J. Chern

发表

Design, synthesis, and anti-HCV activity of thiourea compounds.

Y. Chao, T. Hsu, Iou-Jiun Kang, 2009, Bioorganic & medicinal chemistry letters.

A Novel Dengue Virus Inhibitor, BP13944, Discovered by High-Throughput Screening with Dengue Virus Replicon Cells Selects for Resistance in the Viral NS2B/NS3 Protease

A. Yueh, Szu-Huei Wu, Shiow-Ju Lee, 2013, Antimicrobial Agents and Chemotherapy.

Novel Dengue Virus-Specific NS2B/NS3 Protease Inhibitor, BP2109, Discovered by a High-Throughput Screening Assay

A. Yueh, Y. Chao, Szu-Huei Wu, 2010, Antimicrobial Agents and Chemotherapy.

Synthesis and antipicornavirus activity of (R)- and (S)-1-[5-(4'-chlorobiphenyl-4-yloxy)-3-methylpentyl]-3-pyridin-4-yl-imidazolidin-2-one.

S. Shih, Iou-Jiun Kang, Chung-Chi Lee, 2005, Bioorganic & medicinal chemistry letters.

Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidines: a novel class of potent enterovirus inhibitors.

S. Shih, T. Hsu, Kak‐Shan Shia, 2004, Bioorganic & medicinal chemistry letters.

Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors.

A. Yueh, Y. Chao, T. Yeh, 2010, Bioorganic & medicinal chemistry.

Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors.

A. Yueh, Y. Chao, T. Hsu, 2009, Bioorganic & medicinal chemistry letters.

Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors.

A. Yueh, Y. Chao, T. Hsu, 2009, Bioorganic & medicinal chemistry letters.

Mutagenesis of Dengue Virus Protein NS2A Revealed a Novel Domain Responsible for Virus-Induced Cytopathic Effect and Interactions between NS2A and NS2B Transmembrane Segments

A. Yueh, Su-Ying Wu, Jian-Sung Wu, 2017, Journal of Virology.

A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus.

C. Chen, A. Yueh, Y. Chao, 2019, European journal of medicinal chemistry.

A Potent, Selective, and Orally Bioavailable HCV NS5A Inhibitor for Treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazol-2-yl)pyrrolidine-2-carboxamide.

A. Yueh, Y. Chao, Jen‐Shin Song, 2017, Journal of medicinal chemistry.

BPR0C261 is a novel orally active antitumor agent with antimitotic and anti‐angiogenic activities

Chi-Hung Lin, C. Chen, Y. Chao, 2011, Cancer science.

Modulation of microglial immune responses by a novel thiourea derivative.

Pei-Chien Hsu, F. Shie, Iou-Jiun Kang, 2010, Chemico-biological interactions.

Development of robust genotype 1a hepatitis C replicons harboring adaptive mutations for facilitating the antiviral drug discovery and study of virus replication.

A. Yueh, Han-Shu Hu, J. Chern, 2018, Journal of virological methods.

Resistance Studies of a Dithiazol Analogue, DBPR110, as a Potential Hepatitis C Virus NS5A Inhibitor in Replicon Systems

A. Yueh, Y. Chao, Su-Ying Wu, 2012, Antimicrobial Agents and Chemotherapy.

Antiviral activity of pyridyl imidazolidinones against enterovirus 71 variants.

Hwan-You Chang, Peng-Nien Huang, S. Shih, 2008, Journal of biomedical science.

Synthesis of 4-oxo- and 4-anti-formyl-8,10,12,13-tetraoxapentacyclo-[5.5.1.02,6.03,11.05,9]tridecanes

J. Chern, H. Wu, 1997 .

Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors

J. Horng, Hui‐Ming Yu, Y. Chan, 2020, Emerging microbes & infections.

Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma.

Y. Chao, Shiow-Ju Lee, Iou-Jiun Kang, 2008, Bioorganic & medicinal chemistry letters.

Novel Antiviral Agent DTriP-22 Targets RNA-Dependent RNA Polymerase of Enterovirus 71

J. Hsu, Hwan-You Chang, S. Shih, 2009, Antimicrobial Agents and Chemotherapy.

Design, synthesis, and antipicornavirus activity of 1-[5-(4-arylphenoxy)alkyl]-3-pyridin-4-ylimidazolidin-2-one derivatives.

Ying-Ting Lin, S. Shih, Chung-Chi Lee, 2005, Journal of medicinal chemistry.

Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors.

A. Yueh, Y. Chao, S. Shih, 2011, Bioorganic & medicinal chemistry letters.

SYNTHESIS OF DIACETAL TRIOXA-CAGE COMPOUNDS VIA A SEQUENTIAL CYCLIZATION REACTION OF NORBORNENE DERIVATIVES INDUCED BY ELECTROPHILES

J. Chern, H. Wu, Hui-Chang Lin, 1997 .

Chemical transformation of tetraacetal tetraoxa-cages to aza-cages and amido-cages mediated by iodotrimethylsilane and the combination of chlorotrimethylsilane and sodium iodide in nitriles

J. Chern, H. Wu, 1998 .

Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitors.

Chia-Liang Tai, Yen-Chun Lee, Shin-Ru Shih, 2002, Journal of medicinal chemistry.

Synthesis and antienteroviral activity of a series of novel, oxime ether-containing pyridyl imidazolidinones.

Chia-Liang Tai, Yen-Chun Lee, Ying-Ting Lin, 2004, Bioorganic & medicinal chemistry letters.

A novel one-pot conversion of tetraacetal tetraoxa-cages to aza-cages mediated by iodotrimethylsilane in acetonitrile

J. Chern, H. Wu, 1997 .

A novel hydride rearrangement of the acetal group of tetraacetal tetraoxa-cages mediated by Lewis acids

J. Chern, H. Wu, 1997 .

Design, Synthesis, and Structure—Activity Relationships of Pyrazolo[3,4‐d]pyrimidines: A Novel Class of Potent Enterovirus Inhibitors.

S. Shih, T. Hsu, Kak‐Shan Shia, 2004 .

Mutation in Enterovirus 71 Capsid Protein VP1 Confers Resistance to the Inhibitory Effects of Pyridyl Imidazolidinone

Y. Chao, Guang-Wu Chen, S. Shih, 2004, Antimicrobial Agents and Chemotherapy.

A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses.

C. Chen, A. Yueh, Szu-Huei Wu, 2019, Antiviral research.

Antitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer

J. Chern, Yong-Yi Wu, Zih-Ning Huang, 2011, Investigational New Drugs.

Stimulatory actions of a novel thiourea derivative on large‐conductance, calcium‐activated potassium channels

Sheng-Nan Wu, F. Shie, J. Chern, 2017, Journal of cellular physiology.

Synthesis and in vitro cytotoxicity of 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives.

Ying-Ting Lin, Chung-Ming Chang, Kak‐Shan Shia, 2004, Bioorganic & medicinal chemistry letters.

Chemistry of cage-shaped hydrocarbons. Reactions of pentacyclo[6.6.0.02,6.03,13.010,14]tetradecane-4,11-diene

Kuan-Jiuh Lin, J. Chern, T. J. Chow, 1998 .

Chemistry of cage-shaped hydrocarbons. Ring transformations on a tricyclo[5.2.1.04,10]decane system

Kuan-Jiuh Lin, J. Chern, T. J. Chow, 1999 .

Chemical Transformations of 4,6‐Dimethyl‐2β‐hydroxy‐8‐oxo‐3,5,7‐trioxatetracyclo[7.2.1.04,11.06,10]dodecane

J. Chern, H. Wu, 1997 .

Synthesis of Tetraacetal Tetraoxa‐Cage Compounds with Alkyl Substituents at Different Sites of the Oxa‐Cage Skeleton

Chung-Yi Wu, J. Chern, H. Wu, 1996 .

In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71.

C. Chiu, J. Horng, S. Shih, 2016, The Journal of antimicrobial chemotherapy.

Resistance Analysis and Characterization of a Thiazole Analogue, BP008, as a Potent Hepatitis C Virus NS5A Inhibitor

A. Yueh, Y. Chao, T. Yeh, 2011, Antimicrobial Agents and Chemotherapy.

Ozonolysis of 2-endo-7-anti-diacylnorbornenes. A new entry for the synthesis of 2,4,6,13-tetraoxapentacyclo[5.5.1.03,11.05,9.08,12]tridecanes

Chung-Yi Wu, J. Chern, H. Wu, 1997 .