K. Sarma

发表

Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors

B. Graves, A. Kuglstatter, M. Stahl, 2011, Journal of medicinal chemistry.

Physicochemical Properties of the Nucleoside Prodrug R1626 Leading to High Oral Bioavailability

Michael Brandl, Micaela B. Reddy, Xiaoyang Wu, 2008 .

Synthesis of Rovafovir Etalafenamide (Part III): Evolution of the Synthetic Process to the Phosphonamidate Fragment

S. Mohan, O. Lapina, K. Sarma, 2021 .

The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture*

R. Devos, J. Symons, N. Cammack, 2006, Journal of Biological Chemistry.

Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.

Wen Jiang, R. Devos, J. Symons, 2007, Bioorganic & medicinal chemistry letters.

Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis.

A. Kuglstatter, D. Davis, Jaehyeon Park, 2015, Journal of medicinal chemistry.

Aminolysis of oxime ethers in protic and aprotic solvents

Anurag Kumar, A. Jain, K. Sarma, 1989 .

Stabilization energy of polyenyl radicals: all-trans-nonatetraenyl radical by thermal rearrangement of a semirigid {4-1-2} heptaene. Model for thermal lability of .beta.-carotene

K. Sarma, W. Doering, 1992 .

Synthesis of Rovafovir Etalafenamide (Part IV): Evolution of the Synthetic Process to the Fluorinated Nucleoside Fragment

O. Lapina, Sura Ha, K. Sarma, 2021 .

Diphenyl Ether Non‐Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties

Y. Li, D. Stefanidis, N. Arora, 2009, ChemMedChem.

Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold.

A. Kuglstatter, D. Davis, R. Kondru, 2015, Bioorganic & medicinal chemistry letters.

Development of a Scalable Synthesis of a Bruton’s Tyrosine Kinase Inhibitor via C–N and C–C Bond Couplings as an End Game Strategy

E. O'brien, K. Sarma, J. P. Davidson, 2014 .

Perturbation of the Degenerate, Concerted Cope Rearrangement by Two Phenyl Groups in Active Positions of (E)-1,4-Diphenylhexa-1,5-diene. Acceleration by High Pressure as Criterion of Cyclic Transition States

K. Sarma, J. Teles, W. Doering, 1994 .

Synthesis of Rovafovir Etalafenamide (Part II): Dynamic Control for Successful Scale-Up of an Oxygen-Releasing Elimination Reaction Mediated by Oxone

K. Sarma, B. J. Roberts, D. Bringley, 2021 .

Design and Characterization of R1626, A Prodrug of the HCV Replication Inhibitor R1479 (4′-Azidocytidine) With Enhanced Oral Bioavailability

G. Dore, Xiaoyang Wu, D. Shaw, 2007 .

LDDI 34(07).book(LDDI_A_283794.fm)

Xiaoyang Wu, M. Reddy, K. Sarma, 2008 .

Kinetic studies and micellar effect on the aminolys is of certain o-aryl oximes

A. Jain, K. Sarma, V. K. Velu, 1988 .

Kinetics of n-propylaminolysis of some oxime ethers in 1:1 aqueous acetonitrile

A. Jain, K. Sarma, V. K. Velu, 1987 .

Process Development and Scale-up of a Selective α1-Adrenoceptor Antagonist

K. Sarma, T. J. Connolly, M. Matchett, 2005 .

Synthesis of Rovafovir Etalafenamide (Part I): Active Pharmaceutical Ingredient Process Development, Scale-Up, and Impurity Control Strategy

O. Lapina, K. Sarma, A. Ambrosi, 2021 .

Isolation and identification of ester impurities in RG7128, an HCV polymerase inhibitor.

Fujun Li, K. Sarma, Yanzhou Liu, 2010, Journal of pharmaceutical and biomedical analysis.

Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs.

H. V. Van Wart, N. Dewdney, H. Arzeno, 2003, Bioorganic & Medicinal Chemistry Letters.