J. O'brien

发表

Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity.

W. Schleif, J. Quintero, J. Nunberg, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Discovery, Optimization, and Biological Characterization of 2,3,6‐Trisubstituted Pyridine‐Containing M4 Positive Allosteric Modulators

Scott T. Harrison, J. Uslaner, Sean M. Smith, 2019, ChemMedChem.

Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

W. M. Sanders, T. Tucker, M. Goldman, 1994, Journal of Medicinal Chemistry.

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

P Jeffrey Conn, Craig W Lindsley, Tsing-Bau Chen, 2003, Molecular pharmacology.

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

A. Dilella, T. Mcdonald, J. Hess, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

P Jeffrey Conn, Craig W Lindsley, J. Huff, 2004, Journal of medicinal chemistry.

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C. Lindsley, P. Conn, M. Jacobson, 2004 .

A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain

P Jeffrey Conn, Craig W Lindsley, C. Lindsley, 2004, Journal of Pharmacology and Experimental Therapeutics.

Quinoxapeptins: novel chromodepsipeptide inhibitors of HIV-1 and HIV-2 reverse transcriptase. I. The producing organism and biological activity.

Russell, Zink, Suzanne, 1996, The Journal of antibiotics.

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target

Sarah L. Huszar, J. Uslaner, T. Tucker, 2014, Neuropharmacology.

Progress in the development of oxytocin antagonists for use in preterm labor.

B. E. Evans, M. Bock, D. Reiss, 1995, Advances in experimental medicine and biology.

Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells.

J. Jasper, J. O'brien, D. Pettibone, 1995, Life sciences.

L-696,229 specifically inhibits human immunodeficiency virus type 1 reverse transcriptase and possesses antiviral activity in vitro

W. Schleif, J. Quintero, E. Emini, 1992, Antimicrobial Agents and Chemotherapy.

Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist.

T. Hayama, J. O'brien, S. Ozaki, 1999, The Journal of pharmacology and experimental therapeutics.

Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology.

J. Renger, P. Coleman, A. Gotter, 2016, Bioorganic & medicinal chemistry letters.

A rapid bioassay for the determination of non-nucleoside HIV-1 reverse transcriptase inhibitor plasma levels.

S. Smith, M. Goldman, J. O'brien, 1993, Life sciences.

Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.

Sarah L. Huszar, J. Uslaner, M. Jacobson, 2016, Bioorganic & medicinal chemistry letters.

A novel radioligand for glycine transporter 1: characterization and use in autoradiographic and in vivo brain occupancy studies.

C. Lindsley, J. O'brien, M. Wallace, 2008, Nuclear medicine and biology.

Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.

J. Renger, P. Coleman, A. Gotter, 2015, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant.

J. Renger, P. Coleman, A. Gotter, 2014, Bioorganic & medicinal chemistry letters.

Pharmacology of L-744,453, a novel nonpeptidyl endothelin antagonist.

W. Greenlee, D. Veber, P. Chakravarty, 1996, Life sciences.

Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides.

C. Lindsley, M. Jacobson, G. Hartman, 2006, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and In Vivo Efficacy of Glycine Transporter‐1 (GlyT1) Inhibitors Derived from a Series of [4‐Phenyl‐1‐(propylsulfonyl)piperidin‐4‐yl]methyl Benzamides

R. Chang, Tsing-bau Chen, C. Lindsley, 2006, ChemMedChem.

Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.

B. Ma, C. Lindsley, M. Jacobson, 2009, Bioorganic & medicinal chemistry letters.

2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.

Christopher M Thomas, J. Nunberg, W. S. Saari, 1991, Journal of medicinal chemistry.

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

E A Emini, K., W. Schleif, 1991, Journal of virology.

Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

C. Lindsley, P. Conn, M. Jacobson, 2007, Bioorganic & medicinal chemistry letters.

A nonpeptide oxytocin receptor antagonist radioligand highly selective for human receptors.

R. Freidinger, D. Dean, J. O'brien, 2002, European journal of pharmacology.

5‐Chloro‐3‐(phenylsulfonyl)indole‐2‐carboxamide: A Novel, Non‐ Nucleoside Inhibitor of HIV‐1 Reverse Transcriptase.

W. Greenlee, P. Anderson, T. Ciccarone, 1994 .

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.

Leo A. Joyce, Sarah L. Huszar, J. Uslaner, 2016, ACS medicinal chemistry letters.

3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts.

Sarah L. Huszar, J. Uslaner, C. Culberson, 2010, Bioorganic & medicinal chemistry letters.

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

M. Rudd, T. Mcdonald, S. Stachel, 2021, Nature Communications.

2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptase

W. Schleif, J. Huff, J. O'brien, 1995 .

Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor.

Sarah L. Huszar, J. Uslaner, M. Jacobson, 2010, ACS medicinal chemistry letters.

A nonnucleoside reverse transcriptase inhibitor active on human immunodeficiency virus type 1 isolates resistant to related inhibitors

J. Condra, W. Schleif, E. Emini, 1993, Antimicrobial Agents and Chemotherapy.

A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

C. Lindsley, P. Conn, M. Jacobson, 2005, Journal of Pharmacology and Experimental Therapeutics.

The M1 Muscarinic Receptor Allosteric Agonists AC-42 and 1-[1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one Bind to a Unique Site Distinct from the Acetylcholine Orthosteric Site

M. Jacobson, J. O'brien, Constantine Kreatsoulas, 2010, Molecular Pharmacology.

Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues.

Christopher M Thomas, J. Hoffman, J. Wai, 1992, Journal of medicinal chemistry.

Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.

C. Lindsley, M. Jacobson, G. Hartman, 2009, Bioorganic & medicinal chemistry letters.

L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

P. Anderson, W. Schleif, E. Emini, 1995, Antimicrobial agents and chemotherapy.

Synthesis of a Series of 4-(Arylethynyl)-6-chloro-4-cyclopropyl-3,4- dihydroquinazolin-2(1H)-ones as Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.

W. M. Sanders, P. Anderson, W. Schleif, 1994 .

Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models.

J. Uslaner, V. Uebele, J. O'brien, 2020, Bioorganic & medicinal chemistry letters.

Metabolism of 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2 (1H)-one (L-696,229), an HIV-1 reverse transcriptase inhibitor, by rat liver slices and in humans.

T. Olah, B. Arison, S. Varga, 1994, Drug metabolism and disposition: the biological fate of chemicals.