, L. Arnold, K. Foreman, 2009, Future medicinal chemistry.